Published in J Biol Chem on April 30, 2004
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat Genet (2007) 9.80
Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein. Proc Natl Acad Sci U S A (2007) 2.05
Membrane localization of LRRK2 is associated with increased formation of the highly active LRRK2 dimer and changes in its phosphorylation. Biochemistry (2010) 1.47
Neuropathology of non-Alzheimer degenerative disorders. Int J Clin Exp Pathol (2009) 1.27
Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes. J Biol Chem (2008) 1.20
Development and mechanism of γ-secretase modulators for Alzheimer's disease. Biochemistry (2013) 1.18
Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases. Proc Natl Acad Sci U S A (2005) 1.05
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Characterization of an atypical gamma-secretase complex from hematopoietic origin. Biochemistry (2010) 0.95
Nontranscriptional role of Hif-1α in activation of γ-secretase and notch signaling in breast cancer. Cell Rep (2014) 0.94
APH1 polar transmembrane residues regulate the assembly and activity of presenilin complexes. J Biol Chem (2009) 0.94
TMP21 transmembrane domain regulates gamma-secretase cleavage. J Biol Chem (2009) 0.90
Structural biology of presenilin 1 complexes. Mol Neurodegener (2014) 0.88
p53-dependent control of transactivation of the Pen2 promoter by presenilins. J Cell Sci (2009) 0.82
Soluble oligomers of the intramembrane serine protease YqgP are catalytically active in the absence of detergents. Biochemistry (2008) 0.80
Clues to γ-secretase, huntingtin and Hirano body normal function using the model organism Dictyostelium discoideum. J Biomed Sci (2012) 0.78
Physiological and pathological roles of the γ-secretase complex. Brain Res Bull (2016) 0.76
Natural Modulators of Amyloid-Beta Precursor Protein Processing. Curr Alzheimer Res (2012) 0.76
Presenilin 1 and Presenilin 2 Target γ-Secretase Complexes to Distinct Cellular Compartments. J Biol Chem (2016) 0.75
TREM2 variants in Alzheimer's disease. N Engl J Med (2012) 11.35
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet (2011) 10.07
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat Genet (2007) 9.80
The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium. Cell Stem Cell (2009) 6.44
Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations. Cell (2010) 5.09
Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress. Proc Natl Acad Sci U S A (2005) 3.83
Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP. Neuron (2005) 3.83
Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes. Arch Neurol (2010) 2.91
Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits. Brain (2011) 2.76
G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes. Nat Med (2005) 2.64
TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity. Nature (2006) 2.56
Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway. Proc Natl Acad Sci U S A (2010) 2.53
Prospective 10-year surveillance of human prion diseases in Japan. Brain (2010) 2.41
The adult mouse and human pancreas contain rare multipotent stem cells that express insulin. Cell Stem Cell (2011) 2.31
Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model. Nat Med (2006) 2.28
Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations. J Biol Chem (2005) 2.26
Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis. Science (2009) 2.23
The association between genetic variants in SORL1 and Alzheimer disease in an urban, multiethnic, community-based cohort. Arch Neurol (2007) 2.21
Peroxisome proliferator-activated receptor gamma plays a critical role in inhibition of cardiac hypertrophy in vitro and in vivo. Circulation (2002) 2.12
Mesothelium contributes to vascular smooth muscle and mesenchyme during lung development. Proc Natl Acad Sci U S A (2008) 2.08
Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology (2012) 2.08
Microbleed topography, leukoaraiosis, and cognition in probable Alzheimer disease from the Sunnybrook dementia study. Arch Neurol (2008) 2.03
Analysis of the glucocerebrosidase gene in Parkinson's disease. Mov Disord (2005) 1.99
Novel splicing mutation in the progranulin gene causing familial corticobasal syndrome. Brain (2006) 1.86
A proteome resource of ovarian cancer ascites: integrated proteomic and bioinformatic analyses to identify putative biomarkers. J Proteome Res (2007) 1.80
Analysis of the PINK1 gene in a large cohort of cases with Parkinson disease. Arch Neurol (2004) 1.63
Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD. BMC Neurol (2006) 1.60
Association between SORL1 and Alzheimer's disease in a genome-wide study. Neuroreport (2007) 1.57
Mass spectrometric analysis of protein mixtures at low levels using cleavable 13C-isotope-coded affinity tag and multidimensional chromatography. Mol Cell Proteomics (2003) 1.53
Defects in the striatal neuropeptide Y system in X-linked dystonia-parkinsonism. Brain (2013) 1.53
Feasibility and safety of granulocyte colony-stimulating factor treatment in patients with acute myocardial infarction. Int J Cardiol (2006) 1.52
In vivo reduction of amyloid-beta by a mutant copper transporter. Proc Natl Acad Sci U S A (2003) 1.52
Defective membrane interactions of familial Parkinson's disease mutant A30P alpha-synuclein. J Mol Biol (2002) 1.52
The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections. EMBO J (2007) 1.49
Small ubiquitin-like modifier (SUMO) modification of natively unfolded proteins tau and alpha-synuclein. J Biol Chem (2006) 1.48
A novel PS1 gene mutation in a large Aboriginal kindred. Can J Neurol Sci (2010) 1.46
SPATACSIN mutations cause autosomal recessive juvenile amyotrophic lateral sclerosis. Brain (2010) 1.45
The expanding universe of prion diseases. PLoS Pathog (2006) 1.45
N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma. Genes Dev (2009) 1.45
Restrictive left ventricular filling pattern does not result from increased left atrial pressure alone. Circulation (2008) 1.45
Proteome-wide identification of mycobacterial pupylation targets. Mol Syst Biol (2010) 1.44
New laboratory procedures and Rh blood type changes in a pregnant woman. Obstet Gynecol (2012) 1.42
Interactome analyses identify ties of PrP and its mammalian paralogs to oligomannosidic N-glycans and endoplasmic reticulum-derived chaperones. PLoS Pathog (2009) 1.41
The genetics of adult-onset neuropsychiatric disease: complexities and conundra? Science (2003) 1.40
Oxidative stress-induced signal transduction pathways in cardiac myocytes: involvement of ROS in heart diseases. Antioxid Redox Signal (2003) 1.40
Mapping Cu(II) binding sites in prion proteins by diethyl pyrocarbonate modification and matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometric footprinting. J Biol Chem (2001) 1.39
DHA supplemented in peptamen diet offers no advantage in pathways to amyloidosis: is it time to evaluate composite lipid diet? PLoS One (2011) 1.39
Endonasal endoscopic transsphenoidal chiasmapexy with silicone plates for empty sella syndrome: technical note. Neurol Med Chir (Tokyo) (2005) 1.39
The in vivo brain interactome of the amyloid precursor protein. Mol Cell Proteomics (2007) 1.38
Genome-wide linkage scan of a large family with IgA nephropathy localizes a novel susceptibility locus to chromosome 2q36. J Am Soc Nephrol (2007) 1.36
SUMO on the road to neurodegeneration. Biochim Biophys Acta (2007) 1.35
APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes. J Biol Chem (2002) 1.34
Species differences in mGluR5 binding sites in mammalian central nervous system determined using in vitro binding with [18F]F-PEB. Nucl Med Biol (2007) 1.34
Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into leydig cell mitochondria. Mol Endocrinol (2004) 1.33
Progressive loss of renal function is an age-dependent heritable trait in type 1 autosomal dominant polycystic kidney disease. J Am Soc Nephrol (2005) 1.32
Investigation of c9orf72 in 4 neurodegenerative disorders. Arch Neurol (2012) 1.32
Identification of Alzheimer disease-associated variants in genes that regulate retromer function. Neurobiol Aging (2012) 1.30
Early detection of abnormal prion protein in genetic human prion diseases now possible using real-time QUIC assay. PLoS One (2013) 1.30
Interactions between beta-amyloid and central cholinergic neurons: implications for Alzheimer's disease. J Psychiatry Neurosci (2004) 1.30
Presenilin-dependent gamma-secretase-mediated control of p53-associated cell death in Alzheimer's disease. J Neurosci (2006) 1.29