Published in J Biol Chem on August 15, 2007
Sialic acids in the brain: gangliosides and polysialic acid in nervous system development, stability, disease, and regeneration. Physiol Rev (2014) 1.32
Synaptic cell adhesion molecule SynCAM 1 is a target for polysialylation in postnatal mouse brain. Proc Natl Acad Sci U S A (2010) 1.30
Molecular mechanism underlying sialic acid as an essential nutrient for brain development and cognition. Adv Nutr (2012) 1.19
Polysialic acid, a glycan with highly restricted expression, is found on human and murine leukocytes and modulates immune responses. J Immunol (2008) 1.11
LPS-induced cytokine production in human dendritic cells is regulated by sialidase activity. J Leukoc Biol (2010) 1.03
Function of members of the neuropilin family as essential pleiotropic cell surface receptors. Biochemistry (2012) 0.99
Interaction of polysialic acid with CCL21 regulates the migratory capacity of human dendritic cells. PLoS One (2009) 0.96
Polysialylation controls dendritic cell trafficking by regulating chemokine recognition. Science (2015) 0.92
Neuropilins: a new target for cancer therapy. Cancers (Basel) (2011) 0.90
Glycosyltransferase and sulfotransferase gene expression profiles in human monocytes, dendritic cells and macrophages. Glycoconj J (2009) 0.88
Structure and mutagenesis of neural cell adhesion molecule domains: evidence for flexibility in the placement of polysialic acid attachment sites. J Biol Chem (2010) 0.88
Polysialic acid glycomimetic promotes functional recovery and plasticity after spinal cord injury in mice. Mol Ther (2009) 0.87
The emerging role of class-3 semaphorins and their neuropilin receptors in oncology. Onco Targets Ther (2014) 0.86
Functional role of the interaction between polysialic acid and myristoylated alanine-rich C kinase substrate at the plasma membrane. J Biol Chem (2013) 0.85
Polysialic acid on neuropilin-2 is exclusively synthesized by the polysialyltransferase ST8SiaIV and attached to mucin-type o-glycans located between the b2 and c domain. J Biol Chem (2013) 0.84
Integration of genotypic and phenotypic screening reveals molecular mediators of melanoma-stromal interaction. Cancer Res (2011) 0.84
Identification of sequences in the polysialyltransferases ST8Sia II and ST8Sia IV that are required for the protein-specific polysialylation of the neural cell adhesion molecule, NCAM. J Biol Chem (2009) 0.83
Sequences prior to conserved catalytic motifs of polysialyltransferase ST8Sia IV are required for substrate recognition. J Biol Chem (2011) 0.83
Polysialylation of the synaptic cell adhesion molecule 1 (SynCAM 1) depends exclusively on the polysialyltransferase ST8SiaII in vivo. J Biol Chem (2012) 0.83
Polysialic acid enhances the migration and invasion of human cytotrophoblasts. Glycobiology (2012) 0.82
The polysialyltransferases interact with sequences in two domains of the neural cell adhesion molecule to allow its polysialylation. J Biol Chem (2013) 0.81
Sequences at the interface of the fifth immunoglobulin domain and first fibronectin type III repeat of the neural cell adhesion molecule are critical for its polysialylation. J Biol Chem (2010) 0.81
Sequences from the first fibronectin type III repeat of the neural cell adhesion molecule allow O-glycan polysialylation of an adhesion molecule chimera. J Biol Chem (2010) 0.81
Developmental regulation of oligosialylation in zebrafish. Glycoconj J (2008) 0.81
Rapid Trimming of Cell Surface Polysialic Acid (PolySia) by Exovesicular Sialidase Triggers Release of Preexisting Surface Neurotrophin. J Biol Chem (2015) 0.81
Polysialic acid is present in mammalian semen as a post-translational modification of the neural cell adhesion molecule NCAM and the polysialyltransferase ST8SiaII. J Biol Chem (2013) 0.81
A novel unbalanced de novo translocation der(5)t(4;5)(q26;q21.1) in adult T-cell precursor lymphoblastic leukemia. Mol Cytogenet (2012) 0.80
Changes in polysialic acid expression on myeloid cells during differentiation and recruitment to sites of inflammation: role in phagocytosis. Glycobiology (2014) 0.80
Molecular cloning and characterization of the expression pattern of the zebrafish alpha2, 8-sialyltransferases (ST8Sia) in the developing nervous system. Glycoconj J (2008) 0.79
ST8SIA4-Dependent Polysialylation is Part of a Developmental Program Required for Germ Layer Formation from Human Pluripotent Stem Cells. Stem Cells (2016) 0.78
Sequence Requirements for Neuropilin-2 Recognition by ST8SiaIV and Polysialylation of Its O-Glycans. J Biol Chem (2016) 0.78
Polysialylation of NCAM characterizes the proliferation period of contractile elements during postnatal development of the epididymis. PLoS One (2015) 0.77
NCAM1 Polysialylation: The Prion Protein's Elusive Reason for Being? ASN Neuro (2016) 0.77
Chronic allograft rejection: a fresh look. Curr Opin Organ Transplant (2015) 0.77
Polysialic acid expression is not necessary for motor neuron target selectivity. Muscle Nerve (2012) 0.77
An antibody to de-N-acetyl sialic acid containing-polysialic acid identifies an intracellular antigen and induces apoptosis in human cancer cell lines. PLoS One (2011) 0.77
Molecular mechanisms underlying activity-dependent GABAergic synapse development and plasticity and its implications for neurodevelopmental disorders. Neural Plast (2011) 0.76
Effects of polysialic acid on sensory innervation of the cornea. Dev Biol (2014) 0.75
Polysialylated N-glycans identified in human serum through combined developments in sample preparation, separations, and electrospray ionization-mass spectrometry. Anal Chem (2014) 0.75
The expression profile of de-N-acetyl polysialic acid (NeuPSA) in normal and diseased human tissue. J Biol Chem (2011) 0.75
Class 3 semaphorins induce F-actin reorganization in human dendritic cells: Role in cell migration. J Leukoc Biol (2016) 0.75
Sialylation of N-glycans: mechanism, cellular compartmentalization and function. Histochem Cell Biol (2016) 0.75
Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study. J Vis Exp (2016) 0.75
Retargeted oncolytic viruses provoke tumor-directed T-cell responses. Oncoimmunology (2015) 0.75
The intragraft microenvironment as a central determinant of chronic rejection or local immunoregulation/tolerance. Curr Opin Organ Transplant (2016) 0.75
Molecular characterization and expression analyses of ST8Sia II and IV in piglets during postnatal development: lack of correlation between transcription and posttranslational levels. Glycoconj J (2015) 0.75
The polysialic acid mimetics idarubicin and irinotecan stimulate neuronal survival and neurite outgrowth and signal via protein kinase C. J Neurochem (2017) 0.75
Restoration of immunity in lymphopenic individuals with cancer by vaccination and adoptive T-cell transfer. Nat Med (2005) 3.65
A syndrome with congenital neutropenia and mutations in G6PC3. N Engl J Med (2009) 2.30
Genetic ablation of polysialic acid causes severe neurodevelopmental defects rescued by deletion of the neural cell adhesion molecule. J Biol Chem (2005) 1.62
Evolution of bacteriophages infecting encapsulated bacteria: lessons from Escherichia coli K1-specific phages. Mol Microbiol (2006) 1.60
TLR4 signaling is coupled to SRC family kinase activation, tyrosine phosphorylation of zonula adherens proteins, and opening of the paracellular pathway in human lung microvascular endothelia. J Biol Chem (2008) 1.55
The structures of bacteriophages K1E and K1-5 explain processive degradation of polysaccharide capsules and evolution of new host specificities. J Mol Biol (2007) 1.48
Deficits in sialylation impair podocyte maturation. J Am Soc Nephrol (2012) 1.47
Toward a carbohydrate-based HIV-1 vaccine: synthesis and immunological studies of oligomannose-containing glycoconjugates. Bioconjug Chem (2006) 1.42
Crystal structure of the polysialic acid-degrading endosialidase of bacteriophage K1F. Nat Struct Mol Biol (2004) 1.36
Sialic acids in the brain: gangliosides and polysialic acid in nervous system development, stability, disease, and regeneration. Physiol Rev (2014) 1.32
Polysialylated neural cell adhesion molecule is involved in induction of long-term potentiation and memory acquisition and consolidation in a fear-conditioning paradigm. J Neurosci (2006) 1.23
Functional UDP-xylose transport across the endoplasmic reticulum/Golgi membrane in a Chinese hamster ovary cell mutant defective in UDP-xylose Synthase. J Biol Chem (2008) 1.23
Targeted gene deletion of Leishmania major UDP-galactopyranose mutase leads to attenuated virulence. J Biol Chem (2007) 1.22
The human solute carrier gene SLC35B4 encodes a bifunctional nucleotide sugar transporter with specificity for UDP-xylose and UDP-N-acetylglucosamine. J Biol Chem (2005) 1.19
Fc-dependent expression of CD137 on human NK cells: insights into "agonistic" effects of anti-CD137 monoclonal antibodies. Blood (2008) 1.18
Dissecting polysialic acid and NCAM functions in brain development. J Neurochem (2007) 1.18
Monocyte differentiation up-regulates the expression of the lysosomal sialidase, Neu1, and triggers its targeting to the plasma membrane via major histocompatibility complex class II-positive compartments. J Biol Chem (2006) 1.13
Biochemical characterization of a Neisseria meningitidis polysialyltransferase reveals novel functional motifs in bacterial sialyltransferases. Mol Microbiol (2007) 1.13
In vivo synaptic plasticity in the dentate gyrus of mice deficient in the neural cell adhesion molecule NCAM or its polysialic acid. Eur J Neurosci (2006) 1.12
Identification and partial characterization of two eukaryotic UDP-galactopyranose mutases. Biol Chem (2005) 1.11
Polysialic acid, a glycan with highly restricted expression, is found on human and murine leukocytes and modulates immune responses. J Immunol (2008) 1.11
Proteolytic processing and oligomerization of bacteriophage-derived endosialidases. J Biol Chem (2003) 1.09
Crystal structure of an intramolecular chaperone mediating triple-beta-helix folding. Nat Struct Mol Biol (2010) 1.08
Imbalance of neural cell adhesion molecule and polysialyltransferase alleles causes defective brain connectivity. Brain (2009) 1.08
Neural cell adhesion molecule-associated polysialic acid regulates synaptic plasticity and learning by restraining the signaling through GluN2B-containing NMDA receptors. J Neurosci (2010) 1.07
Impact of the polysialyltransferases ST8SiaII and ST8SiaIV on polysialic acid synthesis during postnatal mouse brain development. J Biol Chem (2007) 1.02
Epidermal growth factor-like repeats of thrombospondins activate phospholipase Cgamma and increase epithelial cell migration through indirect epidermal growth factor receptor activation. J Biol Chem (2009) 1.02
Polysialic acid directs tumor cell growth by controlling heterophilic neural cell adhesion molecule interactions. Mol Cell Biol (2003) 1.01
Mobilization of neutrophil sialidase activity desialylates the pulmonary vascular endothelial surface and increases resting neutrophil adhesion to and migration across the endothelium. Glycobiology (2004) 1.01
Characterization of a novel intramolecular chaperone domain conserved in endosialidases and other bacteriophage tail spike and fiber proteins. J Biol Chem (2006) 1.01
Combination immunotherapy after ASCT for multiple myeloma using MAGE-A3/Poly-ICLC immunizations followed by adoptive transfer of vaccine-primed and costimulated autologous T cells. Clin Cancer Res (2014) 1.01
ST3GAL3 mutations impair the development of higher cognitive functions. Am J Hum Genet (2011) 1.01
A mechanistic perspective of monoclonal antibodies in cancer therapy beyond target-related effects. Oncologist (2007) 1.00
Sialidase expression in activated human T lymphocytes influences production of IFN-gamma. J Leukoc Biol (2006) 1.00
Food intake adaptation to dietary fat involves PSA-dependent rewiring of the arcuate melanocortin system in mice. J Neurosci (2012) 0.99
CMP-sialic acid synthetase of the nucleus. Biochim Biophys Acta (2004) 0.99
Identification of glycosyltransferase 8 family members as xylosyltransferases acting on O-glucosylated notch epidermal growth factor repeats. J Biol Chem (2009) 0.99
Brain development needs sugar: the role of polysialic acid in controlling NCAM functions. Biol Chem (2009) 0.98
A multivalent adsorption apparatus explains the broad host range of phage phi92: a comprehensive genomic and structural analysis. J Virol (2012) 0.98
Localization and characterization of polysialic acid-containing N-linked glycans from bovine NCAM. Glycobiology (2002) 0.97
Polysialic acid is required for neuropilin-2a/b-mediated control of CCL21-driven chemotaxis of mature dendritic cells and for their migration in vivo. Glycobiology (2011) 0.96
Polysialic acid profiles of mice expressing variant allelic combinations of the polysialyltransferases ST8SiaII and ST8SiaIV. J Biol Chem (2006) 0.96
Molecular cloning of two Arabidopsis UDP-galactose transporters by complementation of a deficient Chinese hamster ovary cell line. Glycobiology (2004) 0.96
Polysialic acid governs T-cell development by regulating progenitor access to the thymus. Proc Natl Acad Sci U S A (2009) 0.94
Polysialylated neuropilin-2 enhances human dendritic cell migration through the basic C-terminal region of CCL21. Glycobiology (2010) 0.93
Targeting epileptogenesis-associated induction of neurogenesis by enzymatic depolysialylation of NCAM counteracts spatial learning dysfunction but fails to impact epilepsy development. J Neurochem (2008) 0.93
The crystal structure of murine CMP-5-N-acetylneuraminic acid synthetase. J Mol Biol (2003) 0.93
Polysialic acid: versatile modification of NCAM, SynCAM 1 and neuropilin-2. Neurochem Res (2013) 0.93
Restoration of synaptic plasticity and learning in young and aged NCAM-deficient mice by enhancing neurotransmission mediated by GluN2A-containing NMDA receptors. J Neurosci (2012) 0.92
Molecular cloning of a xylosyltransferase that transfers the second xylose to O-glucosylated epidermal growth factor repeats of notch. J Biol Chem (2011) 0.92
Enzyme-dependent variations in the polysialylation of the neural cell adhesion molecule (NCAM) in vivo. J Biol Chem (2007) 0.91
Open and closed structures of the UDP-glucose pyrophosphorylase from Leishmania major. J Biol Chem (2007) 0.91
A CMP-sialic acid transporter cloned from Arabidopsis thaliana. Carbohydr Res (2008) 0.91
Molecular cloning of the Leishmania major UDP-glucose pyrophosphorylase, functional characterization, and ligand binding analyses using NMR spectroscopy. J Biol Chem (2006) 0.91
Quantification of nucleotide-activated sialic acids by a combination of reduction and fluorescent labeling. Anal Chem (2010) 0.90
Peptide-based candidate vaccine against respiratory syncytial virus. Vaccine (2005) 0.90
Syntaxin 11 marks a distinct intracellular compartment recruited to the immunological synapse of NK cells to colocalize with cytotoxic granules. J Cell Mol Med (2012) 0.89
Increase in plasmacytoid and myeloid dendritic cells by progenipoietin-1, a chimeric Flt-3 and G-CSF receptor agonist, in SIV-Infected rhesus macaques. Hum Immunol (2004) 0.89
Nuclear localization signal of murine CMP-Neu5Ac synthetase includes residues required for both nuclear targeting and enzymatic activity. J Biol Chem (2002) 0.89
Selective inhibition of polysialyltransferase ST8SiaII by unnatural sialic acids. Exp Cell Res (2004) 0.89
Localization of defined carbohydrate epitopes in bovine polysialylated NCAM. Biochimie (2003) 0.88
Induction of MAGE-A3 and HPV-16 immunity by Trojan vaccines in patients with head and neck carcinoma. Head Neck (2012) 0.88
Structure and function of vertebrate CMP-sialic acid synthetases. Glycobiology (2004) 0.88
Chemoenzymatic synthesis of CMP-N-acetyl-7-fluoro-7-deoxy-neuraminic acid. Carbohydr Res (2008) 0.87
Sialyl residues modulate LPS-mediated signaling through the Toll-like receptor 4 complex. PLoS One (2012) 0.87
West syndrome caused by ST3Gal-III deficiency. Epilepsia (2012) 0.87
Expression of sialyltransferase activity on intact human neutrophils. J Leukoc Biol (2008) 0.87
Structural basis for the recognition and cleavage of polysialic acid by the bacteriophage K1F tailspike protein EndoNF. J Mol Biol (2010) 0.86
Reduction of STAT3 expression induces mitochondrial dysfunction and autophagy in cardiac HL-1 cells. Eur J Cell Biol (2012) 0.86
Endoplasmic reticulum retention of the large splice variant of the UDP-galactose transporter is caused by a dilysine motif. Glycobiology (2005) 0.86
Proteolytic release of the intramolecular chaperone domain confers processivity to endosialidase F. J Biol Chem (2009) 0.86
The intracellular concentration of sialic acid regulates the polysialylation of the neural cell adhesion molecule. FEBS Lett (2005) 0.86
Level and localization of polysialic acid is critical for early peripheral nerve regeneration. Mol Cell Neurosci (2008) 0.86
Soluble polysialylated NCAM: a novel player of the innate immune system in the lung. Cell Mol Life Sci (2013) 0.86
Negative impact of human leukocyte antigen matching in the outcome of polyomavirus nephropathy. Transplantation (2005) 0.86
Distinct contributions of beta 4GalNAcTA and beta 4GalNAcTB to Drosophila glycosphingolipid biosynthesis. Glycoconj J (2007) 0.85
Mutations in SLC35A3 cause autism spectrum disorder, epilepsy and arthrogryposis. J Med Genet (2013) 0.84
Polysialic acid on neuropilin-2 is exclusively synthesized by the polysialyltransferase ST8SiaIV and attached to mucin-type o-glycans located between the b2 and c domain. J Biol Chem (2013) 0.84
Golgi targeting of Drosophila melanogaster beta4GalNAcTB requires a DHHC protein family-related protein as a pilot. J Cell Biol (2009) 0.84
A phase I dose escalation trial of MAGE-A3- and HPV16-specific peptide immunomodulatory vaccines in patients with recurrent/metastatic (RM) squamous cell carcinoma of the head and neck (SCCHN). Cancer Immunol Immunother (2014) 0.84
Intellectual disability and bleeding diathesis due to deficient CMP--sialic acid transport. Neurology (2013) 0.84
The effect of modified polysialic acid based hydrogels on the adhesion and viability of primary neurons and glial cells. Biomaterials (2008) 0.83
Impact of the PSA-NCAM system on pathophysiology in a chronic rodent model of temporal lobe epilepsy. Neurobiol Dis (2007) 0.83
Polysialic acid controls NCAM-induced differentiation of neuronal precursors into calretinin-positive olfactory bulb interneurons. Dev Neurobiol (2008) 0.83
Incorporation of podoplanin into HIV released from HEK-293T cells, but not PBMC, is required for efficient binding to the attachment factor CLEC-2. Retrovirology (2010) 0.83
LARGE2 generates the same xylose- and glucuronic acid-containing glycan structures as LARGE. Glycobiology (2012) 0.83
Functional expression of the CMP-sialic acid transporter in Escherichia coli and its identification as a simple mobile carrier. Glycobiology (2005) 0.83
Biochemical and biophysical characterization of the sialyl-/hexosyltransferase synthesizing the meningococcal serogroup W135 heteropolysaccharide capsule. J Biol Chem (2013) 0.82
A universal fluorescent acceptor for high-performance liquid chromatography analysis of pro- and eukaryotic polysialyltransferases. Anal Biochem (2012) 0.82
Large-scale production and homogenous purification of long chain polysialic acids from E. coli K1. J Biotechnol (2008) 0.82
Polysialic acid is present in mammalian semen as a post-translational modification of the neural cell adhesion molecule NCAM and the polysialyltransferase ST8SiaII. J Biol Chem (2013) 0.81
Direct detection of ligand binding to Sepharose-immobilised protein using saturation transfer double difference (STDD) NMR spectroscopy. Biochem Biophys Res Commun (2007) 0.81
The IL-23/Th17 axis is involved in the adaptive immune response to Bacillus anthracis in humans. Eur J Immunol (2014) 0.81
In vivo evaluation of polysialic acid as part of tissue-engineered nerve transplants. Tissue Eng Part A (2010) 0.81
Defective polysialylation and sialylation induce opposite effects on gating of the skeletal Na+ channel NaV1.4 in Chinese hamster ovary cells. Pharmacology (2011) 0.81
Polysialic acid/neural cell adhesion molecule modulates the formation of ductular reactions in liver injury. Hepatology (2014) 0.81
Functional expression of the capsule polymerase of Neisseria meningitidis serogroup X: a new perspective for vaccine development. Glycobiology (2013) 0.80
Schizophrenia-like phenotype of polysialyltransferase ST8SIA2-deficient mice. Brain Struct Funct (2013) 0.80