Published in Biochem J on April 01, 2007
Mouse mast cell protease-4 deteriorates renal function by contributing to inflammation and fibrosis in immune complex-mediated glomerulonephritis. J Immunol (2010) 0.97
Serglycin is a major proteoglycan in polarized human endothelial cells and is implicated in the secretion of the chemokine GROalpha/CXCL1. J Biol Chem (2010) 0.96
Serglycin proteoglycan deletion induces defects in platelet aggregation and thrombus formation in mice. Blood (2007) 0.93
Mast cells produce novel shorter forms of perlecan that contain functional endorepellin: a role in angiogenesis and wound healing. J Biol Chem (2012) 0.92
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The Role of Mast Cell Specific Chymases and Tryptases in Tumor Angiogenesis. Biomed Res Int (2015) 0.91
Polyamines are present in mast cell secretory granules and are important for granule homeostasis. PLoS One (2010) 0.89
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A role for serglycin proteoglycan in mast cell apoptosis induced by a secretory granule-mediated pathway. J Biol Chem (2010) 0.86
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Infection of mast cells with live streptococci causes a toll-like receptor 2- and cell-cell contact-dependent cytokine and chemokine response. Infect Immun (2009) 0.85
Serglycin in human cancers. Chin J Cancer (2011) 0.85
Serglycin-independent release of active mast cell proteases in response to Toxoplasma gondii infection. J Biol Chem (2010) 0.84
Mast cells and gastrointestinal dysmotility in the cystic fibrosis mouse. PLoS One (2009) 0.82
Serglycin proteoglycan promotes apoptotic versus necrotic cell death in mast cells. J Biol Chem (2012) 0.82
Proteoglycans support proper granule formation in pancreatic acinar cells. Histochem Cell Biol (2015) 0.78
Ctr2 Regulates Mast Cell Maturation by Affecting the Storage and Expression of Tryptase and Proteoglycans. J Immunol (2015) 0.78
Low Mass Blood Peptides Discriminative of Inflammatory Bowel Disease (IBD) Severity: A Quantitative Proteomic Perspective. Mol Cell Proteomics (2015) 0.78
Granzyme D is a novel murine mast cell protease that is highly induced by multiple pathways of mast cell activation. Infect Immun (2013) 0.77
Targeting Serglycin Prevents Metastasis in Murine Mammary Carcinoma. PLoS One (2016) 0.76
Serglycin proteoglycans limit enteropathy in Trichinella spiralis-infected mice. BMC Immunol (2016) 0.75
Acidic pH is essential for maintaining mast cell secretory granule homeostasis. Cell Death Dis (2017) 0.75
Mast Cells Produce a Unique Chondroitin Sulfate Epitope. J Histochem Cytochem (2015) 0.75
Increased Bone Mass in Female Mice Lacking Mast Cell Chymase. PLoS One (2016) 0.75
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A key role for mast cell chymase in the activation of pro-matrix metalloprotease-9 and pro-matrix metalloprotease-2. J Biol Chem (2004) 1.70
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Critical role of mast cell chymase in mouse abdominal aortic aneurysm formation. Circulation (2009) 1.43
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Mast cells regulate homeostatic intestinal epithelial migration and barrier function by a chymase/Mcpt4-dependent mechanism. Proc Natl Acad Sci U S A (2009) 1.34
Serglycin is essential for maturation of mast cell secretory granule. J Biol Chem (2004) 1.32
Independent degeneration of photoreceptors and retinal pigment epithelium in conditional knockout mouse models of choroideremia. J Clin Invest (2006) 1.29
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Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis. Nat Med (2008) 1.23
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A tick salivary protein targets cathepsin G and chymase and inhibits host inflammation and platelet aggregation. Blood (2010) 1.20
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Lyn kinase controls basophil GATA-3 transcription factor expression and induction of Th2 cell differentiation. Immunity (2009) 1.17
Neutrophil elastase depends on serglycin proteoglycan for localization in granules. Blood (2007) 1.16
Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice. J Clin Invest (2011) 1.16
Mouse mast cell protease 4 is the major chymase in murine airways and has a protective role in allergic airway inflammation. J Immunol (2009) 1.15
The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells. J Clin Invest (2012) 1.13
Increased levels of hypoxia-sensitive proteins in allergic airway inflammation. Am J Respir Crit Care Med (2004) 1.11
Serglycin: a structural and functional chameleon with wide impact on immune cells. J Immunol (2011) 1.11
Presence of Rickettsia helvetica in granulomatous tissue from patients with sarcoidosis. J Infect Dis (2002) 1.10
The extended cleavage specificity of the rodent beta-chymases rMCP-1 and mMCP-4 reveal major functional similarities to the human mast cell chymase. Mol Immunol (2007) 1.10
Serglycin-deficient cytotoxic T lymphocytes display defective secretory granule maturation and granzyme B storage. J Biol Chem (2005) 1.09
Loss of histochemical identity in mast cells lacking carboxypeptidase A. Mol Cell Biol (2005) 1.09
Serotonin and histamine storage in mast cell secretory granules is dependent on serglycin proteoglycan. J Allergy Clin Immunol (2008) 1.07
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Serglycin is the major secreted proteoglycan in macrophages and has a role in the regulation of macrophage tumor necrosis factor-alpha secretion in response to lipopolysaccharide. J Biol Chem (2006) 1.02
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The extended cleavage specificity of human thrombin. PLoS One (2012) 0.99
Human mast cell beta-tryptase is a gelatinase. J Immunol (2003) 0.99
Mouse mast cell protease-4 deteriorates renal function by contributing to inflammation and fibrosis in immune complex-mediated glomerulonephritis. J Immunol (2010) 0.97
Rapid lineage-specific diversification of the mast cell chymase locus during mammalian evolution. Immunogenetics (2006) 0.97
Mast cell chymase degrades the alarmins heat shock protein 70, biglycan, HMGB1, and interleukin-33 (IL-33) and limits danger-induced inflammation. J Biol Chem (2013) 0.97
Serglycin is a major proteoglycan in polarized human endothelial cells and is implicated in the secretion of the chemokine GROalpha/CXCL1. J Biol Chem (2010) 0.96
Mast cell chymase contributes to the antibody response and the severity of autoimmune arthritis. FASEB J (2008) 0.96
The inflammatory response after an epidermal burn depends on the activities of mouse mast cell proteases 4 and 5. J Immunol (2010) 0.95
Extended substrate specificity of rat mast cell protease 5, a rodent alpha-chymase with elastase-like primary specificity. J Biol Chem (2003) 0.95
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A role for serglycin proteoglycan in granular retention and processing of mast cell secretory granule components. FEBS J (2006) 0.94
Serglycin proteoglycan: regulating the storage and activities of hematopoietic proteases. Biofactors (2009) 0.93
Serglycin proteoglycan deletion induces defects in platelet aggregation and thrombus formation in mice. Blood (2007) 0.93
Vaccination against the extra domain-B of fibronectin as a novel tumor therapy. FASEB J (2010) 0.92
The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis. Am J Pathol (2012) 0.92
The extended substrate specificity of the human mast cell chymase reveals a serine protease with well-defined substrate recognition profile. Int Immunol (2008) 0.92
Mast cell proteoglycans. J Histochem Cytochem (2012) 0.92
Altered storage of proteases in mast cells from mice lacking heparin: a possible role for heparin in carboxypeptidase A processing. Biol Chem (2002) 0.91
Rat mast cell protease 4 is a beta-chymase with unusually stringent substrate recognition profile. J Biol Chem (2002) 0.91
Mast cell cathepsins C and S control levels of carboxypeptidase A and the chymase, mouse mast cell protease 5. Biol Chem (2003) 0.90
A role for cathepsin E in the processing of mast-cell carboxypeptidase A. J Cell Sci (2005) 0.90
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Lowered expression of heparan sulfate/heparin biosynthesis enzyme N-deacetylase/n-sulfotransferase 1 results in increased sulfation of mast cell heparin. J Biol Chem (2011) 0.89
Vitamin a is a negative regulator of osteoblast mineralization. PLoS One (2013) 0.89
Expression profile of novel members of the rat mast cell protease (rMCP)-2 and (rMCP)-8 families, and functional analyses of mouse mast cell protease (mMCP)-8. Immunogenetics (2007) 0.89
Polyamines are present in mast cell secretory granules and are important for granule homeostasis. PLoS One (2010) 0.89
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