The desmosomal plaque proteins of the plakophilin family.

Plakophilin-associated RNA-binding proteins in prostate cancer and their implications in tumor progression and metastasis. Virchows Arch (2013) 0.79

Aberrantly methylated PKP1 in the progression of Barrett's esophagus to esophageal adenocarcinoma. Genes Chromosomes Cancer (2011) 0.79

Characterizing the Molecular Pathology of Arrhythmogenic Cardiomyopathy in Patient Buccal Mucosa Cells. Circ Arrhythm Electrophysiol (2016) 0.78

Multiple regulatory variants located in cell type-specific enhancers within the PKP2 locus form major risk and protective haplotypes for canine atopic dermatitis in German shepherd dogs. BMC Genet (2016) 0.78

Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins. Mol Cell Biol (2014) 0.76

Desmosomal defects in acantholytic squamous cell carcinomas. J Cutan Pathol (2014) 0.75

Comparison of cellular location and expression of Plakophilin-2 in epidermal cells from nonlesional atopic skin and healthy skin in German shepherd dogs. Vet Dermatol (2017) 0.75

Junctional complexes in various epithelia. J Cell Biol (1963) 31.83

RNA granules: post-transcriptional and epigenetic modulators of gene expression. Nat Rev Mol Cell Biol (2009) 4.57

Wnt signaling: is the party in the nucleus? Genes Dev (2006) 4.10

Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy. Nat Genet (2004) 3.88

Balancing cell adhesion and Wnt signaling, the key role of beta-catenin. Curr Opin Genet Dev (2005) 3.79

SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell-cell junctions. Nucleic Acids Res (2005) 3.41

Desmoplakin is essential in epidermal sheet formation. Nat Cell Biol (2001) 3.31

Suppression of canonical Wnt/beta-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy. J Clin Invest (2006) 3.22

Connexin43 remodeling caused by inhibition of plakophilin-2 expression in cardiac cells. Circ Res (2007) 3.16

Desmosomes: new perspectives on a classic. J Invest Dermatol (2007) 2.78

Evidence of apoptosis in arrhythmogenic right ventricular dysplasia. N Engl J Med (1996) 2.37

Protein kinase C and the regulation of the actin cytoskeleton. Cell Signal (2005) 2.35

The amino-terminal domain of desmoplakin binds to plakoglobin and clusters desmosomal cadherin-plakoglobin complexes. J Cell Biol (1997) 1.93

Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation. J Cell Biol (2004) 1.92

Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling. J Biol Chem (2002) 1.84

Plakophilins 2a and 2b: constitutive proteins of dual location in the karyoplasm and the desmosomal plaque. J Cell Biol (1996) 1.80

Defining the interactions between intermediate filaments and desmosomes. J Cell Biol (1998) 1.78

Mutations in the plakophilin 1 gene result in ectodermal dysplasia/skin fragility syndrome. Nat Genet (1997) 1.68

The armadillo family of structural proteins. Int Rev Cytol (1999) 1.56

Desmosomes: a role in cancer? Br J Cancer (2007) 1.55

The desmosome and pemphigus. Histochem Cell Biol (2008) 1.54

Desmosomes and cytoskeletal architecture in epithelial differentiation: cell type-specific plaque components and intermediate filament anchorage. Eur J Cell Biol (1994) 1.53

Compound heterozygosity for new splice site mutations in the plakophilin 1 gene (PKP1) in a Chinese case of ectodermal dysplasia-skin fragility syndrome. Acta Derm Venereol (2005) 1.53

Shaping mitochondria: The complex posttranslational regulation of the mitochondrial fission protein DRP1. IUBMB Life (2008) 1.52

Structure and function of desmosomes. Int Rev Cytol (2007) 1.51

Cell type-specific desmosomal plaque proteins of the plakoglobin family: plakophilin 1 (band 6 protein). Differentiation (1994) 1.51

Plakophilins: Multifunctional proteins or just regulators of desmosomal adhesion? Biochim Biophys Acta (2006) 1.49

Plakophilin 2: a critical scaffold for PKC alpha that regulates intercellular junction assembly. J Cell Biol (2008) 1.47

The control of peroxisome number and size during division and proliferation. Curr Opin Cell Biol (2005) 1.45

Identification of a basic protein of Mr 75,000 as an accessory desmosomal plaque protein in stratified and complex epithelia. J Cell Biol (1988) 1.43

The p120 family of cell adhesion molecules. Eur J Cell Biol (2005) 1.41

Genetic diseases of junctions. J Invest Dermatol (2007) 1.38

Defining desmosomal plakophilin-3 interactions. J Cell Biol (2003) 1.36

The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression. FEBS Lett (2007) 1.36

Dancing in and out of the nucleus: p120(ctn) and the transcription factor Kaiso. Biochim Biophys Acta (2006) 1.36

Plakophilins 1a and 1b: widespread nuclear proteins recruited in specific epithelial cells as desmosomal plaque components. Cell Tissue Res (1997) 1.33

Discriminating roles of desmosomal cadherins: beyond desmosomal adhesion. J Dermatol Sci (2006) 1.32

Identification of the junctional plaque protein plakophilin 3 in cytoplasmic particles containing RNA-binding proteins and the recruitment of plakophilins 1 and 3 to stress granules. Mol Biol Cell (2006) 1.23

The head domain of plakophilin-1 binds to desmoplakin and enhances its recruitment to desmosomes. Implications for cutaneous disease. J Biol Chem (1999) 1.21

The function of plakophilin 1 in desmosome assembly and actin filament organization. J Cell Biol (2000) 1.20

Arrhythmogenic right ventricular cardiomyopathy/dysplasia: a not so rare "disease of the desmosome" with multiple clinical presentations. Clin Res Cardiol (2009) 1.20

Plakophilin 3--a novel cell-type-specific desmosomal plaque protein. Differentiation (1999) 1.19

Plakophilin 3 oncogene as prognostic marker and therapeutic target for lung cancer. Cancer Res (2005) 1.18

Lack of plakophilin 1 increases keratinocyte migration and reduces desmosome stability. J Cell Sci (2003) 1.16

Nuclear particles containing RNA polymerase III complexes associated with the junctional plaque protein plakophilin 2. Proc Natl Acad Sci U S A (2001) 1.14

Plakophilins: multifunctional scaffolds for adhesion and signaling. Curr Opin Cell Biol (2009) 1.13

Plakophilin 1 interferes with plakoglobin binding to desmoplakin, yet together with plakoglobin promotes clustering of desmosomal plaque complexes at cell-cell borders. J Cell Sci (2001) 1.13

Structure of the armadillo repeat domain of plakophilin 1. J Mol Biol (2004) 1.10

Plakophilin-3, a novel armadillo-like protein present in nuclei and desmosomes of epithelial cells. J Cell Sci (1999) 1.10

Desmosomal plakophilin 2 as a differentiation marker in normal and malignant tissues. Differentiation (1999) 1.06

The fate of desmosomal proteins in apoptotic cells. J Biol Chem (2001) 1.04

Alterations in desmosome size and number coincide with the loss of keratinocyte cohesion in skin with homozygous and heterozygous defects in the desmosomal protein plakophilin 1. J Invest Dermatol (2003) 1.04

The junctions that don't fit the scheme: special symmetrical cell-cell junctions of their own kind. Cell Tissue Res (2009) 1.03

Plakophilins--hard work in the desmosome, recreation in the nucleus? Eur J Cell Biol (2005) 1.02

The distribution of the desmosomal protein, plakophilin 1, in human skin and skin tumors. J Invest Dermatol (1997) 1.02

Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate. EMBO J (2003) 1.01

Immunohistochemical localization of plakophilins (PKP1, PKP2, PKP3, and p0071) in primary oropharyngeal tumors: correlation with clinical parameters. Hum Pathol (2003) 1.01

Myocyte transdifferentiation: a possible pathogenetic mechanism for arrhythmogenic right ventricular cardiomyopathy. Arch Pathol Lab Med (2000) 1.01

Mechanisms of gap junction traffic in health and disease. J Cardiovasc Pharmacol (2009) 1.00

Ectodermal dysplasia-skin fragility syndrome resulting from a new homozygous mutation, 888delC, in the desmosomal protein plakophilin 1. J Am Acad Dermatol (2006) 0.96

Carboxyl terminus of Plakophilin-1 recruits it to plasma membrane, whereas amino terminus recruits desmoplakin and promotes desmosome assembly. J Biol Chem (2006) 0.96

Decreased plakophilin-1 expression promotes increased motility in head and neck squamous cell carcinoma cells. Cell Commun Adhes (2007) 0.95

Differential expression of desmosomal plakophilins in various types of carcinomas: correlation with cell type and differentiation. Hum Pathol (2006) 0.94

Genotype-phenotype correlation in skin fragility-ectodermal dysplasia syndrome resulting from mutations in plakophilin 1. Exp Dermatol (2002) 0.93

Novel truncating mutations in PKP1 and DSP cause similar skin phenotypes in two Brazilian families. Br J Dermatol (2008) 0.93

Plakophilin-3-deficient mice develop hair coat abnormalities and are prone to cutaneous inflammation. J Invest Dermatol (2007) 0.93

Genomic amplification of the human plakophilin 1 gene and detection of a new mutation in ectodermal dysplasia/skin fragility syndrome. J Invest Dermatol (2000) 0.91

Homozygous splice site mutations in PKP1 result in loss of epidermal plakophilin 1 expression and underlie ectodermal dysplasia/skin fragility syndrome in two consanguineous families. J Invest Dermatol (2004) 0.89

Plakophilin, armadillo repeats, and nuclear localization. Microsc Res Tech (1999) 0.87

Desmosomal cell adhesion in mammalian development. Eur J Cell Biol (2005) 0.87

Cryptic splicing at a non-consensus splice-donor in a patient with a novel mutation in the plakophilin-1 gene. J Invest Dermatol (2004) 0.86

Desmosomal interactome in keratinocytes: a systems biology approach leading to an understanding of the pathogenesis of skin disease. Cell Mol Life Sci (2009) 0.78

A novel genodermatosis caused by mutations in plakophilin 1, a structural component of desmosomes. J Dermatol (1999) 0.76

The ubiquitin-specific protease USP28 is required for MYC stability. Nat Cell Biol (2007) 3.63

Common adult stem cells in the human breast give rise to glandular and myoepithelial cell lineages: a new cell biological concept. Lab Invest (2002) 2.33

Deregulated MYC expression induces dependence upon AMPK-related kinase 5. Nature (2012) 1.88

An unexpected role for keratin 10 end domains in susceptibility to skin cancer. J Cell Sci (2006) 1.64

Usual ductal hyperplasia of the breast is a committed stem (progenitor) cell lesion distinct from atypical ductal hyperplasia and ductal carcinoma in situ. J Pathol (2002) 1.56

Effectiveness of radiochemotherapy on lymph node metastases in patients with stage IV oropharyngeal cancer. Oral Oncol (2004) 1.42

Loss of desmoglein 2 suggests essential functions for early embryonic development and proliferation of embryonal stem cells. Eur J Cell Biol (2002) 1.33

Deregulation of tumor angiogenesis and blockade of tumor growth in PPARbeta-deficient mice. EMBO J (2007) 1.24

Octreotide versus octreotide plus interferon-alpha in endocrine gastroenteropancreatic tumors: a randomized trial. Clin Gastroenterol Hepatol (2005) 1.23

Her-2/neu gene amplification and protein expression in primary male breast cancer. Breast Cancer Res Treat (2004) 1.23

p16INK4a is a prognostic marker in resected ductal pancreatic cancer: an analysis of p16INK4a, p53, MDM2, an Rb. Ann Surg (2002) 1.17

Loss of desmocollin 3 in mice leads to epidermal blistering. J Cell Sci (2008) 1.16

CD34+ fibrocytes, alpha-smooth muscle antigen-positive myofibroblasts, and CD117 expression in the stroma of invasive squamous cell carcinomas of the oral cavity, pharynx, and larynx. Virchows Arch (2004) 1.15

Tight junction-related structures in the absence of a lumen: occludin, claudins and tight junction plaque proteins in densely packed cell formations of stratified epithelia and squamous cell carcinomas. Eur J Cell Biol (2003) 1.13

Human Merkel cells--aspects of cell biology, distribution and functions. Eur J Cell Biol (2005) 1.13

Assessment of splice variant-specific functions of desmocollin 1 in the skin. Mol Cell Biol (2004) 1.12

In vivo function of desmosomes. J Dermatol (2004) 1.12

CD34+ fibrocytes in invasive ductal carcinoma, ductal carcinoma in situ, and benign breast lesions. Virchows Arch (2001) 1.09

Desmocollin 3 is required for pre-implantation development of the mouse embryo. J Cell Sci (2006) 1.08

Detection of the human organic anion transporters SLC21A6 (OATP2) and SLC21A8 (OATP8) in liver and hepatocellular carcinoma. Lab Invest (2003) 1.07

Epidermal detachment, desmosomal dissociation, and destabilization of corneodesmosin in Spink5-/- mice. Genes Dev (2004) 1.06

The sentinel node concept in head and neck cancer: solution for the controversies in the N0 neck? Head Neck (2004) 1.05

Localization of FOXP3-positive cells in renal cell carcinoma. Tumour Biol (2011) 1.05

Mice expressing a mutant Krt75 (K6hf) allele develop hair and nail defects resembling pachyonychia congenita. J Invest Dermatol (2007) 1.02

Expression of keratins in cutaneous epithelial tumors and related disorders--distribution and clinical significance. Exp Dermatol (2011) 1.02

Stromal remodeling and SPARC (secreted protein acid rich in cysteine) expression in invasive ductal carcinomas of the breast. Virchows Arch (2005) 0.98

Lin9, a subunit of the mammalian DREAM complex, is essential for embryonic development, for survival of adult mice, and for tumor suppression. Mol Cell Biol (2010) 0.97

CD34+ fibrocytes in neoplastic and inflammatory pancreatic lesions. Virchows Arch (2002) 0.97

Alternative splicing of TGF-betas and their high-affinity receptors T beta RI, T beta RII and T beta RIII (betaglycan) reveal new variants in human prostatic cells. BMC Genomics (2007) 0.96

Human intronic enhancers control distinct sub-domains of Gli3 expression during mouse CNS and limb development. BMC Dev Biol (2010) 0.95

Identification of a stem cell candidate in the normal human prostate gland. Eur J Cell Biol (2005) 0.95

Desmosomes: just cell adhesion or is there more? Cell Adh Migr (2007) 0.94

Differential expression of desmosomal plakophilins in various types of carcinomas: correlation with cell type and differentiation. Hum Pathol (2006) 0.94

Growth of transgenic RAF-induced lung adenomas is increased in mice with a disrupted PPARbeta/delta gene. Int J Oncol (2007) 0.93

Endothelial and virgultar cell formations in the mammalian lymph node sinus: endothelial differentiation morphotypes characterized by a special kind of junction (complexus adhaerens). Cell Tissue Res (2008) 0.92

Direct and indirect roles for β-catenin in facultative basal progenitor cell differentiation. Am J Physiol Lung Cell Mol Physiol (2012) 0.91

Cystadenocarcinoma of the gallbladder. J Hepatobiliary Pancreat Surg (2006) 0.90

CD34(+) fibrocytes in normal cervical stroma, cervical intraepithelial neoplasia III, and invasive squamous cell carcinoma of the cervix uteri. Virchows Arch (2002) 0.90

Loss of Desmocollin 3 in skin tumor development and progression. Mol Carcinog (2011) 0.89

IL-24 is expressed by rat and human macrophages. Immunobiology (2002) 0.89

Downregulation of HMGA2 by the pan-deacetylase inhibitor panobinostat is dependent on hsa-let-7b expression in liver cancer cell lines. Exp Cell Res (2012) 0.89

The complexus adhaerens of mammalian lymphatic endothelia revisited: a junction even more complex than hitherto thought. Cell Tissue Res (2005) 0.88

Desmosomal cell adhesion in mammalian development. Eur J Cell Biol (2005) 0.87

Intermediate-filament expression in ocular tissue. Prog Retin Eye Res (2002) 0.87

Gross cystic disease fluid protein 15 (GCDFP-15) expression in breast cancer subtypes. BMC Cancer (2014) 0.86

Urothelial umbrella cells of human ureter are heterogeneous with respect to their uroplakin composition: different degrees of urothelial maturity in ureter and bladder? Eur J Cell Biol (2005) 0.86

CD34+ fibrocytes in chronic cystitis and noninvasive and invasive urothelial carcinomas of the urinary bladder. Virchows Arch (2007) 0.86

Mature cystic teratoma of the ovary with struma and benign Brenner tumor: a case report with immunohistochemical characterization. Int J Gynecol Pathol (2002) 0.83

Imatinib-associated pulmonary alveolar proteinosis. Am J Med (2003) 0.82

Recurrent Johanson-Blizzard syndrome in a triplet pregnancy complicated by urethral obstruction sequence: a clinical, molecular, and immunohistochemical approach. Pediatr Dev Pathol (2011) 0.82

Mouse models for blistering skin disorders. Dermatol Res Pract (2010) 0.81

Epidermal growth factor-induced modulation of cytokeratin expression levels influences the morphological phenotype of head and neck squamous cell carcinoma cells. Cell Tissue Res (2012) 0.81

Comparative genomic hybridization analysis on male breast cancer. Int J Cancer (2006) 0.81

Integrating animal models and in vitro tissue models to elucidate the role of desmosomal proteins in diseases. Cell Commun Adhes (2014) 0.81

Plakoglobin as a regulator of desmocollin gene expression. J Invest Dermatol (2013) 0.81

An adult passive transfer mouse model to study desmoglein 3 signaling in pemphigus vulgaris. J Invest Dermatol (2011) 0.81

Is Warthin's tumour of the parotid gland a lymph node disease? Histopathology (2011) 0.81

Genetic pathways and new progression markers for prostate cancer suggested by microsatellite allelotyping. Clin Cancer Res (2004) 0.80

Cis-regulatory underpinnings of human GLI3 expression in embryonic craniofacial structures and internal organs. Dev Growth Differ (2013) 0.80

Images in cardiovascular medicine. Unusual manifestation of Libman-Sacks endocarditis in systemic lupus erythematosus. Circulation (2003) 0.78

CD34+ fibrocytes in tubular carcinomas and radial scars of the breast. Virchows Arch (2003) 0.78

Systematic analysis and validation of differential gene expression in ovarian serous adenocarcinomas and normal ovary. J Cancer Res Clin Oncol (2012) 0.77

A novel kind of tumor type-characteristic junction: plakophilin-2 as a major protein of adherens junctions in cardiac myxomata. Mod Pathol (2010) 0.77

β-Catenin signaling: no relevance in Hodgkin lymphoma? Leuk Lymphoma (2011) 0.77

Role of ventriculoperitoneal shunt valve design in the treatment of pediatric hydrocephalus--a single center study of valve performance in the clinical setting. Childs Nerv Syst (2013) 0.77

Desmosomes and desmosomal cadherin function in skin and heart diseases-advancements in basic and clinical research. Dermatol Res Pract (2010) 0.76

Loss of Chromosome 18 in Neuroendocrine Tumors of the Small Intestine: The Enigma Remains. Neuroendocrinology (2016) 0.76

Value of sentinel lymphadenectomy in head and neck cancer. Ann Surg Oncol (2004) 0.75

Desmosomal defects in acantholytic squamous cell carcinomas. J Cutan Pathol (2014) 0.75

Images in cardiovascular medicine. Phenotype of infiltrating T lymphocytes in cardiac sarcoidosis. Circulation (2002) 0.75

Genetic pathways and new progression markers for prostate cancer defined by microsatellite allelotyping. Urologe A (2004) 0.75

Arrhythmogenic right ventricular cardiomyopathy as lethal complication factor after cardiac surgery. Herz (2009) 0.75

An alternative promoter of the human plakophilin-3 gene controls the expression of the new isoform PKP3b. Cell Tissue Res (2013) 0.75

Image of the month. Behind the curtain of pericardial tamponade: cardiac hemangioendotheliosarcoma. Herz (2009) 0.75

c-Src mediated tyrosine phosphorylation of plakophilin 3 as a new mechanism to control desmosome composition in cells exposed to oxidative stress. Cell Tissue Res (2014) 0.75