A dual role of lipocalin 2 in the apoptosis and deramification of activated microglia.

PubWeight™: 1.31‹?› | Rank: Top 10%

🔗 View Article (PMID 17709539)

Published in J Immunol on September 01, 2007

Authors

Shinrye Lee1, Jayoung Lee, Sangseop Kim, Jae-Yong Park, Won-Ha Lee, Kiyoshi Mori, Sang-Hyun Kim, In Kyeom Kim, Kyoungho Suk

Author Affiliations

1: Department of Pharmacology, Kyungpook National University School of Medicine, 101 Dong-in, Joong-gu, Daegu 700-422, Korea.

Articles citing this

Reactive astrocytes secrete lcn2 to promote neuron death. Proc Natl Acad Sci U S A (2013) 1.59

Lipocalin-2 controls neuronal excitability and anxiety by regulating dendritic spine formation and maturation. Proc Natl Acad Sci U S A (2011) 1.23

Time course profiling of the retinal transcriptome after optic nerve transection and optic nerve crush. Mol Vis (2008) 1.13

Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype. J Neuroinflammation (2010) 1.12

Lipocalin 2 in the central nervous system host response to systemic lipopolysaccharide administration. J Neuroinflammation (2011) 1.10

Lipocalin-2 Is a chemokine inducer in the central nervous system: role of chemokine ligand 10 (CXCL10) in lipocalin-2-induced cell migration. J Biol Chem (2011) 1.10

MyD88 expression by CNS-resident cells is pivotal for eliciting protective immunity in brain abscesses. ASN Neuro (2009) 1.09

Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in rats. EMBO J (2013) 1.05

Lipocalin 2: novel component of proinflammatory signaling in Alzheimer's disease. FASEB J (2012) 1.03

Identification of stage biomarkers for human African trypanosomiasis. Am J Trop Med Hyg (2010) 0.98

Lipocalin-2 deficiency attenuates neuroinflammation and brain injury after transient middle cerebral artery occlusion in mice. J Cereb Blood Flow Metab (2014) 0.92

Lipocalin-type prostaglandin D2 synthase protein regulates glial cell migration and morphology through myristoylated alanine-rich C-kinase substrate: prostaglandin D2-independent effects. J Biol Chem (2012) 0.91

Regulation of microglia activity by glaucocalyxin-A: attenuation of lipopolysaccharide-stimulated neuroinflammation through NF-κB and p38 MAPK signaling pathways. PLoS One (2013) 0.91

Redox control of microglial function: molecular mechanisms and functional significance. Antioxid Redox Signal (2014) 0.90

Increased Lipocalin-2 in the retinal pigment epithelium of Cryba1 cKO mice is associated with a chronic inflammatory response. Aging Cell (2014) 0.88

Lipocalin-2-induced cytokine production enhances endometrial carcinoma cell survival and migration. Int J Biol Sci (2011) 0.87

CCR5 knockout prevents neuronal injury and behavioral impairment induced in a transgenic mouse model by a CXCR4-using HIV-1 glycoprotein 120. J Immunol (2014) 0.87

Multiple apoptotic defects in hematopoietic cells from mice lacking lipocalin 24p3. J Biol Chem (2011) 0.84

Profiling the genes affected by pathogenic TDP-43 in astrocytes. J Neurochem (2014) 0.83

Role of lipocalin-2-chemokine axis in the development of neuropathic pain following peripheral nerve injury. J Biol Chem (2013) 0.82

Role of lipocalin-2 in brain injury after intracerebral hemorrhage. J Cereb Blood Flow Metab (2015) 0.81

Stress-induced lipocalin-2 controls dendritic spine formation and neuronal activity in the amygdala. PLoS One (2013) 0.81

Modulation of glial and neuronal migration by lipocalin-2 in zebrafish. Immune Netw (2011) 0.81

Lipocalin-2 is involved in emotional behaviors and cognitive function. Front Cell Neurosci (2013) 0.81

Lipocalin-2 protein deficiency ameliorates experimental autoimmune encephalomyelitis: the pathogenic role of lipocalin-2 in the central nervous system and peripheral lymphoid tissues. J Biol Chem (2014) 0.79

Inflammogenesis of Secondary Spinal Cord Injury. Front Cell Neurosci (2016) 0.78

Searching for novel intercellular signal-transducing molecules in the kidney and their clinical application. Clin Exp Nephrol (2010) 0.77

Salvianolic acid B ameliorates depressive-like behaviors in chronic mild stress-treated mice: involvement of the neuroinflammatory pathway. Acta Pharmacol Sin (2016) 0.77

The bacteriostatic protein lipocalin 2 is induced in the central nervous system of mice with west Nile virus encephalitis. J Virol (2013) 0.76

Acute Phase Protein Lipocalin-2 Is Associated with Formalin-induced Nociception and Pathological Pain. Immune Netw (2013) 0.76

Transient IKK2 activation in astrocytes initiates selective non-cell-autonomous neurodegeneration. Mol Neurodegener (2017) 0.75

Lipocalin-2 is increased in progressive multiple sclerosis and inhibits remyelination. Neurol Neuroimmunol Neuroinflamm (2016) 0.75

Deficiency of Lipocalin-2 Promotes Proliferation and Differentiation of Osteoclast Precursors via Regulation of c-Fms Expression and Nuclear Factor-kappa B Activation. J Bone Metab (2016) 0.75

Role of lipocalin 2 in intraventricular haemoglobin-induced brain injury. Stroke Vasc Neurol (2016) 0.75

Chronic diazepam administration increases the expression of Lcn2 in the CNS. Pharmacol Res Perspect (2017) 0.75

Articles by these authors

Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet (2005) 13.77

Irinotecan plus cisplatin compared with etoposide plus cisplatin for extensive small-cell lung cancer. N Engl J Med (2002) 7.59

Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury. Ann Intern Med (2008) 5.89

Dual action of neutrophil gelatinase-associated lipocalin. J Am Soc Nephrol (2007) 4.99

Association between increases in urinary neutrophil gelatinase-associated lipocalin and acute renal dysfunction after adult cardiac surgery. Anesthesiology (2006) 3.66

CT-guided needle biopsy of lung lesions: a survey of severe complication based on 9783 biopsies in Japan. Eur J Radiol (2006) 3.39

An iron delivery pathway mediated by a lipocalin. Mol Cell (2002) 3.38

The Ngal reporter mouse detects the response of the kidney to injury in real time. Nat Med (2011) 3.20

Amelioration of ischemic acute renal injury by neutrophil gelatinase-associated lipocalin. J Am Soc Nephrol (2004) 2.96

Neutrophil gelatinase-associated lipocalin: a novel early urinary biomarker for cisplatin nephrotoxicity. Am J Nephrol (2004) 2.91

Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum. Neuron (2005) 2.66

BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha. J Exp Med (2003) 2.62

CD4+ T-cell memory: generation and multi-faceted roles for CD4+ T cells in protective immunity to influenza. Immunol Rev (2006) 2.49

Kidney NGAL is a novel early marker of acute injury following transplantation. Pediatr Nephrol (2006) 2.48

Neutrophil gelatinase-associated lipocalin-mediated iron traffic in kidney epithelia. Curr Opin Nephrol Hypertens (2006) 2.34

Sulfonate chalcone as new class voltage-dependent K+ channel blocker. Bioorg Med Chem Lett (2007) 2.26

Lipocalin 2 is essential for chronic kidney disease progression in mice and humans. J Clin Invest (2010) 2.23

Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex. Nat Chem Biol (2010) 2.06

Late target lesion revascularization after implantation of sirolimus-eluting stent. Catheter Cardiovasc Interv (2008) 2.03

Cyclophilin A may contribute to the inflammatory processes in rheumatoid arthritis through induction of matrix degrading enzymes and inflammatory cytokines from macrophages. Clin Immunol (2005) 1.91

Proportion of ground-glass opacity on high-resolution computed tomography in clinical T1 N0 M0 adenocarcinoma of the lung: A predictor of lymph node metastasis. J Thorac Cardiovasc Surg (2002) 1.90

Gram-positive bacteria produce membrane vesicles: proteomics-based characterization of Staphylococcus aureus-derived membrane vesicles. Proteomics (2009) 1.89

Urinary neutrophil gelatinase-associated lipocalin levels reflect damage to glomeruli, proximal tubules, and distal nephrons. Kidney Int (2008) 1.85

Reduction in connective tissue growth factor by antisense treatment ameliorates renal tubulointerstitial fibrosis. J Am Soc Nephrol (2004) 1.70

Rapid default transition of CD4 T cell effectors to functional memory cells. J Exp Med (2007) 1.69

Randomized phase II study of first-line carboplatin-paclitaxel with or without bevacizumab in Japanese patients with advanced non-squamous non-small-cell lung cancer. Lung Cancer (2012) 1.67

Clinical and physiological outcomes of fractional flow reserve-guided percutaneous coronary intervention in patients with serial stenoses within one coronary artery. JACC Cardiovasc Interv (2012) 1.62

Total thyroidectomy plus neck dissection in differentiated papillary thyroid carcinoma patients: pattern of nodal metastasis, morbidity, recurrence, and postoperative levels of serum parathyroid hormone. Ann Surg (2007) 1.61

Comparison of three measurements on computed tomography for the prediction of less invasiveness in patients with clinical stage I non-small cell lung cancer. Ann Thorac Surg (2013) 1.61

TREK-1 and Best1 channels mediate fast and slow glutamate release in astrocytes upon GPCR activation. Cell (2012) 1.60

Septic pulmonary embolism in Korea: Microbiology, clinicoradiologic features, and treatment outcome. J Infect (2006) 1.58

Proposal of new nodal classifications for non-small-cell lung cancer based on the number and ratio of metastatic lymph nodes. Eur J Cardiothorac Surg (2012) 1.55

Lipocalin-2 is an autocrine mediator of reactive astrocytosis. J Neurosci (2009) 1.54

Direct effect of ropivacaine involves lipoxygenase pathway activation in rat aortic smooth muscle. Can J Anaesth (2009) 1.50

Long-term clinical outcomes after sirolimus-eluting stent implantation for treatment of restenosis within bare-metal versus drug-eluting stents. Catheter Cardiovasc Interv (2008) 1.47

Role of p38 mitogen-activated protein kinase activation in podocyte injury and proteinuria in experimental nephrotic syndrome. J Am Soc Nephrol (2005) 1.47

Expression of Na+-K+ -2Cl- cotransporter 1 is epigenetically regulated during postnatal development of hypertension. Am J Hypertens (2011) 1.46

Incremental Prognostic Value of Brachial-Ankle Pulse Wave Velocity to Single-Photon Emission Computed Tomography in Patients with Suspected Coronary Artery Disease. J Atheroscler Thromb (2015) 1.46

The effect of aspirin on C-reactive protein in hypertensive patients. Clin Exp Hypertens (2010) 1.45

Iron, lipocalin, and kidney epithelia. Am J Physiol Renal Physiol (2003) 1.43

Involvement of TL1A and DR3 in induction of pro-inflammatory cytokines and matrix metalloproteinase-9 in atherogenesis. Cytokine (2005) 1.40

Plasma ghrelin and desacyl ghrelin concentrations in renal failure. J Am Soc Nephrol (2002) 1.37

Lipocalin 2 diminishes invasiveness and metastasis of Ras-transformed cells. J Biol Chem (2005) 1.36

Identification of putative serum glycoprotein biomarkers for human lung adenocarcinoma by multilectin affinity chromatography and LC-MS/MS. Proteomics (2007) 1.35

Secondary acylation of Klebsiella pneumoniae lipopolysaccharide contributes to sensitivity to antibacterial peptides. J Biol Chem (2007) 1.33

Novel regulators of kidney development from the tips of the ureteric bud. J Am Soc Nephrol (2005) 1.33

TWEAK can induce pro-inflammatory cytokines and matrix metalloproteinase-9 in macrophages. Circ J (2004) 1.33

TLR4, but not TLR2, signals autoregulatory apoptosis of cultured microglia: a critical role of IFN-beta as a decision maker. J Immunol (2005) 1.33

Middle mediastinal thymoma. J Thorac Cardiovasc Surg (2002) 1.32

NGAL (Lcn2) monomer is associated with tubulointerstitial damage in chronic kidney disease. Kidney Int (2012) 1.30

Flavonoids inhibit histamine release and expression of proinflammatory cytokines in mast cells. Arch Pharm Res (2008) 1.28

Results of arthroscopic treatment of superior labral lesions. J Bone Joint Surg Am (2002) 1.25

Beta ig-h3 promotes renal proximal tubular epithelial cell adhesion, migration and proliferation through the interaction with alpha3beta1 integrin. Exp Mol Med (2004) 1.23

Identification of the hypoxia-inducible factor 1 alpha-responsive HGTD-P gene as a mediator in the mitochondrial apoptotic pathway. Mol Cell Biol (2004) 1.22

Prevention of postoperative hypocalcemia with routine oral calcium and vitamin D supplements in patients with differentiated papillary thyroid carcinoma undergoing total thyroidectomy plus central neck dissection. Cancer (2009) 1.22

Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity. Int Immunopharmacol (2008) 1.21

Secreted protein lipocalin-2 promotes microglial M1 polarization. FASEB J (2012) 1.20

Is central neck dissection necessary for the treatment of lateral cervical nodal recurrence of papillary thyroid carcinoma? Head Neck (2007) 1.20

Delayed short-term secretory regulation of ghrelin in obese animals: evidenced by a specific RIA for the active form of ghrelin. Endocrinology (2002) 1.19

α-Intercalated cells defend the urinary system from bacterial infection. J Clin Invest (2014) 1.18

Levobupivacaine-induced contraction of isolated rat aorta is calcium dependent. Can J Physiol Pharmacol (2011) 1.15

RhoGDI2 expression is associated with tumor growth and malignant progression of gastric cancer. Clin Cancer Res (2009) 1.15

Tsunami lung. J Anesth (2011) 1.14

Caffeine-mediated inhibition of calcium release channel inositol 1,4,5-trisphosphate receptor subtype 3 blocks glioblastoma invasion and extends survival. Cancer Res (2010) 1.14

Cell biology: iron thievery. Nature (2004) 1.13

Role of connective tissue growth factor in fibronectin expression and tubulointerstitial fibrosis. Am J Physiol Renal Physiol (2002) 1.13

Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia. FASEB J (2003) 1.12

Characteristics of subsolid pulmonary nodules showing growth during follow-up with CT scanning. Chest (2013) 1.11

The comparative effects of mesoporous silica nanoparticles and colloidal silica on inflammation and apoptosis. Biomaterials (2011) 1.11

Lipocalin-2 Is a chemokine inducer in the central nervous system: role of chemokine ligand 10 (CXCL10) in lipocalin-2-induced cell migration. J Biol Chem (2011) 1.10

Multidisciplinary treatment for advanced invasive thymoma with cisplatin, doxorubicin, and methylprednisolone. J Thorac Oncol (2007) 1.10

Prediction of occult central lymph node metastasis in papillary thyroid carcinoma by preoperative BRAF analysis using fine-needle aspiration biopsy: a prospective study. J Clin Endocrinol Metab (2012) 1.09

Altered gene expression related to glomerulogenesis and podocyte structure in early diabetic nephropathy of db/db mice and its restoration by pioglitazone. Diabetes (2006) 1.09

Nationwide groundwater surveillance of noroviruses in South Korea, 2008. Appl Environ Microbiol (2010) 1.09

Identification and validation of SAA as a potential lung cancer biomarker and its involvement in metastatic pathogenesis of lung cancer. J Proteome Res (2011) 1.08

Role of prostaglandin E receptor EP1 subtype in the development of renal injury in genetically hypertensive rats. Hypertension (2003) 1.08

CHI3L1 (YKL-40) is expressed in human gliomas and regulates the invasion, growth and survival of glioma cells. Int J Cancer (2011) 1.07

Detection of intracellular iron by its regulatory effect. Am J Physiol Cell Physiol (2004) 1.06

Inhibitors of microglial neurotoxicity: focus on natural products. Molecules (2011) 1.06

Epidemiologic survey of head and neck cancers in Korea. J Korean Med Sci (2003) 1.05

Inhibition of glial inflammatory activation and neurotoxicity by tricyclic antidepressants. Neuropharmacology (2008) 1.05

Decursin inhibits induction of inflammatory mediators by blocking nuclear factor-kappaB activation in macrophages. Mol Pharmacol (2006) 1.04

Neuronal pentraxin receptor in cerebrospinal fluid as a potential biomarker for neurodegenerative diseases. Brain Res (2009) 1.04

The direct effect of levobupivacaine in isolated rat aorta involves lipoxygenase pathway activation and endothelial nitric oxide release. Anesth Analg (2009) 1.03

Severe coronary artery spasm can be associated with hyperthyroidism. Coron Artery Dis (2005) 1.03

The function and integrity of the neurovascular unit rests upon the integration of the vascular and inflammatory cell systems. Curr Neurovasc Res (2005) 1.03

Action of Rubus coreanus extract on systemic and local anaphylaxis. Phytother Res (2002) 1.03

Bankart repair in traumatic anterior shoulder instability: open versus arthroscopic technique. Arthroscopy (2002) 1.02

Objective definition and measurement method of ground-glass opacity for planning limited resection in patients with clinical stage IA adenocarcinoma of the lung. Eur J Cardiothorac Surg (2004) 1.02