Published in Amyloid on September 01, 2007
Amyloid fibrils: abnormal protein assembly. Prion (2008) 1.15
The α-helix to β-sheet transition in stretched and compressed hydrated fibrin clots. Biophys J (2012) 0.90
Three German fibrinogen Aalpha-chain amyloidosis patients with the p.Glu526Val mutation. Virchows Arch (2008) 0.88
Aliphatic peptides show similar self-assembly to amyloid core sequences, challenging the importance of aromatic interactions in amyloidosis. Proc Natl Acad Sci U S A (2012) 0.87
MetAmyl: a METa-predictor for AMYLoid proteins. PLoS One (2013) 0.84
Molecular modeling of the misfolded insulin subunit and amyloid fibril. Biophys J (2009) 0.83
Glycosylphosphatidylinositol anchoring directs the assembly of Sup35NM protein into non-fibrillar, membrane-bound aggregates. J Biol Chem (2014) 0.78
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat Genet (2007) 9.80
The adult mouse and human pancreas contain rare multipotent stem cells that express insulin. Cell Stem Cell (2011) 2.31
Hereditary fibrinogen A alpha-chain amyloidosis: phenotypic characterization of a systemic disease and the role of liver transplantation. Blood (2009) 2.30
Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model. Nat Med (2006) 2.28
Defective membrane interactions of familial Parkinson's disease mutant A30P alpha-synuclein. J Mol Biol (2002) 1.52
The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections. EMBO J (2007) 1.49
Small ubiquitin-like modifier (SUMO) modification of natively unfolded proteins tau and alpha-synuclein. J Biol Chem (2006) 1.48
Leukocyte chemotactic factor 2: A novel renal amyloid protein. Kidney Int (2008) 1.47
The in vivo brain interactome of the amyloid precursor protein. Mol Cell Proteomics (2007) 1.38
SUMO on the road to neurodegeneration. Biochim Biophys Acta (2007) 1.35
APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes. J Biol Chem (2002) 1.34
Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins. J Biol Chem (2002) 1.26
Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes. J Biol Chem (2004) 1.23
Genetic mapping of activity determinants within cellular prion proteins: N-terminal modules in PrPC offset pro-apoptotic activity of the Doppel helix B/B' region. J Biol Chem (2004) 1.23
Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants. BMC Neurosci (2008) 1.17
Clinical development of an antisense therapy for the treatment of transthyretin-associated polyneuropathy. Amyloid (2012) 1.16
The presenilin proteins are components of multiple membrane-bound complexes that have different biological activities. J Biol Chem (2004) 1.15
Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer's amyloid(beta)42 from isolated intact nerve terminals. J Neurosci (2010) 1.14
Design of peptide-based inhibitors of human islet amyloid polypeptide fibrillogenesis. J Mol Biol (2002) 1.11
Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases. Proc Natl Acad Sci U S A (2005) 1.05
alpha-Synuclein-synaptosomal membrane interactions: implications for fibrillogenesis. Eur J Biochem (2004) 1.01
Alternate aggregation pathways of the Alzheimer beta-amyloid peptide: Abeta association kinetics at endosomal pH. J Mol Biol (2003) 1.01
Aging in heterozygous Dnmt1-deficient mice: effects on survival, the DNA methylation genes, and the development of amyloidosis. J Gerontol A Biol Sci Med Sci (2006) 0.97
Brain levels of CDK5 activator p25 are not increased in Alzheimer's or other neurodegenerative diseases with neurofibrillary tangles. J Neurochem (2003) 0.96
Amyloid-beta42 signals tau hyperphosphorylation and compromises neuronal viability by disrupting alkylacylglycerophosphocholine metabolism. Proc Natl Acad Sci U S A (2009) 0.96
Amyloid inhibitors enhance survival of cultured human islets. Biochim Biophys Acta (2009) 0.94
APH1 polar transmembrane residues regulate the assembly and activity of presenilin complexes. J Biol Chem (2009) 0.94
Small interfering RNA-mediated suppression of proislet amyloid polypeptide expression inhibits islet amyloid formation and enhances survival of human islets in culture. Diabetes (2008) 0.93
TgCRND8 amyloid precursor protein transgenic mice exhibit an altered gamma-secretase processing and an aggressive, additive amyloid pathology subject to immunotherapeutic modulation. Biochemistry (2007) 0.92
Effect of Ser-129 phosphorylation on interaction of α-synuclein with synaptic and cellular membranes. J Biol Chem (2011) 0.91
Contribution of wild-type transthyretin to hereditary peripheral nerve amyloid. Muscle Nerve (2003) 0.91
Differential regulation of wild-type and mutant alpha-synuclein binding to synaptic membranes by cytosolic factors. BMC Neurosci (2008) 0.91
TMP21 transmembrane domain regulates gamma-secretase cleavage. J Biol Chem (2009) 0.90
Modulation of Abeta generation by small ubiquitin-like modifiers does not require conjugation to target proteins. Biochem J (2007) 0.90
α-Synuclein membrane association is regulated by the Rab3a recycling machinery and presynaptic activity. J Biol Chem (2013) 0.89
Structural biology of presenilin 1 complexes. Mol Neurodegener (2014) 0.88
Identification of minimal peptide sequences in the (8-20) domain of human islet amyloid polypeptide involved in fibrillogenesis. J Struct Biol (2003) 0.88
The PrP-like protein Doppel binds copper. J Biol Chem (2002) 0.86
Wild-type Shadoo proteins convert to amyloid-like forms under native conditions. J Neurochem (2010) 0.85
The isotropic fractionator provides evidence for differential loss of hippocampal neurons in two mouse models of Alzheimer's disease. Mol Neurodegener (2012) 0.84
Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain. J Biol Chem (2003) 0.84
A pulse-chase study tracking the conversion of macrophage-endocytosed serum amyloid A into extracellular amyloid. Arthritis Rheum (2002) 0.84
Biochemical characterisation of amyloid by endomyocardial biopsy. Amyloid (2009) 0.83
A transthyretin mutation (Tyr78Phe) associated with peripheral neuropathy, carpal tunnel syndrome and skin amyloidosis. Amyloid (2003) 0.83
Phenotypic and functional changes in glial cells as a function of age. Neurobiol Aging (2001) 0.83
Early fear memory defects are associated with altered synaptic plasticity and molecular architecture in the TgCRND8 Alzheimer's disease mouse model. J Comp Neurol (2014) 0.82
The levels of mature glycosylated nicastrin are regulated and correlate with gamma-secretase processing of amyloid beta-precursor protein. J Neurochem (2002) 0.82
Hereditary systemic amyloidosis associated with a new apolipoprotein AII stop codon mutation Stop78Arg. Kidney Int (2003) 0.81
Anti-amyloid-β-mediated positron emission tomography imaging in Alzheimer's disease mouse brains. PLoS One (2012) 0.81
Cellular events associated with the initial phase of AA amyloidogenesis: insights from a human monocyte model. Amyloid (2007) 0.81
Overexpression of human CRB1 or related isoforms, CRB2 and CRB3, does not regulate the human presenilin complex in culture cells. Biochemistry (2007) 0.80
Alzheimer amyloid precursor aspartyl proteinase activity in CHAPSO homogenates of Spodoptera frugiperda cells. Alzheimer Dis Assoc Disord (2004) 0.80
TMP21 regulates Abeta production but does not affect caspase-3, p53, and neprilysin. Biochem Biophys Res Commun (2008) 0.79
κ I light chain AL amyloidosis presenting with rapidly progressive renal and hepatic failure with unusual renal amyloid distribution. Clin Nephrol (2012) 0.79
Interactome analyses of mature γ-secretase complexes reveal distinct molecular environments of presenilin (PS) paralogs and preferential binding of signal peptide peptidase to PS2. J Biol Chem (2013) 0.79
Human SAA1-derived amyloid deposition in cell culture: a consistent model utilizing human peripheral blood mononuclear cells and serum-free medium. Amyloid (2013) 0.78
Presenilin-1 holoprotein is an interacting partner of sarco endoplasmic reticulum calcium-ATPase and confers resistance to endoplasmic reticulum stress. J Alzheimers Dis (2010) 0.78
Kappa III immunoglobulin light chain origin of localized orbital amyloidosis. Amyloid (2004) 0.78
Renal transplantation for apolipoprotein AII amyloidosis. Amyloid (2003) 0.78
Amyloidoma of the esophagus. Am J Gastroenterol (2007) 0.78
Lambda II immunoglobulin light chain protein in primary localized rectal amyloidosis. Amyloid (2007) 0.78
Amyloid-enhancing factor mediates amyloid formation on fibroblasts via a nidus/template mechanism. Arthritis Rheum (2003) 0.78
Human pro-islet amyloid polypeptide (ProIAPP(1-48)) forms amyloid fibrils and amyloid spherulites in vitro. J Inorg Biochem (2010) 0.77
Potential roles for presenilin-1 in oxygen sensing and in glial-specific gene expression. Neuroreport (2004) 0.76
Transient abundance of presenilin 1 fragments/nicastrin complex associated with synaptogenesis during development in rat cerebellum. Neurobiol Aging (2005) 0.76
Systemic diseases: from amyloidosis to cryoglobulinemia. Clin J Am Soc Nephrol (2010) 0.75
Chemical characterization of a lambda I amyloid protein isolated from formalin-fixed and paraffin-embedded tissue sections. Amyloid (2004) 0.75
IX International Symposium on Amyloidosis, July 15-21, 2001, Budapest, Hungary. Amyloid (2002) 0.75
Localization and trafficking of endogenous anterior pharynx-defective 1, a component of Alzheimer's disease related gamma-secretase. Neurosci Lett (2010) 0.75