Published in Neural Dev on August 15, 2007
Protein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injury. J Cell Biol (2010) 2.40
Drosophila Rae1 controls the abundance of the ubiquitin ligase Highwire in post-mitotic neurons. Nat Neurosci (2011) 1.66
The Highwire ubiquitin ligase promotes axonal degeneration by tuning levels of Nmnat protein. PLoS Biol (2012) 1.60
The Phr1 ubiquitin ligase promotes injury-induced axon self-destruction. Cell Rep (2013) 1.39
Think locally: control of ubiquitin-dependent protein degradation in neurons. EMBO Rep (2008) 1.33
Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development. Mol Cell Biol (2009) 1.28
Roles of ubiquitination at the synapse. Biochim Biophys Acta (2008) 1.19
Cellular and molecular determinants targeting the Caenorhabditis elegans PHR protein RPM-1 to perisynaptic regions. Dev Dyn (2008) 1.08
Fbxo45, a novel ubiquitin ligase, regulates synaptic activity. J Biol Chem (2009) 1.08
A mechanism distinct from highwire for the Drosophila ubiquitin conjugase bendless in synaptic growth and maturation. J Neurosci (2008) 1.02
The role of the ubiquitin proteasome system in synapse remodeling and neurodegenerative diseases. Bioessays (2008) 1.01
Loss of the spectraplakin short stop activates the DLK injury response pathway in Drosophila. J Neurosci (2013) 0.97
Highwire regulates guidance of sister axons in the Drosophila mushroom body. J Neurosci (2011) 0.96
Regulation of Drosophila vasa in vivo through paralogous cullin-RING E3 ligase specificity receptors. Mol Cell Biol (2010) 0.95
The ubiquitin ligase MYCBP2 regulates transient receptor potential vanilloid receptor 1 (TRPV1) internalization through inhibition of p38 MAPK signaling. J Biol Chem (2010) 0.93
PPM-1, a PP2Cα/β phosphatase, regulates axon termination and synapse formation in Caenorhabditis elegans. Genetics (2011) 0.93
The nonsense-mediated decay pathway maintains synapse architecture and synaptic vesicle cycle efficacy. J Cell Sci (2010) 0.92
The role of ubiquitin-mediated pathways in regulating synaptic development, axonal degeneration and regeneration: insights from fly and worm. J Physiol (2013) 0.91
Transmission, Development, and Plasticity of Synapses. Genetics (2015) 0.89
Attenuation of insulin signalling contributes to FSN-1-mediated regulation of synapse development. EMBO J (2013) 0.88
RPM-1 uses both ubiquitin ligase and phosphatase-based mechanisms to regulate DLK-1 during neuronal development. PLoS Genet (2014) 0.87
SkpA restrains synaptic terminal growth during development and promotes axonal degeneration following injury. J Neurosci (2014) 0.87
Breaking it down: the ubiquitin proteasome system in neuronal morphogenesis. Neural Plast (2013) 0.87
A ubiquitin E2 variant protein acts in axon termination and synaptogenesis in Caenorhabditis elegans. Genetics (2010) 0.86
Fbxo45-mediated degradation of the tumor-suppressor Par-4 regulates cancer cell survival. Cell Death Differ (2014) 0.85
The E3 ubiquitin ligase protein associated with Myc (Pam) regulates mammalian/mechanistic target of rapamycin complex 1 (mTORC1) signaling in vivo through N- and C-terminal domains. J Biol Chem (2012) 0.84
Identification of a peptide inhibitor of the RPM-1 · FSN-1 ubiquitin ligase complex. J Biol Chem (2014) 0.80
Identifying protein-protein interaction in Drosophila adult heads by Tandem Affinity Purification (TAP). J Vis Exp (2013) 0.79
Fly neurobiology: development and function of the brain. Meeting on the Neurobiology of Drosophila. EMBO Rep (2008) 0.78
The PHR proteins: intracellular signaling hubs in neuronal development and axon degeneration. Neural Dev (2016) 0.78
Structures of PHR domains from Mus musculus Phr1 (Mycbp2) explain the loss-of-function mutation (Gly1092-->Glu) of the C. elegans ortholog RPM-1. J Mol Biol (2010) 0.77
Fbxo45 inhibits calcium-sensitive proteolysis of N-cadherin and promotes neuronal differentiation. J Biol Chem (2014) 0.77
The F-box protein MEC-15 (FBXW9) promotes synaptic transmission in GABAergic motor neurons in C. elegans. PLoS One (2013) 0.76
MYCBP2 Is a Guanosine Exchange Factor for Ran Protein and Determines Its Localization in Neurons of Dorsal Root Ganglia. J Biol Chem (2015) 0.75
Defining minimal binding regions in Regulator of Presynaptic Morphology 1 (RPM-1) using C. elegans neurons reveals differential signaling complexes. J Biol Chem (2016) 0.75
Axon Branch-Specific Semaphorin-1a Signaling in Drosophila Mushroom Body Development. Front Cell Neurosci (2016) 0.75
Wallenda/DLK protein levels are temporally downregulated by Tramtrack69 to allow R7 growth cones to become stationary boutons. Development (2016) 0.75
Identification of potential mediators of retinotopic mapping: a comparative proteomic analysis of optic nerve from WT and Phr1 retinal knockout mice. J Proteome Res (2012) 0.75
Restraint of presynaptic protein levels by Wnd/DLK signaling mediates synaptic defects associated with the kinesin-3 motor Unc-104. Elife (2017) 0.75
Genome-wide atlas of gene expression in the adult mouse brain. Nature (2006) 28.02
A generic protein purification method for protein complex characterization and proteome exploration. Nat Biotechnol (1999) 25.13
RING finger proteins: mediators of ubiquitin ligase activity. Cell (2000) 7.75
Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons. Nat Genet (1998) 5.55
A conditional tissue-specific transgene expression system using inducible GAL4. Proc Natl Acad Sci U S A (2001) 4.93
Improved stability of Drosophila larval neuromuscular preparations in haemolymph-like physiological solutions. J Comp Physiol A (1994) 4.24
The F-box protein family. Genome Biol (2000) 4.00
RING for destruction? Curr Biol (2000) 3.60
Highwire restrains synaptic growth by attenuating a MAP kinase signal. Neuron (2006) 3.17
Regulation of synapse structure and function by the Drosophila tumor suppressor gene dlg. Neuron (1996) 2.97
Regulation of a DLK-1 and p38 MAP kinase pathway by the ubiquitin ligase RPM-1 is required for presynaptic development. Cell (2005) 2.93
Ubiquitination-dependent mechanisms regulate synaptic growth and function. Nature (2001) 2.70
Highwire regulates synaptic growth in Drosophila. Neuron (2000) 2.70
Synaptic development: insights from Drosophila. Curr Opin Neurobiol (2007) 2.67
Differential localization of glutamate receptor subunits at the Drosophila neuromuscular junction. J Neurosci (2004) 2.43
rpm-1, a conserved neuronal gene that regulates targeting and synaptogenesis in C. elegans. Neuron (2000) 2.36
Highwire function at the Drosophila neuromuscular junction: spatial, structural, and temporal requirements. J Neurosci (2005) 2.30
Increased expression of the Drosophila vesicular glutamate transporter leads to excess glutamate release and a compensatory decrease in quantal content. J Neurosci (2004) 2.30
Regulation of presynaptic terminal organization by C. elegans RPM-1, a putative guanine nucleotide exchanger with a RING-H2 finger domain. Neuron (2000) 2.12
An SCF-like ubiquitin ligase complex that controls presynaptic differentiation. Nature (2004) 2.02
Highwire regulates presynaptic BMP signaling essential for synaptic growth. Neuron (2004) 1.91
Neural specificity of elav expression: defining a Drosophila promoter for directing expression to the nervous system. J Neurochem (1994) 1.76
Single-cell analysis of Drosophila larval neuromuscular synapses. Dev Biol (2001) 1.67
Formation of the retinotectal projection requires Esrom, an ortholog of PAM (protein associated with Myc). Development (2004) 1.50
Evidence for a conserved function in synapse formation reveals Phr1 as a candidate gene for respiratory failure in newborn mice. Mol Cell Biol (2004) 1.44
Identification of a large Myc-binding protein that contains RCC1-like repeats. Proc Natl Acad Sci U S A (1998) 1.34
The role of neuronal identity in synaptic competition. Nature (2003) 1.30
Vectors for the expression of tagged proteins in Drosophila. Biotechniques (2001) 1.27
Pam and its ortholog highwire interact with and may negatively regulate the TSC1.TSC2 complex. J Biol Chem (2003) 1.26
PAM mediates sustained inhibition of cAMP signaling by sphingosine-1-phosphate. EMBO J (2004) 1.06
Developmental expression of PAM (protein associated with MYC) in the rodent brain. Brain Res Dev Brain Res (2002) 0.95
Control of protein degradation by E3 ubiquitin ligases in Drosophila eye development. Trends Genet (2003) 0.91
Highwire restrains synaptic growth by attenuating a MAP kinase signal. Neuron (2006) 3.17
Dual leucine zipper kinase is required for retrograde injury signaling and axonal regeneration. Neuron (2012) 2.88
Synaptic development: insights from Drosophila. Curr Opin Neurobiol (2007) 2.67
Differential localization of glutamate receptor subunits at the Drosophila neuromuscular junction. J Neurosci (2004) 2.43
A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration. Nat Neurosci (2009) 2.42
Highwire function at the Drosophila neuromuscular junction: spatial, structural, and temporal requirements. J Neurosci (2005) 2.30
Increased expression of the Drosophila vesicular glutamate transporter leads to excess glutamate release and a compensatory decrease in quantal content. J Neurosci (2004) 2.30
A single vesicular glutamate transporter is sufficient to fill a synaptic vesicle. Neuron (2006) 2.09
Rab3 dynamically controls protein composition at active zones. Neuron (2009) 2.07
The requirement for Phr1 in CNS axon tract formation reveals the corticostriatal boundary as a choice point for cortical axons. Genes Dev (2007) 1.85
Drosophila Rae1 controls the abundance of the ubiquitin ligase Highwire in post-mitotic neurons. Nat Neurosci (2011) 1.66
Visualizing glutamatergic cell bodies and synapses in Drosophila larval and adult CNS. J Comp Neurol (2008) 1.54
Preferential localization of glutamate receptors opposite sites of high presynaptic release. Curr Biol (2004) 1.46
The Phr1 ubiquitin ligase promotes injury-induced axon self-destruction. Cell Rep (2013) 1.39
Amyloid precursor protein cleavage-dependent and -independent axonal degeneration programs share a common nicotinamide mononucleotide adenylyltransferase 1-sensitive pathway. J Neurosci (2010) 1.37
Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death. Proc Natl Acad Sci U S A (2013) 1.36
Sarm1-mediated axon degeneration requires both SAM and TIR interactions. J Neurosci (2013) 1.32
Ubiquitin and the synapse. Nat Rev Neurosci (2002) 1.29
Postfusional control of quantal current shape. Neuron (2004) 1.26
AP180 maintains the distribution of synaptic and vesicle proteins in the nerve terminal and indirectly regulates the efficacy of Ca2+-triggered exocytosis. J Neurophysiol (2005) 1.18
SCG10 is a JNK target in the axonal degeneration pathway. Proc Natl Acad Sci U S A (2012) 1.16
The novel endosomal membrane protein Ema interacts with the class C Vps-HOPS complex to promote endosomal maturation. J Cell Biol (2010) 1.13
Modification of a hydrophobic layer by a point mutation in syntaxin 1A regulates the rate of synaptic vesicle fusion. PLoS Biol (2007) 1.07
A model of toxic neuropathy in Drosophila reveals a role for MORN4 in promoting axonal degeneration. J Neurosci (2012) 1.05
Synaptic defects in a Drosophila model of congenital muscular dystrophy. J Neurosci (2008) 1.05
Increased vesicular glutamate transporter expression causes excitotoxic neurodegeneration. Neurobiol Dis (2010) 1.03
Genomewide analysis of the Drosophila tetraspanins reveals a subset with similar function in the formation of the embryonic synapse. Proc Natl Acad Sci U S A (2002) 1.02
The B' protein phosphatase 2A regulatory subunit well-rounded regulates synaptic growth and cytoskeletal stability at the Drosophila neuromuscular junction. J Neurosci (2006) 1.01
Genetic modifiers of abnormal organelle biogenesis in a Drosophila model of BLOC-1 deficiency. Hum Mol Genet (2009) 1.00
RIM promotes calcium channel accumulation at active zones of the Drosophila neuromuscular junction. J Neurosci (2012) 1.00
Loss of the spectraplakin short stop activates the DLK injury response pathway in Drosophila. J Neurosci (2013) 0.97
Phr1 regulates retinogeniculate targeting independent of activity and ephrin-A signalling. Mol Cell Neurosci (2009) 0.96
Highwire regulates guidance of sister axons in the Drosophila mushroom body. J Neurosci (2011) 0.96
PP2A and GSK-3beta act antagonistically to regulate active zone development. J Neurosci (2009) 0.94
Drosophila Golgi membrane protein Ema promotes autophagosomal growth and function. Proc Natl Acad Sci U S A (2012) 0.90
Stathmin is required for stability of the Drosophila neuromuscular junction. J Neurosci (2011) 0.89
The cytoplasmic adaptor protein Caskin mediates Lar signal transduction during Drosophila motor axon guidance. J Neurosci (2011) 0.87
A screen for neurotransmitter transporters expressed in the visual system of Drosophila melanogaster identifies three novel genes. Dev Neurobiol (2007) 0.87
The atypical cadherin flamingo regulates synaptogenesis and helps prevent axonal and synaptic degeneration in Drosophila. Mol Cell Neurosci (2007) 0.86
A large-scale RNAi screen identifies functional classes of genes shaping synaptic development and maintenance. Dev Biol (2012) 0.85
The E3 ubiquitin ligase protein associated with Myc (Pam) regulates mammalian/mechanistic target of rapamycin complex 1 (mTORC1) signaling in vivo through N- and C-terminal domains. J Biol Chem (2012) 0.84
Investigating the safety factor at an invertebrate neuromuscular junction. J Neurobiol (2005) 0.82
A tyrosine-based motif localizes a Drosophila vesicular transporter to synaptic vesicles in vivo. J Biol Chem (2010) 0.80
A role for the membrane Golgi protein Ema in autophagy. Autophagy (2012) 0.79
Coordinating synaptic growth without being a nervous wreck. Neuron (2004) 0.78
EGFR signaling modulates synaptic connectivity via Gurken. Dev Neurobiol (2012) 0.76
Identification of potential mediators of retinotopic mapping: a comparative proteomic analysis of optic nerve from WT and Phr1 retinal knockout mice. J Proteome Res (2012) 0.75
Fast flies take a quantum leap. Neuron (2006) 0.75
Vesicular neurotransmitter transporter trafficking in vivo: moving from cells to flies. Fly (Austin) (2010) 0.75
For nonscientists and subjects, consent forms are too technical. IRB (1993) 0.75