Published in Mol Immunol on August 06, 2007
Granule Associated Serine Proteases of Hematopoietic Cells - An Analysis of Their Appearance and Diversification during Vertebrate Evolution. PLoS One (2015) 1.41
Mast cells regulate homeostatic intestinal epithelial migration and barrier function by a chymase/Mcpt4-dependent mechanism. Proc Natl Acad Sci U S A (2009) 1.34
Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice. J Clin Invest (2011) 1.16
The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells. J Clin Invest (2012) 1.13
The extended cleavage specificity of human thrombin. PLoS One (2012) 0.99
Mast cell chymase degrades the alarmins heat shock protein 70, biglycan, HMGB1, and interleukin-33 (IL-33) and limits danger-induced inflammation. J Biol Chem (2013) 0.97
The inflammatory response after an epidermal burn depends on the activities of mouse mast cell proteases 4 and 5. J Immunol (2010) 0.95
The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis. Am J Pathol (2012) 0.92
Development of mast cells and importance of their tryptase and chymase serine proteases in inflammation and wound healing. Adv Immunol (2014) 0.90
Dual targets for mouse mast cell protease-4 in mediating tissue damage in experimental bullous pemphigoid. J Biol Chem (2011) 0.86
Guinea pig chymase is leucine-specific: a novel example of functional plasticity in the chymase/granzyme family of serine peptidases. J Biol Chem (2008) 0.86
Potential effector and immunoregulatory functions of mast cells in mucosal immunity. Mucosal Immunol (2015) 0.86
Generation of a new congenic mouse strain with enhanced chymase expression in mast cells. PLoS One (2013) 0.83
The anti-allergic compound tranilast attenuates inflammation and inhibits bone destruction in collagen-induced arthritis in mice. Br J Pharmacol (2010) 0.82
Chymase-mediated intestinal epithelial permeability is regulated by a protease-activating receptor/matrix metalloproteinase-2-dependent mechanism. Am J Physiol Gastrointest Liver Physiol (2013) 0.81
Chymase inhibition as a pharmacological target: a role in inflammatory and functional gastrointestinal disorders? Br J Pharmacol (2012) 0.78
Mutations in Arg143 and Lys192 of the Human Mast Cell Chymase Markedly Affect the Activity of Five Potent Human Chymase Inhibitors. PLoS One (2013) 0.76
Pivotal role of mouse mast cell protease 4 in the conversion and pressor properties of Big-endothelin-1. J Pharmacol Exp Ther (2013) 0.76
Proteome analysis of mast cell releasates reveals a role for chymase in the regulation of coagulation factor XIIIA levels via proteolytic degradation. J Allergy Clin Immunol (2016) 0.75
Asp-ase Activity of the Opossum Granzyme B Supports the Role of Granzyme B as Part of Anti-Viral Immunity Already during Early Mammalian Evolution. PLoS One (2016) 0.75
Significant Contribution of Mouse Mast Cell Protease 4 in Early Phases of Experimental Autoimmune Encephalomyelitis. Mediators Inflamm (2016) 0.75
IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction. Proc Natl Acad Sci U S A (2016) 0.75
KRAB zinc finger proteins: an analysis of the molecular mechanisms governing their increase in numbers and complexity during evolution. Mol Biol Evol (2002) 2.27
Lyn kinase controls basophil GATA-3 transcription factor expression and induction of Th2 cell differentiation. Immunity (2009) 1.17
Loss of histochemical identity in mast cells lacking carboxypeptidase A. Mol Cell Biol (2005) 1.09
Serglycin proteoglycan is required for secretory granule integrity in mucosal mast cells. Biochem J (2007) 1.03
The extended cleavage specificity of human thrombin. PLoS One (2012) 0.99
Mast cell chymase degrades the alarmins heat shock protein 70, biglycan, HMGB1, and interleukin-33 (IL-33) and limits danger-induced inflammation. J Biol Chem (2013) 0.97
Rapid lineage-specific diversification of the mast cell chymase locus during mammalian evolution. Immunogenetics (2006) 0.97
Extended substrate specificity of rat mast cell protease 5, a rodent alpha-chymase with elastase-like primary specificity. J Biol Chem (2003) 0.95
Expansion of the mast cell chymase locus over the past 200 million years of mammalian evolution. Immunogenetics (2006) 0.95
Vaccination against the extra domain-B of fibronectin as a novel tumor therapy. FASEB J (2010) 0.92
The extended substrate specificity of the human mast cell chymase reveals a serine protease with well-defined substrate recognition profile. Int Immunol (2008) 0.92
Altered storage of proteases in mast cells from mice lacking heparin: a possible role for heparin in carboxypeptidase A processing. Biol Chem (2002) 0.91
Rat mast cell protease 4 is a beta-chymase with unusually stringent substrate recognition profile. J Biol Chem (2002) 0.91
Evolution of the major histocompatibility complex: Isolation of class II beta cDNAs from two monotremes, the platypus and the short-beaked echidna. Immunogenetics (2003) 0.90
Generation of therapeutic antibody responses against IgE through vaccination. FASEB J (2002) 0.90
Heavy chain V region diversity in the duck-billed platypus (Ornithorhynchus anatinus): long and highly variable complementarity-determining region 3 compensates for limited germline diversity. J Immunol (2002) 0.89
Expression profile of novel members of the rat mast cell protease (rMCP)-2 and (rMCP)-8 families, and functional analyses of mouse mast cell protease (mMCP)-8. Immunogenetics (2007) 0.89
A recombinant vaccine effectively induces c5a-specific neutralizing antibodies and prevents arthritis. PLoS One (2010) 0.88
Evidence for an early appearance of modern post-switch immunoglobulin isotypes in mammalian evolution (II); cloning of IgE, IgG1 and IgG2 from a monotreme, the duck-billed platypus, Ornithorhynchus anatinus. Eur J Immunol (2002) 0.88
Arg143 and Lys192 of the human mast cell chymase mediate the preference for acidic amino acids in position P2' of substrates. FEBS J (2010) 0.87
A novel Krüppel-Associated Box identified in a panel of mammalian zinc finger proteins. Mamm Genome (2004) 0.87
Extended substrate specificity of opossum chymase--implications for the origin of mast cell chymases. Mol Immunol (2007) 0.87
Extended cleavage specificity of the mast cell chymase from the crab-eating macaque (Macaca fascicularis): an interesting animal model for the analysis of the function of the human mast cell chymase. Int Immunol (2012) 0.86
Immunoglobulin genetics of Ornithorhynchus anatinus (platypus) and Tachyglossus aculeatus (short-beaked echidna). Comp Biochem Physiol A Mol Integr Physiol (2003) 0.85
Granule proteases of hematopoietic cells, a family of versatile inflammatory mediators - an update on their cleavage specificity, in vivo substrates, and evolution. Biol Chem (2014) 0.84
Extended cleavage specificity of mMCP-1, the major mucosal mast cell protease in mouse-high specificity indicates high substrate selectivity. Mol Immunol (2008) 0.84
Ornithorhynchus anatinus (platypus) links the evolution of immunoglobulin genes in eutherian mammals and nonmammalian tetrapods. J Immunol (2009) 0.84
Granzyme-like sequences in bony fish shed light on the emergence of hematopoietic serine proteases during vertebrate evolution. Dev Comp Immunol (2005) 0.83
TCR gamma chain diversity in the spleen of the duckbill platypus (Ornithorhynchus anatinus). Dev Comp Immunol (2005) 0.83
The extended substrate recognition profile of the dog mast cell chymase reveals similarities and differences to the human chymase. Int Immunol (2010) 0.82
High degree of conservation of the multigene tryptase locus over the past 150-200 million years of mammalian evolution. Immunogenetics (2010) 0.82
MZF6D, a novel KRAB zinc-finger gene expressed exclusively in meiotic male germ cells. DNA Cell Biol (2003) 0.81
The non-toxic and biodegradable adjuvant Montanide ISA 720/CpG can replace Freund's in a cancer vaccine targeting ED-B--a prerequisite for clinical development. Vaccine (2011) 0.81
The major histocompatibility complex in monotremes: an analysis of the evolution of Mhc class I genes across all three mammalian subclasses. Immunogenetics (2002) 0.81
Modifications increasing the efficacy of recombinant vaccines; marked increase in antibody titers with moderately repetitive variants of a therapeutic allergy vaccine. Vaccine (2006) 0.81
Mast cells limit extracellular levels of IL-13 via a serglycin proteoglycan-serine protease axis. Biol Chem (2012) 0.81
Generation of therapeutic antibody responses against IgE in dogs, an animal species with exceptionally high plasma IgE levels. Vaccine (2005) 0.81
High plasma IgE levels within the Scandinavian wolf population, and its implications for mammalian IgE homeostasis. Mol Immunol (2007) 0.80
Human cord blood derived immature basophils show dual characteristics, expressing both basophil and eosinophil associated proteins. PLoS One (2012) 0.80
Cloning of IgE from the echidna (Tachyglossus aculeatus) and a comparative analysis of epsilon chains from all three extant mammalian lineages. Dev Comp Immunol (2004) 0.80
Identification of potent biodegradable adjuvants that efficiently break self-tolerance--a key issue in the development of therapeutic vaccines. Vaccine (2009) 0.80
Isolation of monotreme T-cell receptor alpha and beta chains. Immunogenetics (2004) 0.80
The complexity of expressed kappa light chains in egg-laying mammals. Immunogenetics (2004) 0.80
Discriminating between the activities of human cathepsin G and chymase using fluorogenic substrates. FEBS J (2011) 0.79
Characterisation of echidna IgM provides insights into the time of divergence of extant mammals. Dev Comp Immunol (2002) 0.79
Echidna IgA supports mammalian unity and traditional Therian relationship. Mamm Genome (2002) 0.79
Identification of adjuvants that enhance the therapeutic antibody response to host IgE. Vaccine (2004) 0.79
Characterization of beta(2)-microglobulin coding sequence from three non-placental mammals: the duckbill platypus, the short-beaked echidna, and the grey short-tailed opossum. Dev Comp Immunol (2003) 0.78
High variability in complementarity-determining regions compensates for a low number of V gene families in the lambda light chain locus of the platypus. Eur J Immunol (2005) 0.77
IgA deficiency in wolves. Dev Comp Immunol (2013) 0.76
Mutations in Arg143 and Lys192 of the Human Mast Cell Chymase Markedly Affect the Activity of Five Potent Human Chymase Inhibitors. PLoS One (2013) 0.76
Correction: Granule Associated Serine Proteases of Hematopoietic Cells - An Analysis of Their Appearance and Diversification during Vertebrate Evolution. PLoS One (2015) 0.75
Characterization of immunoglobulin gamma 1 from a monotreme, Tachyglossus aculeatus. Immunogenetics (2002) 0.75