Published in Biochem Biophys Res Commun on August 13, 2007
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Obscurin determines the architecture of the longitudinal sarcoplasmic reticulum. J Cell Sci (2009) 1.40
Titin is a major human disease gene. Circulation (2013) 1.29
Obscurin interacts with a novel isoform of MyBP-C slow at the periphery of the sarcomeric M-band and regulates thick filament assembly. Mol Biol Cell (2009) 1.23
The rho-guanine nucleotide exchange factor domain of obscurin regulates assembly of titin at the Z-disk through interactions with Ran binding protein 9. Mol Biol Cell (2008) 1.15
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Cardiac titin and heart disease. J Cardiovasc Pharmacol (2014) 1.08
New aspects of obscurin in human striated muscles. Histochem Cell Biol (2008) 1.05
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Rescue of familial cardiomyopathies by modifications at the level of sarcomere and Ca2+ fluxes. J Mol Cell Cardiol (2010) 0.96
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Early incorporation of obscurin into nascent sarcomeres: implication for myofibril assembly during cardiac myogenesis. Histochem Cell Biol (2008) 0.95
Loss of giant obscurins promotes breast epithelial cell survival through apoptotic resistance. FASEB J (2012) 0.94
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Obscurins: unassuming giants enter the spotlight. IUBMB Life (2013) 0.89
Investigation of Pathogenic Genes in Chinese sporadic Hypertrophic Cardiomyopathy Patients by Whole Exome Sequencing. Sci Rep (2015) 0.82
Binding of Myomesin to Obscurin-Like-1 to the Muscle M-Band Provides a Strategy for Isoform-Specific Mechanical Protection. Structure (2016) 0.78
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Obscurin variants and inherited cardiomyopathies. Biophys Rev (2017) 0.77
The sarcomeric M-region: a molecular command center for diverse cellular processes. Biomed Res Int (2015) 0.76
Contribution of the OBSCN nonsynonymous variants to aspirin exacerbated respiratory disease susceptibility in Korean population. DNA Cell Biol (2012) 0.76
Cardiac spectrins: alternative splicing encodes functional diversity. J Mol Cell Cardiol (2010) 0.76
Deregulated Ca(2+) cycling underlies the development of arrhythmia and heart disease due to mutant obscurin. Sci Adv (2017) 0.75
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Obscure functions: the location-function relationship of obscurins. Biophys Rev (2017) 0.75
Targeted next-generation sequencing detects novel gene-phenotype associations and expands the mutational spectrum in cardiomyopathies. PLoS One (2017) 0.75
The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell (2002) 4.72
Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite. Drug Metab Dispos (2010) 3.06
Cytotoxic T lymphocyte-based control of simian immunodeficiency virus replication in a preclinical AIDS vaccine trial. J Exp Med (2004) 2.99
A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Cell (2010) 2.27
Alpha B-crystallin mutation in dilated cardiomyopathy. Biochem Biophys Res Commun (2006) 2.27
Assessment of coronary artery disease using magnetic resonance coronary angiography: a national multicenter trial. J Am Coll Cardiol (2010) 2.11
Replication of the association between a chromosome 9p21 polymorphism and coronary artery disease in Japanese and Korean populations. J Hum Genet (2008) 1.94
Nebulette mutations are associated with dilated cardiomyopathy and endocardial fibroelastosis. J Am Coll Cardiol (2010) 1.88
Dilated cardiomyopathy-associated BAG3 mutations impair Z-disc assembly and enhance sensitivity to apoptosis in cardiomyocytes. Hum Mutat (2011) 1.85
Lifelong left ventricular remodeling of hypertrophic cardiomyopathy caused by a founder frameshift deletion mutation in the cardiac Myosin-binding protein C gene among Japanese. J Am Coll Cardiol (2005) 1.80
Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy. J Am Coll Cardiol (2004) 1.79
Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia. J Biol Chem (2004) 1.75
Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload. Circ Res (2007) 1.74
Electrocardiographic characteristics and SCN5A mutations in idiopathic ventricular fibrillation associated with early repolarization. Circ Arrhythm Electrophysiol (2011) 1.74
Coreference based event-argument relation extraction on biomedical text. J Biomed Semantics (2011) 1.73
Titin mutations as the molecular basis for dilated cardiomyopathy. Biochem Biophys Res Commun (2002) 1.70
Prevalence and distribution of sarcomeric gene mutations in Japanese patients with familial hypertrophic cardiomyopathy. Circ J (2011) 1.64
Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells. Circulation (2007) 1.57
Novel SCN3B mutation associated with brugada syndrome affects intracellular trafficking and function of Nav1.5. Circ J (2012) 1.52
Evaluation of pharmacogenetic algorithm for warfarin dose requirements in Japanese patients. Circ J (2010) 1.49
Dilated cardiomyopathy-associated FHOD3 variant impairs the ability to induce activation of transcription factor serum response factor. Circ J (2013) 1.47
Identification of a glutamic acid repeat polymorphism of ALMS1 as a novel genetic risk marker for early-onset myocardial infarction by genome-wide linkage analysis. Circ Cardiovasc Genet (2013) 1.47
High-density association study and nomination of susceptibility genes for hypertension in the Japanese National Project. Hum Mol Genet (2007) 1.44
Involvement of platelet activation by P2Y12 receptor in the development of transplant arteriosclerosis in mice. Transplantation (2009) 1.42
Incidental focal FDG uptake in heart is a lighthouse for considering cardiac screening. Ann Nucl Med (2013) 1.41
Identification and functional analysis of a caveolin-3 mutation associated with familial hypertrophic cardiomyopathy. Biochem Biophys Res Commun (2004) 1.39
Cardiac ankyrin repeat protein gene (ANKRD1) mutations in hypertrophic cardiomyopathy. J Am Coll Cardiol (2009) 1.38
Complications with Endobronchial Ultrasound with a Guide Sheath for the Diagnosis of Peripheral Pulmonary Lesions. Respiration (2015) 1.36
Molecular imaging of matrix metalloproteinase in atherosclerotic lesions: resolution with dietary modification and statin therapy. J Am Coll Cardiol (2008) 1.29
Novel calmodulin mutations associated with congenital arrhythmia susceptibility. Circ Cardiovasc Genet (2014) 1.27
A Cypher/ZASP mutation associated with dilated cardiomyopathy alters the binding affinity to protein kinase C. J Biol Chem (2003) 1.23
ANKRD1, the gene encoding cardiac ankyrin repeat protein, is a novel dilated cardiomyopathy gene. J Am Coll Cardiol (2009) 1.22
E-selectin polymorphism associated with myocardial infarction causes enhanced leukocyte-endothelial interactions under flow conditions. Arterioscler Thromb Vasc Biol (2003) 1.20
Functional analysis of titin/connectin N2-B mutations found in cardiomyopathy. J Muscle Res Cell Motil (2005) 1.16
Ratio of erythro and threo forms of beta-O-4 structures in tension wood lignin. Phytochemistry (2003) 1.16
Multiscale modeling in rodent ventricular myocytes. IEEE Eng Med Biol Mag (2009) 1.13
Impaired binding of ZASP/Cypher with phosphoglucomutase 1 is associated with dilated cardiomyopathy. Cardiovasc Res (2009) 1.12
Association of Takayasu arteritis with HLA-B 67:01 and two amino acids in HLA-B protein. Rheumatology (Oxford) (2013) 1.12
Identification of I kappa BL as the second major histocompatibility complex-linked susceptibility locus for rheumatoid arthritis. Am J Hum Genet (2002) 1.11
Molecular basis for clinical heterogeneity in inherited cardiomyopathies due to myopalladin mutations. Hum Mol Genet (2012) 1.10
A mutant cardiac sodium channel with multiple biophysical defects associated with overlapping clinical features of Brugada syndrome and cardiac conduction disease. Cardiovasc Res (2002) 1.06
A possible mechanism for the differences in efficiency and variability of active metabolite formation from thienopyridine antiplatelet agents, prasugrel and clopidogrel. Drug Metab Dispos (2009) 1.05
CS-8958, a prodrug of the novel neuraminidase inhibitor R-125489, demonstrates a favorable long-retention profile in the mouse respiratory tract. Antimicrob Agents Chemother (2009) 1.04
Copy number variations of CCL3L1 and long-term prognosis of HIV-1 infection in asymptomatic HIV-infected Japanese with hemophilia. Immunogenetics (2007) 1.03
Analytical method for determination of disaccharides derived from keratan sulfates in human serum and plasma by high-performance liquid chromatography/turbo-ionspray ionization tandem mass spectrometry. Biomed Chromatogr (2007) 1.03
Association between the chromosome 9p21 locus and angiographic coronary artery disease burden: a collaborative meta-analysis. J Am Coll Cardiol (2013) 1.02
A novel disease gene for Brugada syndrome: sarcolemmal membrane-associated protein gene mutations impair intracellular trafficking of hNav1.5. Circ Arrhythm Electrophysiol (2012) 1.02
Diversity of MHC class I genes in Burmese-origin rhesus macaques. Immunogenetics (2010) 1.01
Synergistic contribution of CD14 and HLA loci in the susceptibility to Buerger disease. Hum Genet (2007) 1.00
Serum C-reactive protein elevation predicts poor clinical outcome in patients with distal type acute aortic dissection: association with the occurrence of oxygenation impairment. Int J Cardiol (2005) 1.00
Two critical genes (HLA-DRB1 and ABCF1)in the HLA region are associated with the susceptibility to autoimmune pancreatitis. Immunogenetics (2006) 1.00
Influence of glycosylation on the efficacy of an Env-based vaccine against simian immunodeficiency virus SIVmac239 in a macaque AIDS model. J Virol (2005) 0.98
Truncated KCNQ1 mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking defect. FEBS Lett (2004) 0.97
Role of HCN4 channel in preventing ventricular arrhythmia. J Hum Genet (2009) 0.97
Metabolic syndrome among pre- and post-menopausal rural women in Bangladesh: result from a population-based study. BMC Res Notes (2013) 0.96
Roles of DRB1 *1501 and DRB1 *1502 in the pathogenesis of aplastic anemia. Exp Hematol (2007) 0.96
Use of morphological analysis in protein name recognition. J Biomed Inform (2004) 0.96
Epitaxial Bi5Ti3FeO15-CoFe2O4 pillar-matrix multiferroic nanostructures. ACS Nano (2013) 0.95
Natural selection in the TLR-related genes in the course of primate evolution. Immunogenetics (2008) 0.95
Three-dimensional geometric modeling of membrane-bound organelles in ventricular myocytes: bridging the gap between microscopic imaging and mathematical simulation. J Struct Biol (2008) 0.95
Apelin is a positive regulator of ACE2 in failing hearts. J Clin Invest (2013) 0.95
Loss of function of hNav1.5 by a ZASP1 mutation associated with intraventricular conduction disturbances in left ventricular noncompaction. Circ Arrhythm Electrophysiol (2012) 0.94
HLA-DPB1*0202 is associated with a predictor of good prognosis of Graves' disease in the Japanese. Hum Immunol (2006) 0.94
Reference strand-mediated conformation analysis-based typing of multiple alleles in the rhesus macaque MHC class I Mamu-A and Mamu-B loci. Electrophoresis (2007) 0.94
Further investigation of the modifying effect of various chemopreventive agents on apoptosis and cell proliferation in human colon cancer cells. J Cancer Res Clin Oncol (2002) 0.94
Delta-sarcoglycan gene therapy halts progression of cardiac dysfunction, improves respiratory failure, and prolongs life in myopathic hamsters. Circ Heart Fail (2010) 0.93