Published in J Am Chem Soc on March 07, 2011
Structural basis for the function and inhibition of an influenza virus proton channel. Nature (2008) 5.69
Influences of membrane mimetic environments on membrane protein structures. Annu Rev Biophys (2013) 1.58
Membrane protein structure and dynamics from NMR spectroscopy. Annu Rev Phys Chem (2011) 1.43
Molecular dynamics simulation directed rational design of inhibitors targeting drug-resistant mutants of influenza A virus M2. J Am Chem Soc (2011) 1.37
Structural basis for proton conduction and inhibition by the influenza M2 protein. Protein Sci (2012) 1.36
Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus. Proc Natl Acad Sci U S A (2013) 1.34
Membrane-dependent effects of a cytoplasmic helix on the structure and drug binding of the influenza virus M2 protein. J Am Chem Soc (2011) 1.29
NMR determination of protein partitioning into membrane domains with different curvatures and application to the influenza M2 peptide. Biophys J (2012) 1.04
Discovery of novel dual inhibitors of the wild-type and the most prevalent drug-resistant mutant, S31N, of the M2 proton channel from influenza A virus. J Med Chem (2013) 1.03
Exploring organosilane amines as potent inhibitors and structural probes of influenza a virus M2 proton channel. J Am Chem Soc (2011) 1.01
The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives. Chem Rev (2013) 0.98
Conformational analysis of the full-length M2 protein of the influenza A virus using solid-state NMR. Protein Sci (2013) 0.94
Dynamic nuclear polarization study of inhibitor binding to the M2(18-60) proton transporter from influenza A. Biochemistry (2013) 0.93
Drug-induced conformational and dynamical changes of the S31N mutant of the influenza M2 proton channel investigated by solid-state NMR. J Am Chem Soc (2013) 0.92
Aminoadamantanes with persistent in vitro efficacy against H1N1 (2009) influenza A. J Med Chem (2014) 0.90
Proton association constants of His 37 in the Influenza-A M218-60 dimer-of-dimers. Biochemistry (2014) 0.88
Flipping in the pore: discovery of dual inhibitors that bind in different orientations to the wild-type versus the amantadine-resistant S31N mutant of the influenza A virus M2 proton channel. J Am Chem Soc (2014) 0.85
Structure and Mechanism of the Influenza A M218-60 Dimer of Dimers. J Am Chem Soc (2015) 0.85
3-Azatetracyclo[5.2.1.1(5,8).0(1,5)]undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant. J Med Chem (2013) 0.85
2D IR spectroscopy reveals the role of water in the binding of channel-blocking drugs to the influenza M2 channel. J Chem Phys (2014) 0.82
Hydrogen-bonded water molecules in the M2 channel of the influenza A virus guide the binding preferences of ammonium-based inhibitors. J Phys Chem B (2014) 0.80
Pharmacological Characterization of the Spectrum of Antiviral Activity and Genetic Barrier to Drug Resistance of M2-S31N Channel Blockers. Mol Pharmacol (2016) 0.79
Magic-angle-spinning NMR techniques for measuring long-range distances in biological macromolecules. Acc Chem Res (2013) 0.79
Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory. J Membr Biol (2015) 0.79
Novel treatment with neuroprotective and antiviral properties against a neuroinvasive human respiratory virus. J Virol (2013) 0.78
Efficient DNP NMR of membrane proteins: sample preparation protocols, sensitivity, and radical location. J Biomol NMR (2016) 0.78
Inhibitors of the influenza A virus M2 proton channel discovered using a high-throughput yeast growth restoration assay. PLoS One (2013) 0.78
Nanosecond Dynamics of InfluenzaA/M2TM and an Amantadine Resistant Mutant Probed by Time-Dependent Red Shifts of a Native Tryptophan. Chem Phys (2013) 0.77
Magic angle spinning NMR of viruses. Prog Nucl Magn Reson Spectrosc (2015) 0.76
Solid-State NMR Investigation of the Conformation, Proton Conduction, and Hydration of the Influenza B Virus M2 Transmembrane Proton Channel. J Am Chem Soc (2016) 0.75
The Influenza M2 Ectodomain Regulates the Conformational Equilibria of the Transmembrane Proton Channel: Insights from Solid-State Nuclear Magnetic Resonance. Biochemistry (2016) 0.75
Affinity of Rimantadine Enantiomers against Influenza A/M2 Protein Revisited. ACS Med Chem Lett (2017) 0.75
Why bound amantadine fails to inhibit proton conductance according to simulations of the drug-resistant influenza A M2 (S31N). J Phys Chem B (2014) 0.75
NMRPipe: a multidimensional spectral processing system based on UNIX pipes. J Biomol NMR (1995) 93.94
Recognition dynamics up to microseconds revealed from an RDC-derived ubiquitin ensemble in solution. Science (2008) 8.04
Structure and mechanism of the M2 proton channel of influenza A virus. Nature (2008) 6.79
Structural basis for the function and inhibition of an influenza virus proton channel. Nature (2008) 5.69
Ion channel activity of influenza A virus M2 protein: characterization of the amantadine block. J Virol (1993) 4.76
Influenza virus M2 protein mediates ESCRT-independent membrane scission. Cell (2010) 4.33
Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers. Nature (2010) 3.95
Matrix protein 2 of influenza A virus blocks autophagosome fusion with lysosomes. Cell Host Microbe (2009) 3.79
The M2 proton channels of influenza A and B viruses. J Biol Chem (2005) 3.49
Insight into the mechanism of the influenza A proton channel from a structure in a lipid bilayer. Science (2010) 3.32
Frequency selective heteronuclear dipolar recoupling in rotating solids: accurate (13)C-(15)N distance measurements in uniformly (13)C,(15)N-labeled peptides. J Am Chem Soc (2001) 3.26
Folding funnels and binding mechanisms. Protein Eng (1999) 3.25
Histidines, heart of the hydrogen ion channel from influenza A virus: toward an understanding of conductance and proton selectivity. Proc Natl Acad Sci U S A (2006) 3.22
Activation of the M2 ion channel of influenza virus: a role for the transmembrane domain histidine residue. Biophys J (1995) 3.06
Mechanism of drug inhibition and drug resistance of influenza A M2 channel. Proc Natl Acad Sci U S A (2009) 2.44
Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus. Proc Natl Acad Sci U S A (2010) 2.43
Mechanisms of proton conduction and gating in influenza M2 proton channels from solid-state NMR. Science (2010) 2.40
Identification of the functional core of the influenza A virus A/M2 proton-selective ion channel. Proc Natl Acad Sci U S A (2009) 2.32
Distinct domains of the influenza a virus M2 protein cytoplasmic tail mediate binding to the M1 protein and facilitate infectious virus production. J Virol (2006) 2.18
Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel. Proc Natl Acad Sci U S A (2008) 2.15
Structure of amantadine-bound M2 transmembrane peptide of influenza A in lipid bilayers from magic-angle-spinning solid-state NMR: the role of Ser31 in amantadine binding. J Mol Biol (2008) 2.15
pH-dependent tetramerization and amantadine binding of the transmembrane helix of M2 from the influenza A virus. Biochemistry (2000) 2.14
Amantadine-induced conformational and dynamical changes of the influenza M2 transmembrane proton channel. Proc Natl Acad Sci U S A (2008) 2.07
Conformer selection and induced fit in flexible backbone protein-protein docking using computational and NMR ensembles. J Mol Biol (2008) 2.03
Total chemical synthesis of the integral membrane protein influenza A virus M2: role of its C-terminal domain in tetramer assembly. Biochemistry (1999) 2.02
Solid-state NMR characterization of conformational plasticity within the transmembrane domain of the influenza A M2 proton channel. Biochim Biophys Acta (2007) 1.98
A secondary gate as a mechanism for inhibition of the M2 proton channel by amantadine. J Phys Chem B (2008) 1.97
Proton transport behavior through the influenza A M2 channel: insights from molecular simulation. Biophys J (2007) 1.96
Conformational heterogeneity of the M2 proton channel and a structural model for channel activation. Proc Natl Acad Sci U S A (2009) 1.94
The influenza A virus M2 channel: a molecular modeling and simulation study. Virology (1997) 1.94
Molecular dynamics calculations suggest a conduction mechanism for the M2 proton channel from influenza A virus. Proc Natl Acad Sci U S A (2009) 1.93
Effect of cytoplasmic tail truncations on the activity of the M(2) ion channel of influenza A virus. J Virol (1999) 1.87
Use of thiol-disulfide equilibria to measure the energetics of assembly of transmembrane helices in phospholipid bilayers. Proc Natl Acad Sci U S A (2003) 1.82
Influenza virus m2 ion channel protein is necessary for filamentous virion formation. J Virol (2010) 1.73
Functional studies and modeling of pore-lining residue mutants of the influenza a virus M2 ion channel. Biochemistry (2010) 1.73
Structure and function of the influenza A M2 proton channel. Biochemistry (2009) 1.67
Influenza virus M2 protein: a molecular modelling study of the ion channel. Protein Eng (1993) 1.66
Determining the orientation of uniaxially rotating membrane proteins using unoriented samples: a 2H, 13C, AND 15N solid-state NMR investigation of the dynamics and orientation of a transmembrane helical bundle. J Am Chem Soc (2007) 1.63
Immobilization of the influenza A M2 transmembrane peptide in virus envelope-mimetic lipid membranes: a solid-state NMR investigation. Biochemistry (2009) 1.54
The conformation of the pore region of the M2 proton channel depends on lipid bilayer environment. Protein Sci (2005) 1.52
pH-induced conformational change of the influenza M2 protein C-terminal domain. Biochemistry (2008) 1.48
A novel method of resistance for influenza against a channel-blocking antiviral drug. Proteins (2004) 1.48
Design and pharmacological characterization of inhibitors of amantadine-resistant mutants of the M2 ion channel of influenza A virus. Biochemistry (2009) 1.47
The chemical and dynamical influence of the anti-viral drug amantadine on the M2 proton channel transmembrane domain. Biophys J (2007) 1.44
Sequence determinants of the energetics of folding of a transmembrane four-helix-bundle protein. Proc Natl Acad Sci U S A (2002) 1.39
Multidimensional NMR methods for protein structure determination. IUBMB Life (2001) 1.38
The interplay of functional tuning, drug resistance, and thermodynamic stability in the evolution of the M2 proton channel from the influenza A virus. Structure (2008) 1.38
Magic angle spinning NMR investigation of influenza A M2(18-60): support for an allosteric mechanism of inhibition. J Am Chem Soc (2010) 1.36
Sequence determinants of a transmembrane proton channel: an inverse relationship between stability and function. J Mol Biol (2005) 1.35
Conformational changes of an ion channel detected through water-protein interactions using solid-state NMR spectroscopy. J Am Chem Soc (2010) 1.33
An amantadine-sensitive chimeric BM2 ion channel of influenza B virus has implications for the mechanism of drug inhibition. Proc Natl Acad Sci U S A (2009) 1.30
Solid-state NMR and MD simulations of the antiviral drug amantadine solubilized in DMPC bilayers. Biophys J (2007) 1.29
Discovery of spiro-piperidine inhibitors and their modulation of the dynamics of the M2 proton channel from influenza A virus. J Am Chem Soc (2009) 1.28
The M2 ectodomain is important for its incorporation into influenza A virions. J Virol (1998) 1.25
Solution NMR of membrane proteins in bilayer mimics: small is beautiful, but sometimes bigger is better. Biochim Biophys Acta (2007) 1.21
Coexistence of two adamantane binding sites in the influenza A M2 ion channel. Proc Natl Acad Sci U S A (2010) 1.08
Determination of membrane protein stability via thermodynamic coupling of folding to thiol-disulfide interchange. Protein Sci (2003) 1.08
Binding hot spots and amantadine orientation in the influenza a virus M2 proton channel. Biophys J (2009) 1.05
Effects of jump dynamics on solid state nuclear magnetic resonance line shapes and spin relaxation times. J Magn Reson (2009) 1.04
How amantadine and rimantadine inhibit proton transport in the M2 protein channel. J Mol Graph Model (2008) 1.02
Effects of amantadine on the dynamics of membrane-bound influenza A M2 transmembrane peptide studied by NMR relaxation. J Biomol NMR (2009) 0.96
Cholesterol-binding viral proteins in virus entry and morphogenesis. Subcell Biochem (2010) 0.96
Why amantadine loses its function in influenza m2 mutants: MD simulations. J Chem Inf Model (2009) 0.89
SOAP: short oligonucleotide alignment program. Bioinformatics (2008) 68.13
De novo assembly of human genomes with massively parallel short read sequencing. Genome Res (2009) 45.91
A human gut microbial gene catalogue established by metagenomic sequencing. Nature (2010) 43.63
A draft sequence of the rice genome (Oryza sativa L. ssp. indica). Science (2002) 42.78
SOAP2: an improved ultrafast tool for short read alignment. Bioinformatics (2009) 39.47
Enterotypes of the human gut microbiome. Nature (2011) 24.36
SOAPdenovo2: an empirically improved memory-efficient short-read de novo assembler. Gigascience (2012) 20.89
Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res (2008) 20.59
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A (2002) 20.48
Evolution of genes and genomes on the Drosophila phylogeny. Nature (2007) 18.01
SNP detection for massively parallel whole-genome resequencing. Genome Res (2009) 15.96
The sequence and de novo assembly of the giant panda genome. Nature (2009) 15.76
WEGO: a web tool for plotting GO annotations. Nucleic Acids Res (2006) 13.06
Mapping copy number variation by population-scale genome sequencing. Nature (2011) 12.55
A systematic survey of loss-of-function variants in human protein-coding genes. Science (2012) 12.25
A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature (2012) 11.68
Sequencing of 50 human exomes reveals adaptation to high altitude. Science (2010) 11.27
TreeFam: a curated database of phylogenetic trees of animal gene families. Nucleic Acids Res (2006) 8.83
The genome of the mesopolyploid crop species Brassica rapa. Nat Genet (2011) 8.23
The genome of the cucumber, Cucumis sativus L. Nat Genet (2009) 8.19
An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people. Science (2012) 7.94
Genome sequence and analysis of the tuber crop potato. Nature (2011) 7.77
The Genomes of Oryza sativa: a history of duplications. PLoS Biol (2005) 7.67
Ancient human genome sequence of an extinct Palaeo-Eskimo. Nature (2010) 7.51
A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. Cancer Res (2008) 7.45
Open-source genomic analysis of Shiga-toxin-producing E. coli O104:H4. N Engl J Med (2011) 7.11
Richness of human gut microbiome correlates with metabolic markers. Nature (2013) 6.93
Consistent blind protein structure generation from NMR chemical shift data. Proc Natl Acad Sci U S A (2008) 6.76
TreeFam: 2008 Update. Nucleic Acids Res (2007) 6.63
A draft sequence for the genome of the domesticated silkworm (Bombyx mori). Science (2004) 6.62
Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease. Neuron (2007) 6.60
TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains. Mol Cell (2004) 6.00
Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder. Nat Genet (2011) 5.73
Structural basis for the function and inhibition of an influenza virus proton channel. Nature (2008) 5.69
Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor. Cell (2012) 5.62
Analyses of pig genomes provide insight into porcine demography and evolution. Nature (2012) 5.58
Building the sequence map of the human pan-genome. Nat Biotechnol (2009) 5.53
Resequencing of 200 human exomes identifies an excess of low-frequency non-synonymous coding variants. Nat Genet (2010) 5.44
The oyster genome reveals stress adaptation and complexity of shell formation. Nature (2012) 5.30
A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms. Nature (2004) 5.24
Resequencing of 31 wild and cultivated soybean genomes identifies patterns of genetic diversity and selection. Nat Genet (2010) 5.20
Single-cell exome sequencing and monoclonal evolution of a JAK2-negative myeloproliferative neoplasm. Cell (2012) 5.16
Resequencing 50 accessions of cultivated and wild rice yields markers for identifying agronomically important genes. Nat Biotechnol (2011) 4.84
An Aboriginal Australian genome reveals separate human dispersals into Asia. Science (2011) 4.84
Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size. Science (2011) 4.76
Non-invasive prenatal assessment of trisomy 21 by multiplexed maternal plasma DNA sequencing: large scale validity study. BMJ (2011) 4.50
Distinct DNA methylomes of newborns and centenarians. Proc Natl Acad Sci U S A (2012) 4.26
The DNA methylome of human peripheral blood mononuclear cells. PLoS Biol (2010) 4.25
Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor. Cancer Cell (2010) 4.16
KaKs_Calculator: calculating Ka and Ks through model selection and model averaging. Genomics Proteomics Bioinformatics (2006) 4.15
Assemblathon 2: evaluating de novo methods of genome assembly in three vertebrate species. Gigascience (2013) 4.11
Dynamic T cell migration program provides resident memory within intestinal epithelium. J Exp Med (2010) 4.09
Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet (2012) 4.07
Genome-wide patterns of genetic variation among elite maize inbred lines. Nat Genet (2010) 4.06
Whole-genome sequencing in autism identifies hot spots for de novo germline mutation. Cell (2012) 4.03
Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers. Nature (2010) 3.95
Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation. Nat Genet (2013) 3.87
Comprehensive analysis of RNA-Seq data reveals extensive RNA editing in a human transcriptome. Nat Biotechnol (2012) 3.83
Comparative population genomics of maize domestication and improvement. Nat Genet (2012) 3.78
Two Dobzhansky-Muller genes interact to cause hybrid lethality in Drosophila. Science (2006) 3.77
Maize HapMap2 identifies extant variation from a genome in flux. Nat Genet (2012) 3.74
Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling. J Bone Miner Res (2009) 3.69
Epidemiological evidence for the link between sleep duration and high blood pressure: a systematic review and meta-analysis. Sleep Med (2013) 3.68
Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma. Nat Genet (2011) 3.66
TGM6 identified as a novel causative gene of spinocerebellar ataxias using exome sequencing. Brain (2010) 3.66
Clinical application of massively parallel sequencing-based prenatal noninvasive fetal trisomy test for trisomies 21 and 18 in 11,105 pregnancies with mixed risk factors. Prenat Diagn (2012) 3.54
Draft genome sequence of pigeonpea (Cajanus cajan), an orphan legume crop of resource-poor farmers. Nat Biotechnol (2011) 3.51
Recalibrating Equus evolution using the genome sequence of an early Middle Pleistocene horse. Nature (2013) 3.45
Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs. Curr Opin Struct Biol (2004) 3.42
Draft genome sequence of chickpea (Cicer arietinum) provides a resource for trait improvement. Nat Biotechnol (2013) 3.41
Aegilops tauschii draft genome sequence reveals a gene repertoire for wheat adaptation. Nature (2013) 3.40
Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. J Biol Chem (2006) 3.40
Deep RNA sequencing at single base-pair resolution reveals high complexity of the rice transcriptome. Genome Res (2010) 3.34
Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations. Science (2003) 3.22
Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Nature (2011) 3.19
The draft genome of a diploid cotton Gossypium raimondii. Nat Genet (2012) 3.18
BioMart Central Portal: an open database network for the biological community. Database (Oxford) (2011) 3.03
Snap: an integrated SNP annotation platform. Nucleic Acids Res (2006) 2.99
Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans. DNA Res (2004) 2.95
Whole-genome sequence of Schistosoma haematobium. Nat Genet (2012) 2.91
The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line. Nat Biotechnol (2011) 2.87
Draft genome of the wheat A-genome progenitor Triticum urartu. Nature (2013) 2.86
Genome sequence of foxtail millet (Setaria italica) provides insights into grass evolution and biofuel potential. Nat Biotechnol (2012) 2.82
Foldamers as versatile frameworks for the design and evolution of function. Nat Chem Biol (2007) 2.79
Genomic comparison of the ants Camponotus floridanus and Harpegnathos saltator. Science (2010) 2.78
Constrained motion control of flexible robot manipulators based on recurrent neural networks. IEEE Trans Syst Man Cybern B Cybern (2004) 2.75
BGI-RIS: an integrated information resource and comparative analysis workbench for rice genomics. Nucleic Acids Res (2004) 2.69
Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx). Science (2009) 2.68
Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells. Nat Cell Biol (2012) 2.56
Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease. FASEB J (2004) 2.56
The genome of the pear (Pyrus bretschneideri Rehd.). Genome Res (2012) 2.55
Exome sequencing identifies ZNF644 mutations in high myopia. PLoS Genet (2011) 2.52
Metagenomic species profiling using universal phylogenetic marker genes. Nat Methods (2013) 2.51
SilkDB: a knowledgebase for silkworm biology and genomics. Nucleic Acids Res (2005) 2.50
Genome-wide and caste-specific DNA methylomes of the ants Camponotus floridanus and Harpegnathos saltator. Curr Biol (2012) 2.50
Detection of clinically relevant genetic variants in autism spectrum disorder by whole-genome sequencing. Am J Hum Genet (2013) 2.47
A glimpse of streptococcal toxic shock syndrome from comparative genomics of S. suis 2 Chinese isolates. PLoS One (2007) 2.47
Sequencing and automated whole-genome optical mapping of the genome of a domestic goat (Capra hircus). Nat Biotechnol (2012) 2.45