Published in Proc Natl Acad Sci U S A on April 04, 2011
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Interplay between gene expression noise and regulatory network architecture. Trends Genet (2012) 1.61
Stochasticity of metabolism and growth at the single-cell level. Nature (2014) 1.44
The genomic landscape and evolutionary resolution of antagonistic pleiotropy in yeast. Cell Rep (2012) 1.36
Promoter sequence determines the relationship between expression level and noise. PLoS Biol (2013) 1.28
Genomic evidence for elevated mutation rates in highly expressed genes. EMBO Rep (2012) 1.19
Noise-mean relationship in mutated promoters. Genome Res (2012) 1.18
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Phenotypic heterogeneity is a selected trait in natural yeast populations subject to environmental stress. Environ Microbiol (2013) 0.93
Reconciling molecular regulatory mechanisms with noise patterns of bacterial metabolic promoters in induced and repressed states. Proc Natl Acad Sci U S A (2011) 0.93
Error prevention and mitigation as forces in the evolution of genes and genomes. Nat Rev Genet (2011) 0.89
Bistability in feedback circuits as a byproduct of evolution of evolvability. Mol Syst Biol (2012) 0.89
Additive, epistatic, and environmental effects through the lens of expression variability QTL in a twin cohort. Genetics (2013) 0.88
The genotype-phenotype map of yeast complex traits: basic parameters and the role of natural selection. Mol Biol Evol (2014) 0.87
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Teasing apart translational and transcriptional components of stochastic variations in eukaryotic gene expression. PLoS Comput Biol (2012) 0.85
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Constitutive versus responsive gene expression strategies for growth in changing environments. PLoS One (2011) 0.80
Mutation induced extinction in finite populations: lethal mutagenesis and lethal isolation. PLoS Comput Biol (2012) 0.80
The ADH7 Promoter of Saccharomyces cerevisiae is Vanillin-Inducible and Enables mRNA Translation Under Severe Vanillin Stress. Front Microbiol (2015) 0.80
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Coordinating expression of RNA binding proteins with their mRNA targets. Sci Rep (2014) 0.78
Neutral and adaptive explanations for an association between caste-biased gene expression and rate of sequence evolution. Front Genet (2014) 0.78
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Uncovering the functional constraints underlying the genomic organization of the odorant-binding protein genes. Genome Biol Evol (2013) 0.77
Under-dominance constrains the evolution of negative autoregulation in diploids. PLoS Comput Biol (2013) 0.77
Determinative developmental cell lineages are robust to cell deaths. PLoS Genet (2014) 0.77
Over-expression of Arabidopsis AtCHR23 chromatin remodeling ATPase results in increased variability of growth and gene expression. BMC Plant Biol (2014) 0.76
Microbial consortia at steady supply. Elife (2017) 0.75
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An Individual-Based Diploid Model Predicts Limited Conditions Under Which Stochastic Gene Expression Becomes Advantageous. Front Genet (2015) 0.75
A Philosophical Perspective on Evolutionary Systems Biology. Biol Theory (2015) 0.75
Minimum-noise production of translation factor eIF4G maps to a mechanistically determined optimal rate control window for protein synthesis. Nucleic Acids Res (2016) 0.75
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Control of stochasticity in eukaryotic gene expression. Science (2004) 12.85
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Gene regulation at the single-cell level. Science (2005) 11.52
Quantifying E. coli proteome and transcriptome with single-molecule sensitivity in single cells. Science (2010) 11.37
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Noise in gene expression: origins, consequences, and control. Science (2005) 9.64
Summing up the noise in gene networks. Nature (2004) 9.62
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Escherichia coli K-12 undergoes adaptive evolution to achieve in silico predicted optimal growth. Nature (2002) 7.38
Mistranslation-induced protein misfolding as a dominant constraint on coding-sequence evolution. Cell (2008) 6.91
Dosage sensitivity and the evolution of gene families in yeast. Nature (2003) 6.77
Quantitative prediction of cellular metabolism with constraint-based models: the COBRA Toolbox. Nat Protoc (2007) 6.24
Reconstruction and validation of Saccharomyces cerevisiae iND750, a fully compartmentalized genome-scale metabolic model. Genome Res (2004) 6.21
Stochastic switching as a survival strategy in fluctuating environments. Nat Genet (2008) 5.87
Systematic screen for human disease genes in yeast. Nat Genet (2002) 4.97
Phenotypic consequences of promoter-mediated transcriptional noise. Mol Cell (2006) 4.93
Noise minimization in eukaryotic gene expression. PLoS Biol (2004) 4.36
Adaptive evolution of bacterial metabolic networks by horizontal gene transfer. Nat Genet (2005) 4.19
The effects of molecular noise and size control on variability in the budding yeast cell cycle. Nature (2007) 4.15
Metabolic network analysis of the causes and evolution of enzyme dispensability in yeast. Nature (2004) 4.06
Increased cell-to-cell variation in gene expression in ageing mouse heart. Nature (2006) 4.00
Metabolic modelling of microbes: the flux-balance approach. Environ Microbiol (2002) 3.79
Flux coupling analysis of genome-scale metabolic network reconstructions. Genome Res (2004) 3.61
Living with noisy genes: how cells function reliably with inherent variability in gene expression. Annu Rev Biophys Biomol Struct (2007) 3.36
Metabolic gene-deletion strains of Escherichia coli evolve to computationally predicted growth phenotypes. Nat Genet (2004) 3.31
Origins of extrinsic variability in eukaryotic gene expression. Nature (2005) 3.18
Saccharomyces cerevisiae phenotypes can be predicted by using constraint-based analysis of a genome-scale reconstructed metabolic network. Proc Natl Acad Sci U S A (2003) 3.15
Energy constraints on the evolution of gene expression. Mol Biol Evol (2005) 2.76
Fundamental limits on the suppression of molecular fluctuations. Nature (2010) 2.75
Noise in transcription negative feedback loops: simulation and experimental analysis. Mol Syst Biol (2006) 2.69
Population genomics of the wild yeast Saccharomyces paradoxus: Quantifying the life cycle. Proc Natl Acad Sci U S A (2008) 2.56
Evolution of chromosome organization driven by selection for reduced gene expression noise. Nat Genet (2007) 2.55
Chance and necessity in the evolution of minimal metabolic networks. Nature (2006) 2.48
Plasticity of genetic interactions in metabolic networks of yeast. Proc Natl Acad Sci U S A (2007) 2.40
Intrinsic protein disorder and interaction promiscuity are widely associated with dosage sensitivity. Cell (2009) 2.32
Large-scale evaluation of in silico gene deletions in Saccharomyces cerevisiae. OMICS (2003) 2.31
Prevalent positive epistasis in Escherichia coli and Saccharomyces cerevisiae metabolic networks. Nat Genet (2010) 2.16
Selection to minimise noise in living systems and its implications for the evolution of gene expression. Mol Syst Biol (2008) 1.88
Cell-to-cell stochastic variation in gene expression is a complex genetic trait. PLoS Genet (2008) 1.79
Dual feedback loops in the GAL regulon suppress cellular heterogeneity in yeast. Nat Genet (2006) 1.70
Effects on phenotypic variability of directional selection arising through genetic differences in residual variability. Genet Res (2004) 1.56
Evolutionary plasticity and innovations in complex metabolic reaction networks. PLoS Comput Biol (2009) 1.43
Increased noise as an effect of haploinsufficiency of the tumor-suppressor gene neurofibromatosis type 1 in vitro. Proc Natl Acad Sci U S A (2002) 1.36
Impact of translational error-induced and error-free misfolding on the rate of protein evolution. Mol Syst Biol (2010) 1.35
Natural selection for within-generation variance in offspring number II. Discrite haploid models. Genetics (1975) 1.33
Positive selection for elevated gene expression noise in yeast. Mol Syst Biol (2009) 1.30
Model-driven analysis of experimentally determined growth phenotypes for 465 yeast gene deletion mutants under 16 different conditions. Genome Biol (2008) 1.24
Why is the correlation between gene importance and gene evolutionary rate so weak? PLoS Genet (2009) 1.16
Energy costs constrain the evolution of gene expression. J Exp Zool B Mol Dev Evol (2007) 1.12
Stochasticity in protein levels drives colinearity of gene order in metabolic operons of Escherichia coli. PLoS Biol (2009) 1.08
Transcriptional noise and cellular heterogeneity in mammalian macrophages. Philos Trans R Soc Lond B Biol Sci (2006) 0.97
From bit to it: how a complex metabolic network transforms information into living matter. BMC Syst Biol (2007) 0.82
Rapid subfunctionalization accompanied by prolonged and substantial neofunctionalization in duplicate gene evolution. Genetics (2005) 3.98
Evolutionary conservation of expression profiles between human and mouse orthologous genes. Mol Biol Evol (2005) 3.62
Gene sequence-based criteria for identification of new rickettsia isolates and description of Rickettsia heilongjiangensis sp. nov. J Clin Microbiol (2003) 3.59
The pleiotropic structure of the genotype-phenotype map: the evolvability of complex organisms. Nat Rev Genet (2011) 3.57
Why do hubs tend to be essential in protein networks? PLoS Genet (2006) 3.29
Gene losses during human origins. PLoS Biol (2006) 3.17
RNA sequencing shows no dosage compensation of the active X-chromosome. Nat Genet (2010) 2.71
Null mutations in human and mouse orthologs frequently result in different phenotypes. Proc Natl Acad Sci U S A (2008) 2.60
Balanced codon usage optimizes eukaryotic translational efficiency. PLoS Genet (2012) 2.32
Impacts of gene essentiality, expression pattern, and gene compactness on the evolutionary rate of mammalian proteins. Mol Biol Evol (2006) 2.22
Genomic patterns of pleiotropy and the evolution of complexity. Proc Natl Acad Sci U S A (2010) 2.19
Prevalent positive epistasis in Escherichia coli and Saccharomyces cerevisiae metabolic networks. Nat Genet (2010) 2.16
Mouse duplicate genes are as essential as singletons. Trends Genet (2007) 2.12
More genes underwent positive selection in chimpanzee evolution than in human evolution. Proc Natl Acad Sci U S A (2007) 2.00
Low rates of expression profile divergence in highly expressed genes and tissue-specific genes during mammalian evolution. Mol Biol Evol (2006) 1.97
Dramatic variation of the vomeronasal pheromone receptor gene repertoire among five orders of placental and marsupial mammals. Proc Natl Acad Sci U S A (2005) 1.88
Toward a molecular understanding of pleiotropy. Genetics (2006) 1.88
Comparative genomic analysis identifies an evolutionary shift of vomeronasal receptor gene repertoires in the vertebrate transition from water to land. Genome Res (2007) 1.85
Adaptive diversification of bitter taste receptor genes in Mammalian evolution. Mol Biol Evol (2003) 1.82
Contrasting modes of evolution between vertebrate sweet/umami receptor genes and bitter receptor genes. Mol Biol Evol (2005) 1.77
Expression of hiwi gene in human gastric cancer was associated with proliferation of cancer cells. Int J Cancer (2006) 1.76
The hearing gene Prestin unites echolocating bats and whales. Curr Biol (2010) 1.62
Higher duplicability of less important genes in yeast genomes. Mol Biol Evol (2005) 1.57
Pseudogenization of the umami taste receptor gene Tas1r1 in the giant panda coincided with its dietary switch to bamboo. Mol Biol Evol (2010) 1.53
Maintenance of duplicate genes and their functional redundancy by reduced expression. Trends Genet (2010) 1.51
Composition and evolution of the V2r vomeronasal receptor gene repertoire in mice and rats. Genomics (2005) 1.47
The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. Genomics (2005) 1.43
Sex-specific splicing of the honeybee doublesex gene reveals 300 million years of evolution at the bottom of the insect sex-determination pathway. Genetics (2007) 1.43
Gene complexity and gene duplicability. Curr Biol (2005) 1.42
In search of the biological significance of modular structures in protein networks. PLoS Comput Biol (2007) 1.38
Relaxation of selective constraint and loss of function in the evolution of human bitter taste receptor genes. Hum Mol Genet (2004) 1.38
The genomic landscape and evolutionary resolution of antagonistic pleiotropy in yeast. Cell Rep (2012) 1.36
Evolution of the sweet taste receptor gene Tas1r2 in bats. Mol Biol Evol (2010) 1.36
Impact of translational error-induced and error-free misfolding on the rate of protein evolution. Mol Syst Biol (2010) 1.35
Origin of the genetic components of the vomeronasal system in the common ancestor of all extant vertebrates. Mol Biol Evol (2008) 1.33
Measuring the evolutionary rate of protein-protein interaction. Proc Natl Acad Sci U S A (2011) 1.32
MicroRNA let-7c inhibits migration and invasion of human non-small cell lung cancer by targeting ITGB3 and MAP4K3. Cancer Lett (2013) 1.31
Positive selection for elevated gene expression noise in yeast. Mol Syst Biol (2009) 1.30
Protein misinteraction avoidance causes highly expressed proteins to evolve slowly. Proc Natl Acad Sci U S A (2012) 1.29
Genomic and genetic evidence for the loss of umami taste in bats. Genome Biol Evol (2011) 1.27
Did brain-specific genes evolve faster in humans than in chimpanzees? Trends Genet (2006) 1.26
Positive selection on protein-length in the evolution of a primate sperm ion channel. Proc Natl Acad Sci U S A (2003) 1.26
Gene dosage and gene duplicability. Genetics (2008) 1.23
Abundant indispensable redundancies in cellular metabolic networks. Genome Biol Evol (2009) 1.23
Expression reduction in mammalian X chromosome evolution refutes Ohno's hypothesis of dosage compensation. Proc Natl Acad Sci U S A (2012) 1.22
Rapid turnover and species-specificity of vomeronasal pheromone receptor genes in mice and rats. Gene (2004) 1.21
p37 from Mycoplasma hyorhinis promotes cancer cell invasiveness and metastasis through activation of MMP-2 and followed by phosphorylation of EGFR. Mol Cancer Ther (2008) 1.21
Genomic evidence for elevated mutation rates in highly expressed genes. EMBO Rep (2012) 1.19
Largest vertebrate vomeronasal type 1 receptor gene repertoire in the semiaquatic platypus. Mol Biol Evol (2007) 1.19
Why are some human disease-associated mutations fixed in mice? Trends Genet (2003) 1.19
Why is the correlation between gene importance and gene evolutionary rate so weak? PLoS Genet (2009) 1.16
On the definition and measurement of pleiotropy. Trends Genet (2013) 1.14
Distinct evolutionary patterns between chemoreceptors of 2 vertebrate olfactory systems and the differential tuning hypothesis. Mol Biol Evol (2008) 1.13
No gene-specific optimization of mutation rate in Escherichia coli. Mol Biol Evol (2013) 1.13
Coexpression of linked genes in Mammalian genomes is generally disadvantageous. Mol Biol Evol (2008) 1.12
Nonneutral evolution of the transcribed pseudogene Makorin1-p1 in mice. Mol Biol Evol (2004) 1.11
Neuronal protein synuclein gamma predicts poor clinical outcome in breast cancer. Int J Cancer (2007) 1.10
Differential requirements for mRNA folding partially explain why highly expressed proteins evolve slowly. Proc Natl Acad Sci U S A (2013) 1.09
Diet shapes the evolution of the vertebrate bitter taste receptor gene repertoire. Mol Biol Evol (2013) 1.08
Positive selection for indel substitutions in the rodent sperm protein catsper1. Mol Biol Evol (2005) 1.07
Contrasting genetic paths to morphological and physiological evolution. Proc Natl Acad Sci U S A (2010) 1.05
Evolution of the complementary sex-determination gene of honey bees: balancing selection and trans-species polymorphisms. Genome Res (2006) 1.04
Impact of extracellularity on the evolutionary rate of mammalian proteins. Genome Biol Evol (2010) 1.02
The ortholog conjecture is untestable by the current gene ontology but is supported by RNA sequencing data. PLoS Comput Biol (2012) 1.02
Generation of novel monoclonal antibodies and their application for detecting ARD1 expression in colorectal cancer. Cancer Lett (2008) 1.02
High expression hampers horizontal gene transfer. Genome Biol Evol (2012) 1.01
Evaluation of transovarial transmission and transmissibility of Ehrlichia chaffeensis (Rickettsiales: Anaplasmataceae) in Amblyomma americanum (Acari: Ixodidae). J Med Entomol (2003) 1.01
Suppression of tumor growth and metastasis by a VEGFR-1 antagonizing peptide identified from a phage display library. Int J Cancer (2004) 1.01
Evolutionary dynamics of nematode operons: easy come, slow go. Genome Res (2008) 1.00
Remarkable expansions of an X-linked reproductive homeobox gene cluster in rodent evolution. Genomics (2006) 1.00
Protein subcellular relocalization in the evolution of yeast singleton and duplicate genes. Genome Biol Evol (2009) 0.99
Human coding RNA editing is generally nonadaptive. Proc Natl Acad Sci U S A (2014) 0.96
Zebrafish ribonucleases are bactericidal: implications for the origin of the vertebrate RNase A superfamily. Mol Biol Evol (2007) 0.95
Rapid evolution of mammalian X-linked testis-expressed homeobox genes. Genetics (2004) 0.93
Evidence for escape from adaptive conflict? Nature (2009) 0.91
Diagnosis of gastric cancer using decision tree classification of mass spectral data. Cancer Sci (2007) 0.90
Origin and evolution of the vertebrate vomeronasal system viewed through system-specific genes. Bioessays (2006) 0.90
A big world inside small-world networks. PLoS One (2009) 0.90
Widespread losses of vomeronasal signal transduction in bats. Mol Biol Evol (2010) 0.89
Processed pseudogenes: the 'fossilized footprints' of past gene expression. Trends Genet (2009) 0.89
Ancient expansion of the ribonuclease A superfamily revealed by genomic analysis of placental and marsupial mammals. Gene (2006) 0.88
Mismatches between feeding ecology and taste receptor evolution: an inconvenient truth. Proc Natl Acad Sci U S A (2012) 0.85
Genetic evidence for the coexistence of pheromone perception and full trichromatic vision in howler monkeys. Mol Biol Evol (2004) 0.85
Transcriptional reprogramming and backup between duplicate genes: is it a genomewide phenomenon? Genetics (2005) 0.84
Obligate intracellular bacterium Ehrlichia inhibiting mitochondrial activity. Microbes Infect (2010) 0.84
Elevated maspin expression is associated with better overall survival in esophageal squamous cell carcinoma (ESCC). PLoS One (2013) 0.84
Genome-wide evolutionary conservation of N-glycosylation sites. Mol Biol Evol (2011) 0.84
Isolation, characterization, and evolutionary divergence of mouse RNase 6: evidence for unusual evolution in rodents. J Mol Evol (2004) 0.83
Positive selection, not negative selection, in the pseudogenization of rcsA in Yersinia pestis. Proc Natl Acad Sci U S A (2008) 0.83
Rapid evolution of primate ESX1, an X-linked placenta- and testis-expressed homeobox gene. Hum Mol Genet (2007) 0.82
IL1 receptor antagonist gene IL1-RN variable number of tandem repeats polymorphism and cancer risk: a literature review and meta-analysis. PLoS One (2012) 0.82
Preparation and characterization of monoclonal antibodies against nucleostemin, a protein that controls cell proliferation in stem cells and cancer cells. Hybridoma (Larchmt) (2005) 0.81
Accelerated evolution and loss of a domain of the sperm-egg-binding protein SED1 in ancestral primates. Mol Biol Evol (2006) 0.80
Why are genes encoded on the lagging strand of the bacterial genome? Genome Biol Evol (2013) 0.79
Phylogenetic evidence for parallel adaptive origins of digestive RNases in Asian and African leaf monkeys: a response to Xu et al. (2009). Mol Phylogenet Evol (2009) 0.79
On the growth of scientific knowledge: yeast biology as a case study. PLoS Comput Biol (2009) 0.78
Toward genome-wide identification of Bateson-Dobzhansky-Muller incompatibilities in yeast: a simulation study. Genome Biol Evol (2013) 0.78
The microevolution of V1r vomeronasal receptor genes in mice. Genome Biol Evol (2011) 0.77
A panorama of mammalian gene expression evolution. Mol Syst Biol (2011) 0.76