Published in J Am Chem Soc on August 18, 2007
Molecular dynamics simulations suggest a mechanism for translocation of the HIV-1 TAT peptide across lipid membranes. Proc Natl Acad Sci U S A (2007) 1.98
Coupling between the voltage-sensing and phosphatase domains of Ci-VSP. J Gen Physiol (2009) 1.60
Membrane protein structure and dynamics from NMR spectroscopy. Annu Rev Phys Chem (2011) 1.43
Arginine-rich peptides destabilize the plasma membrane, consistent with a pore formation translocation mechanism of cell-penetrating peptides. Biophys J (2009) 1.40
Models of toxic beta-sheet channels of protegrin-1 suggest a common subunit organization motif shared with toxic alzheimer beta-amyloid ion channels. Biophys J (2008) 1.30
Water-protein interactions of an arginine-rich membrane peptide in lipid bilayers investigated by solid-state nuclear magnetic resonance spectroscopy. J Phys Chem B (2010) 1.17
Roles of arginine and lysine residues in the translocation of a cell-penetrating peptide from (13)C, (31)P, and (19)F solid-state NMR. Biochemistry (2009) 1.15
Structure and dynamics of cationic membrane peptides and proteins: insights from solid-state NMR. Protein Sci (2011) 1.13
Membrane-bound dynamic structure of an arginine-rich cell-penetrating peptide, the protein transduction domain of HIV TAT, from solid-state NMR. Biochemistry (2010) 1.09
Free energy of translocating an arginine-rich cell-penetrating peptide across a lipid bilayer suggests pore formation. Biophys J (2013) 1.07
Stimuli-responsive polyguanidino-oxanorbornene membrane transporters as multicomponent sensors in complex matrices. J Am Chem Soc (2008) 1.07
On the nature of antimicrobial activity: a model for protegrin-1 pores. J Am Chem Soc (2008) 1.07
Poisson-Nernst-Planck models of nonequilibrium ion electrodiffusion through a protegrin transmembrane pore. PLoS Comput Biol (2009) 1.06
Influenza virus A M2 protein generates negative Gaussian membrane curvature necessary for budding and scission. J Am Chem Soc (2013) 1.04
Asymmetric insertion of membrane proteins in lipid bilayers by solid-state NMR paramagnetic relaxation enhancement: a cell-penetrating Peptide example. J Am Chem Soc (2008) 1.03
The membrane-bound structure and topology of a human α-defensin indicate a dimer pore mechanism for membrane disruption. Biochemistry (2010) 1.01
Arginine dynamics in a membrane-bound cationic beta-hairpin peptide from solid-state NMR. Chembiochem (2008) 1.01
Cell penetrating peptides: how do they do it? J Biol Phys (2008) 1.01
Structure and mechanism of beta-hairpin antimicrobial peptides in lipid bilayers from solid-state NMR spectroscopy. Mol Biosyst (2009) 1.00
High-resolution orientation and depth of insertion of the voltage-sensing S4 helix of a potassium channel in lipid bilayers. J Mol Biol (2010) 0.99
Antimicrobial protegrin-1 forms ion channels: molecular dynamic simulation, atomic force microscopy, and electrical conductance studies. Biophys J (2010) 0.98
Computational studies of protegrin antimicrobial peptides: a review. Peptides (2010) 0.97
Effects of arginine density on the membrane-bound structure of a cationic antimicrobial peptide from solid-state NMR. Biochim Biophys Acta (2008) 0.91
Mechanism of membrane permeation induced by synthetic β-hairpin peptides. Biophys J (2013) 0.90
Resonance assignment and three-dimensional structure determination of a human alpha-defensin, HNP-1, by solid-state NMR. J Mol Biol (2010) 0.90
Reversible sheet-turn conformational change of a cell-penetrating peptide in lipid bilayers studied by solid-state NMR. J Mol Biol (2008) 0.89
Antimicrobial peptides and induced membrane curvature: geometry, coordination chemistry, and molecular engineering. Curr Opin Solid State Mater Sci (2013) 0.89
Structures of β-hairpin antimicrobial protegrin peptides in lipopolysaccharide membranes: mechanism of gram selectivity obtained from solid-state nuclear magnetic resonance. Biochemistry (2011) 0.88
Comparative molecular dynamics simulation studies of protegrin-1 monomer and dimer in two different lipid bilayers. Biophys J (2009) 0.88
Membrane-dependent conformation, dynamics, and lipid interactions of the fusion peptide of the paramyxovirus PIV5 from solid-state NMR. J Mol Biol (2012) 0.87
Conformational disorder of membrane peptides investigated from solid-state NMR line widths and line shapes. J Phys Chem B (2011) 0.84
Thermodynamics of peptide insertion and aggregation in a lipid bilayer. J Phys Chem B (2008) 0.84
Structural transformations of cytochrome c upon interaction with cardiolipin. Chem Phys Lipids (2013) 0.84
A 2H solid-state NMR study of lipid clustering by cationic antimicrobial and cell-penetrating peptides in model bacterial membranes. Biophys J (2013) 0.83
Membrane interactions and pore formation by the antimicrobial peptide protegrin. Biophys J (2013) 0.82
Determining the orientation and localization of membrane-bound peptides. Curr Protein Pept Sci (2012) 0.82
Interaction of Tarantula Venom Peptide ProTx-II with Lipid Membranes Is a Prerequisite for Its Inhibition of Human Voltage-gated Sodium Channel NaV1.7. J Biol Chem (2016) 0.80
Protein arcs may form stable pores in lipid membranes. Biophys J (2014) 0.80
Determining the depth of insertion of dynamically invisible membrane peptides by gel-phase ¹H spin diffusion heteronuclear correlation NMR. J Biomol NMR (2013) 0.80
Cationic membrane peptides: atomic-level insight of structure-activity relationships from solid-state NMR. Amino Acids (2012) 0.79
Magic-angle-spinning NMR techniques for measuring long-range distances in biological macromolecules. Acc Chem Res (2013) 0.79
Understanding Lipid Recognition by Protein-Mimicking Cyclic Peptides. Tetrahedron (2014) 0.79
Activation of Bax by joint action of tBid and mitochondrial outer membrane: Monte Carlo simulations. Eur Biophys J (2009) 0.78
Interactions between the conserved hydrophobic region of the prion protein and dodecylphosphocholine micelles. J Biol Chem (2011) 0.77
Translocation thermodynamics of linear and cyclic nonaarginine into model DPPC bilayer via coarse-grained molecular dynamics simulation: implications of pore formation and nonadditivity. J Phys Chem B (2014) 0.77
Design, synthesis and structure-activity relationship study of wollamide B; a new potential anti TB agent. PLoS One (2017) 0.75
Structure-Dependent Immune Modulatory Activity of Protegrin-1 Analogs. Antibiotics (Basel) (2014) 0.75
Antimicrobial Peptides Share a Common Interaction Driven by Membrane Line Tension Reduction. Biophys J (2016) 0.75
The total synthesis of 2-O-arachidonoyl-1-O-stearoyl-sn-glycero-3-phosphocholine-1,3,1'-(13)C3 and -2,1'-(13)C2 by a novel chemoenzymatic method. Chem Phys Lipids (2010) 0.75
Concentration dependence of NaCl ion distributions around DPPC lipid bilayers. Interdiscip Sci (2011) 0.75
The Influenza M2 Ectodomain Regulates the Conformational Equilibria of the Transmembrane Proton Channel: Insights from Solid-State Nuclear Magnetic Resonance. Biochemistry (2016) 0.75
Frequency-selective REDOR and spin-diffusion relays in uniformly labeled whole cells. Solid State Nucl Magn Reson (2015) 0.75
Glycosaminoglycan Binding and Non-Endocytic Membrane Translocation of Cell-Permeable Octaarginine Monitored by Real-Time In-Cell NMR Spectroscopy. Pharmaceuticals (Basel) (2017) 0.75
TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains. Mol Cell (2004) 6.00
Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers. Nature (2010) 3.95
Functional and structural diversity in the Als protein family of Candida albicans. J Biol Chem (2004) 2.77
Mechanisms of proton conduction and gating in influenza M2 proton channels from solid-state NMR. Science (2010) 2.40
Anti-inflammatory apoA-I-mimetic peptides bind oxidized lipids with much higher affinity than human apoA-I. J Lipid Res (2008) 2.27
Carbohydrate-binding molecules inhibit viral fusion and entry by crosslinking membrane glycoproteins. Nat Immunol (2005) 2.24
Structure of amantadine-bound M2 transmembrane peptide of influenza A in lipid bilayers from magic-angle-spinning solid-state NMR: the role of Ser31 in amantadine binding. J Mol Biol (2008) 2.15
Retrocyclin: a primate peptide that protects cells from infection by T- and M-tropic strains of HIV-1. Proc Natl Acad Sci U S A (2002) 2.14
Integration of estrogen and Wnt signaling circuits by the polycomb group protein EZH2 in breast cancer cells. Mol Cell Biol (2007) 2.14
Mechanism of radiation-induced bystander effects: a unifying model. J Pharm Pharmacol (2008) 2.07
Amantadine-induced conformational and dynamical changes of the influenza M2 transmembrane proton channel. Proc Natl Acad Sci U S A (2008) 2.07
Membrane-dependent oligomeric structure and pore formation of a beta-hairpin antimicrobial peptide in lipid bilayers from solid-state NMR. Proc Natl Acad Sci U S A (2006) 1.87
Reawakening retrocyclins: ancestral human defensins active against HIV-1. PLoS Biol (2009) 1.80
Retrocyclin, an antiretroviral theta-defensin, is a lectin. J Immunol (2003) 1.69
Structure and function of the influenza A M2 proton channel. Biochemistry (2009) 1.67
Determining the orientation of uniaxially rotating membrane proteins using unoriented samples: a 2H, 13C, AND 15N solid-state NMR investigation of the dynamics and orientation of a transmembrane helical bundle. J Am Chem Soc (2007) 1.63
Interaction of antimicrobial peptide protegrin with biomembranes. Proc Natl Acad Sci U S A (2003) 1.61
The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study. Blood (2005) 1.60
Theta defensins protect cells from infection by herpes simplex virus by inhibiting viral adhesion and entry. J Virol (2004) 1.58
Structure and interactions of plant cell-wall polysaccharides by two- and three-dimensional magic-angle-spinning solid-state NMR. Biochemistry (2011) 1.57
Membrane protein topology probed by (1)H spin diffusion from lipids using solid-state NMR spectroscopy. J Am Chem Soc (2002) 1.56
Solid-state NMR investigation of the depth of insertion of protegrin-1 in lipid bilayers using paramagnetic Mn2+. Biophys J (2003) 1.55
Theta-defensins prevent HIV-1 Env-mediated fusion by binding gp41 and blocking 6-helix bundle formation. J Biol Chem (2006) 1.54
Solid-state NMR investigations of peptide-lipid interaction and orientation of a beta-sheet antimicrobial peptide, protegrin. Biochemistry (2002) 1.54
Immobilization of the influenza A M2 transmembrane peptide in virus envelope-mimetic lipid membranes: a solid-state NMR investigation. Biochemistry (2009) 1.54
NMR detection of pH-dependent histidine-water proton exchange reveals the conduction mechanism of a transmembrane proton channel. J Am Chem Soc (2011) 1.53
Determination of the oligomeric number and intermolecular distances of membrane protein assemblies by anisotropic 1H-driven spin diffusion NMR spectroscopy. J Am Chem Soc (2006) 1.51
Activity of alpha- and theta-defensins against primary isolates of HIV-1. J Immunol (2004) 1.50
Side-chain conformation of the M2 transmembrane peptide proton channel of influenza a virus from 19F solid-state NMR. J Phys Chem B (2007) 1.50
Cellulose microfibril crystallinity is reduced by mutating C-terminal transmembrane region residues CESA1A903V and CESA3T942I of cellulose synthase. Proc Natl Acad Sci U S A (2012) 1.41
The theta-defensin, retrocyclin, inhibits HIV-1 entry. AIDS Res Hum Retroviruses (2003) 1.40
BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential. Cancer Lett (2003) 1.38
A novel method for oral delivery of apolipoprotein mimetic peptides synthesized from all L-amino acids. J Lipid Res (2009) 1.37
Protonation, tautomerization, and rotameric structure of histidine: a comprehensive study by magic-angle-spinning solid-state NMR. J Am Chem Soc (2011) 1.37
Molecular dynamics simulation directed rational design of inhibitors targeting drug-resistant mutants of influenza A virus M2. J Am Chem Soc (2011) 1.37
Shigella flexneri DegP facilitates IcsA surface expression and is required for efficient intercellular spread. Infect Immun (2002) 1.35
Organic anion transporter OAT1 undergoes constitutive and protein kinase C-regulated trafficking through a dynamin- and clathrin-dependent pathway. J Biol Chem (2008) 1.34
Conformational changes of an ion channel detected through water-protein interactions using solid-state NMR spectroscopy. J Am Chem Soc (2010) 1.33
The role of ubiquitination in Drosophila innate immunity. J Biol Chem (2005) 1.32
Specific binding of adamantane drugs and direction of their polar amines in the pore of the influenza M2 transmembrane domain in lipid bilayers and dodecylphosphocholine micelles determined by NMR spectroscopy. J Am Chem Soc (2011) 1.30
Membrane-dependent effects of a cytoplasmic helix on the structure and drug binding of the influenza virus M2 protein. J Am Chem Soc (2011) 1.29
Sensitivity-enhanced solid-state NMR detection of expansin's target in plant cell walls. Proc Natl Acad Sci U S A (2013) 1.28
Discovery of spiro-piperidine inhibitors and their modulation of the dynamics of the M2 proton channel from influenza A virus. J Am Chem Soc (2009) 1.28
Determination of peptide oligomerization in lipid bilayers using 19F spin diffusion NMR. J Am Chem Soc (2005) 1.26
Retrocyclins kill bacilli and germinating spores of Bacillus anthracis and inactivate anthrax lethal toxin. J Biol Chem (2006) 1.25
RC-101, a retrocyclin-1 analogue with enhanced activity against primary HIV type 1 isolates. AIDS Res Hum Retroviruses (2004) 1.23
The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4. Mol Pharmacol (2004) 1.22
Interactions of alpha-, beta-, and theta-defensins with influenza A virus and surfactant protein D. J Immunol (2009) 1.22
The formulated microbicide RC-101 was safe and antivirally active following intravaginal application in pigtailed macaques. PLoS One (2010) 1.19
Effects of guanidinium-phosphate hydrogen bonding on the membrane-bound structure and activity of an arginine-rich membrane peptide from solid-state NMR spectroscopy. Angew Chem Int Ed Engl (2008) 1.19
Solid-state NMR investigation of the selective disruption of lipid membranes by protegrin-1. Biochemistry (2004) 1.18
Water-protein interactions of an arginine-rich membrane peptide in lipid bilayers investigated by solid-state nuclear magnetic resonance spectroscopy. J Phys Chem B (2010) 1.17
HIV-1 adapts to a retrocyclin with cationic amino acid substitutions that reduce fusion efficiency of gp41. J Immunol (2006) 1.17
Conformational plasticity of the influenza A M2 transmembrane helix in lipid bilayers under varying pH, drug binding, and membrane thickness. Biochim Biophys Acta (2010) 1.16
Roles of arginine and lysine residues in the translocation of a cell-penetrating peptide from (13)C, (31)P, and (19)F solid-state NMR. Biochemistry (2009) 1.15
Impact of single-residue mutations on the structure and function of ovispirin/novispirin antimicrobial peptides. Protein Eng (2002) 1.14
Immobilization and aggregation of the antimicrobial peptide protegrin-1 in lipid bilayers investigated by solid-state NMR. Biochemistry (2003) 1.14
SMAP-29 has two LPS-binding sites and a central hinge. Eur J Biochem (2002) 1.13
Fluorine distribution in aquatic environment and its health effect in the Western Region of the Songnen Plain, Northeast China. Environ Monit Assess (2007) 1.13
Selective reciprocity in antimicrobial activity versus cytotoxicity of hBD-2 and crotamine. Proc Natl Acad Sci U S A (2009) 1.11
Pectin-cellulose interactions in the Arabidopsis primary cell wall from two-dimensional magic-angle-spinning solid-state nuclear magnetic resonance. Biochemistry (2012) 1.11
Activity of novispirin G10 against Pseudomonas aeruginosa in vitro and in infected burns. Antimicrob Agents Chemother (2002) 1.11
Retrocyclin-2: structural analysis of a potent anti-HIV theta-defensin. Biochemistry (2007) 1.11
Membrane-bound dynamic structure of an arginine-rich cell-penetrating peptide, the protein transduction domain of HIV TAT, from solid-state NMR. Biochemistry (2010) 1.09
Intermolecular packing and alignment in an ordered beta-hairpin antimicrobial peptide aggregate from 2D solid-state NMR. J Am Chem Soc (2005) 1.09
Molecular epidemiology of coxsackievirus A16: intratype and prevalent intertype recombination identified. PLoS One (2013) 1.08
Lateral stress relaxation and collapse in lipid monolayers. Soft Matter (2008) 1.07
Regulation of human organic anion transporter 4 by progesterone and protein kinase C in human placental BeWo cells. Am J Physiol Endocrinol Metab (2007) 1.07
Compensation for pulse imperfections in rotational-echo double-resonance NMR by composite pulses and EXORCYCLE. J Magn Reson (2004) 1.07
The retrocyclin analogue RC-101 prevents human immunodeficiency virus type 1 infection of a model human cervicovaginal tissue construct. Immunology (2007) 1.06
CotH3 mediates fungal invasion of host cells during mucormycosis. J Clin Invest (2013) 1.04
Two states of cyclic antimicrobial peptide RTD-1 in lipid bilayers. Biochemistry (2002) 1.04
Structure of mini-B, a functional fragment of surfactant protein B, in detergent micelles. Biochemistry (2007) 1.04
NMR determination of protein partitioning into membrane domains with different curvatures and application to the influenza M2 peptide. Biophys J (2012) 1.04
Hydrophobic surfactant proteins and their analogues. Neonatology (2007) 1.04
Asymmetric insertion of membrane proteins in lipid bilayers by solid-state NMR paramagnetic relaxation enhancement: a cell-penetrating Peptide example. J Am Chem Soc (2008) 1.03
pH-dependent conformation, dynamics, and aromatic interaction of the gating tryptophan residue of the influenza M2 proton channel from solid-state NMR. Biophys J (2013) 1.02
Interaction of antimicrobial peptides with lipopolysaccharides. Biochemistry (2003) 1.02
Conformational mapping of the N-terminal peptide of HIV-1 gp41 in membrane environments using (13)C-enhanced Fourier transform infrared spectroscopy. Biochim Biophys Acta (2002) 1.01
Modulation of melanogenesis by aloesin: a competitive inhibitor of tyrosinase. Pigment Cell Res (2002) 1.01
Effective targeting of liposomes to liver and hepatocytes in vivo by incorporation of a Plasmodium amino acid sequence. Pharm Res (2006) 1.01
Arginine dynamics in a membrane-bound cationic beta-hairpin peptide from solid-state NMR. Chembiochem (2008) 1.01
Human alpha-defensins inhibit hemolysis mediated by cholesterol-dependent cytolysins. Infect Immun (2009) 1.01
The membrane-bound structure and topology of a human α-defensin indicate a dimer pore mechanism for membrane disruption. Biochemistry (2010) 1.01
Evaluation of a theta-defensin in a Murine model of herpes simplex virus type 1 keratitis. Invest Ophthalmol Vis Sci (2007) 1.00
The role of defensins in lung biology and therapy. Am J Respir Med (2002) 1.00
Structure and mechanism of beta-hairpin antimicrobial peptides in lipid bilayers from solid-state NMR spectroscopy. Mol Biosyst (2009) 1.00
Solid-state NMR investigation of the selective perturbation of lipid bilayers by the cyclic antimicrobial peptide RTD-1. Biochemistry (2004) 1.00
Insertion selectivity of antimicrobial peptide protegrin-1 into lipid monolayers: effect of head group electrostatics and tail group packing. Biochim Biophys Acta (2006) 0.99