PubRank

Shigeki Sasaki

Author PubWeight™ 35.19‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Intracellular inducible alkylation system that exhibits antisense effects with greater potency and selectivity than the natural oligonucleotide. Angew Chem Int Ed Engl 2006 0.93
2 Extensive sugar modification improves triple helix forming oligonucleotide activity in vitro but reduces activity in vivo. Biochemistry 2007 0.92
3 Hybridization-promoted and cytidine-selective activation for cross-linking with the use of 2-amino-6-vinylpurine derivatives. J Org Chem 2005 0.89
4 pH-responsive oligodeoxynucleotide (ODN)-poly(ethylene glycol) conjugate through acid-labile beta-thiopropionate linkage: preparation and polyion complex micelle formation. Biomacromolecules 2003 0.89
5 Supramolecular assemblies for the cytoplasmic delivery of antisense oligodeoxynucleotide: polyion complex (PIC) micelles based on poly(ethylene glycol)-SS-oligodeoxynucleotide conjugate. Biomacromolecules 2005 0.87
6 Identification of the fused bicyclic 4-amino-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors. Bioorg Med Chem Lett 2013 0.87
7 Site-specific covalent modification of RNA guided by functionality-transfer oligodeoxynucleotides. Bioconjug Chem 2009 0.86
8 Site-specific mutagenesis by triple helix-forming oligonucleotides containing a reactive nucleoside analog. Nucleic Acids Res 2003 0.85
9 Smart polyion complex micelles for targeted intracellular delivery of PEGylated antisense oligonucleotides containing acid-labile linkages. Chembiochem 2005 0.84
10 4-vinyl-substituted pyrimidine nucleosides exhibit the efficient and selective formation of interstrand cross-links with RNA and duplex DNA. Nucleic Acids Res 2013 0.83
11 The alkyl-connected 2-amino-6-vinylpurine (AVP) crosslinking agent for improved selectivity to the cytosine base in RNA. Bioorg Med Chem 2010 0.83
12 Development of efficient packaging method of oligodeoxynucleotides by a condensed nano particle in lipid envelope structure. Biol Pharm Bull 2005 0.83
13 Adenosine-1,3-diazaphenoxazine derivative for selective base pair formation with 8-oxo-2'-deoxyguanosine in DNA. J Am Chem Soc 2011 0.82
14 Pin-point chemical modification of RNA with diverse molecules through the functionality transfer reaction and the copper-catalyzed azide-alkyne cycloaddition reaction. Chem Commun (Camb) 2011 0.82
15 Selective cross-linking to the adenine of the TA interrupting site within the triple helix. Bioorg Med Chem Lett 2002 0.81
16 Alteration of cross-linking selectivity with the 2'-OMe analogue of 2-amino-6-vinylpurine and evaluation of antisense effects. Bioorg Med Chem Lett 2010 0.81
17 Specific fluorescent probe for 8-oxoguanosine. Angew Chem Int Ed Engl 2007 0.81
18 Design of new bidentate ligands constructed of two Hoechst 33258 units for discrimination of the length of two A3T3 binding motifs. J Org Chem 2006 0.80
19 Addition of a 2-month low-dose course of levofloxacin to long-term erythromycin therapy in sinobronchial syndrome. Respirology 2002 0.80
20 A new odorless procedure for the synthesis of 2'-deoxy-6-thioguanosine and its incorporation into oligodeoxynucleotides. Nucleosides Nucleotides Nucleic Acids 2009 0.79
21 Sequence- and base-specific delivery of nitric oxide to cytidine and 5-methylcytidine leading to efficient deamination. J Am Chem Soc 2004 0.79
22 Activation and alteration of base selectivity by metal cations in the functionality-transfer reaction for RNA modification. Bioconjug Chem 2010 0.79
23 Selective fluorescence quenching of the 8-oxoG-clamp by 8-oxodeoxyguanosine in ODN. Bioorg Med Chem Lett 2008 0.78
24 An efficient and simple method for site-selective modification of O6-methyl-2'-deoxyguanosine in DNA. Chem Commun (Camb) 2012 0.78
25 An efficient antigene activity and antiproliferative effect by targeting the Bcl-2 or survivin gene with triplex forming oligonucleotides containing a W-shaped nucleoside analogue (WNA-βT). Org Biomol Chem 2012 0.78
26 Recognition of CG interrupting site by W-shaped nucleoside analogs (WNA) having the pyrazole ring in an anti-parallel triplex DNA. Bioorg Med Chem 2009 0.78
27 Expansion of triplex recognition codes by the use of novel bicyclic nucleoside derivatives (WNA). Nucleosides Nucleotides Nucleic Acids 2005 0.77
28 Chemical tools for targeted mutagenesis of DNA based on triple helix formation. Biol Pharm Bull 2004 0.77
29 A new usage of functionalized oligodeoxynucleotide probe for site-specific modification of a guanine base within RNA. Nucleic Acids Res 2010 0.77
30 The ODN probes conjugating the Cu(II) complex enhance the luminol chemiluminescence by assembling on the DNA template. Bioorg Med Chem 2010 0.77
31 Modification of the aromatic ring of the WNA analogues for expansion of the triplex recognition codes. Nucleic Acids Symp Ser (Oxf) 2005 0.77
32 Effects of halogenated WNA derivatives on sequence dependency for expansion of recognition sequences in non-natural-type triplexes. J Org Chem 2006 0.77
33 Synthesis and biological evaluation of 5-carbamoyl-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors. Bioorg Med Chem 2013 0.76
34 Incorporation of an inducible nucleotide analog into DNA by DNA polymerases. Bioorg Med Chem 2009 0.76
35 The spermine-bisaryl conjugate as a potent inducer of B- to Z-DNA transition. Chemistry 2010 0.76
36 Development of a specific fluorescent probe for 8-oxoguanosine. Nucleic Acids Symp Ser (Oxf) 2007 0.76
37 OFF-to-ON type fluorescent probe for the detection of 8-oxo-dG in DNA by the Adap-masked ODN probe. Bioorg Med Chem Lett 2011 0.76
38 Site-specific modification of RNA by functionality-transfer ODN probes. Nucleic Acids Symp Ser (Oxf) 2009 0.76
39 Difference in brain distributions of carbon 11-labeled 4-hydroxy-2(1H)-quinolones as PET radioligands for the glycine-binding site of the NMDA ion channel. Nucl Med Biol 2008 0.76
40 Synthesis of the oligoribonucleotides incorporating 8-oxo-guanosine and evaluation of their base pairing properties. Nucleosides Nucleotides Nucleic Acids 2013 0.76
41 Discrimination between 8-oxo-2'-deoxyguanosine and 2'-deoxyguanosine in DNA by the single nucleotide primer extension reaction with adap triphosphate. Angew Chem Int Ed Engl 2015 0.76
42 A new copper(II) complex as an efficient catalyst of luminol chemiluminescence. Org Lett 2007 0.75
43 Selective fluorescence detection of 8-oxoguanosine with 8-oxoG-clamp. Nucleosides Nucleotides Nucleic Acids 2007 0.75
44 Synthesis, in vitro and in vivo pharmacology of a C-11 labeled analog of CP-101,606, (+/-)threo-1-(4-hydroxyphenyl)-2-[4-hydroxy-4-(p-[11C]methoxyphenyl)piperidino]-1-propanol, as a PET tracer for NR2B subunit-containing NMDA receptors. Nucl Med Biol 2002 0.75
45 B-Z transition of (dA-T)(n) duplexes induced by a spermine porphyrin-conjugate via an intermediate DNA conformation. Chem Commun (Camb) 2013 0.75
46 Application of 2-amino-6-vinylpurine as an efficient agent for conjugation of oligonucleotides. Nucleosides Nucleotides Nucleic Acids 2006 0.75
47 New DNA binding ligands as a model of chromomycin A3. Bioorg Med Chem Lett 2004 0.75
48 Design and evaluation of novel nucleoside analogs (WNA) for specific formation of non-natural type triplexes containing a TA or CG interrupting site. Nucleic Acids Res Suppl 2003 0.75
49 N-(guanidinoethyl)-2'-deoxy-5-methylisocytidine exhibits selective recognition of a CG interrupting site for the formation of anti-parallel triplexes. Org Biomol Chem 2013 0.75
50 Substituent effects on the in situ activation of the double activated cross-linking reaction. Nucleic Acids Symp Ser (Oxf) 2005 0.75
51 Effects of 5-substituted pyrimidine nucleoside bases of WNA on stability of triplex DNA. Nucleic Acids Symp Ser (Oxf) 2004 0.75
52 Novel drug releasing system triggered by hybridization with target sequence. Nucleic Acids Symp Ser (Oxf) 2006 0.75
53 Enzymatic incorporation of 2-amino-6-vinylpurine derivative. Nucleic Acids Symp Ser (Oxf) 2007 0.75
54 An isocytidine derivative with a 2-amino-6-methylpyridine unit for selective recognition of the CG interrupting site in an antiparallel triplex DNA. Chembiochem 2014 0.75
55 Synthesis of the new nucleoside analogue connecting 2-amino-6-vinylpurine to the 2'-deoxyribose skeleton via the methylene linker. Nucleic Acids Symp Ser (Oxf) 2008 0.75
56 Enantioselective binding of chiral 1,14-dimethyl[5]helicene-spermine ligands with B- and Z-DNA. Bioorg Med Chem 2013 0.75
57 Synthesis and evaluation of the functional oligonucleotides-PEG conjugates. Nucleic Acids Symp Ser (Oxf) 2004 0.75
58 Cu2+ -mediated assembly of the minor groove binders on the DNA template with sequence selectivity. Org Lett 2006 0.75
59 Recognition of DNA with assembly of minor groove binders mediated by metal complexation. Nucleic Acids Symp Ser (Oxf) 2006 0.75
60 Synthesis and evaluation of the luciferase-oligodeoxynucleotide for the sequence-selective detection of nucleic acids. Arch Pharm (Weinheim) 2008 0.75
61 Binding of two bis-bipyridine minor groove binders to a DNA template in the presence of Cu2+ ions. Nucleic Acids Symp Ser (Oxf) 2008 0.75
62 Formation of a stable triplex incorporating a CG interrupting site by a new WNA derivative containing 3-aminopyrazole as a nucleobase. Nucleic Acids Symp Ser (Oxf) 2008 0.75
63 Evaluation of the antisense effect of PEGylated oligodeoxynucleotides containing intelligent nucleoside analogues. Nucleic Acids Symp Ser (Oxf) 2009 0.75
64 Effects of the modified aromatic ring of WNA on stability of triplex DNA. Nucleic Acids Symp Ser (Oxf) 2006 0.75
65 Development of novel thioguanosine analogs with the ability to specifically modify cytidine. Nucleic Acids Symp Ser (Oxf) 2007 0.75
66 Enhancement of TFO Triplex Formation by Conjugation with Pyrene via Click Chemistry. Chem Pharm Bull (Tokyo) 2015 0.75
67 Efficient cross-linking reactions by functional nucleobases capable of in situ activation under neutral conditions. Nucleic Acids Res Suppl 2003 0.75
68 Fluorescence detection of 8-oxoguanosine by G-clamp derivatives. Nucleic Acids Symp Ser (Oxf) 2006 0.75
69 Synthesis of 8-oxoguanosine phosphoramidite and its incorporation. Curr Protoc Nucleic Acid Chem 2014 0.75
70 Efficient Thymidine-Selective DNA Interstrand Photo-activated Crosslinking by the 6-Thioguanine Connected via an Ethylene-Linker to the 2'-Deoxyribose Unit. Chem Pharm Bull (Tokyo) 2016 0.75
71 Efficient DNA strand displacement by a W-shaped nucleoside analogue (WNA-βT) containing an ortho-methyl-substituted phenyl ring. Chembiochem 2012 0.75
72 Design of highly efficient and selective transfer reaction of nitrosyl group to dc and d(M)C resulting in specific deamination. Nucleosides Nucleotides Nucleic Acids 2005 0.75
73 Synthesis of new derivatives of 8-oxoG-clamp for better understanding the recognition mode and improvement of selective affinity. Bioorg Med Chem 2010 0.75
74 2-Amino-6-vinyl purine as a tool for post synthetic conjugation of DNA with radio-, spin-, fluorescence labels and peptides. Nucleic Acids Res Suppl 2002 0.75
75 Discrimination of the length of two remote binding sites by the spacer-linked DNA minor groove binders. Nucleic Acids Symp Ser (Oxf) 2005 0.75
76 Selective formation of non-natural type triplexes containing TA interrupting sites with the TFO incorporating W-shape nucleic acid (WNA) analogs. Nucleic Acids Res Suppl 2002 0.75
77 Enhancements in the utilization of antigene oligonucleotides in the nucleus by booster oligonucleotides. Chem Commun (Camb) 2020 0.75
78 Selective nitrosyl group transfer reaction to cytidine using oligonucleotides bearing S-nitrosothioguanosine. Nucleic Acids Symp Ser (Oxf) 2004 0.75
79 Synthesis and evaluation of 4-bromo-1-(3-[18F]fluoropropyl)-2-nitroimidazole with a low energy LUMO orbital designed as brain hypoxia-targeting imaging agent. Biol Pharm Bull 2002 0.75
80 Properties of oligonucleotide with phenyl-substituted carbocyclic nucleoside analogs for the formation of duplex and triplex DNA. Nucleosides Nucleotides Nucleic Acids 2012 0.75
81 Development of the novel drug releasing system triggered by hybridization with target sequence. Nucleosides Nucleotides Nucleic Acids 2007 0.75
82 Structural activity relationship between Salmonella-mutagenicity and nitro-orientation of nitroazaphenanthrenes. Chem Biol Interact 2003 0.75
83 Synthesis and binding properties of new selective ligands for the nucleobase opposite the AP site. Bioorg Med Chem 2012 0.75
84 Fluorescence and chemiluminescence properties of indolylmaleimides: experimental and theoretical studies. Phys Chem Chem Phys 2010 0.75
85 Synthesis and brain regional distribution of [11C]NPS 1506 in mice and rat: an N-methyl-D-aspartate (NMDA) receptor antagonist. Biol Pharm Bull 2003 0.75
86 Mutagenesis targeted by triple-helix forming oligonucleotides containing a reactive nucleoside analogue. Nucleic Acids Res Suppl 2002 0.75
87 Effective strand invasion ODN incorporating a new bicyclic nucleoside analogue (WNA). Nucleic Acids Symp Ser (Oxf) 2007 0.75
88 Efficient covalent capture of 8-nitroguanosine via a multiple hydrogen-bonded complex. Org Lett 2014 0.75
89 New NitroG-Grasp Molecules with Enhanced Capture Reactivity for 8-Nitroguanosine in the Aqueous Media. Chem Pharm Bull (Tokyo) 2015 0.75
90 Equilibrium shift by target DNA substrates for determination of DNA binding ligands. Bioorg Med Chem Lett 2006 0.75
91 Site-specific modification by functionality-transfer oligonucleotide with the photo-inducible reactivity. Nucleic Acids Symp Ser (Oxf) 2008 0.75