Published in Proc Natl Acad Sci U S A on January 20, 2011
Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nat Chem Biol (2013) 1.72
The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development. Cell Stem Cell (2012) 1.08
Acquired deficiency of A20 results in rapid apoptosis, systemic inflammation, and abnormal hematopoietic stem cell function. PLoS One (2014) 0.84
ALK(R1275Q) perturbs extracellular matrix, enhances cell invasion and leads to the development of neuroblastoma in cooperation with MYCN. Oncogene (2016) 0.77
Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science (1996) 12.54
Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature (1996) 6.23
Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. Genes Dev (1994) 6.10
Developmental potential and dynamic behavior of hematopoietic stem cells. Cell (1986) 5.98
Tudor, MBT and chromo domains gauge the degree of lysine methylation. EMBO Rep (2006) 5.19
Of lineage and legacy: the development of mammalian hematopoietic stem cells. Nat Immunol (2008) 4.04
L3MBTL1, a histone-methylation-dependent chromatin lock. Cell (2007) 3.70
A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activities. Genes Dev (2006) 3.49
SOCS proteins: negative regulators of cytokine signaling. Stem Cells (2001) 3.40
Defects in cardiac outflow tract formation and pro-B-lymphocyte expansion in mice lacking Sox-4. Nature (1996) 2.91
The genetic program of hematopoietic stem cells. Science (2000) 2.85
Enhanced purification of fetal liver hematopoietic stem cells using SLAM family receptors. Blood (2006) 2.67
A role for mel-18, a Polycomb group-related vertebrate gene, during theanteroposterior specification of the axial skeleton. Development (1996) 2.33
Intrinsic and extrinsic control of haematopoietic stem-cell self-renewal. Nature (2008) 2.13
L3MBTL1 recognition of mono- and dimethylated histones. Nat Struct Mol Biol (2007) 2.12
Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice. Development (1997) 2.00
A novel gene, MEL1, mapped to 1p36.3 is highly homologous to the MDS1/EVI1 gene and is transcriptionally activated in t(1;3)(p36;q21)-positive leukemia cells. Blood (2000) 1.86
Functional analysis of mouse Polycomb group genes. Cell Mol Life Sci (1998) 1.86
A functional screen to identify novel effectors of hematopoietic stem cell activity. Cell (2009) 1.86
Sox-4 facilitates thymocyte differentiation. Eur J Immunol (1997) 1.67
A domain shared by the Polycomb group proteins Scm and ph mediates heterotypic and homotypic interactions. Mol Cell Biol (1997) 1.63
The Drosophila Polycomb group gene Sex comb on midleg (Scm) encodes a zinc finger protein with similarity to polyhomeotic protein. Development (1996) 1.54
A human homolog of Drosophila lethal(3)malignant brain tumor (l(3)mbt) protein associates with condensed mitotic chromosomes. Oncogene (1999) 1.48
Molecular recognition of histone lysine methylation by the Polycomb group repressor dSfmbt. EMBO J (2009) 1.42
Hematopoietic stem cell self-renewal. Curr Opin Genet Dev (2006) 1.42
The Drosophila melanogaster tumor suppressor gene lethal(3)malignant brain tumor encodes a proline-rich protein with a novel zinc finger. Mech Dev (1995) 1.39
Developmental regulation of yolk sac hematopoiesis by Kruppel-like factor 6. Blood (2005) 1.39
Imaging the craniocervical junction. Childs Nerv Syst (2008) 1.38
Hematopoietic progenitor kinase 1 negatively regulates T cell receptor signaling and T cell-mediated immune responses. Nat Immunol (2006) 1.34
Methylation-state-specific recognition of histones by the MBT repeat protein L3MBTL2. Nucleic Acids Res (2009) 1.32
Congenital anomalies of the cervical spine. Neurosurg Clin N Am (2007) 1.24
Caspase-cleaved HPK1 induces CD95L-independent activation-induced cell death in T and B lymphocytes. Blood (2007) 1.05
Endothelial protein C receptor-expressing hematopoietic stem cells reside in the perisinusoidal niche in fetal liver. Blood (2010) 1.05
Cloning of a novel murine gene Sfmbt, Scm-related gene containing four mbt domains, structurally belonging to the Polycomb group of genes. Gene (2000) 1.04
Identification of SCML2, a second human gene homologous to the Drosophila sex comb on midleg (Scm): A new gene cluster on Xp22. Genomics (1999) 1.04
Impaired maturation of myeloid progenitors in mice lacking novel Polycomb group protein MBT-1. EMBO J (2005) 1.02
Molecular characterization of h-l(3)mbt-like: a new member of the human mbt family. FEBS Lett (2001) 0.96
Pulmonary disability in the Klippel-Feil syndrome. A study of two siblings. Clin Orthop Relat Res (1970) 0.94
The human homolog of Sex comb on midleg (SCMH1) maps to chromosome 1p34. Gene (1999) 0.92
Erythroid differentiation regulator (EDR), a novel, highly conserved factor I. Induction of haemoglobin synthesis in erythroleukaemic cells. Cytokine (2004) 0.90
Regulation of hematopoiesis by chemokine family members. Int J Hematol (2001) 0.90
De novo apparently balanced reciprocal translocation between 5q11.2 and 17q23 associated with Klippel-Feil anomaly and type A1 brachydactyly. Am J Med Genet (1995) 0.89
Regulation of hematopoietic cell development and function by Stat3. Front Biosci (Landmark Ed) (2009) 0.84
A novel de novo 1.1 Mb duplication of 17q21.33 associated with cognitive impairment and other anomalies. Am J Med Genet A (2009) 0.81
De novo t(12;17)(p13.3;q21.3) translocation with a breakpoint near the 5' end of the HOXB gene cluster in a patient with developmental delay and skeletal malformations. Eur J Hum Genet (2007) 0.81
Klippel-Feil syndrome. An unusual association with Sprengel deformity, omovertebral bone, and other skeletal, hematologic, and respiratory disorders. A case report. Bull Hosp Jt Dis Orthop Inst (1991) 0.80
Multiple congenital anomalies in a patient with Diamond-Blackfan syndrome. Clin Pediatr (Phila) (1984) 0.79
Familial Klippel-Feil anomaly and t(5;8)(q35.1;p21.1) translocation. Am J Med Genet A (2006) 0.79
Proliferation-linked expression of the novel murine gene m4mbt encoding a nuclear zinc finger protein with four mbt domains. Gene (2003) 0.77
A 580 kb microdeletion in 17q21.32 associated with mental retardation, microcephaly, cleft palate, and cardiac malformation. Eur J Med Genet (2007) 0.76
Klippel-Feil anomaly in Fanconi anemia. Clin Dysmorphol (2003) 0.76
A stem cell molecular signature. Science (2002) 14.47
Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell (2004) 12.67
Dissecting self-renewal in stem cells with RNA interference. Nature (2006) 11.66
Stem cells and their niches. Science (2006) 7.86
Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells. Nat Med (2006) 7.62
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature (2004) 7.21
Foxo3a is essential for maintenance of the hematopoietic stem cell pool. Cell Stem Cell (2007) 5.94
Regulation of the HIF-1alpha level is essential for hematopoietic stem cells. Cell Stem Cell (2010) 4.90
The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells. Nat Neurosci (2006) 4.49
Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome. Nature (2010) 4.38
Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis. Cell Metab (2006) 4.33
Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche. Cell Stem Cell (2007) 4.31
Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network. Cell (2011) 4.04
Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow. J Exp Med (2009) 4.03
DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells. J Exp Med (2005) 4.02
Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms. Nature (2009) 3.80
v-ATPase V0 subunit d2-deficient mice exhibit impaired osteoclast fusion and increased bone formation. Nat Med (2006) 3.78
shRNA knockdown of Bmi-1 reveals a critical role for p21-Rb pathway in NSC self-renewal during development. Cell Stem Cell (2007) 3.40
A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance. Nat Med (2012) 3.33
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. Mol Cell Biol (2002) 3.08
Metabolic regulation of hematopoietic stem cells in the hypoxic niche. Cell Stem Cell (2011) 3.05
Systems biology of stem cell fate and cellular reprogramming. Nat Rev Mol Cell Biol (2009) 2.93
Induction of a hemogenic program in mouse fibroblasts. Cell Stem Cell (2013) 2.71
Systems-level dynamic analyses of fate change in murine embryonic stem cells. Nature (2009) 2.70
Ontogeny and multipotency of neural crest-derived stem cells in mouse bone marrow, dorsal root ganglia, and whisker pad. Cell Stem Cell (2008) 2.69
Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon-dependent exhaustion. Nat Med (2009) 2.66
Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development. J Biol Chem (2003) 2.59
p57(Kip2) and p27(Kip1) cooperate to maintain hematopoietic stem cell quiescence through interactions with Hsc70. Cell Stem Cell (2011) 2.58
Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells. Cell Stem Cell (2013) 2.58
KrasG12D-induced IKK2/β/NF-κB activation by IL-1α and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma. Cancer Cell (2012) 2.55
Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1. Nature (2010) 2.47
Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche. Cell (2012) 2.36
M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis. J Exp Med (2009) 2.29
A genomewide functional network for the laboratory mouse. PLoS Comput Biol (2008) 2.25
Identification and characterization of stem cells in prepubertal spermatogenesis in mice. Dev Biol (2003) 2.24
Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells. Nat Biotechnol (2011) 2.22
Angiogenic role of LYVE-1-positive macrophages in adipose tissue. Circ Res (2007) 2.22
The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. Genes Dev (2005) 2.18
Global changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fate. Nat Immunol (2012) 2.16
Stem cell defects in ATM-deficient undifferentiated spermatogonia through DNA damage-induced cell-cycle arrest. Cell Stem Cell (2008) 2.14
Neurogenin3 delineates the earliest stages of spermatogenesis in the mouse testis. Dev Biol (2004) 2.13
Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance. Cell Metab (2009) 2.13
Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL. Genes Dev (2008) 2.12
The first round of mouse spermatogenesis is a distinctive program that lacks the self-renewing spermatogonia stage. Development (2006) 2.07
VEGFR1 tyrosine kinase signaling promotes lymphangiogenesis as well as angiogenesis indirectly via macrophage recruitment. Arterioscler Thromb Vasc Biol (2008) 1.90
Positive contribution of pathogenic mutations in the mitochondrial genome to the promotion of cancer by prevention from apoptosis. Cancer Res (2005) 1.90
Prdm16 is a physiologic regulator of hematopoietic stem cells. Blood (2011) 1.86
Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization. J Exp Med (2011) 1.79
Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells. Blood (2010) 1.78
Maintenance of quiescent hematopoietic stem cells in the osteoblastic niche. Ann N Y Acad Sci (2007) 1.78
Inhibition of angiogenesis and vascular leakiness by angiopoietin-related protein 4. Cancer Res (2003) 1.78
Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA-2 expression. EMBO J (2005) 1.77
Wnt-inhibitory factor 1 dysregulation of the bone marrow niche exhausts hematopoietic stem cells. Blood (2011) 1.76
Pathology of encapsulating peritoneal sclerosis. Perit Dial Int (2005) 1.75
Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation. Blood (2005) 1.75
Smarcc1/Baf155 couples self-renewal gene repression with changes in chromatin structure in mouse embryonic stem cells. Stem Cells (2009) 1.72
Angiopoietin-1 promotes lymphatic sprouting and hyperplasia. Blood (2005) 1.71
Function of oxidative stress in the regulation of hematopoietic stem cell-niche interaction. Biochem Biophys Res Commun (2007) 1.66
Mesenchymal stem cells in perichondrium express activated leukocyte cell adhesion molecule and participate in bone marrow formation. J Exp Med (2002) 1.63
Regulation of reactive oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes. J Immunol (2007) 1.62
Angiopoietin-related growth factor antagonizes obesity and insulin resistance. Nat Med (2005) 1.61
The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis. J Exp Med (2010) 1.59
Nanog-dependent feedback loops regulate murine embryonic stem cell heterogeneity. Nat Cell Biol (2012) 1.56
The opposing roles of the transcription factor E2A and its antagonist Id3 that orchestrate and enforce the naive fate of T cells. Nat Immunol (2011) 1.54
Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling. Cell Stem Cell (2012) 1.54
Hypoxia disrupts the barrier function of neural blood vessels through changes in the expression of claudin-5 in endothelial cells. Am J Pathol (2007) 1.54
A molecular profile of a hematopoietic stem cell niche. Proc Natl Acad Sci U S A (2002) 1.53
Bone marrow long label-retaining cells reside in the sinusoidal hypoxic niche. Biochem Biophys Res Commun (2007) 1.45
Phenotypic spectrum of CHARGE syndrome with CHD7 mutations. J Pediatr (2006) 1.45
Prox1 induces lymphatic endothelial differentiation via integrin alpha9 and other signaling cascades. Mol Biol Cell (2007) 1.44
Hematopoietic cells regulate the angiogenic switch during tumorigenesis. Blood (2004) 1.44
Stem cells: interactive niches. Nature (2003) 1.42
Angiopoietin-like proteins: potential new targets for metabolic syndrome therapy. Trends Mol Med (2005) 1.40
Activated protein C induces endothelial cell proliferation by mitogen-activated protein kinase activation in vitro and angiogenesis in vivo. Circ Res (2004) 1.40
Cancer stem cells and their niche. Cancer Sci (2009) 1.39
Bmi-1 cooperates with Foxg1 to maintain neural stem cell self-renewal in the forebrain. Genes Dev (2009) 1.39
Bidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis. J Biol Chem (2009) 1.39
Genitourinary anomaly in congenital varicella syndrome: case report and review. Pediatr Nephrol (2004) 1.38
Angiopoietin-related/angiopoietin-like proteins regulate angiogenesis. Int J Hematol (2004) 1.37
Alternative induced pluripotent stem cell characterization criteria for in vitro applications. Cell Stem Cell (2009) 1.36
Genomewide gain-of-function genetic screen identifies functionally active genes in mouse embryonic stem cells. Proc Natl Acad Sci U S A (2006) 1.35
CD24 is expressed specifically in the nucleus pulposus of intervertebral discs. Biochem Biophys Res Commun (2005) 1.32
Role of Dok-1 and Dok-2 in myeloid homeostasis and suppression of leukemia. J Exp Med (2004) 1.31
Regulation of reactive oxygen species in stem cells and cancer stem cells. J Cell Physiol (2012) 1.30
Induction of DC-STAMP by alternative activation and downstream signaling mechanisms. J Bone Miner Res (2007) 1.30
Role of DC-STAMP in cellular fusion of osteoclasts and macrophage giant cells. J Bone Miner Metab (2006) 1.29