Published in J Nutr Biochem on August 03, 2007
Gene-environment interactions in the causation of neural tube defects: folate deficiency increases susceptibility conferred by loss of Pax3 function. Hum Mol Genet (2008) 1.33
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ALDH1L1 inhibits cell motility via dephosphorylation of cofilin by PP1 and PP2A. Oncogene (2010) 1.10
Folate and vitamin B6 intake and risk of colon cancer in relation to p53 expression. Gastroenterology (2008) 1.06
Polyamine biosynthesis impacts cellular folate requirements necessary to maintain S-adenosylmethionine and nucleotide pools. FASEB J (2009) 1.01
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Mild folate deficiency induces genetic and epigenetic instability and phenotype changes in prostate cancer cells. BMC Biol (2010) 0.95
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Folate deficient tumor microenvironment promotes epithelial-to-mesenchymal transition and cancer stem-like phenotypes. Oncotarget (2016) 0.81
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The role of folate metabolism in orofacial development and clefting. Dev Biol (2015) 0.80
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Mutation at the folate receptor 4 locus modulates gene expression profiles in the mouse uterus in response to periconceptional folate supplementation. Biochim Biophys Acta (2013) 0.80
Photobiological implications of folate depletion and repletion in cultured human keratinocytes. J Photochem Photobiol B (2010) 0.80
Folate deficiency provides protection against colon carcinogenesis in DNA polymerase beta haploinsufficient mice. J Biol Chem (2010) 0.80
Cervical Microbiota Associated with Higher Grade Cervical Intraepithelial Neoplasia in Women Infected with High-Risk Human Papillomaviruses. Cancer Prev Res (Phila) (2016) 0.79
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Alcohol intake and folate antagonism via CYP2E1 and ALDH1: effects on oral carcinogenesis. Med Hypotheses (2011) 0.76
CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress. J Biol Chem (2016) 0.75
Identification of Candidate Genes Related to Inflammatory Bowel Disease Using Minimum Redundancy Maximum Relevance, Incremental Feature Selection, and the Shortest-Path Approach. Biomed Res Int (2017) 0.75
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Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women. J Nutr (1998) 2.36
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Effects of dietary folate on intestinal tumorigenesis in the apcMin mouse. Cancer Res (2000) 1.81
A method to assess genomic DNA methylation using high-performance liquid chromatography/electrospray ionization mass spectrometry. Anal Chem (2002) 1.81
Folate deficiency in rats induces DNA strand breaks and hypomethylation within the p53 tumor suppressor gene. Am J Clin Nutr (1997) 1.75
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Chemopreventive effects of dietary folate on intestinal polyps in Apc+/-Msh2-/- mice. Cancer Res (2000) 1.56
Elevation in S-adenosylhomocysteine and DNA hypomethylation: potential epigenetic mechanism for homocysteine-related pathology. J Nutr (2002) 1.47
DNA instability (strand breakage, uracil misincorporation, and defective repair) is increased by folic acid depletion in human lymphocytes in vitro. FASEB J (1998) 1.46
MTHFR polymorphisms, dietary folate intake, and breast cancer risk: results from the Shanghai Breast Cancer Study. Cancer Epidemiol Biomarkers Prev (2004) 1.33
Alterations in hepatic p53 gene methylation patterns during tumor progression with folate/methyl deficiency in the rat. Cancer Lett (1997) 1.29
Folate deficiency in vitro induces uracil misincorporation and DNA hypomethylation and inhibits DNA excision repair in immortalized normal human colon epithelial cells. Nutr Cancer (2000) 1.29
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Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig. Proc Natl Acad Sci U S A (2002) 1.28
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Beta-catenin up-regulates the expression of the urokinase plasminogen activator in human colorectal tumors. Cancer Res (2004) 1.17
Folate deficiency and cervical dysplasia. JAMA (1992) 1.15
DPC4/SMAD4 mediated tumor suppression of colon carcinoma cells is associated with reduced urokinase expression. Oncogene (1999) 1.13
Dietary folate intake and lung cancer risk in former smokers: a case-control analysis. Cancer Epidemiol Biomarkers Prev (2003) 1.12
Impact of extracellular folate levels on global gene expression. Mol Pharmacol (2001) 1.10
The effect of folic acid deficiency and MTHFR C677T polymorphism on chromosome damage in human lymphocytes in vitro. Cancer Epidemiol Biomarkers Prev (2001) 1.07
Uracil misincorporation, DNA strand breaks, and gene amplification are associated with tumorigenic cell transformation in folate deficient/repleted Chinese hamster ovary cells. Cancer Lett (1999) 1.06
A prospective cohort study on antioxidant and folate intake and male lung cancer risk. Cancer Epidemiol Biomarkers Prev (2000) 1.06
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Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells. Carcinogenesis (2005) 1.03
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Investigation of systemic folate status, impact of alcohol intake and levels of DNA damage in mononuclear cells of breast cancer patients. Br J Cancer (2005) 0.94
Reduced breast cancer risk with increasing serum folate in a case-control study of the C677T genotype of the methylenetetrahydrofolate reductase gene. Eur J Cancer (2004) 0.94
Methylenetetrahydrofolate reductase C677T polymorphism does not alter folic acid deficiency-induced uracil incorporation into primary human lymphocyte DNA in vitro. Carcinogenesis (2001) 0.94
In vitro folate deficiency induces deoxynucleotide pool imbalance, apoptosis, and mutagenesis in Chinese hamster ovary cells. Cancer Res (1994) 0.93
Expression of a folate binding protein in L1210 cells grown in low folate medium. Cancer Res (1989) 0.93
Inhibition of folate-dependent enzymes by non-steroidal anti-inflammatory drugs. Biochem J (1992) 0.93
Apoptosis of late-stage erythroblasts in megaloblastic anemia: association with DNA damage and macrocyte production. Blood (1997) 0.92
Folate deficiency and ionizing radiation cause DNA breaks in primary human lymphocytes: a comparison. FASEB J (2003) 0.89
Effects of dietary folate and aging on gene expression in the colonic mucosa of rats: implications for carcinogenesis. Carcinogenesis (2003) 0.88
Effects of folate deficiency on the metastatic potential of murine melanoma cells. Cancer Res (1988) 0.88
Folate depletion in human lymphocytes up-regulates p53 expression despite marked induction of strand breaks in exons 5-8 of the gene. Mutat Res (2006) 0.87
Diet and premalignant lesions of the cervix: evidence of a protective role for folate, riboflavin, thiamin, and vitamin B12. Cancer Causes Control (2003) 0.83
Altered folate-binding protein mRNA stability in KB cells grown in folate-deficient medium. Biochem Pharmacol (1993) 0.82
Regulation of urokinase plasminogen activator (uPA) activity by E-cadherin and hormones in mammary epithelial cells. J Cell Physiol (1999) 0.79
Folate deficiency and cervical intraepithelial neoplasia. Eur J Gynaecol Oncol (1997) 0.78
Metallothionein is overexpressed by hamster fibroblasts selected for growth in 15 pm folinic acid and provides a growth advantage in low folate. Cancer Res (1999) 0.77
Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development. Cell Stem Cell (2011) 4.52
A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc Natl Acad Sci U S A (2002) 4.22
Chemoprevention of colorectal cancer by targeting APC-deficient cells for apoptosis. Nature (2010) 2.78
DNA methylation changes after 5-aza-2'-deoxycytidine therapy in patients with leukemia. Cancer Res (2006) 2.69
GIT1 is associated with ADHD in humans and ADHD-like behaviors in mice. Nat Med (2011) 1.91
Chronic cigarette smoking is associated with diminished folate status, altered folate form distribution, and increased genetic damage in the buccal mucosa of healthy adults. Am J Clin Nutr (2006) 1.89
Folate status: effects on pathways of colorectal carcinogenesis. J Nutr (2002) 1.88
Genomic methylation of leukocyte DNA in relation to colorectal adenoma among asymptomatic women. Gastroenterology (2007) 1.83
A method to assess genomic DNA methylation using high-performance liquid chromatography/electrospray ionization mass spectrometry. Anal Chem (2002) 1.81
The draft genome of the fast-growing non-timber forest species moso bamboo (Phyllostachys heterocycla). Nat Genet (2013) 1.68
Effects of alcohol on folate metabolism: implications for carcinogenesis. Alcohol (2005) 1.51
Gene-nutrient interactions and DNA methylation. J Nutr (2002) 1.49
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The potential role of a self-management intervention for benign prostate hyperplasia. Urology (2012) 1.42
MEK is a key modulator for TLR5-induced interleukin-8 and MIP3alpha gene expression in non-transformed human colonic epithelial cells. J Biol Chem (2004) 1.42
Long term cannabinoid receptor (CB1) blockade in obesity: implications for the development of colorectal cancer. Int J Cancer (2008) 1.39
Metalloproteinases and transforming growth factor-alpha mediate substance P-induced mitogen-activated protein kinase activation and proliferation in human colonocytes. J Biol Chem (2004) 1.38
gp96 is a human colonocyte plasma membrane binding protein for Clostridium difficile toxin A. Infect Immun (2008) 1.30
Role of MyD88 in phosphatidylinositol 3-kinase activation by flagellin/toll-like receptor 5 engagement in colonic epithelial cells. J Biol Chem (2006) 1.27
Epigenetic control of 11 beta-hydroxysteroid dehydrogenase 2 gene promoter is related to human hypertension. Atherosclerosis (2008) 1.26
Substance P mediates antiapoptotic responses in human colonocytes by Akt activation. Proc Natl Acad Sci U S A (2007) 1.25
Clostridium difficile toxin A-induced colonocyte apoptosis involves p53-dependent p21(WAF1/CIP1) induction via p38 mitogen-activated protein kinase. Gastroenterology (2005) 1.25
Low concentrations of resveratrol inhibit Wnt signal throughput in colon-derived cells: implications for colon cancer prevention. Mol Nutr Food Res (2008) 1.24
Epigenetics: the link between nature and nurture. Mol Aspects Med (2012) 1.18
Older age and dietary folate are determinants of genomic and p16-specific DNA methylation in mouse colon. J Nutr (2007) 1.17
Effects of commercial anthocyanin-rich extracts on colonic cancer and nontumorigenic colonic cell growth. J Agric Food Chem (2004) 1.16
Clostridium difficile toxin A regulates inducible cyclooxygenase-2 and prostaglandin E2 synthesis in colonocytes via reactive oxygen species and activation of p38 MAPK. J Biol Chem (2005) 1.16
Not all cases of neural-tube defect can be prevented by increasing the intake of folic acid. Br J Nutr (2008) 1.15
Diet-induced obesity elevates colonic TNF-α in mice and is accompanied by an activation of Wnt signaling: a mechanism for obesity-associated colorectal cancer. J Nutr Biochem (2011) 1.14
The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: a possible molecular basis for the site-specific cancer risk modification. Int J Cancer (2009) 1.14
Nutritional influences on epigenetics and age-related disease. Proc Nutr Soc (2011) 1.11
Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/β-catenin signaling. Mol Cancer Ther (2013) 1.10
Substance P stimulates cyclooxygenase-2 and prostaglandin E2 expression through JAK-STAT activation in human colonic epithelial cells. J Immunol (2006) 1.08
The MTHFR 1298A>C polymorphism and genomic DNA methylation in human lymphocytes. Cancer Epidemiol Biomarkers Prev (2005) 1.08
Vitamin B-12 deficiency induces anomalies of base substitution and methylation in the DNA of rat colonic epithelium. J Nutr (2004) 1.07
Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves Rho family small GTPases. Biochem J (2002) 1.07
Neurotensin stimulates IL-8 expression in human colonic epithelial cells through Rho GTPase-mediated NF-kappa B pathways. Am J Physiol Cell Physiol (2003) 1.07
Cardiovascular epigenetics: from DNA methylation to microRNAs. Mol Aspects Med (2012) 1.06
DNA methylation, an epigenetic mechanism connecting folate to healthy embryonic development and aging. J Nutr Biochem (2009) 1.06
Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves protein kinase Cdelta activation. J Pharmacol Exp Ther (2005) 1.06
Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer. Cancer Manag Res (2009) 1.05
Extracellular calcium sensing receptor stimulation in human colonic epithelial cells induces intracellular calcium oscillations and proliferation inhibition. J Cell Physiol (2010) 1.05
Urocortin II mediates pro-inflammatory effects in human colonocytes via corticotropin-releasing hormone receptor 2alpha. Gut (2007) 1.05
Mild depletion of dietary folate combined with other B vitamins alters multiple components of the Wnt pathway in mouse colon. J Nutr (2007) 1.04
Toxoplasma gondii and Cryptosporidium parvum lack detectable DNA cytosine methylation. Eukaryot Cell (2008) 1.03
Coagulation parameters and plasma total homocysteine levels in Behcet's disease. Thromb Res (2002) 1.03
Too much folate: a risk factor for cancer and cardiovascular disease? Curr Opin Clin Nutr Metab Care (2009) 1.02
Global DNA hypomethylation in peripheral blood mononuclear cells as a biomarker of cancer risk. Cancer Epidemiol Biomarkers Prev (2013) 1.01
Genetic and epigenetic interactions between folate and aging in carcinogenesis. J Nutr (2005) 1.00
The effect of dietary folate on genomic and p53-specific DNA methylation in rat colon. Carcinogenesis (2003) 1.00
Increased cancer cell proliferation in prostate cancer patients with high levels of serum folate. Prostate (2011) 1.00
Metalloproteinase-dependent transforming growth factor-alpha release mediates neurotensin-stimulated MAP kinase activation in human colonic epithelial cells. J Biol Chem (2004) 1.00
Chemopreventive n-3 fatty acids activate RXRalpha in colonocytes. Carcinogenesis (2003) 1.00
Associations between single nucleotide polymorphisms in folate uptake and metabolizing genes with blood folate, homocysteine, and DNA uracil concentrations. Am J Clin Nutr (2008) 0.99
Contribution of glutathione status to oxidant-induced mitochondrial DNA damage in colonic epithelial cells. Free Radic Biol Med (2009) 0.99
Clostridium difficile toxin B activates the EGF receptor and the ERK/MAP kinase pathway in human colonocytes. Gastroenterology (2005) 0.97
Relationship of aging and tobacco use with the development of aberrant crypt foci in a predominantly African-American population. Clin Gastroenterol Hepatol (2005) 0.96
Folate supplementation increases genomic DNA methylation in the liver of elder rats. Br J Nutr (2005) 0.95
Severe folate deficiency impairs natural killer cell-mediated cytotoxicity in rats. J Nutr (2002) 0.95
The unique pharmacological characteristics of mifepristone (RU486): from terminating pregnancy to preventing cancer metastasis. Med Res Rev (2014) 0.94
Vitamin B6: a challenging link between nutrition and inflammation in CVD. Br J Nutr (2011) 0.94
Neurotensin stimulates interleukin-8 expression through modulation of I kappa B alpha phosphorylation and p65 transcriptional activity: involvement of protein kinase C alpha. Mol Pharmacol (2005) 0.94
Infrapatellar fat pad in the knee: is local fat good or bad for knee osteoarthritis? Arthritis Res Ther (2014) 0.93
Effect of maternal and postweaning folic acid supplementation on colorectal cancer risk in the offspring. Gut (2011) 0.93
Biochemical and molecular aberrations in the rat colon due to folate depletion are age-specific. J Nutr (2003) 0.93
Ageing, chronic alcohol consumption and folate are determinants of genomic DNA methylation, p16 promoter methylation and the expression of p16 in the mouse colon. Br J Nutr (2010) 0.93
Neurotensin stimulates expression of early growth response gene-1 and EGF receptor through MAP kinase activation in human colonic epithelial cells. Int J Cancer (2007) 0.93
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Ghrelin stimulates interleukin-8 gene expression through protein kinase C-mediated NF-kappaB pathway in human colonic epithelial cells. J Cell Biochem (2006) 0.92
Substance P-mediated expression of the pro-angiogenic factor CCN1 modulates the course of colitis. Am J Pathol (2008) 0.92
Proper regeneration from in vitro cultured Arabidopsis thaliana requires the microRNA-directed action of an auxin response factor. Plant J (2012) 0.91
LC/ESI-MS demonstrates the absence of 5-methyl-2'-deoxycytosine in Plasmodium falciparum genomic DNA. Mol Biochem Parasitol (2006) 0.91
Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway. Neurosci Lett (2013) 0.91
Blocking p38/ERK crosstalk affects colorectal cancer growth by inducing apoptosis in vitro and in preclinical mouse models. Cancer Lett (2012) 0.91
Promoter methylation in coagulation F7 gene influences plasma FVII concentrations and relates to coronary artery disease. J Med Genet (2012) 0.90
Combined inadequacies of multiple B vitamins amplify colonic Wnt signaling and promote intestinal tumorigenesis in BAT-LacZxApc1638N mice. FASEB J (2011) 0.90