Published in Dev Cell on December 01, 2004
The trip of the tip: understanding the growth cone machinery. Nat Rev Mol Cell Biol (2009) 3.38
Anisotropy of cell adhesive microenvironment governs cell internal organization and orientation of polarity. Proc Natl Acad Sci U S A (2006) 3.15
To build a synapse: signaling pathways in neuromuscular junction assembly. Development (2010) 2.65
The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA. J Cell Biol (2008) 2.39
IQGAPs in cancer: a family of scaffold proteins underlying tumorigenesis. FEBS Lett (2009) 2.35
The β-catenin destruction complex. Cold Spring Harb Perspect Biol (2013) 2.22
Integrin-linked kinase controls microtubule dynamics required for plasma membrane targeting of caveolae. Dev Cell (2010) 2.17
IQGAP1 is a scaffold for mitogen-activated protein kinase signaling. Mol Cell Biol (2005) 2.16
Dia1 and IQGAP1 interact in cell migration and phagocytic cup formation. J Cell Biol (2007) 2.15
APC and EB1 function together in mitosis to regulate spindle dynamics and chromosome alignment. Mol Biol Cell (2005) 2.14
Cell polarity triggered by cell-cell adhesion via E-cadherin. J Cell Sci (2009) 2.04
Genome-wide screen reveals APC-associated RNAs enriched in cell protrusions. Nature (2008) 1.98
Big roles for small GTPases in the control of directed cell movement. Biochem J (2007) 1.89
The canonical Wnt signalling pathway and its APC partner in colon cancer development. Gut (2006) 1.86
IQGAP1 and its binding proteins control diverse biological functions. Cell Signal (2011) 1.77
Cdc42 and noncanonical Wnt signal transduction pathways cooperate to promote cell polarity. J Cell Biol (2007) 1.75
Get to grips: steering local actin dynamics with IQGAPs. EMBO Rep (2007) 1.68
The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growth. J Cell Biol (2006) 1.66
Cdc42 is not essential for filopodium formation, directed migration, cell polarization, and mitosis in fibroblastoid cells. Mol Biol Cell (2005) 1.66
The actin cytoskeleton in endothelial cell phenotypes. Microvasc Res (2008) 1.65
Regulation of cell migration by dynamic microtubules. Semin Cell Dev Biol (2011) 1.64
APC binds intermediate filaments and is required for their reorganization during cell migration. J Cell Biol (2013) 1.62
Targeting and transport: how microtubules control focal adhesion dynamics. J Cell Biol (2012) 1.62
Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1. J Cell Biol (2010) 1.59
IQGAP1 modulates activation of B-Raf. Proc Natl Acad Sci U S A (2007) 1.57
APC is a component of an organizing template for cortical microtubule networks. Nat Cell Biol (2005) 1.54
Cytoskeleton out of the cupboard: colon cancer and cytoskeletal changes induced by loss of APC. Nat Rev Cancer (2006) 1.53
Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli. J Neurosci (2008) 1.50
Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability. Mol Biol Cell (2006) 1.50
TDP-43 depletion induces neuronal cell damage through dysregulation of Rho family GTPases. J Biol Chem (2009) 1.44
Adenomatous polyposis coli on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1. Mol Biol Cell (2006) 1.42
Structural basis for tubulin recognition by cytoplasmic linker protein 170 and its autoinhibition. Proc Natl Acad Sci U S A (2007) 1.41
Paxillin-dependent stimulation of microtubule catastrophes at focal adhesion sites. J Cell Sci (2008) 1.34
Rocket launcher mechanism of collaborative actin assembly defined by single-molecule imaging. Science (2012) 1.32
The Salmonella SPI2 effector SseI mediates long-term systemic infection by modulating host cell migration. PLoS Pathog (2009) 1.30
Extracellular signal-regulated kinase regulates clathrin-independent endosomal trafficking. Mol Biol Cell (2005) 1.30
The role of Rho GTPase proteins in CNS neuronal migration. Dev Neurobiol (2011) 1.28
Cellular responses to extracellular guidance cues. EMBO J (2010) 1.25
Role of adenomatous polyposis coli (APC) and microtubules in directional cell migration and neuronal polarization. Semin Cell Dev Biol (2008) 1.24
Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression. Nat Struct Mol Biol (2007) 1.22
KIF17 stabilizes microtubules and contributes to epithelial morphogenesis by acting at MT plus ends with EB1 and APC. J Cell Biol (2010) 1.21
Adenomatous polyposis coli (APC) plays multiple roles in the intestinal and colorectal epithelia. Med Mol Morphol (2007) 1.20
LARG and mDia1 link Galpha12/13 to cell polarity and microtubule dynamics. Mol Biol Cell (2007) 1.20
The tumor suppressor DAPK inhibits cell motility by blocking the integrin-mediated polarity pathway. J Cell Biol (2006) 1.19
Interaction of Moloney murine leukemia virus matrix protein with IQGAP. EMBO J (2006) 1.19
Angiopoietin-1 requires IQ domain GTPase-activating protein 1 to activate Rac1 and promote endothelial barrier defense. Arterioscler Thromb Vasc Biol (2011) 1.14
GTSE1 is a microtubule plus-end tracking protein that regulates EB1-dependent cell migration. PLoS One (2012) 1.12
Phospholipase D-mediated activation of IQGAP1 through Rac1 regulates hyperoxia-induced p47phox translocation and reactive oxygen species generation in lung endothelial cells. J Biol Chem (2009) 1.11
Microtubule network asymmetry in motile cells: role of Golgi-derived array. Cell Cycle (2009) 1.10
Microtubule plus-ends within a mitotic cell are 'moving platforms' with anchoring, signalling and force-coupling roles. Open Biol (2012) 1.10
Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells. EMBO J (2010) 1.10
S. pombe CLASP needs dynein, not EB1 or CLIP170, to induce microtubule instability and slows polymerization rates at cell tips in a dynein-dependent manner. Genes Dev (2006) 1.09
Patterned collagen fibers orient branching mammary epithelium through distinct signaling modules. Curr Biol (2013) 1.09
Adenomatous polyposis coli is required for early events in the normal growth and differentiation of the developing cerebral cortex. Neural Dev (2009) 1.08
RNA localization and polarity: from A(PC) to Z(BP). Trends Cell Biol (2009) 1.07
Muscle length and myonuclear position are independently regulated by distinct Dynein pathways. Development (2012) 1.05
IQGAPs choreograph cellular signaling from the membrane to the nucleus. Trends Cell Biol (2015) 1.02
Adenomatous polyposis coli plays a key role, in vivo, in coordinating assembly of the neuronal nicotinic postsynaptic complex. Mol Cell Neurosci (2008) 1.02
S100B Protein Regulates Astrocyte Shape and Migration via Interaction with Src Kinase: IMPLICATIONS FOR ASTROCYTE DEVELOPMENT, ACTIVATION, AND TUMOR GROWTH. J Biol Chem (2009) 1.01
Multiple proteins mediate IQGAP1-stimulated cell migration. Cell Signal (2007) 1.01
Changes in gene expression and cellular architecture in an ovarian cancer progression model. PLoS One (2011) 1.01
Genotype to phenotype: analyzing the effects of inherited mutations in colorectal cancer families. Mutat Res (2009) 1.00
Menin interacts with IQGAP1 to enhance intercellular adhesion of beta-cells. Oncogene (2008) 1.00
Interaction between tumor suppressor adenomatous polyposis coli and topoisomerase IIalpha: implication for the G2/M transition. Mol Biol Cell (2008) 0.99
IQGAP1 and IQGAP2 are reciprocally altered in hepatocellular carcinoma. BMC Gastroenterol (2010) 0.98
Contact inhibition of locomotion probabilities drive solitary versus collective cell migration. J R Soc Interface (2013) 0.98
APC/β-catenin-rich complexes at membrane protrusions regulate mammary tumor cell migration and mesenchymal morphology. BMC Cancer (2013) 0.98
The biology of IQGAP proteins: beyond the cytoskeleton. EMBO Rep (2015) 0.97
Rap1b facilitates NK cell functions via IQGAP1-mediated signalosomes. J Exp Med (2010) 0.97
Novel association of APC with intermediate filaments identified using a new versatile APC antibody. BMC Cell Biol (2009) 0.97
Determination of dissociation constants in living zebrafish embryos with single wavelength fluorescence cross-correlation spectroscopy. Biophys J (2009) 0.97
Wnt/β-catenin signaling plays an ever-expanding role in stem cell self-renewal, tumorigenesis and cancer chemoresistance. Genes Dis (2016) 0.97
The late endosomal p14-MP1 (LAMTOR2/3) complex regulates focal adhesion dynamics during cell migration. J Cell Biol (2014) 0.96
IQGAP1 is a novel phosphatidylinositol 4,5 bisphosphate effector in regulation of directional cell migration. EMBO J (2013) 0.96
EGFR controls IQGAP basolateral membrane localization and mitotic spindle orientation during epithelial morphogenesis. EMBO J (2014) 0.96
Agrin regulates CLASP2-mediated capture of microtubules at the neuromuscular junction synaptic membrane. J Cell Biol (2012) 0.94
Extracellular beta-nicotinamide adenine dinucleotide (beta-NAD) promotes the endothelial cell barrier integrity via PKA- and EPAC1/Rac1-dependent actin cytoskeleton rearrangement. J Cell Physiol (2010) 0.94
A novel role for an APC2-Diaphanous complex in regulating actin organization in Drosophila. Development (2009) 0.94
Examination of actin and microtubule dependent APC localisations in living mammalian cells. BMC Cell Biol (2006) 0.94
IQGAP1 links PDGF receptor-β signal to focal adhesions involved in vascular smooth muscle cell migration: role in neointimal formation after vascular injury. Am J Physiol Cell Physiol (2013) 0.92
The IQGAP1 protein is a calmodulin-regulated barbed end capper of actin filaments: possible implications in its function in cell migration. J Biol Chem (2011) 0.91
CDC42 inhibition suppresses progression of incipient intestinal tumors. Cancer Res (2014) 0.91
Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis. Proc Natl Acad Sci U S A (2010) 0.91
The Dishevelled-associating protein Daple controls the non-canonical Wnt/Rac pathway and cell motility. Nat Commun (2012) 0.91
An emerging role for IQGAP1 in regulating protein traffic. ScientificWorldJournal (2010) 0.90
Cortical localization of APC2 plays a role in actin organization but not in Wnt signaling in Drosophila. J Cell Sci (2011) 0.89
Centrosome positioning in non-dividing cells. Protoplasma (2015) 0.89
AKAP220 protein organizes signaling elements that impact cell migration. J Biol Chem (2011) 0.89
Cytoskeletal social networking in the growth cone: How +TIPs mediate microtubule-actin cross-linking to drive axon outgrowth and guidance. Cytoskeleton (Hoboken) (2016) 0.88
Proteomic investigation of human burn wounds by 2D-difference gel electrophoresis and mass spectrometry. J Surg Res (2007) 0.88
PIP kinases define PI4,5P₂signaling specificity by association with effectors. Biochim Biophys Acta (2015) 0.88
APC2 and Axin promote mitotic fidelity by facilitating centrosome separation and cytoskeletal regulation. Development (2013) 0.88
IQGAP1 interacts with components of the slit diaphragm complex in podocytes and is involved in podocyte migration and permeability in vitro. PLoS One (2012) 0.88
The PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1. EMBO J (2010) 0.87
The armadillo repeat domain of Apc suppresses intestinal tumorigenesis. Mamm Genome (2010) 0.87
Structural basis for the recognition of Asef by adenomatous polyposis coli. Cell Res (2011) 0.87
Adenomatous polyposis coli and Asef function downstream of hepatocyte growth factor and phosphatidylinositol 3-kinase. J Biol Chem (2009) 0.87
Apical constriction and invagination downstream of the canonical Wnt signaling pathway require Rho1 and Myosin II. Dev Biol (2010) 0.86
The cytoskeletal adaptor protein IQGAP1 regulates TCR-mediated signaling and filamentous actin dynamics. J Immunol (2012) 0.86
Generation of mouse induced pluripotent stem cells without viral vectors. Science (2008) 15.25
Generation of pluripotent stem cells from adult mouse liver and stomach cells. Science (2008) 10.55
Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature (2009) 9.75
A more efficient method to generate integration-free human iPS cells. Nat Methods (2011) 7.39
Induction of pluripotent stem cells from fibroblast cultures. Nat Protoc (2007) 7.01
Variation in the safety of induced pluripotent stem cell lines. Nat Biotechnol (2009) 6.39
Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170. Cell (2002) 4.68
GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity. Cell (2005) 4.42
CRMP-2 binds to tubulin heterodimers to promote microtubule assembly. Nat Cell Biol (2002) 3.71
Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission. Science (2006) 3.52
Neuronal polarity: from extracellular signals to intracellular mechanisms. Nat Rev Neurosci (2007) 3.31
Roles of Rho-family GTPases in cell polarisation and directional migration. Curr Opin Cell Biol (2003) 3.31
PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1. Nat Cell Biol (2005) 3.30
Akt/PKB regulates actin organization and cell motility via Girdin/APE. Dev Cell (2005) 3.01
The Wnt/beta-catenin pathway directs neuronal differentiation of cortical neural precursor cells. Development (2004) 2.94
Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3. Dev Cell (2007) 2.83
DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin/TCF pathway. Oncogene (2004) 2.73
Protein palmitoylation in neuronal development and synaptic plasticity. Nat Rev Neurosci (2010) 2.66
IQGAP1: a key regulator of adhesion and migration. J Cell Sci (2005) 2.65
Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity. Cytoskeleton (Hoboken) (2010) 2.59
Transcriptional repression and DNA hypermethylation of a small set of ES cell marker genes in male germline stem cells. BMC Dev Biol (2006) 2.50
Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells. Mol Cell Biol (2002) 2.40
Mutated APC and Asef are involved in the migration of colorectal tumour cells. Nat Cell Biol (2003) 2.34
Regulation of microtubules in cell migration. Trends Cell Biol (2005) 2.29
The muscle protein Dok-7 is essential for neuromuscular synaptogenesis. Science (2006) 2.26
Essential roles for GSK-3s and GSK-3-primed substrates in neurotrophin-induced and hippocampal axon growth. Neuron (2006) 2.23
Role of the PAR-3-KIF3 complex in the establishment of neuronal polarity. Nat Cell Biol (2004) 2.19
Dia1 and IQGAP1 interact in cell migration and phagocytic cup formation. J Cell Biol (2007) 2.15
Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats. Circ Res (2003) 2.08
Role of Rho GTPases in thrombin-induced lung vascular endothelial cells barrier dysfunction. Microvasc Res (2004) 2.07
Disruption of LGI1-linked synaptic complex causes abnormal synaptic transmission and epilepsy. Proc Natl Acad Sci U S A (2010) 2.07
How to make the best use of intraoperative motor evoked potential monitoring? Experience in 1162 consecutive spinal deformity surgical procedures. Spine (Phila Pa 1976) (2014) 2.02
Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus. Neuron (2009) 2.01
Novel role of microtubules in thrombin-induced endothelial barrier dysfunction. FASEB J (2004) 1.98
Dynamic interaction of stargazin-like TARPs with cycling AMPA receptors at synapses. Science (2004) 1.97
PIP3 is involved in neuronal polarization and axon formation. J Neurochem (2004) 1.97
Identification of a link between the tumour suppressor APC and the kinesin superfamily. Nat Cell Biol (2002) 1.93
Mobile DHHC palmitoylating enzyme mediates activity-sensitive synaptic targeting of PSD-95. J Cell Biol (2009) 1.91
Spatial regulation of VEGF receptor endocytosis in angiogenesis. Nat Cell Biol (2013) 1.89
Genome-wide association study of schizophrenia in a Japanese population. Biol Psychiatry (2010) 1.89
Rho-mediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE). Blood (2006) 1.85
DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex through kinesin-1. J Neurosci (2007) 1.84
Establishment of a tissue-specific RNAi system in C. elegans. Gene (2007) 1.82
CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth. Nat Cell Biol (2003) 1.80
Integrin activation and matrix binding mediate cellular responses to mechanical stretch. J Biol Chem (2005) 1.80
Tubulin and CRMP-2 complex is transported via Kinesin-1. J Neurochem (2005) 1.80
Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase. J Cell Biol (2006) 1.79
miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues. Aging (Albany NY) (2010) 1.76
Impaired activation and localization of LAT in anergic T cells as a consequence of a selective palmitoylation defect. Immunity (2006) 1.75
Differential activity-dependent secretion of brain-derived neurotrophic factor from axon and dendrite. J Neurosci (2009) 1.74
Complete genetic correction of ips cells from Duchenne muscular dystrophy. Mol Ther (2009) 1.74
Role of Rho-kinase in regulation of insulin action and glucose homeostasis. Cell Metab (2005) 1.73
AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation. Nat Cell Biol (2010) 1.72
Microtubule disassembly induces cytoskeletal remodeling and lung vascular barrier dysfunction: role of Rho-dependent mechanisms. J Cell Physiol (2004) 1.70
GODZ-mediated palmitoylation of GABA(A) receptors is required for normal assembly and function of GABAergic inhibitory synapses. J Neurosci (2006) 1.68
Rho-kinase phosphorylates PAR-3 and disrupts PAR complex formation. Dev Cell (2008) 1.67
CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation. Mol Cell Biol (2005) 1.64
Differential membrane localization of ERas and Rheb, two Ras-related proteins involved in the phosphatidylinositol 3-kinase/mTOR pathway. J Biol Chem (2005) 1.64
Wnt/beta-catenin and estrogen signaling converge in vivo. J Biol Chem (2004) 1.60
RICS, a novel GTPase-activating protein for Cdc42 and Rac1, is involved in the beta-catenin-N-cadherin and N-methyl-D-aspartate receptor signaling. J Biol Chem (2003) 1.58
The GEX-2 and GEX-3 proteins are required for tissue morphogenesis and cell migrations in C. elegans. Genes Dev (2002) 1.56
Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones. Mol Cell Biol (2005) 1.56
Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells. Am J Pathol (2008) 1.55
Palmitoylation and membrane interactions of the neuroprotective chaperone cysteine-string protein. J Biol Chem (2008) 1.55
Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice. Circulation (2004) 1.53
Roles of Sall4 in the generation of pluripotent stem cells from blastocysts and fibroblasts. Genes Cells (2009) 1.53
A mass conserved reaction-diffusion system captures properties of cell polarity. PLoS Comput Biol (2007) 1.51
Autoantibodies to epilepsy-related LGI1 in limbic encephalitis neutralize LGI1-ADAM22 interaction and reduce synaptic AMPA receptors. J Neurosci (2013) 1.48
Phosphorylation of CLASP2 by GSK-3beta regulates its interaction with IQGAP1, EB1 and microtubules. J Cell Sci (2009) 1.46
Key regulators in neuronal polarity. Neuron (2005) 1.46
Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells. J Biol Chem (2005) 1.46
Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27. Dev Cell (2009) 1.45
Identification of G protein alpha subunit-palmitoylating enzyme. Mol Cell Biol (2008) 1.45
TDP-43 depletion induces neuronal cell damage through dysregulation of Rho family GTPases. J Biol Chem (2009) 1.44
Dynamic protein palmitoylation in cellular signaling. Prog Lipid Res (2009) 1.42
Structural basis for tubulin recognition by cytoplasmic linker protein 170 and its autoinhibition. Proc Natl Acad Sci U S A (2007) 1.41
Role of numb in dendritic spine development with a Cdc42 GEF intersectin and EphB2. Mol Biol Cell (2006) 1.40
Systematic screening for palmitoyl transferase activity of the DHHC protein family in mammalian cells. Methods (2006) 1.40
Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands. Proc Natl Acad Sci U S A (2009) 1.40
Positive role of IQGAP1, an effector of Rac1, in actin-meshwork formation at sites of cell-cell contact. Mol Biol Cell (2003) 1.39
Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1. Dev Cell (2008) 1.38
Role of CRMP-2 in neuronal polarity. J Neurobiol (2004) 1.37