Published in Blood on August 21, 2007
Caspases and kinases in a death grip. Cell (2009) 2.47
The regulatory crosstalk between kinases and proteases in cancer. Nat Rev Cancer (2010) 1.80
The pan-caspase inhibitor Q-VD-OPh has anti-leukemia effects and can interact with vitamin D analogs to increase HPK1 signaling in AML cells. Leuk Res (2012) 1.39
The power and the promise of restimulation-induced cell death in human immune diseases. Immunol Rev (2010) 1.09
Critical role for BIM in T cell receptor restimulation-induced death. Biol Direct (2008) 1.02
Phosphorylation of CARMA1 by HPK1 is critical for NF-kappaB activation in T cells. Proc Natl Acad Sci U S A (2009) 1.02
Pro- and anti-apoptotic CD95 signaling in T cells. Cell Commun Signal (2011) 0.98
Dual role of hematopoietic progenitor kinase 1 (HPK1) as a positive regulator of 1α,25-dihydroxyvitamin D-induced differentiation and cell cycle arrest of AML cells and as a mediator of vitamin D resistance. Cell Cycle (2012) 0.92
Hemp, an mbt domain-containing protein, plays essential roles in hematopoietic stem cell function and skeletal formation. Proc Natl Acad Sci U S A (2011) 0.86
Hematopoietic progenitor kinase 1 is a critical component of prostaglandin E2-mediated suppression of the anti-tumor immune response. Cancer Immunol Immunother (2009) 0.80
Germinal center kinases in immune regulation. Cell Mol Immunol (2012) 0.78
The granzyme B-Serpinb9 axis controls the fate of lymphocytes after lysosomal stress. Cell Death Differ (2014) 0.78
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Death and anti-death: tumour resistance to apoptosis. Nat Rev Cancer (2002) 5.87
Life and death in peripheral T cells. Nat Rev Immunol (2007) 3.67
CTCF is conserved from Drosophila to humans and confers enhancer blocking of the Fab-8 insulator. EMBO Rep (2005) 2.80
Death receptors in chemotherapy and cancer. Oncogene (2004) 2.64
Mechanotransduction, PROX1, and FOXC2 cooperate to control connexin37 and calcineurin during lymphatic-valve formation. Dev Cell (2012) 2.45
Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis. Eur J Immunol (2005) 2.28
Death receptor signaling. J Cell Sci (2005) 2.21
Pharmacologic cholinesterase inhibition improves survival in experimental sepsis. Crit Care Med (2008) 2.18
GS-9620, an oral agonist of Toll-like receptor-7, induces prolonged suppression of hepatitis B virus in chronically infected chimpanzees. Gastroenterology (2013) 2.14
Caspases: pharmacological manipulation of cell death. J Clin Invest (2005) 2.10
Immune escape of tumors: apoptosis resistance and tumor counterattack. J Leukoc Biol (2002) 2.04
Neutralization of CD95 ligand promotes regeneration and functional recovery after spinal cord injury. Nat Med (2004) 1.95
Deleterious mutations in LRBA are associated with a syndrome of immune deficiency and autoimmunity. Am J Hum Genet (2012) 1.94
c-FLIPR, a new regulator of death receptor-induced apoptosis. J Biol Chem (2005) 1.93
The c-FLIP-NH2 terminus (p22-FLIP) induces NF-kappaB activation. J Exp Med (2006) 1.91
TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria. EMBO J (2005) 1.90
The JNK cascade as a biochemical switch in mammalian cells: ultrasensitive and all-or-none responses. Curr Biol (2003) 1.87
The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity. J Cell Sci (2003) 1.84
TAp63 and DeltaNp63 in cancer and epidermal development. Cell Cycle (2007) 1.84
Accumulation of apoptotic cells in the epidermis of patients with cutaneous lupus erythematosus after ultraviolet irradiation. Arthritis Rheum (2006) 1.83
Cyclooxygenase-2 inhibition induces apoptosis signaling via death receptors and mitochondria in hepatocellular carcinoma. Cancer Res (2006) 1.82
B-cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in aging. Blood (2011) 1.82
The natural anticancer compounds rocaglamides inhibit the Raf-MEK-ERK pathway by targeting prohibitin 1 and 2. Chem Biol (2012) 1.82
IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Ig alpha/beta. J Exp Med (2007) 1.75
Hepatocyte-specific deletion of the antiapoptotic protein myeloid cell leukemia-1 triggers proliferation and hepatocarcinogenesis in mice. Hepatology (2010) 1.75
Prevalence of newly generated naive regulatory T cells (Treg) is critical for Treg suppressive function and determines Treg dysfunction in multiple sclerosis. J Immunol (2007) 1.74
Stabilizing the VE-cadherin-catenin complex blocks leukocyte extravasation and vascular permeability. EMBO J (2011) 1.69
SABIO-RK--database for biochemical reaction kinetics. Nucleic Acids Res (2011) 1.63
A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy. EMBO J (2013) 1.58
In contrast to effector T cells, CD4+CD25+FoxP3+ regulatory T cells are highly susceptible to CD95 ligand- but not to TCR-mediated cell death. J Immunol (2005) 1.58
Dynamics within the CD95 death-inducing signaling complex decide life and death of cells. Mol Syst Biol (2010) 1.57
Stoichiometry of the CD95 death-inducing signaling complex: experimental and modeling evidence for a death effector domain chain model. Mol Cell (2012) 1.57
Analysis of CD95 threshold signaling: triggering of CD95 (FAS/APO-1) at low concentrations primarily results in survival signaling. J Biol Chem (2007) 1.55
Suramin inhibits death receptor-induced apoptosis in vitro and fulminant apoptotic liver damage in mice. Nat Med (2004) 1.54
Upregulation of Bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines. Int J Cancer (2002) 1.46
Dual interaction of JAM-C with JAM-B and alpha(M)beta2 integrin: function in junctional complexes and leukocyte adhesion. Mol Biol Cell (2005) 1.45
The traditional Chinese herbal compound rocaglamide preferentially induces apoptosis in leukemia cells by modulation of mitogen-activated protein kinase activities. Int J Cancer (2007) 1.45
Adjuvant auricular electroacupuncture and autogenic training in rheumatoid arthritis: a randomized controlled trial. Auricular acupuncture and autogenic training in rheumatoid arthritis. Forsch Komplementmed (2008) 1.44
Pillars article: T cell-derived B cell differentiation factor(s). Effect on the isotype switch of murine B cells. J. Exp. Med. 1982. 155: 734-748. J Immunol (2013) 1.43
p73 induces apoptosis by different mechanisms. Biochem Biophys Res Commun (2005) 1.42
Glucocorticoid cotreatment induces apoptosis resistance toward cancer therapy in carcinomas. Cancer Res (2003) 1.42
Hematopoietic progenitor kinase 1 (HPK1) is required for LFA-1-mediated neutrophil recruitment during the acute inflammatory response. Blood (2013) 1.41
The role of CD95 in the regulation of peripheral T-cell apoptosis. Immunol Rev (2003) 1.41
One, two, three--p53, p63, p73 and chemosensitivity. Drug Resist Updat (2007) 1.41
Molecular mechanisms of treg-mediated T cell suppression. Front Immunol (2012) 1.41
Artesunate induces ROS-mediated apoptosis in doxorubicin-resistant T leukemia cells. PLoS One (2007) 1.40
Suppression of Mcl-1 via RNA interference sensitizes human hepatocellular carcinoma cells towards apoptosis induction. BMC Cancer (2006) 1.35
Human CD19(+)CD25(high) B regulatory cells suppress proliferation of CD4(+) T cells and enhance Foxp3 and CTLA-4 expression in T-regulatory cells. Autoimmun Rev (2011) 1.33
Concepts of activated T cell death. Crit Rev Oncol Hematol (2008) 1.33
Mitochondrial reactive oxygen species control T cell activation by regulating IL-2 and IL-4 expression: mechanism of ciprofloxacin-mediated immunosuppression. J Immunol (2010) 1.33
Regulation of IL4 gene expression by T cells and therapeutic perspectives. Nat Rev Immunol (2003) 1.32
VE-PTP controls blood vessel development by balancing Tie-2 activity. J Cell Biol (2009) 1.32
IFN-gamma represses IL-4 expression via IRF-1 and IRF-2. Immunity (2002) 1.32
Knockout of myeloid cell leukemia-1 induces liver damage and increases apoptosis susceptibility of murine hepatocytes. Hepatology (2009) 1.31
Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIPL. J Cell Biol (2010) 1.30
Path2Models: large-scale generation of computational models from biochemical pathway maps. BMC Syst Biol (2013) 1.29
Mutant p53 gain of function: repression of CD95(Fas/APO-1) gene expression by tumor-associated p53 mutants. Oncogene (2003) 1.28
Endogenous Ca2+ buffer concentration and Ca2+ microdomains in hippocampal neurons. J Neurosci (2005) 1.28
High-throughput mutation profiling of CTCL samples reveals KRAS and NRAS mutations sensitizing tumors toward inhibition of the RAS/RAF/MEK signaling cascade. Blood (2011) 1.28
Hepatocyte growth factor induces Mcl-1 in primary human hepatocytes and inhibits CD95-mediated apoptosis via Akt. Hepatology (2004) 1.28
Apoptosis in cancer--implications for therapy. Semin Oncol (2004) 1.27
Rocaglamide derivatives are immunosuppressive phytochemicals that target NF-AT activity in T cells. J Immunol (2005) 1.26
Volcanic ash layers illuminate the resilience of Neanderthals and early modern humans to natural hazards. Proc Natl Acad Sci U S A (2012) 1.25
SBML2L(A)T(E)X: conversion of SBML files into human-readable reports. Bioinformatics (2009) 1.24
Upregulation of major histocompatibility complex class I on liver cells by hepatitis C virus core protein via p53 and TAP1 impairs natural killer cell cytotoxicity. J Virol (2003) 1.23
Regulation of developmental lymphangiogenesis by Syk(+) leukocytes. Dev Cell (2010) 1.22
Mcl-1 is an anti-apoptotic factor for human hepatocellular carcinoma. Int J Oncol (2006) 1.20
Rapid suppression of cytokine transcription in human CD4+CD25 T cells by CD4+Foxp3+ regulatory T cells: independence of IL-2 consumption, TGF-beta, and various inhibitors of TCR signaling. J Immunol (2007) 1.20
Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLCgamma1- and Ca2+-dependent apoptosis. Blood (2007) 1.20
How T lymphocytes switch between life and death. Eur J Immunol (2006) 1.20
Identification of a clonally expanding haematopoietic compartment in bone marrow. EMBO J (2012) 1.19
T cell activation is driven by an ADP-dependent glucokinase linking enhanced glycolysis with mitochondrial reactive oxygen species generation. Cell Rep (2012) 1.16
Novel role for mitochondria: protein kinase Ctheta-dependent oxidative signaling organelles in activation-induced T-cell death. Mol Cell Biol (2007) 1.14
Activation of hematopoietic progenitor kinase 1 involves relocation, autophosphorylation, and transphosphorylation by protein kinase D1. Mol Cell Biol (2005) 1.13
CD and NMR studies of prion protein (PrP) helix 1. Novel implications for its role in the PrPC-->PrPSc conversion process. J Biol Chem (2003) 1.13
Implantable 9-channel telemetry system for in vivo load measurements with orthopedic implants. IEEE Trans Biomed Eng (2007) 1.12
Primary human hepatocytes--a valuable tool for investigation of apoptosis and hepatitis B virus infection. J Hepatol (2003) 1.11
Receptor editing in positive and negative selection of B lymphopoiesis. J Immunol (2004) 1.10
CCR7-mediated LFA-1 functions in T cells are regulated by 2 independent ADAP/SKAP55 modules. Blood (2011) 1.10
HTLV-1 Tax protects against CD95-mediated apoptosis by induction of the cellular FLICE-inhibitory protein (c-FLIP). Blood (2006) 1.10
CD4(+)CD25 (+) regulatory T cells in human lupus erythematosus. Arch Dermatol Res (2008) 1.10
Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain. J Neurosci (2002) 1.09
Wogonin sensitizes resistant malignant cells to TNFalpha- and TRAIL-induced apoptosis. Blood (2006) 1.09
Function and regulation of the CD95 (APO-1/Fas) ligand in the immune system. Semin Immunol (2003) 1.09
Caspase-2 is activated at the CD95 death-inducing signaling complex in the course of CD95-induced apoptosis. Blood (2006) 1.08
Clinical and mechanistic aspects of glucocorticoid-induced chemotherapy resistance in the majority of solid tumors. Cancer Biol Ther (2007) 1.07
Enzyme kinetics informatics: from instrument to browser. FEBS J (2010) 1.06
Regulation of T cell apoptosis during the immune response. Curr Mol Med (2002) 1.06
HIV-1 trans-activator of transcription substitutes for oxidative signaling in activation-induced T cell death. J Immunol (2005) 1.06
Inhibition of constitutively activated nuclear factor-kappaB induces reactive oxygen species- and iron-dependent cell death in cutaneous T-cell lymphoma. Cancer Res (2009) 1.06