Published in Proc Natl Acad Sci U S A on August 08, 2007
Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer. Proc Natl Acad Sci U S A (2008) 1.95
Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not. Nature (2010) 1.56
Netrin-1 acts as a survival factor for aggressive neuroblastoma. J Exp Med (2009) 1.36
Trafficking of receptor tyrosine kinases to the nucleus. Exp Cell Res (2008) 1.33
EphrinB3 is an anti-apoptotic ligand that inhibits the dependence receptor functions of EphA4 receptors during adult neurogenesis. Biochim Biophys Acta (2008) 1.31
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Netrin-1 is a survival factor during commissural neuron navigation. Proc Natl Acad Sci U S A (2008) 1.16
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Dependence receptor TrkC is a putative colon cancer tumor suppressor. Proc Natl Acad Sci U S A (2013) 0.93
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Inhibition of neuroepithelial patched-induced apoptosis by sonic hedgehog. Science (2003) 3.62
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Netrin-1 controls colorectal tumorigenesis by regulating apoptosis. Nature (2004) 3.05
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Netrin-1 acts as a survival factor via its receptors UNC5H and DCC. EMBO J (2001) 2.17
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Targeted deletion of all isoforms of the trkC gene suggests the use of alternate receptors by its ligand neurotrophin-3 in neuronal development and implicates trkC in normal cardiogenesis. Proc Natl Acad Sci U S A (1997) 1.62
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Inhibition of neuroepithelial patched-induced apoptosis by sonic hedgehog. Science (2003) 3.62
Netrin-1 controls colorectal tumorigenesis by regulating apoptosis. Nature (2004) 3.05
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Interference with netrin-1 and tumor cell death in non-small cell lung cancer. J Natl Cancer Inst (2009) 2.16
RGM and its receptor neogenin regulate neuronal survival. Nat Cell Biol (2004) 2.14
Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer. Proc Natl Acad Sci U S A (2008) 1.95
Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation. Nature (2002) 1.94
The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase. Mol Cell (2010) 1.90
Inactivation of the UNC5C Netrin-1 receptor is associated with tumor progression in colorectal malignancies. Gastroenterology (2007) 1.83
The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. Proc Natl Acad Sci U S A (2003) 1.69
Semaphorin 3E suppresses tumor cell death triggered by the plexin D1 dependence receptor in metastatic breast cancers. Cancer Cell (2013) 1.68
The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase. EMBO J (2005) 1.52
Inhibition of endothelial cell apoptosis by netrin-1 during angiogenesis. Dev Cell (2009) 1.50
Netrin-1 acts as a survival factor for aggressive neuroblastoma. J Exp Med (2009) 1.36
Netrin-1 overexpression protects kidney from ischemia reperfusion injury by suppressing apoptosis. Am J Pathol (2009) 1.32
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Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B. Nat Cell Biol (2008) 1.27
DCC constrains tumour progression via its dependence receptor activity. Nature (2011) 1.21
NF-kappaB regulates netrin-1 expression and affects the conditional tumor suppressive activity of the netrin-1 receptors. Gastroenterology (2008) 1.19
Anaplastic lymphoma kinase is a dependence receptor whose proapoptotic functions are activated by caspase cleavage. Mol Cell Biol (2006) 1.19
Apoptosis and dependence receptors: a molecular basis for cellular addiction. Physiol Rev (2004) 1.16
Netrin-1 is a survival factor during commissural neuron navigation. Proc Natl Acad Sci U S A (2008) 1.16
Mesencephalic astrocyte-derived neurotrophic factor (MANF) has a unique mechanism to rescue apoptotic neurons. J Biol Chem (2010) 1.15
The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex. Nat Cell Biol (2009) 1.14
Netrin-1 up-regulation in inflammatory bowel diseases is required for colorectal cancer progression. Proc Natl Acad Sci U S A (2009) 1.13
Proapoptotic function of the MET tyrosine kinase receptor through caspase cleavage. Mol Cell Biol (2004) 1.09
Netrin-1 role in angiogenesis: to be or not to be a pro-angiogenic factor? Cell Cycle (2010) 1.07
Neurotrophins and cell death. Exp Cell Res (2012) 1.06
GDNF-deprived sympathetic neurons die via a novel nonmitochondrial pathway. J Cell Biol (2003) 1.03
DCC association with lipid rafts is required for netrin-1-mediated axon guidance. J Cell Sci (2005) 1.02
Large-scale production of dsRNA and siRNA pools for RNA interference utilizing bacteriophage phi6 RNA-dependent RNA polymerase. RNA (2007) 1.01
The dependence receptor DCC requires lipid raft localization for cell death signaling. Proc Natl Acad Sci U S A (2006) 0.98
Selective vulnerability in Alzheimer's disease: amyloid precursor protein and p75(NTR) interaction. Ann Neurol (2009) 0.97
Death receptors and caspases but not mitochondria are activated in the GDNF- or BDNF-deprived dopaminergic neurons. J Neurosci (2008) 0.94
Neurotrophin-3 production promotes human neuroblastoma cell survival by inhibiting TrkC-induced apoptosis. J Clin Invest (2010) 0.94
Dependence receptor TrkC is a putative colon cancer tumor suppressor. Proc Natl Acad Sci U S A (2013) 0.93
Netrin-1 overexpression in kidney proximal tubular epithelium ameliorates cisplatin nephrotoxicity. Lab Invest (2011) 0.92
Nucleolar localization of a netrin-1 isoform enhances tumor cell proliferation. Sci Signal (2012) 0.92
Netrin-4 acts as a pro-angiogenic factor during zebrafish development. J Biol Chem (2011) 0.91
Amyloid precursor protein regulates netrin-1-mediated commissural axon outgrowth. J Biol Chem (2012) 0.90
The neogenin intracellular domain regulates gene transcription via nuclear translocation. Mol Cell Biol (2008) 0.89
Dependence receptor UNC5D mediates nerve growth factor depletion-induced neuroblastoma regression. J Clin Invest (2013) 0.87
The loop diuretic bumetanide blocks posttraumatic p75NTR upregulation and rescues injured neurons. J Neurosci (2012) 0.87
Characterization of the structural and functional determinants of MANF/CDNF in Drosophila in vivo model. PLoS One (2013) 0.87
Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9. Proc Natl Acad Sci U S A (2012) 0.87
Acetylcholinesterase inhibitors rapidly activate Trk neurotrophin receptors in the mouse hippocampus. Neuropharmacology (2011) 0.86
Variants in the netrin-1 receptor UNC5C prevent apoptosis and increase risk of familial colorectal cancer. Gastroenterology (2011) 0.86
PCSK9 regulates neuronal apoptosis by adjusting ApoER2 levels and signaling. Cell Mol Life Sci (2012) 0.85
Persephin signaling through GFRalpha1: the potential for the treatment of Parkinson's disease. Mol Cell Neurosci (2010) 0.83
Neuronal apoptosis inhibitory protein: Structural requirements for hippocalcin binding and effects on survival of NGF-dependent sympathetic neurons. Biochim Biophys Acta (2002) 0.83
Survival assay of transiently transfected dopaminergic neurons. J Neurosci Methods (2007) 0.83
Sonic Hedgehog promotes tumor cell survival by inhibiting CDON pro-apoptotic activity. PLoS Biol (2013) 0.82
Neurotrophic factors switch between two signaling pathways that trigger axonal growth. J Cell Sci (2007) 0.81
Regulation of sympathetic neuron and neuroblastoma cell death by XIAP and its association with proteasomes in neural cells. Mol Cell Neurosci (2003) 0.81
Combining chemotherapeutic agents and netrin-1 interference potentiates cancer cell death. EMBO Mol Med (2013) 0.81
Inhibitory role of endophilin 3 in receptor-mediated endocytosis. J Biol Chem (2004) 0.81
Netrin-1, a missing link between chronic inflammation and tumor progression. Cell Cycle (2010) 0.81
Clonal expansion of HTLV-1 positive CD8+ cells relies on cIAP-2 but not on c-FLIP expression. Virology (2010) 0.81
Dependence receptors: when apoptosis controls tumor progression. Bull Cancer (2007) 0.80
RET modulates cell adhesion via its cleavage by caspase in sympathetic neurons. J Biol Chem (2011) 0.79
Cell differentiation: reciprocal regulation of Apaf-1 and the inhibitor of apoptosis proteins. J Cell Biol (2004) 0.79
Analysis of the dominant effects mediated by wild type or R120G mutant of αB-crystallin (HspB5) towards Hsp27 (HspB1). PLoS One (2013) 0.79
Mutational analysis of N-Bak reveals different structural requirements for antiapoptotic activity in neurons and proapoptotic activity in nonneuronal cells. Mol Cell Neurosci (2003) 0.78
Targeting neurotrophin-3 and its dependence receptor tyrosine kinase receptor C: a new antitumoral strategy. Expert Opin Ther Targets (2011) 0.78
Lipid raft localization and palmitoylation: identification of two requirements for cell death induction by the tumor suppressors UNC5H. Exp Cell Res (2008) 0.77
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Insights into the thermal stabilization and conformational transitions of DNA by hyperthermophile protein Sso7d: molecular dynamics simulations and MM-PBSA analysis. J Biomol Struct Dyn (2012) 0.77
Epidermal growth factor triggers an original, caspase-independent pituitary cell death with heterogeneous phenotype. Mol Biol Cell (2004) 0.77
Caspase cleavage of the transcription factor FLI-1 during preB leukemic cell death. Biochim Biophys Acta (2002) 0.76
The dependence receptor TrkC triggers mitochondria-dependent apoptosis upon Cobra-1 recruitment. Mol Cell (2013) 0.76
Netrin PIPes up. Nat Cell Biol (2005) 0.75
Neurobiology: a new way to network. Nature (2003) 0.75
Influence of hyperthermophilic protein Cren7 on the stability and conformation of DNA: insights from molecular dynamics simulation and free energy analysis. J Phys Chem B (2012) 0.75
Caprine arthritis-encephalitis virus induces apoptosis in infected cells in vitro through the intrinsic pathway. Virology (2008) 0.75
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Bevacizumab impairs hepatocyte proliferation after partial hepatectomy in a rabbit model. Anticancer Res (2012) 0.75
Small ruminant lentivirus Tat protein induces apoptosis in caprine cells in vitro by the intrinsic pathway. Virology (2008) 0.75