Blocking Scn10a channels in heart reduces late sodium current and is antiarrhythmic.

PubWeight™: 2.61‹?› | Rank: Top 1%

🔗 View Article (PMC 3412150)

Published in Circ Res on June 20, 2012

Authors

Tao Yang1, Thomas C Atack, Dina Myers Stroud, Wei Zhang, Lynn Hall, Dan M Roden

Author Affiliations

1: Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

Articles citing this

Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk. Circulation (2013) 2.06

Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death. Nat Genet (2013) 1.86

Screening for acute IKr block is insufficient to detect torsades de pointes liability: role of late sodium current. Circulation (2014) 1.86

Mutations in SCN10A are responsible for a large fraction of cases of Brugada syndrome. J Am Coll Cardiol (2014) 1.82

Role of common and rare variants in SCN10A: results from the Brugada syndrome QRS locus gene discovery collaborative study. Cardiovasc Res (2015) 1.61

Late sodium current: A mechanism for angina, heart failure, and arrhythmia. Trends Cardiovasc Med (2015) 1.44

A common genetic variant within SCN10A modulates cardiac SCN5A expression. J Clin Invest (2014) 1.17

Post-translational modifications of the cardiac Na channel: contribution of CaMKII-dependent phosphorylation to acquired arrhythmias. Am J Physiol Heart Circ Physiol (2013) 1.00

A novel mechanism for the treatment of angina, arrhythmias, and diastolic dysfunction: inhibition of late I(Na) using ranolazine. J Cardiovasc Pharmacol (2009) 0.97

Genetics of atrial fibrillation: from families to genomes. J Hum Genet (2015) 0.96

Cardiac sodium channel mutations: why so many phenotypes? Nat Rev Cardiol (2014) 0.96

SCN10A/Nav1.8 modulation of peak and late sodium currents in patients with early onset atrial fibrillation. Cardiovasc Res (2014) 0.96

Voltage-gated sodium channels: biophysics, pharmacology, and related channelopathies. Front Pharmacol (2012) 0.94

Dynamics of the late Na(+) current during cardiac action potential and its contribution to afterdepolarizations. J Mol Cell Cardiol (2013) 0.94

Common and rare variants in SCN10A modulate the risk of atrial fibrillation. Circ Cardiovasc Genet (2015) 0.90

CrossTalk proposal: The late sodium current is an important player in the development of diastolic heart failure (heart failure with a preserved ejection fraction). J Physiol (2014) 0.90

Common SCN10A variants modulate PR interval and heart rate response during atrial fibrillation. Europace (2013) 0.89

Na+ channel function, regulation, structure, trafficking and sequestration. J Physiol (2015) 0.88

Targeting the late component of the cardiac L-type Ca2+ current to suppress early afterdepolarizations. J Gen Physiol (2015) 0.88

Whither art thou, SCN10A, and what art thou doing? Circ Res (2012) 0.87

Brugada Syndrome: Clinical, Genetic, Molecular, Cellular, and Ionic Aspects. Curr Probl Cardiol (2015) 0.86

CaMKII Phosphorylation of Na(V)1.5: Novel in Vitro Sites Identified by Mass Spectrometry and Reduced S516 Phosphorylation in Human Heart Failure. J Proteome Res (2015) 0.85

Quantifying the origins of population variability in cardiac electrical activity through sensitivity analysis of the electrocardiogram. J Physiol (2013) 0.85

Voltage-gated sodium channels in the mammalian heart. Glob Cardiol Sci Pract (2014) 0.85

Nav1.7 and other voltage-gated sodium channels as drug targets for pain relief. Expert Opin Ther Targets (2016) 0.84

Proarrhythmic and Torsadogenic Effects of Potassium Channel Blockers in Patients. Card Electrophysiol Clin (2016) 0.82

Improved understanding of the pathophysiology of atrial fibrillation through the lens of discrete pathological pathways. Glob Cardiol Sci Pract (2014) 0.80

The late Na+ current--origin and pathophysiological relevance. Cardiovasc Drugs Ther (2013) 0.80

Cardiac ion channels. Channels (Austin) (2015) 0.80

A web portal for in-silico action potential predictions. J Pharmacol Toxicol Methods (2015) 0.79

Nav-igating through a complex landscape: SCN10A and cardiac conduction. J Clin Invest (2014) 0.79

Cellular hyper-excitability caused by mutations that alter the activation process of voltage-gated sodium channels. Front Physiol (2015) 0.78

Cardiac ablation of Rheb1 reduces sodium currents in infant mice. Int J Clin Exp Med (2014) 0.78

Voltage-gated sodium channels and cancer: is excitability their primary role? Front Pharmacol (2015) 0.78

The Brugada Syndrome: A Rare Arrhythmia Disorder with Complex Inheritance. Front Cardiovasc Med (2016) 0.78

Recent genetic discoveries implicating ion channels in human cardiovascular diseases. Curr Opin Pharmacol (2013) 0.77

Late Sodium Current in Human Atrial Cardiomyocytes from Patients in Sinus Rhythm and Atrial Fibrillation. PLoS One (2015) 0.76

Novel Therapeutic Strategies for the Management of Ventricular Arrhythmias Associated with the Brugada Syndrome. Expert Opin Orphan Drugs (2015) 0.76

Brugada syndrome risk loci seem protective against atrial fibrillation. Eur J Hum Genet (2014) 0.76

Atrial Fibrillation and SCN5A Variants. Card Electrophysiol Clin (2014) 0.76

The Role of Pharmacogenetics in Atrial Fibrillation Therapeutics: Is Personalized Therapy in Sight? J Cardiovasc Pharmacol (2016) 0.76

Treat the Patient, Not Just the Cell! Circ Res (2017) 0.75

Neuronal Nav1.8 Channels as a Novel Therapeutic Target of Acute Atrial Fibrillation Prevention. J Am Heart Assoc (2016) 0.75

Letter to the editor on NaV1.8. Circ Res (2012) 0.75

Deletion of PDK1 causes cardiac sodium current reduction in mice. PLoS One (2015) 0.75

Enhanced cardiac TBC1D10C expression lowers heart rate and enhances exercise capacity and survival. Sci Rep (2016) 0.75

Contrasting Nav1.8 Activity in Scn10a-/- Ventricular Myocytes and the Intact Heart. J Am Heart Assoc (2016) 0.75

The Use of Non-Variant Sites to Improve the Clinical Assessment of Whole-Genome Sequence Data. PLoS One (2015) 0.75

A SCN10A SNP biases human pain sensitivity. Mol Pain (2016) 0.75

Tetrodotoxin-sensitive α-subunits of voltage-gated sodium channels are relevant for inhibition of cardiac sodium currents by local anesthetics. Naunyn Schmiedebergs Arch Pharmacol (2016) 0.75

Deleterious Protein-altering Mutations in the SCN10A Voltage-gated Sodium Channel Gene are Associated with Prolonged QT. Clin Genet (2017) 0.75

Dynamics of sodium current mediated early afterdepolarizations. Heliyon (2017) 0.75

Articles cited by this

Genomewide association studies and assessment of the risk of disease. N Engl J Med (2010) 11.51

Preliminary report: effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction. The Cardiac Arrhythmia Suppression Trial (CAST) Investigators. N Engl J Med (1989) 9.08

The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways. Nat Neurosci (1999) 4.35

Genome-wide association study of PR interval. Nat Genet (2010) 3.73

The M cell: its contribution to the ECG and to normal and abnormal electrical function of the heart. J Cardiovasc Electrophysiol (1999) 3.57

Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nat Genet (2010) 3.55

Identification of genomic predictors of atrioventricular conduction: using electronic medical records as a tool for genome science. Circulation (2010) 3.35

Several common variants modulate heart rate, PR interval and QRS duration. Nat Genet (2010) 3.34

Effect of ranolazine, an antianginal agent with novel electrophysiological properties, on the incidence of arrhythmias in patients with non ST-segment elevation acute coronary syndrome: results from the Metabolic Efficiency With Ranolazine for Less Ischemia in Non ST-Elevation Acute Coronary Syndrome Thrombolysis in Myocardial Infarction 36 (MERLIN-TIMI 36) randomized controlled trial. Circulation (2007) 2.64

A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat. Proc Natl Acad Sci U S A (2007) 2.60

Effects of ranolazine on recurrent cardiovascular events in patients with non-ST-elevation acute coronary syndromes: the MERLIN-TIMI 36 randomized trial. JAMA (2007) 2.57

An unexpected role for brain-type sodium channels in coupling of cell surface depolarization to contraction in the heart. Proc Natl Acad Sci U S A (2002) 2.48

Abrupt rate accelerations or premature beats cause life-threatening arrhythmias in mice with long-QT3 syndrome. Nat Med (2001) 2.46

Genetic variation in SCN10A influences cardiac conduction. Nat Genet (2010) 2.30

Larger late sodium conductance in M cells contributes to electrical heterogeneity in canine ventricle. Am J Physiol Heart Circ Physiol (2001) 2.27

Distinct subcellular localization of different sodium channel alpha and beta subunits in single ventricular myocytes from mouse heart. Circulation (2004) 2.15

Effect of tetrodotoxin on action potentials of the conducting system in the dog heart. Am J Physiol (1979) 2.07

Electrophysiologial and beta-receptor blocking effects of MJ 1999 on dog and rabbit cardiac tissue. Circ Res (1970) 1.96

Antiarrhythmic effects of ranolazine in a guinea pig in vitro model of long-QT syndrome. J Pharmacol Exp Ther (2004) 1.88

Phenotypical manifestations of mutations in the genes encoding subunits of the cardiac sodium channel. Circ Res (2011) 1.51

Pathophysiology and pharmacology of the cardiac "late sodium current.". Pharmacol Ther (2008) 1.50

Late sodium current in the node of Ranvier. Pflugers Arch (1975) 1.47

Action potential prolongation and induction of abnormal automaticity by low quinidine concentrations in canine Purkinje fibers. Relationship to potassium and cycle length. Circ Res (1985) 1.39

Striking In vivo phenotype of a disease-associated human SCN5A mutation producing minimal changes in vitro. Circulation (2011) 1.38

Preferential block of late sodium current in the LQT3 DeltaKPQ mutant by the class I(C) antiarrhythmic flecainide. Mol Pharmacol (2000) 1.36

Slow inactivation of a tetrodotoxin-sensitive current in canine cardiac Purkinje fibers. Biophys J (1984) 1.36

Slow inactivation of the sodium current in rabbit cardiac Purkinje fibres. Pflugers Arch (1987) 1.30

Late na(+) current inhibition by ranolazine reduces torsades de pointes in the chronic atrioventricular block dog model. J Am Coll Cardiol (2010) 1.26

Localisation of SCN10A gene product Na(v)1.8 and novel pain-related ion channels in human heart. Int Heart J (2011) 1.10

Cloning and characterization of a mouse sensory neuron tetrodotoxin-resistant voltage-gated sodium channel gene, Scn10a. Genomics (1997) 1.08

A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal root ganglia, hPN3/SCN10A. Pain (1998) 1.07

Ranolazine selectively blocks persistent current evoked by epilepsy-associated Naν1.1 mutations. Br J Pharmacol (2010) 1.00

Sodium channel (dys)function and cardiac arrhythmias. Cardiovasc Ther (2010) 0.97

Effects of ranolazine on wild-type and mutant hNav1.7 channels and on DRG neuron excitability. Mol Pain (2010) 0.97

Vinpocetine is a potent blocker of rat NaV1.8 tetrodotoxin-resistant sodium channels. J Pharmacol Exp Ther (2003) 0.96

Tetrodotoxin-resistant voltage-gated sodium channels Na(v)1.8 and Na(v)1.9 are expressed in the retina. J Comp Neurol (2008) 0.95

Recombinase-mediated cassette exchange to rapidly and efficiently generate mice with human cardiac sodium channels. Genesis (2006) 0.93

A multi PDZ-domain protein Pdzd2 contributes to functional expression of sensory neuron-specific sodium channel Na(V)1.8. Mol Cell Neurosci (2009) 0.89

Use-dependent block of Na+ currents by mexiletine at the single channel level in guinea-pig ventricular myocytes. Br J Pharmacol (1993) 0.89

Further characterization of the effects of imipramine on plateau membrane currents in guinea-pig ventricular myocytes. Naunyn Schmiedebergs Arch Pharmacol (1991) 0.86

Atrial-selective sodium channel block strategy to suppress atrial fibrillation: ranolazine versus propafenone. J Pharmacol Exp Ther (2011) 0.86

Ranolazine block of human Na v 1.4 sodium channels and paramyotonia congenita mutants. Channels (Austin) (2011) 0.83

Articles by these authors

A point-charge force field for molecular mechanics simulations of proteins based on condensed-phase quantum mechanical calculations. J Comput Chem (2003) 15.88

Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell (2006) 15.16

Integrated genomic characterization of endometrial carcinoma. Nature (2013) 14.29

The somatic genomic landscape of glioblastoma. Cell (2013) 11.73

Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS. PLoS Genet (2010) 10.75

The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis. BMC Public Health (2009) 9.79

The eMERGE Network: a consortium of biorepositories linked to electronic medical records data for conducting genomic studies. BMC Med Genomics (2011) 9.20

Structure of dengue virus: implications for flavivirus organization, maturation, and fusion. Cell (2002) 9.13

Effect of PCI on quality of life in patients with stable coronary disease. N Engl J Med (2008) 7.75

HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein. Cell Host Microbe (2007) 7.34

Genetic determinants of response to warfarin during initial anticoagulation. N Engl J Med (2008) 7.13

Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. J Clin Invest (2009) 7.09

PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations. Bioinformatics (2010) 7.07

Probabilistic Boolean Networks: a rule-based uncertainty model for gene regulatory networks. Bioinformatics (2002) 6.90

Association of BRCA1 and BRCA2 mutations with survival, chemotherapy sensitivity, and gene mutator phenotype in patients with ovarian cancer. JAMA (2011) 6.81

Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record. Am J Hum Genet (2010) 6.44

Pten regulates neuronal arborization and social interaction in mice. Neuron (2006) 6.11

SCAN: SNP and copy number annotation. Bioinformatics (2009) 5.96

ACC/AHA/ESC 2006 Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (writing committee to develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death): developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Circulation (2006) 5.95

ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death). J Am Coll Cardiol (2006) 5.81

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. N Engl J Med (2015) 5.71

Inactivating mutations in NPC1L1 and protection from coronary heart disease. N Engl J Med (2014) 4.94

Implementing genomic medicine in the clinic: the future is here. Genet Med (2013) 4.89

Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data. Nat Biotechnol (2013) 4.85

The four-herb Chinese medicine PHY906 reduces chemotherapy-induced gastrointestinal toxicity. Sci Transl Med (2010) 4.78

Sequence and analysis of rice chromosome 4. Nature (2002) 4.39

The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future. Genet Med (2013) 4.37

A genome-wide approach to identify genetic variants that contribute to etoposide-induced cytotoxicity. Proc Natl Acad Sci U S A (2007) 4.35

Concern Calmodulin kinase II and arrhythmias in a mouse model of cardiac hypertrophy. Circulation (2002) 4.16

Casq2 deletion causes sarcoplasmic reticulum volume increase, premature Ca2+ release, and catecholaminergic polymorphic ventricular tachycardia. J Clin Invest (2006) 4.06

A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose. Blood (2008) 4.02

Common variants in KCNN3 are associated with lone atrial fibrillation. Nat Genet (2010) 3.97

A rare variant in MYH6 is associated with high risk of sick sinus syndrome. Nat Genet (2011) 3.94

Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease. N Engl J Med (2016) 3.88

Stargazin modulates AMPA receptor gating and trafficking by distinct domains. Nature (2005) 3.88

Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells. Cancer Cell (2008) 3.87

Structure of the immature dengue virus at low pH primes proteolytic maturation. Science (2008) 3.86

Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome- and phenome-wide studies. Am J Hum Genet (2011) 3.85

Principles of human subjects protections applied in an opt-out, de-identified biobank. Clin Transl Sci (2010) 3.84

Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Nat Genet (2012) 3.71

Variation in virulence among clades of Escherichia coli O157:H7 associated with disease outbreaks. Proc Natl Acad Sci U S A (2008) 3.69

Imaging of amyloid beta in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: proof of mechanism. Lancet Neurol (2008) 3.67

Conformational changes of the flavivirus E glycoprotein. Structure (2004) 3.66

Shell-isolated nanoparticle-enhanced Raman spectroscopy. Nature (2010) 3.64

A missense mutation in KIT kinase domain 1 correlates with imatinib resistance in gastrointestinal stromal tumors. Cancer Res (2004) 3.63

Structures of immature flavivirus particles. EMBO J (2003) 3.62

Genetic architecture of transcript-level variation in humans. Am J Hum Genet (2008) 3.36

Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans. Nat Med (2009) 3.35

Identification of genomic predictors of atrioventricular conduction: using electronic medical records as a tool for genome science. Circulation (2010) 3.35

Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor. Nature (2013) 3.27

Relation of hospital volume to colostomy rates and survival for patients with rectal cancer. J Natl Cancer Inst (2003) 3.21

Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study. Lancet (2013) 3.21

ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death) developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Europace (2006) 3.11

Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. Nat Genet (2010) 3.02

Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26. Nature (2013) 3.00

Allelic variants in long-QT disease genes in patients with drug-associated torsades de pointes. Circulation (2002) 2.98

Precise segmental renal artery clamping under the guidance of dual-source computed tomography angiography during laparoscopic partial nephrectomy. Eur Urol (2012) 2.95

Sudden cardiac death prediction and prevention: report from a National Heart, Lung, and Blood Institute and Heart Rhythm Society Workshop. Circulation (2010) 2.94

High expression of macrophage colony-stimulating factor in peritumoral liver tissue is associated with poor survival after curative resection of hepatocellular carcinoma. J Clin Oncol (2008) 2.92

Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice. J Neurosci (2009) 2.90

Endobronchial ultrasound-guided transbronchial needle aspiration for staging of lung cancer: a systematic review and meta-analysis. Eur J Cancer (2009) 2.85

Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines. PLoS One (2009) 2.79

KCNH2-K897T is a genetic modifier of latent congenital long-QT syndrome. Circulation (2005) 2.78

Metabolic syndrome and risk of development of atrial fibrillation: the Niigata preventive medicine study. Circulation (2008) 2.72

Common sodium channel promoter haplotype in asian subjects underlies variability in cardiac conduction. Circulation (2006) 2.72

GTPase activation of elongation factor EF-Tu by the ribosome during decoding. EMBO J (2009) 2.71

Nitrogen fixation island and rhizosphere competence traits in the genome of root-associated Pseudomonas stutzeri A1501. Proc Natl Acad Sci U S A (2008) 2.70

Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism. J Cell Biol (2006) 2.68

Quantized anomalous Hall effect in magnetic topological insulators. Science (2010) 2.67

The mechanical behaviors of polytetrafluorethylene/Al/W energetic composites. J Phys Condens Matter (2009) 2.64

Polymorphism modulates symptomatic response to antiarrhythmic drug therapy in patients with lone atrial fibrillation. Heart Rhythm (2007) 2.62

Faster STORM using compressed sensing. Nat Methods (2012) 2.61

Trends in prevalence, awareness, management, and control of hypertension among United States adults, 1999 to 2010. J Am Coll Cardiol (2012) 2.57

CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer. Genome Res (2013) 2.57

Circulating plasma MiR-141 is a novel biomarker for metastatic colon cancer and predicts poor prognosis. PLoS One (2011) 2.57

Cardiac sodium channel (SCN5A) variants associated with atrial fibrillation. Circulation (2008) 2.56

Drug-induced long QT syndrome. Pharmacol Rev (2010) 2.55

Sodium channel β1 subunit mutations associated with Brugada syndrome and cardiac conduction disease in humans. J Clin Invest (2008) 2.54

ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death--executive summary: A report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death) Developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Eur Heart J (2006) 2.54

Preclinical properties of 18F-AV-45: a PET agent for Abeta plaques in the brain. J Nucl Med (2009) 2.51

Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. Circulation (2010) 2.49

Structural variation in two human genomes mapped at single-nucleotide resolution by whole genome de novo assembly. Nat Biotechnol (2011) 2.45

Systematic review and meta-analysis of circulatory disease from exposure to low-level ionizing radiation and estimates of potential population mortality risks. Environ Health Perspect (2012) 2.42

Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. J Am Coll Cardiol (2010) 2.41

Defining the cellular phenotype of "ankyrin-B syndrome" variants: human ANK2 variants associated with clinical phenotypes display a spectrum of activities in cardiomyocytes. Circulation (2007) 2.38

Highly accurate two-gene classifier for differentiating gastrointestinal stromal tumors and leiomyosarcomas. Proc Natl Acad Sci U S A (2007) 2.38

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature (2012) 2.36

Integrated analyses identify a master microRNA regulatory network for the mesenchymal subtype in serous ovarian cancer. Cancer Cell (2013) 2.34

Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses. Science (2013) 2.34

The SCF/Slimb ubiquitin ligase limits centrosome amplification through degradation of SAK/PLK4. Curr Biol (2008) 2.33

Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges. Nat Rev Drug Discov (2007) 2.32

[(18)F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease. Alzheimers Dement (2013) 2.31

Unmasking of brugada syndrome by lithium. Circulation (2005) 2.30

Clinical characteristics of 26 human cases of highly pathogenic avian influenza A (H5N1) virus infection in China. PLoS One (2008) 2.28

Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage cardiomyopathy. Circulation (2003) 2.28

In silico microdissection of microarray data from heterogeneous cell populations. BMC Bioinformatics (2005) 2.26

Transjugular intrahepatic portosystemic shunt for Budd-Chiari syndrome: techniques, indications and results on 51 Chinese patients from a single centre. Liver Int (2013) 2.22

Enhanced fluorescence emission from quantum dots on a photonic crystal surface. Nat Nanotechnol (2007) 2.18