Published in J Biol Chem on August 07, 2007
Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcumin. Mol Pharmacol (2008) 1.43
High mesothelin correlates with chemoresistance and poor survival in epithelial ovarian carcinoma. Br J Cancer (2009) 1.24
HO-3867, a synthetic compound, inhibits the migration and invasion of ovarian carcinoma cells through downregulation of fatty acid synthase and focal adhesion kinase. Mol Cancer Res (2010) 1.16
Identifying microRNA/mRNA dysregulations in ovarian cancer. BMC Res Notes (2012) 1.13
Hypoxia induces chemoresistance in ovarian cancer cells by activation of signal transducer and activator of transcription 3. Int J Cancer (2009) 1.07
Anticancer efficacy of a difluorodiarylidenyl piperidone (HO-3867) in human ovarian cancer cells and tumor xenografts. Mol Cancer Ther (2010) 1.02
Cardioprotection by HO-4038, a novel verapamil derivative, targeted against ischemia and reperfusion-mediated acute myocardial infarction. Am J Physiol Heart Circ Physiol (2008) 1.01
HO-3867, a safe STAT3 inhibitor, is selectively cytotoxic to ovarian cancer. Cancer Res (2014) 1.00
PTEN in DNA damage repair. Cancer Lett (2012) 0.98
Trimetazidine, administered at the onset of reperfusion, ameliorates myocardial dysfunction and injury by activation of p38 mitogen-activated protein kinase and Akt signaling. J Pharmacol Exp Ther (2010) 0.98
Inhibition of the NF-κB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties. Int Immunopharmacol (2011) 0.98
Safe and targeted anticancer efficacy of a novel class of antioxidant-conjugated difluorodiarylidenyl piperidones: differential cytotoxicity in healthy and cancer cells. Free Radic Biol Med (2010) 0.97
Activation of the p38 pathway by a novel monoketone curcumin analog, EF24, suggests a potential combination strategy. Biochem Pharmacol (2010) 0.95
Synthetic curcumin analog EF31 inhibits the growth of head and neck squamous cell carcinoma xenografts. Integr Biol (Camb) (2012) 0.93
RY-2f, an isoflavone analog, overcomes cisplatin resistance to inhibit ovarian tumorigenesis via targeting the PI3K/AKT/mTOR signaling pathway. Oncotarget (2015) 0.92
CLEFMA-an anti-proliferative curcuminoid from structure-activity relationship studies on 3,5-bis(benzylidene)-4-piperidones. Bioorg Med Chem (2010) 0.89
Targeting constitutively-activated STAT3 in hypoxic ovarian cancer, using a novel STAT3 inhibitor. Oncoscience (2014) 0.89
Cellular uptake, retention and bioabsorption of HO-3867, a fluorinated curcumin analog with potential antitumor properties. Cancer Biol Ther (2010) 0.87
RAB8 enhances TMEM205-mediated cisplatin resistance. Pharm Res (2011) 0.87
Mouse pharmacokinetics and metabolism of the curcumin analog, 4-piperidinone,3,5-bis[(2-fluorophenyl)methylene]-acetate(3E,5E) (EF-24; NSC 716993). Cancer Chemother Pharmacol (2014) 0.87
Autophagy and apoptosis in hepatocellular carcinoma induced by EF25-(GSH)2: a novel curcumin analog. PLoS One (2014) 0.86
Dysregulation of PTEN in cardiopulmonary vascular remodeling induced by pulmonary hypertension. Cell Biochem Biophys (2013) 0.85
Chemoresistance is associated with Beclin-1 and PTEN expression in epithelial ovarian cancers. Oncol Lett (2015) 0.84
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Connection between Tumor Suppressor BRCA1 and PTEN in Damaged DNA Repair. Front Oncol (2014) 0.83
Diphenyl difluoroketone: a potent chemotherapy candidate for human hepatocellular carcinoma. PLoS One (2011) 0.83
In vivo and in vitro suppression of hepatocellular carcinoma by EF24, a curcumin analog. PLoS One (2012) 0.83
Recombinant viral protein promotes apoptosis and suppresses invasion of ovarian adenocarcinoma cells by targeting α5β1 integrin to down-regulate Akt and MMP-2. Br J Pharmacol (2012) 0.83
The curcuminoid CLEFMA selectively induces cell death in H441 lung adenocarcinoma cells via oxidative stress. Invest New Drugs (2010) 0.81
Cyclodextrin-mediated entrapment of curcuminoid 4-[3,5-bis(2-chlorobenzylidene-4-oxo-piperidine-1-yl)-4-oxo-2-butenoic acid] or CLEFMA in liposomes for treatment of xenograft lung tumor in rats. Colloids Surf B Biointerfaces (2011) 0.81
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Cardioprotective properties of Crataegus oxycantha extract against ischemia-reperfusion injury. Phytomedicine (2010) 0.79
Synergistic effect of allyl isothiocyanate (AITC) on cisplatin efficacy in vitro and in vivo. Am J Cancer Res (2015) 0.79
PDCD5 transfection increases cisplatin sensitivity and decreases invasion in hepatic cancer cells. Oncol Lett (2014) 0.79
EF24 induces ROS-mediated apoptosis via targeting thioredoxin reductase 1 in gastric cancer cells. Oncotarget (2016) 0.78
Safe and targeted anticancer therapy for ovarian cancer using a novel class of curcumin analogs. J Ovarian Res (2013) 0.78
Aberrantly activated pSTAT3-Ser727 in human endometrial cancer is suppressed by HO-3867, a novel STAT3 inhibitor. Gynecol Oncol (2014) 0.77
Synergistic antitumor activity of rapamycin and EF24 via increasing ROS for the treatment of gastric cancer. Redox Biol (2016) 0.76
A general HPLC-UV method for the quantitative determination of curcumin analogues containing the 1,5-diaryl-3-oxo-1,4-pentadienyl pharmacophore in rat biomatrices. J Chromatogr B Analyt Technol Biomed Life Sci (2010) 0.76
Expression of NF-κB and PTEN in primary epithelial ovarian carcinoma and the correlation with chemoresistance. Int J Clin Exp Pathol (2015) 0.75
EF24 Suppresses Invasion and Migration of Hepatocellular Carcinoma Cells In Vitro via Inhibiting the Phosphorylation of Src. Biomed Res Int (2016) 0.75
EF24 inhibits tumor growth and metastasis via suppressing NF-kappaB dependent pathways in human cholangiocarcinoma. Sci Rep (2016) 0.75
A liposomal formulation of the synthetic curcumin analog EF24 (Lipo-EF24) inhibits pancreatic cancer progression: towards future combination therapies. J Nanobiotechnology (2016) 0.75
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EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism. Anticancer Drugs (2005) 1.48
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Reversal to cisplatin sensitivity in recurrent human ovarian cancer cells by NCX-4016, a nitro derivative of aspirin. Proc Natl Acad Sci U S A (2006) 1.20
Inhibition of phosphatidylinositol 3-kinase-Akt signaling blocks growth, promotes apoptosis, and enhances sensitivity of small cell lung cancer cells to chemotherapy. Mol Cancer Ther (2002) 1.20
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Fast EPR imaging at 300 MHz using spinning magnetic field gradients. J Magn Reson (2004) 1.45
In vivo imaging of changes in tumor oxygenation during growth and after treatment. Magn Reson Med (2007) 1.42
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Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK. Cancer Biol Ther (2007) 1.38
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Phase I dose-escalation study of stereotactic body radiotherapy in patients with hepatic metastases. Ann Surg Oncol (2010) 1.31
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A parametric approach to spectral-spatial EPR imaging. J Magn Reson (2007) 1.26
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Reversal to cisplatin sensitivity in recurrent human ovarian cancer cells by NCX-4016, a nitro derivative of aspirin. Proc Natl Acad Sci U S A (2006) 1.20
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HO-3867, a synthetic compound, inhibits the migration and invasion of ovarian carcinoma cells through downregulation of fatty acid synthase and focal adhesion kinase. Mol Cancer Res (2010) 1.16
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Fast 3D spatial EPR imaging using spiral magnetic field gradient. J Magn Reson (2007) 1.14
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Assessment of wound-site redox environment and the significance of Rac2 in cutaneous healing. Free Radic Biol Med (2007) 1.07
Hypoxia induces chemoresistance in ovarian cancer cells by activation of signal transducer and activator of transcription 3. Int J Cancer (2009) 1.07
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Protection against cisplatin-induced nephrotoxicity by Spirulina in rats. Cancer Chemother Pharmacol (2006) 1.03
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Quasi Monte Carlo-based isotropic distribution of gradient directions for improved reconstruction quality of 3D EPR imaging. J Magn Reson (2006) 1.02
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Anticancer efficacy of a difluorodiarylidenyl piperidone (HO-3867) in human ovarian cancer cells and tumor xenografts. Mol Cancer Ther (2010) 1.02
Protective effect of Spirulina against doxorubicin-induced cardiotoxicity. Phytother Res (2005) 1.01
Cardioprotection by HO-4038, a novel verapamil derivative, targeted against ischemia and reperfusion-mediated acute myocardial infarction. Am J Physiol Heart Circ Physiol (2008) 1.01
Oxygen sensitivity and biocompatibility of an implantable paramagnetic probe for repeated measurements of tissue oxygenation. Biomed Microdevices (2009) 1.01
Mapping ischemic risk region and necrosis in the isolated heart using EPR imaging. Magn Reson Med (2003) 1.01
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HO-3867, a safe STAT3 inhibitor, is selectively cytotoxic to ovarian cancer. Cancer Res (2014) 1.00
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Monitoring oxygenation during the growth of a transplanted tumor. Adv Exp Med Biol (2006) 0.99
Trimetazidine, administered at the onset of reperfusion, ameliorates myocardial dysfunction and injury by activation of p38 mitogen-activated protein kinase and Akt signaling. J Pharmacol Exp Ther (2010) 0.98
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