Published in J Nutr on June 03, 2015
The use of mass spectrometry for analysing metabolite biomarkers in epidemiology: methodological and statistical considerations for application to large numbers of biological samples. Eur J Epidemiol (2016) 0.80
Medical cost savings in Sakado City and worldwide achieved by preventing disease by folic acid fortification. Congenit Anom (Kyoto) (2017) 0.76
Arsenic Metabolism in Children Differs From That in Adults. Toxicol Sci (2016) 0.75
Folate deficiency facilitates recruitment of upstream binding factor to hot spots of DNA double-strand breaks of rRNA genes and promotes its transcription. Nucleic Acids Res (2016) 0.75
Folate Transporters in Placentas from Preterm Newborns and Their Relation to Cord Blood Folate and Vitamin B12 Levels. PLoS One (2017) 0.75
Nutrients in Energy and One-Carbon Metabolism: Learning from Metformin Users. Nutrients (2017) 0.75
Role of folic acid in nitric oxide bioavailability and vascular endothelial function. Nutr Rev (2017) 0.75
High dietary folate in pregnant mice leads to pseudo-MTHFR deficiency and altered methyl metabolism, with embryonic growth delay and short-term memory impairment in offspring. Hum Mol Genet (2017) 0.75
Validity of the Food Frequency Questionnaire Assessing the Folate Intake in Women of Reproductive Age Living in a Country without Food Fortification: Application of the Method of Triads. Nutrients (2017) 0.75
Causes, Consequences and Public Health Implications of Low B-Vitamin Status in Ageing. Nutrients (2016) 0.75
Novel Approaches to Investigate One-Carbon Metabolism and Related B-Vitamins in Blood Pressure. Nutrients (2016) 0.75
Challenges and Lessons Learned in Generating and Interpreting NHANES Nutritional Biomarker Data. Adv Nutr (2017) 0.75
Ferritin Levels in Colombian Children: Findings from the 2010 National Nutrition Survey (ENSIN). Int J Environ Res Public Health (2016) 0.75
An overview of folate status in a population-based study from São Paulo, Brazil and the potential impact of 10 years of national folic acid fortification policy. Eur J Clin Nutr (2017) 0.75
Unmetabolized Folic Acid, Tetrahydrofolate and Colorectal Adenoma Risk. Cancer Prev Res (Phila) (2017) 0.75
Estimating safe maximum levels of vitamins and minerals in fortified foods and food supplements. Eur J Nutr (2016) 0.75
Supplementation with the methyl donor betaine prevents congenital defects induced by prenatal alcohol exposure. Alcohol Clin Exp Res (2017) 0.75
A Cross-Sectional Study of Dietary and Genetic Predictors of Blood Folate Levels in Healthy Young Adults. Nutrients (2017) 0.75
The Impact of Western Diet and Nutrients on the Microbiota and Immune Response at Mucosal Interfaces. Front Immunol (2017) 0.75
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet (2003) 25.57
Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. MRC Vitamin Study Research Group. Lancet (1991) 17.95
A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet (1995) 17.27
Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat Rev Genet (2012) 15.21
Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl J Med (1992) 14.22
Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature (2009) 12.58
Global reconstruction of the human metabolic network based on genomic and bibliomic data. Proc Natl Acad Sci U S A (2007) 11.46
Unintended pregnancy in the United States: incidence and disparities, 2006. Contraception (2011) 8.80
A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements. Nucleic Acids Res (2004) 7.92
Using intake biomarkers to evaluate the extent of dietary misreporting in a large sample of adults: the OPEN study. Am J Epidemiol (2003) 7.68
Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: Meta-analysis of 8 randomized trials involving 37 485 individuals. Arch Intern Med (2010) 6.48
Prevention of neural-tube defects with folic acid in China. China-U.S. Collaborative Project for Neural Tube Defect Prevention. N Engl J Med (1999) 6.27
Statistical methods for estimating usual intake of nutrients and foods: a review of the theory. J Am Diet Assoc (2006) 6.26
A new statistical method for estimating the usual intake of episodically consumed foods with application to their distribution. J Am Diet Assoc (2006) 5.61
Neural-tube defects. N Engl J Med (1999) 5.47
Folate levels and neural tube defects. Implications for prevention. JAMA (1995) 5.42
Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA (1993) 5.21
Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption. Cell (2006) 4.84
Efficacy of folic acid supplementation in stroke prevention: a meta-analysis. Lancet (2007) 4.74
DNA methylation analysis by pyrosequencing. Nat Protoc (2007) 4.65
Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation (1996) 4.62
Total folate and folic acid intake from foods and dietary supplements in the United States: 2003-2006. Am J Clin Nutr (2009) 4.57
Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci U S A (1997) 4.38
Facts and recommendations about total homocysteine determinations: an expert opinion. Clin Chem (2004) 4.31
Recommendations for the use of folic acid to reduce the number of cases of spina bifida and other neural tube defects. MMWR Recomm Rep (1992) 4.22
A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc Natl Acad Sci U S A (2002) 4.22
5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review. Am J Epidemiol (2000) 3.94
Cytokinesis-block micronucleus cytome assay. Nat Protoc (2007) 3.91
Dietary assessment resource manual. J Nutr (1994) 3.77
Unmetabolized folic acid in serum: acute studies in subjects consuming fortified food and supplements. Am J Clin Nutr (1997) 3.75
MicroRNA responses to cellular stress. Cancer Res (2006) 3.13
DNA methylation: the nuts and bolts of repression. J Cell Physiol (2007) 3.00
Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies. Am J Med (1994) 2.98
Influence of threonine metabolism on S-adenosylmethionine and histone methylation. Science (2012) 2.98
An automated method for the measurement of folate activity. J Clin Pathol (1970) 2.94
Interrelations of vitamin B12 and folic acid metabolism: folic acid clearance studies. J Clin Invest (1962) 2.86
Effects of homocysteine lowering with B vitamins on cognitive aging: meta-analysis of 11 trials with cognitive data on 22,000 individuals. Am J Clin Nutr (2014) 2.81
Genomic DNA methylation decreases in response to moderate folate depletion in elderly women. Am J Clin Nutr (2000) 2.80
Compartmentalization of Mammalian folate-mediated one-carbon metabolism. Annu Rev Nutr (2010) 2.68
Estimation of usual intake distributions of nutrients and foods. J Nutr (2003) 2.58
Prevalence of severe congenital heart disease after folic acid fortification of grain products: time trend analysis in Quebec, Canada. BMJ (2009) 2.50
Periconceptional dietary intake of choline and betaine and neural tube defects in offspring. Am J Epidemiol (2004) 2.49
The food propensity questionnaire: concept, development, and validation for use as a covariate in a model to estimate usual food intake. J Am Diet Assoc (2006) 2.47
LINE-1 elements in structural variation and disease. Annu Rev Genomics Hum Genet (2011) 2.42
Microbiological assay for serum, plasma, and red cell folate using cryopreserved, microtiter plate method. Methods Enzymol (1997) 2.40
Dietary reference values for food energy and nutrients for the United Kingdom. Report of the Panel on Dietary Reference Values of the Committee on Medical Aspects of Food Policy. Rep Health Soc Subj (Lond) (1991) 2.39
Effects of folic acid supplementation on overall and site-specific cancer incidence during the randomised trials: meta-analyses of data on 50,000 individuals. Lancet (2013) 2.37
Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women. J Nutr (1998) 2.36
Conclusions of a WHO Technical Consultation on folate and vitamin B12 deficiencies. Food Nutr Bull (2008) 2.35
Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues. Expert Rev Mol Med (2009) 2.33
Folic acid source, usual intake, and folate and vitamin B-12 status in US adults: National Health and Nutrition Examination Survey (NHANES) 2003-2006. Am J Clin Nutr (2009) 2.32
Unmetabolized folic acid in plasma is associated with reduced natural killer cell cytotoxicity among postmenopausal women. J Nutr (2006) 2.25
Rapid and accurate HPLC assay for plasma total homocysteine and cysteine in a clinical laboratory setting. Clin Chem (1999) 2.24
Cytoplasmic serine hydroxymethyltransferase mediates competition between folate-dependent deoxyribonucleotide and S-adenosylmethionine biosyntheses. J Biol Chem (2002) 2.20
Thermolabile variant of 5,10-methylenetetrahydrofolate reductase associated with low red-cell folates: implications for folate intake recommendations. Lancet (1997) 2.10
Mouse L cell mitochondrial DNA molecules are selected randomly for replication throughout the cell cycle. Cell (1977) 2.09
Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene. Cancer Epidemiol Biomarkers Prev (2000) 2.06
Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas. Oncogene (2003) 2.02
Megaloblastic anemia and other causes of macrocytosis. Clin Med Res (2006) 1.99
Estimation of trends in serum and RBC folate in the U.S. population from pre- to postfortification using assay-adjusted data from the NHANES 1988-2010. J Nutr (2012) 1.98
Folate-targeted therapeutic and imaging agents for cancer. Curr Opin Chem Biol (2009) 1.97
Quantitative profiling of biomarkers related to B-vitamin status, tryptophan metabolism and inflammation in human plasma by liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom (2009) 1.96
Determination of total homocysteine, methylmalonic acid, and 2-methylcitric acid in dried blood spots by tandem mass spectrometry. Clin Chem (2010) 1.94
Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial. PLoS One (2010) 1.92
Effects of common polymorphisms on the properties of recombinant human methylenetetrahydrofolate reductase. Proc Natl Acad Sci U S A (2001) 1.91
Predictive value of folate, vitamin B12 and homocysteine levels in late-life depression. Br J Psychiatry (2008) 1.88
Metabolomics in human nutrition: opportunities and challenges. Am J Clin Nutr (2005) 1.85
Systematizing the generation of missing metabolic knowledge. Biotechnol Bioeng (2010) 1.85
Do dietary supplements improve micronutrient sufficiency in children and adolescents? J Pediatr (2012) 1.84
Population red blood cell folate concentrations for prevention of neural tube defects: Bayesian model. BMJ (2014) 1.84
A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism. J Nutr (2006) 1.82
Folate-mediated one-carbon metabolism. Vitam Horm (2008) 1.81
A method to assess genomic DNA methylation using high-performance liquid chromatography/electrospray ionization mass spectrometry. Anal Chem (2002) 1.81
Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate's role. Adv Nutr (2012) 1.80
Mechanisms of membrane transport of folates into cells and across epithelia. Annu Rev Nutr (2011) 1.76
Trends in circulating concentrations of total homocysteine among US adolescents and adults: findings from the 1991-1994 and 1999-2004 National Health and Nutrition Examination Surveys. Clin Chem (2008) 1.75
Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans. Proc Natl Acad Sci U S A (2005) 1.73
Microbiological assay on microtitre plates of folate in serum and red cells. J Clin Pathol (1992) 1.73
Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C->T polymorphism. Circulation (2005) 1.70
Neural tube defects and maternal folate intake among pregnancies conceived after folic acid fortification in the United States. Am J Epidemiol (2008) 1.69
Changes in the birth prevalence of selected birth defects after grain fortification with folic acid in the United States: findings from a multi-state population-based study. Birth Defects Res A Clin Mol Teratol (2005) 1.68
Neural tube defects: recent advances, unsolved questions, and controversies. Lancet Neurol (2013) 1.68
RELATIVE FOLATE DEFICIENCY OF ERYTHROCYTES IN PERNICIOUS ANEMIA AND ITS CORRECTION WITH CYANOCOBALAMIN. Blood (1964) 1.67
A method for detecting abasic sites in living cells: age-dependent changes in base excision repair. Proc Natl Acad Sci U S A (2000) 1.67
Genome-scale metabolic modeling elucidates the role of proliferative adaptation in causing the Warburg effect. PLoS Comput Biol (2011) 1.66
Choline deficiency in mice and humans is associated with increased plasma homocysteine concentration after a methionine load. Am J Clin Nutr (2005) 1.66
National Academy of Clinical Biochemistry Laboratory Medicine Practice guidelines: emerging biomarkers for primary prevention of cardiovascular disease. Clin Chem (2008) 1.65
DNA methylation in folate deficiency: use of CpG methylase. Biochem Biophys Res Commun (1993) 1.65
Determination of folate vitamers in human serum by stable-isotope-dilution tandem mass spectrometry and comparison with radioassay and microbiologic assay. Clin Chem (2003) 1.62
Biomarkers of nutrient exposure and status in one-carbon (methyl) metabolism. J Nutr (2003) 1.61
Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial. Int J Geriatr Psychiatry (2011) 1.60
The HUman MicroNucleus Project--An international collaborative study on the use of the micronucleus technique for measuring DNA damage in humans. Mutat Res (1999) 1.60
Large-scale population-based metabolic phenotyping of thirteen genetic polymorphisms related to one-carbon metabolism. Hum Mutat (2007) 1.59
Nutritional epigenetics: impact of folate deficiency on DNA methylation and colon cancer susceptibility. J Nutr (2005) 1.59
Predicting metabolic biomarkers of human inborn errors of metabolism. Mol Syst Biol (2009) 1.59
Macrophages and adipocytes in human obesity: adipose tissue gene expression and insulin sensitivity during calorie restriction and weight stabilization. Diabetes (2009) 1.59
The role of metabolites and metabolomics in clinically applicable biomarkers of disease. Arch Toxicol (2010) 1.58
Absorption of folate from fortified cereal-grain products and of supplemental folate consumed with or without food determined by using a dual-label stable-isotope protocol. Am J Clin Nutr (1997) 1.58
TREATMENT OF "PERNICIOUS ANAEMIA OF PREGNANCY" AND "TROPICAL ANAEMIA". Br Med J (1931) 1.58
Rapid, fully automated measurement of plasma homocyst(e)ine with the Abbott IMx analyzer. Clin Chem (1995) 1.57