Published in Nature on August 23, 2007
Nature, nurture, or chance: stochastic gene expression and its consequences. Cell (2008) 12.13
Functional roles for noise in genetic circuits. Nature (2010) 6.96
Frequency-modulated nuclear localization bursts coordinate gene regulation. Nature (2008) 4.63
Cellular decision making and biological noise: from microbes to mammals. Cell (2011) 4.44
Cell growth and size homeostasis in proliferating animal cells. Science (2009) 3.89
Positive feedback of G1 cyclins ensures coherent cell cycle entry. Nature (2008) 3.32
Bet hedging in yeast by heterogeneous, age-correlated expression of a stress protectant. PLoS Biol (2012) 2.75
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Nucleosome-depleted regions in cell-cycle-regulated promoters ensure reliable gene expression in every cell cycle. Dev Cell (2010) 1.97
Cell size control in yeast. Curr Biol (2012) 1.96
Periodic cyclin-Cdk activity entrains an autonomous Cdc14 release oscillator. Cell (2010) 1.91
A microfluidic device for temporally controlled gene expression and long-term fluorescent imaging in unperturbed dividing yeast cells. PLoS One (2008) 1.90
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Exploring the roles of noise in the eukaryotic cell cycle. Proc Natl Acad Sci U S A (2009) 1.46
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Potential and flux landscapes quantify the stability and robustness of budding yeast cell cycle network. Proc Natl Acad Sci U S A (2010) 1.17
The critical size is set at a single-cell level by growth rate to attain homeostasis and adaptation. Nat Commun (2012) 1.15
Concerted control of Escherichia coli cell division. Proc Natl Acad Sci U S A (2014) 1.14
Forced periodic expression of G1 cyclins phase-locks the budding yeast cell cycle. Proc Natl Acad Sci U S A (2009) 1.13
The E2F functional analogue SBF recruits the Rpd3(L) HDAC, via Whi5 and Stb1, and the FACT chromatin reorganizer, to yeast G1 cyclin promoters. EMBO J (2009) 1.13
Scaling laws governing stochastic growth and division of single bacterial cells. Proc Natl Acad Sci U S A (2014) 1.12
Tightly regulated and heritable division control in single bacterial cells. Biophys J (2008) 1.10
Feedforward regulation ensures stability and rapid reversibility of a cellular state. Mol Cell (2013) 1.09
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TATA is a modular component of synthetic promoters. Genome Res (2010) 1.08
Size homeostasis in adherent cells studied by synthetic phase microscopy. Proc Natl Acad Sci U S A (2013) 1.07
Nuclear repulsion enables division autonomy in a single cytoplasm. Curr Biol (2013) 1.04
Long-term single cell analysis of S. pombe on a microfluidic microchemostat array. PLoS One (2014) 1.04
Topology and control of the cell-cycle-regulated transcriptional circuitry. Genetics (2014) 1.03
Intrinsically disordered segments affect protein half-life in the cell and during evolution. Cell Rep (2014) 1.01
Glucose signaling-mediated coordination of cell growth and cell cycle in Saccharomyces cerevisiae. Sensors (Basel) (2010) 1.01
Division in Escherichia coli is triggered by a size-sensing rather than a timing mechanism. BMC Biol (2014) 0.98
Ccr4 alters cell size in yeast by modulating the timing of CLN1 and CLN2 expression. Genetics (2008) 0.96
An algorithm to automate yeast segmentation and tracking. PLoS One (2013) 0.96
Dilution of the cell cycle inhibitor Whi5 controls budding-yeast cell size. Nature (2015) 0.95
A microfluidic system for studying ageing and dynamic single-cell responses in budding yeast. PLoS One (2014) 0.94
Growth and division--not a one-way road. Curr Opin Cell Biol (2010) 0.94
Mathematical analysis and quantification of fluorescent proteins as transcriptional reporters. Biophys J (2007) 0.94
Temporal switching and cell-to-cell variability in Ca2+ release activity in mammalian cells. Mol Syst Biol (2009) 0.94
Mapping the fine structure of a eukaryotic promoter input-output function. Nat Genet (2013) 0.94
The Chlamydomonas cell cycle. Plant J (2015) 0.92
Enhanced longevity by ibuprofen, conserved in multiple species, occurs in yeast through inhibition of tryptophan import. PLoS Genet (2014) 0.91
Genetic and nongenetic determinants of cell growth variation assessed by high-throughput microscopy. Mol Biol Evol (2013) 0.91
Stochastic expression and epigenetic memory at the yeast HO promoter. Proc Natl Acad Sci U S A (2013) 0.91
The linear interplay of intrinsic and extrinsic noises ensures a high accuracy of cell fate selection in budding yeast. Sci Rep (2014) 0.90
Oscillatory dynamics of cell cycle proteins in single yeast cells analyzed by imaging cytometry. PLoS One (2011) 0.90
Model-based deconvolution of cell cycle time-series data reveals gene expression details at high resolution. PLoS Comput Biol (2009) 0.90
PP2ARts1 is a master regulator of pathways that control cell size. J Cell Biol (2014) 0.89
Systematic identification of cell size regulators in budding yeast. Mol Syst Biol (2014) 0.89
Entrainment to periodic initiation and transition rates in a computational model for gene translation. PLoS One (2014) 0.88
Frequency control of cell cycle oscillators. Curr Opin Genet Dev (2010) 0.87
Cell-Size Homeostasis and the Incremental Rule in a Bacterial Pathogen. Biophys J (2015) 0.87
The volumes and transcript counts of single cells reveal concentration homeostasis and capture biological noise. Mol Biol Cell (2014) 0.87
Reliable cell cycle commitment in budding yeast is ensured by signal integration. Elife (2015) 0.86
Spaceflight enhances cell aggregation and random budding in Candida albicans. PLoS One (2013) 0.86
Identification of the molecular mechanisms for cell-fate selection in budding yeast through mathematical modeling. Biophys J (2013) 0.86
Cell-Size Control. Cold Spring Harb Perspect Biol (2016) 0.86
Hybrid modeling and simulation of stochastic effects on progression through the eukaryotic cell cycle. J Chem Phys (2012) 0.85
Loss of growth homeostasis by genetic decoupling of cell division from biomass growth: implication for size control mechanisms. Mol Syst Biol (2014) 0.85
Stochasticity and homeostasis in the E. coli replication and division cycle. Sci Rep (2015) 0.85
End-of-life cell cycle arrest contributes to stochasticity of yeast replicative aging. FEMS Yeast Res (2013) 0.84
Epigenetic inheritance and genome regulation: is DNA methylation linked to ploidy in haplodiploid insects? Proc Biol Sci (2014) 0.84
High-throughput measurement of single-cell growth rates using serial microfluidic mass sensor arrays. Nat Biotechnol (2016) 0.84
Measuring fast gene dynamics in single cells with time-lapse luminescence microscopy. Mol Biol Cell (2014) 0.82
Genetic determinants of cell size at birth and their impact on cell cycle progression in Saccharomyces cerevisiae. G3 (Bethesda) (2013) 0.82
Using single cell cultivation system for on-chip monitoring of the interdivision timer in Chlamydomonas reinhardtii cell cycle. J Nanobiotechnology (2010) 0.81
Specific genetic interactions between spindle assembly checkpoint proteins and B-Type cyclins in Saccharomyces cerevisiae. Genetics (2009) 0.81
A stochastic model correctly predicts changes in budding yeast cell cycle dynamics upon periodic expression of CLN2. PLoS One (2014) 0.81
Analysis of ER resident proteins in Saccharomyces cerevisiae: implementation of H/KDEL retrieval sequences. Traffic (2013) 0.81
Bud3 activates Cdc42 to establish a proper growth site in budding yeast. J Cell Biol (2014) 0.81
Heterogeneity in mitochondrial morphology and membrane potential is independent of the nuclear division cycle in multinucleate fungal cells. Eukaryot Cell (2012) 0.80
Single-cell phenomics in budding yeast. Mol Biol Cell (2015) 0.79
Size sensors in bacteria, cell cycle control, and size control. Front Microbiol (2015) 0.79
Cell cycle synchronization by nutrient modulation. Integr Biol (Camb) (2012) 0.79
Robustness of cell cycle control and flexible orders of signaling events. Sci Rep (2015) 0.78
A Model of Yeast Cell-Cycle Regulation Based on a Standard Component Modeling Strategy for Protein Regulatory Networks. PLoS One (2016) 0.78
Stochastic gene expression in a single cell. Science (2002) 34.54
Intrinsic and extrinsic contributions to stochasticity in gene expression. Proc Natl Acad Sci U S A (2002) 11.46
Tracking the in vivo evolution of multidrug resistance in Staphylococcus aureus by whole-genome sequencing. Proc Natl Acad Sci U S A (2007) 6.14
How the Venus flytrap snaps. Nature (2005) 5.20
Integrative analysis of cell cycle control in budding yeast. Mol Biol Cell (2004) 4.77
Computational detection of genomic cis-regulatory modules applied to body patterning in the early Drosophila embryo. BMC Bioinformatics (2002) 3.61
Transcriptional control in the segmentation gene network of Drosophila. PLoS Biol (2004) 3.47
PhyloGibbs: a Gibbs sampling motif finder that incorporates phylogeny. PLoS Comput Biol (2005) 3.35
Positive feedback of G1 cyclins ensures coherent cell cycle entry. Nature (2008) 3.32
Analysis of combinatorial cis-regulation in synthetic and genomic promoters. Nature (2008) 3.30
Multiple levels of cyclin specificity in cell-cycle control. Nat Rev Mol Cell Biol (2007) 3.26
A probabilistic method to detect regulatory modules. Bioinformatics (2003) 3.24
APC-dependent proteolysis of the mitotic cyclin Clb2 is essential for mitotic exit. Nature (2002) 3.08
Dissection of COPI and Arf1 dynamics in vivo and role in Golgi membrane transport. Nature (2002) 2.52
Protein-DNA binding specificity predictions with structural models. Nucleic Acids Res (2005) 2.45
The evolution of DNA regulatory regions for proteo-gamma bacteria by interspecies comparisons. Genome Res (2002) 2.22
Control of cell cycle transcription during G1 and S phases. Nat Rev Mol Cell Biol (2013) 2.17
Coherence and timing of cell cycle start examined at single-cell resolution. Mol Cell (2006) 2.11
Protein sequestration generates a flexible ultrasensitive response in a genetic network. Mol Syst Biol (2009) 2.09
Identification of the binding sites of regulatory proteins in bacterial genomes. Proc Natl Acad Sci U S A (2002) 2.07
Conservation of regulatory elements between two species of Drosophila. BMC Bioinformatics (2003) 2.06
KNL1/Spc105 recruits PP1 to silence the spindle assembly checkpoint. Curr Biol (2011) 1.98
Nucleosome-depleted regions in cell-cycle-regulated promoters ensure reliable gene expression in every cell cycle. Dev Cell (2010) 1.97
Cell size control in yeast. Curr Biol (2012) 1.96
Using DNA mechanics to predict in vitro nucleosome positions and formation energies. Nucleic Acids Res (2009) 1.93
Periodic cyclin-Cdk activity entrains an autonomous Cdc14 release oscillator. Cell (2010) 1.91
A microfluidic device for temporally controlled gene expression and long-term fluorescent imaging in unperturbed dividing yeast cells. PLoS One (2008) 1.90
Cross-species comparison significantly improves genome-wide prediction of cis-regulatory modules in Drosophila. BMC Bioinformatics (2004) 1.82
Interaction of the S-phase cyclin Clb5 with an "RXL" docking sequence in the initiator protein Orc6 provides an origin-localized replication control switch. Genes Dev (2004) 1.79
Probabilistic clustering of sequences: inferring new bacterial regulons by comparative genomics. Proc Natl Acad Sci U S A (2002) 1.78
Targeted proteomic study of the cyclin-Cdk module. Mol Cell (2004) 1.56
Disruption of mechanisms that prevent rereplication triggers a DNA damage response. Mol Cell Biol (2005) 1.51
High functional overlap between MluI cell-cycle box binding factor and Swi4/6 cell-cycle box binding factor in the G1/S transcriptional program in Saccharomyces cerevisiae. Genetics (2005) 1.51
Multiple sequence-specific factors generate the nucleosome-depleted region on CLN2 promoter. Mol Cell (2011) 1.49
Daughter-specific transcription factors regulate cell size control in budding yeast. PLoS Biol (2009) 1.48
Connecting protein structure with predictions of regulatory sites. Proc Natl Acad Sci U S A (2007) 1.46
Ribosome biogenesis is sensed at the Start cell cycle checkpoint. Mol Biol Cell (2006) 1.43
Distinct interactions select and maintain a specific cell fate. Mol Cell (2011) 1.38
Gene expression from random libraries of yeast promoters. Genetics (2006) 1.34
The role of proofreading in signal transduction specificity. Biophys J (2002) 1.34
A case study of evolutionary computation of biochemical adaptation. Phys Biol (2008) 1.32
Deriving structure from evolution: metazoan segmentation. Mol Syst Biol (2007) 1.31
Commitment to a cellular transition precedes genome-wide transcriptional change. Mol Cell (2011) 1.31
Origin of irreversibility of cell cycle start in budding yeast. PLoS Biol (2010) 1.30
Evolution of networks and sequences in eukaryotic cell cycle control. Philos Trans R Soc Lond B Biol Sci (2011) 1.30
Sequence turnover and tandem repeats in cis-regulatory modules in drosophila. Mol Biol Evol (2005) 1.26
Dynamics of TGF-β signaling reveal adaptive and pulsatile behaviors reflected in the nuclear localization of transcription factor Smad4. Proc Natl Acad Sci U S A (2012) 1.23
Sequence context affects the rate of short insertions and deletions in flies and primates. Genome Biol (2008) 1.14
Feedforward regulation ensures stability and rapid reversibility of a cellular state. Mol Cell (2013) 1.09
Phenotypic model for early T-cell activation displaying sensitivity, specificity, and antagonism. Proc Natl Acad Sci U S A (2013) 1.05
Genome wide identification of regulatory motifs in Bacillus subtilis. BMC Bioinformatics (2003) 1.05
Global analysis of Cdc14 phosphatase reveals diverse roles in mitotic processes. J Biol Chem (2010) 1.04
Phosphorylation of the Sic1 inhibitor of B-type cyclins in Saccharomyces cerevisiae is not essential but contributes to cell cycle robustness. Genetics (2007) 1.04
Nuclear repulsion enables division autonomy in a single cytoplasm. Curr Biol (2013) 1.04
Genetic and biochemical evaluation of the importance of Cdc6 in regulating mitotic exit. Mol Biol Cell (2003) 1.03
Analysis of the mitotic exit control system using locked levels of stable mitotic cyclin. Mol Syst Biol (2009) 1.02
Start and the restriction point. Curr Opin Cell Biol (2013) 1.01
Predicting embryonic patterning using mutual entropy fitness and in silico evolution. Development (2010) 1.00
Two-faced cyclins with eyes on the targets. Cell Cycle (2005) 0.98
An algorithm to automate yeast segmentation and tracking. PLoS One (2013) 0.96
Pareto evolution of gene networks: an algorithm to optimize multiple fitness objectives. Phys Biol (2012) 0.95
Rising cyclin-CDK levels order cell cycle events. PLoS One (2011) 0.95
Cycling without the cyclosome: modeling a yeast strain lacking the APC. Cell Cycle (2004) 0.93
Requirements and reasons for effective inhibition of the anaphase promoting complex activator CDH1. Mol Biol Cell (2010) 0.92
Adaptive temperature compensation in circadian oscillations. PLoS Comput Biol (2012) 0.91
Stochastic expression and epigenetic memory at the yeast HO promoter. Proc Natl Acad Sci U S A (2013) 0.91
Phenotypic models of evolution and development: geometry as destiny. Curr Opin Genet Dev (2012) 0.90
Regulated degradation of the APC coactivator Cdc20. Cell Div (2010) 0.90
Shake it, don't break it: positive feedback and the evolution of oscillator design. Dev Cell (2005) 0.89
Mode locking the cell cycle. Phys Rev E Stat Nonlin Soft Matter Phys (2005) 0.89
Cyclin and cyclin-dependent kinase substrate requirements for preventing rereplication reveal the need for concomitant activation and inhibition. Genetics (2006) 0.88
Frequency control of cell cycle oscillators. Curr Opin Genet Dev (2010) 0.87
Late paleozoic fusulinoidean gigantism driven by atmospheric hyperoxia. Evolution (2012) 0.87
Novel role for Cdc14 sequestration: Cdc14 dephosphorylates factors that promote DNA replication. Mol Cell Biol (2006) 0.87
Scaling of BMP gradients in Xenopus embryos. Nature (2009) 0.85
Specific genetic interactions between spindle assembly checkpoint proteins and B-Type cyclins in Saccharomyces cerevisiae. Genetics (2009) 0.81
Developmental regulatory bits. Mol Syst Biol (2008) 0.76
A shift in the long-term mode of foraminiferan size evolution caused by the end-Permian mass extinction. Evolution (2012) 0.76
Signaling dynamics and embryonic development. Cell Cycle (2012) 0.75
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Constraints on the adult-offspring size relationship in protists. Evolution (2013) 0.75