Published in J Biol Chem on March 13, 2014
A Structural and Functional Comparison Between Infectious and Non-Infectious Autocatalytic Recombinant PrP Conformers. PLoS Pathog (2015) 0.81
PrP knockout cells expressing transmembrane PrP resist prion infection. J Virol (2016) 0.76
Dissociation of recombinant prion autocatalysis from infectivity. Prion (2015) 0.76
Transmissions to mice indicate that 'new variant' CJD is caused by the BSE agent. Nature (1997) 15.73
Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins. Proc Natl Acad Sci U S A (1993) 10.36
Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie? Cell (1993) 10.15
Atomic structures of amyloid cross-beta spines reveal varied steric zippers. Nature (2007) 10.02
Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts). N Engl J Med (1980) 9.38
Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution. Protein Sci (1993) 7.92
Support for the prion hypothesis for inheritance of a phenotypic trait in yeast. Science (1996) 7.24
Nucleated conformational conversion and the replication of conformational information by a prion determinant. Science (2000) 6.16
Conformational variations in an infectious protein determine prion strain differences. Nature (2004) 6.15
Purification and structural studies of a major scrapie prion protein. Cell (1984) 5.98
Secondary structure analysis of the scrapie-associated protein PrP 27-30 in water by infrared spectroscopy. Biochemistry (1991) 5.53
Anchorless prion protein results in infectious amyloid disease without clinical scrapie. Science (2005) 5.52
Propagation of the yeast prion-like [psi+] determinant is mediated by oligomerization of the SUP35-encoded polypeptide chain release factor. EMBO J (1996) 5.50
Self-seeded fibers formed by Sup35, the protein determinant of [PSI+], a heritable prion-like factor of S. cerevisiae. Cell (1997) 5.24
Scrapie prion protein contains a phosphatidylinositol glycolipid. Cell (1987) 5.12
Prions affect the appearance of other prions: the story of [PIN(+)]. Cell (2001) 5.08
Protein-only transmission of three yeast prion strains. Nature (2004) 4.76
Separation and properties of cellular and scrapie prion proteins. Proc Natl Acad Sci U S A (1986) 4.38
A critical role for amino-terminal glutamine/asparagine repeats in the formation and propagation of a yeast prion. Cell (1998) 4.25
Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis. Science (2010) 3.98
Review: history of the amyloid fibril. J Struct Biol (2000) 3.49
Prion-like transmission of protein aggregates in neurodegenerative diseases. Nat Rev Mol Cell Biol (2010) 3.34
The psi factor of yeast: a problem in inheritance. Yeast (1988) 3.23
Visualizing lipid structure and raft domains in living cells with two-photon microscopy. Proc Natl Acad Sci U S A (2003) 3.17
In vitro propagation of the prion-like state of yeast Sup35 protein. Science (1997) 3.05
Identification of prion amyloid filaments in scrapie-infected brain. Cell (1985) 3.04
Small-molecule aggregates inhibit amyloid polymerization. Nat Chem Biol (2008) 2.98
Pathway complexity of prion protein assembly into amyloid. J Biol Chem (2002) 2.96
Getting a grip on prions: oligomers, amyloids, and pathological membrane interactions. Annu Rev Biochem (2009) 2.80
Evidence for the prion hypothesis: induction of the yeast [PSI+] factor by in vitro- converted Sup35 protein. Science (2000) 2.66
Purified prion proteins and scrapie infectivity copartition into liposomes. Proc Natl Acad Sci U S A (1987) 2.61
Conformational transitions, dissociation, and unfolding of scrapie amyloid (prion) protein. J Biol Chem (1993) 2.59
Molecular architecture of human prion protein amyloid: a parallel, in-register beta-structure. Proc Natl Acad Sci U S A (2007) 2.55
Conversion of raft associated prion protein to the protease-resistant state requires insertion of PrP-res (PrP(Sc)) into contiguous membranes. EMBO J (2002) 2.16
Scrapie prion rod formation in vitro requires both detergent extraction and limited proteolysis. J Virol (1991) 2.11
Neuropathological diagnostic criteria for Creutzfeldt-Jakob disease (CJD) and other human spongiform encephalopathies (prion diseases). Brain Pathol (1995) 2.10
Natural and synthetic prion structure from X-ray fiber diffraction. Proc Natl Acad Sci U S A (2009) 1.97
Structural organization of brain-derived mammalian prions examined by hydrogen-deuterium exchange. Nat Struct Mol Biol (2011) 1.90
Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain. Life Sci (2001) 1.88
Staining methods for identification of amyloid in tissue. Methods Enzymol (1999) 1.80
Amyloids, prions and the inherent infectious nature of misfolded protein aggregates. Trends Biochem Sci (2006) 1.77
The relationship between visible intracellular aggregates that appear after overexpression of Sup35 and the yeast prion-like elements [PSI(+)] and [PIN(+)]. Mol Microbiol (2001) 1.77
Analysis of prion factors in yeast. Methods Enzymol (2002) 1.72
The protofilament substructure of amyloid fibrils. J Mol Biol (2000) 1.69
Visualizing lipid raft dynamics and early signaling events during antigen receptor-mediated B-lymphocyte activation. Mol Biol Cell (2003) 1.66
Prion protein amyloidosis. Brain Pathol (1996) 1.64
Differential release of cellular and scrapie prion proteins from cellular membranes by phosphatidylinositol-specific phospholipase C. Biochemistry (1990) 1.56
Origins and kinetic consequences of diversity in Sup35 yeast prion fibers. Nat Struct Biol (2002) 1.54
Fatal transmissible amyloid encephalopathy: a new type of prion disease associated with lack of prion protein membrane anchoring. PLoS Pathog (2010) 1.49
Properties of scrapie prion protein liposomes. J Biol Chem (1988) 1.47
Prion induction involves an ancient system for the sequestration of aggregated proteins and heritable changes in prion fragmentation. Proc Natl Acad Sci U S A (2010) 1.43
Prion filament networks in [URE3] cells of Saccharomyces cerevisiae. J Cell Biol (2001) 1.41
Prion hypothesis: the end of the controversy? Trends Biochem Sci (2010) 1.40
Incidence and spectrum of sporadic Creutzfeldt-Jakob disease variants with mixed phenotype and co-occurrence of PrPSc types: an updated classification. Acta Neuropathol (2009) 1.32
Highly sensitive diagnosis of amyloid and various amyloid syndromes using Congo red fluorescence. Virchows Arch (2000) 1.31
Effect of glycans and the glycophosphatidylinositol anchor on strain dependent conformations of scrapie prion protein: improved purifications and infrared spectra. Biochemistry (2011) 1.27
Very long term studies of the seeding of beta-amyloidosis in primates. J Neural Transm (Vienna) (2005) 1.26
In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A (2000) 1.24
Normal and scrapie-associated forms of prion protein differ in their sensitivities to phospholipase and proteases in intact neuroblastoma cells. J Virol (1990) 1.24
The yeast Sup35NM domain propagates as a prion in mammalian cells. Proc Natl Acad Sci U S A (2008) 1.16
Immunolocalisation of PrPSc in scrapie-infected N2a mouse neuroblastoma cells by light and electron microscopy. Eur J Cell Biol (2008) 1.14
A comparison of amyloid fibrillogenesis using the novel fluorescent compound K114. J Neurochem (2003) 1.13
Cryo-immunogold electron microscopy for prions: toward identification of a conversion site. J Neurosci (2008) 1.12
Biochemical and functional analysis of the assembly of full-length Sup35p and its prion-forming domain. J Biol Chem (2006) 1.10
Prion protein preamyloid and amyloid deposits in Gerstmann-Sträussler-Scheinker disease, Indiana kindred. Proc Natl Acad Sci U S A (1992) 1.09
Cellular and sub-cellular pathology of animal prion diseases: relationship between morphological changes, accumulation of abnormal prion protein and clinical disease. Acta Neuropathol (2010) 1.09
Specific biarsenical labeling of cell surface proteins allows fluorescent- and biotin-tagging of amyloid precursor protein and prion proteins. Mol Biol Cell (2008) 1.08
Crucial role for prion protein membrane anchoring in the neuroinvasion and neural spread of prion infection. J Virol (2010) 1.06
Multiple ligand binding sites on A beta(1-40) fibrils. Amyloid (2005) 1.05
Strain-associated variations in abnormal PrP trafficking of sheep scrapie. Brain Pathol (2008) 1.02
Two mutant prion proteins expressed in cultured cells acquire biochemical properties reminiscent of the scrapie isoform. Proc Natl Acad Sci U S A (1996) 1.01
In vivo evidence for the fibrillar structures of Sup35 prions in yeast cells. J Cell Biol (2010) 1.00
Gerstmann-Sträussler-Scheinker disease (PRNP P102L): amyloid deposits are best recognized by antibodies directed to epitopes in PrP region 90-165. J Neuropathol Exp Neurol (1995) 0.97
Prion protein conversions: insight into mechanisms, TSE transmission barriers and strains. Br Med Bull (2003) 0.96
Degradation of Chlamydia pneumoniae by peripheral blood monocytic cells. Infect Immun (2005) 0.95
Genetic control of amyloid plaque production and incubation period in scrapie-infected mice. J Neuropathol Exp Neurol (1985) 0.95
Cell-to-cell propagation of infectious cytosolic protein aggregates. Proc Natl Acad Sci U S A (2013) 0.95
In situ identification of protein structural changes in prion-infected tissue. Biochim Biophys Acta (2003) 0.94
Analysis of yeast prion aggregates with amyloid-staining compound in vivo. Cell Struct Funct (2003) 0.93
Prion proteins carrying pathogenic mutations are resistant to phospholipase cleavage of their glycolipid anchors. Biochemistry (1999) 0.92
Dendritic and synaptic alterations of hippocampal pyramidal neurones in scrapie-infected mice. Neuropathol Appl Neurobiol (2000) 0.90
Mechanism of PrP-amyloid formation in mice without transmissible spongiform encephalopathy. Brain Pathol (2011) 0.89
GPI anchoring facilitates propagation and spread of misfolded Sup35 aggregates in mammalian cells. EMBO J (2010) 0.89
Structural organization of mammalian prions as probed by limited proteolysis. PLoS One (2012) 0.87
Structural analyses of fibrinogen amyloid fibrils. Amyloid (2007) 0.84
Amyloid plaques in transmissible spongiform encephalopathies (prion diseases). Folia Neuropathol (2004) 0.82
Introducing Amylo-Glo, a novel fluorescent amyloid specific histochemical tracer especially suited for multiple labeling and large scale quantification studies. J Neurosci Methods (2012) 0.81
Plasma membrane invaginations containing clusters of full-length PrPSc are an early form of prion-associated neuropathology in vivo. Neurobiol Aging (2013) 0.79
Soluble oligomers are sufficient for transmission of a yeast prion but do not confer phenotype. J Cell Biol (2013) 0.79
Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease? J Infect Dis (2006) 8.17
Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA. Nat Med (2007) 7.75
Insights into mechanisms used by Staphylococcus aureus to avoid destruction by human neutrophils. J Immunol (2005) 5.18
Ultrasensitive detection of scrapie prion protein using seeded conversion of recombinant prion protein. Nat Methods (2007) 3.74
Getting a grip on prions: oligomers, amyloids, and pathological membrane interactions. Annu Rev Biochem (2009) 2.80
Prions and their partners in crime. Nature (2006) 2.55
Conversion of raft associated prion protein to the protease-resistant state requires insertion of PrP-res (PrP(Sc)) into contiguous membranes. EMBO J (2002) 2.16
Staphylococcus aureus aconitase inactivation unexpectedly inhibits post-exponential-phase growth and enhances stationary-phase survival. Infect Immun (2002) 2.10
New inhibitors of scrapie-associated prion protein formation in a library of 2000 drugs and natural products. J Virol (2003) 2.09
Genome-wide protective response used by group A Streptococcus to evade destruction by human polymorphonuclear leukocytes. Proc Natl Acad Sci U S A (2003) 1.99
The NS5 protein of the virulent West Nile virus NY99 strain is a potent antagonist of type I interferon-mediated JAK-STAT signaling. J Virol (2010) 1.94
Structural organization of brain-derived mammalian prions examined by hydrogen-deuterium exchange. Nat Struct Mol Biol (2011) 1.90
Increased colonization of indwelling medical devices by quorum-sensing mutants of Staphylococcus epidermidis in vivo. J Infect Dis (2004) 1.86
Uptake and neuritic transport of scrapie prion protein coincident with infection of neuronal cells. J Neurosci (2005) 1.85
Regulated expression of pathogen-associated molecular pattern molecules in Staphylococcus epidermidis: quorum-sensing determines pro-inflammatory capacity and production of phenol-soluble modulins. Cell Microbiol (2004) 1.74
A novel bacterium associated with lymphadenitis in a patient with chronic granulomatous disease. PLoS Pathog (2006) 1.66
Rapid neutrophil destruction following phagocytosis of Staphylococcus aureus. J Innate Immun (2010) 1.62
Requirement for the Rac GTPase in Chlamydia trachomatis invasion of non-phagocytic cells. Traffic (2004) 1.55
Suppression of acute anti-friend virus CD8+ T-cell responses by coinfection with lactate dehydrogenase-elevating virus. J Virol (2007) 1.50
Coxiella burnetii phase I and II variants replicate with similar kinetics in degradative phagolysosome-like compartments of human macrophages. Infect Immun (2010) 1.49
Characterization of the Bhanja serogroup viruses (Bunyaviridae): a novel species of the genus Phlebovirus and its relationship with other emerging tick-borne phleboviruses. J Virol (2013) 1.43
Insight into the molecular basis of pathogen abundance: group A Streptococcus inhibitor of complement inhibits bacterial adherence and internalization into human cells. Proc Natl Acad Sci U S A (2002) 1.42
Dectin-1 promotes fungicidal activity of human neutrophils. Eur J Immunol (2007) 1.41
The heart is an early target of anthrax lethal toxin in mice: a protective role for neuronal nitric oxide synthase (nNOS). PLoS Pathog (2009) 1.30
In vitro suppression of CD8+ T cell function by Friend virus-induced regulatory T cells. J Immunol (2006) 1.30
Induction of Salmonella pathogenicity island 1 under different growth conditions can affect Salmonella-host cell interactions in vitro. Microbiology (2009) 1.28
Effect of glycans and the glycophosphatidylinositol anchor on strain dependent conformations of scrapie prion protein: improved purifications and infrared spectra. Biochemistry (2011) 1.27
Prion seeding activities of mouse scrapie strains with divergent PrPSc protease sensitivities and amyloid plaque content using RT-QuIC and eQuIC. PLoS One (2012) 1.25
Genome sequence analysis of the emerging human pathogenic acetic acid bacterium Granulibacter bethesdensis. J Bacteriol (2007) 1.23
Chimeric human parainfluenza virus bearing the Ebola virus glycoprotein as the sole surface protein is immunogenic and highly protective against Ebola virus challenge. Virology (2008) 1.21
Inhibition of protease-resistant prion protein formation in a transformed deer cell line infected with chronic wasting disease. J Virol (2006) 1.14
Inhibition of protease-resistant prion protein accumulation in vitro by curcumin. J Virol (2003) 1.12
Diversity of murine norovirus strains isolated from asymptomatic mice of different genetic backgrounds within a single U.S. research institute. PLoS One (2011) 1.12
A three-dimensional comparison of tick-borne flavivirus infection in mammalian and tick cell lines. PLoS One (2012) 1.11
Yersinia pestis subverts the dermal neutrophil response in a mouse model of bubonic plague. MBio (2013) 1.09
Specific biarsenical labeling of cell surface proteins allows fluorescent- and biotin-tagging of amyloid precursor protein and prion proteins. Mol Biol Cell (2008) 1.08
A solid-phase assay for identification of modulators of prion protein interactions. Anal Biochem (2003) 1.07
Transcriptomic and innate immune responses to Yersinia pestis in the lymph node during bubonic plague. Infect Immun (2010) 1.05
Staphylococcus aureus leukotoxin GH promotes formation of neutrophil extracellular traps. J Immunol (2013) 1.05
CD137 costimulation of CD8+ T cells confers resistance to suppression by virus-induced regulatory T cells. J Immunol (2008) 1.05
Inhibition of chlamydiae by primary alcohols correlates with the strain-specific complement of plasticity zone phospholipase D genes. Infect Immun (2006) 1.04
Tissue-specific abundance of regulatory T cells correlates with CD8+ T cell dysfunction and chronic retrovirus loads. J Immunol (2009) 1.04
Isolation of novel synthetic prion strains by amplification in transgenic mice coexpressing wild-type and anchorless prion proteins. J Virol (2012) 1.01
Hemin interactions and alterations of the subcellular localization of prion protein. J Biol Chem (2007) 0.94
Acid phosphatases do not contribute to the pathogenesis of type A Francisella tularensis. Infect Immun (2009) 0.91
Characterization of the Bat proteins in the oxidative stress response of Leptospira biflexa. BMC Microbiol (2012) 0.90
Induction of TRAIL- and TNF-alpha-dependent apoptosis in human monocyte-derived dendritic cells by microfilariae of Brugia malayi. J Immunol (2008) 0.90
Role for chlamydial inclusion membrane proteins in inclusion membrane structure and biogenesis. PLoS One (2013) 0.89
GPI anchoring facilitates propagation and spread of misfolded Sup35 aggregates in mammalian cells. EMBO J (2010) 0.89
Biological characterization of Chlamydia trachomatis plasticity zone MACPF domain family protein CT153. Infect Immun (2010) 0.87
IL-2-independent and TNF-α-dependent expansion of Vβ5+ natural regulatory T cells during retrovirus infection. J Immunol (2013) 0.86
Scanning electron microscopy. Curr Protoc Microbiol (2012) 0.86
Role of Yersinia pestis toxin complex family proteins in resistance to phagocytosis by polymorphonuclear leukocytes. Infect Immun (2013) 0.81
The avian malaria parasite Plasmodium gallinaceum causes marked structural changes on the surface of its host erythrocyte. J Struct Biol (2008) 0.80
Tick-borne flaviviruses antagonize both IRF-1 and type I IFN signaling to inhibit dendritic cell function. J Immunol (2014) 0.79
Are cheetahs on the run from prion-like amyloidosis? Proc Natl Acad Sci U S A (2008) 0.77
Age-related differences in neuroinflammatory responses associated with a distinct profile of regulatory markers on neonatal microglia. J Neuroinflammation (2014) 0.77
Efficient screening of high-signal and low-background antibody pairs in the bio-bar code assay using prion protein as the target. Anal Biochem (2008) 0.76
Effects of FlAsH/tetracysteine (TC) Tag on PrP proteolysis and PrPres formation by TC-scanning. Chembiochem (2013) 0.75