Published in Biochem Biophys Res Commun on February 22, 2002
Genetic causes of human heart failure. J Clin Invest (2005) 2.79
Genotype-phenotype relationships involving hypertrophic cardiomyopathy-associated mutations in titin, muscle LIM protein, and telethonin. Mol Genet Metab (2005) 2.72
Recessive truncating titin gene, TTN, mutations presenting as centronuclear myopathy. Neurology (2013) 2.09
RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing. Nat Med (2012) 1.97
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Genome-wide association analysis identifies multiple loci related to resting heart rate. Hum Mol Genet (2010) 1.67
Mutations in PCYT1A, encoding a key regulator of phosphatidylcholine metabolism, cause spondylometaphyseal dysplasia with cone-rod dystrophy. Am J Hum Genet (2014) 1.66
Sarcomeric protein mutations in dilated cardiomyopathy. Heart Fail Rev (2005) 1.54
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Titin is a major human disease gene. Circulation (2013) 1.29
Genetic isolation and characterization of a splicing mutant of zebrafish dystrophin. Hum Mol Genet (2008) 1.23
Titin: physiological function and role in cardiomyopathy and failure. Heart Fail Rev (2005) 1.22
ANKRD1, the gene encoding cardiac ankyrin repeat protein, is a novel dilated cardiomyopathy gene. J Am Coll Cardiol (2009) 1.22
The zebrafish runzel muscular dystrophy is linked to the titin gene. Dev Biol (2007) 1.20
Depletion of zebrafish titin reduces cardiac contractility by disrupting the assembly of Z-discs and A-bands. Circ Res (2006) 1.16
Essential role of obscurin in cardiac myofibrillogenesis and hypertrophic response: evidence from small interfering RNA-mediated gene silencing. Histochem Cell Biol (2005) 1.14
A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics. J Biol Chem (2012) 1.12
S-glutathionylation of cryptic cysteines enhances titin elasticity by blocking protein folding. Cell (2014) 1.09
Cardiac titin and heart disease. J Cardiovasc Pharmacol (2014) 1.08
Molecular genetics and pathogenesis of cardiomyopathy. J Hum Genet (2015) 1.02
Recessive TTN truncating mutations define novel forms of core myopathy with heart disease. Hum Mol Genet (2013) 1.01
HBEGF, SRA1, and IK: Three cosegregating genes as determinants of cardiomyopathy. Genome Res (2008) 1.00
Doubly heterozygous LMNA and TTN mutations revealed by exome sequencing in a severe form of dilated cardiomyopathy. Eur J Hum Genet (2013) 1.00
Myofibrillar remodeling in cardiac hypertrophy, heart failure and cardiomyopathies. Can J Cardiol (2006) 1.00
Ischemia-induced increase of stiffness of alphaB-crystallin/HSPB2-deficient myocardium. Pflugers Arch (2005) 1.00
Genotype, phenotype: upstairs, downstairs in the family of cardiomyopathies. J Clin Invest (2003) 0.99
Association of a single nucleotide polymorphism in titin gene with marbling in Japanese Black beef cattle. BMC Res Notes (2009) 0.97
Finding consistent disease subnetworks across microarray datasets. BMC Bioinformatics (2011) 0.95
Repeat or not repeat?--Statistical validation of tandem repeat prediction in genomic sequences. Nucleic Acids Res (2012) 0.93
Hepatitis B virus and Homo sapiens proteome-wide analysis: A profusion of viral peptide overlaps in neuron-specific human proteins. Biologics (2010) 0.92
Single nucleotide polymorphisms associated with non-contact soft tissue injuries in elite professional soccer players: influence on degree of injury and recovery time. BMC Musculoskelet Disord (2013) 0.91
Novel mutations in the sarcomeric protein myopalladin in patients with dilated cardiomyopathy. Eur J Hum Genet (2012) 0.88
The mutations associated with dilated cardiomyopathy. Biochem Res Int (2012) 0.86
Role of cardiac magnetic resonance in the evaluation of dilated cardiomyopathy: diagnostic contribution and prognostic significance. ISRN Radiol (2014) 0.86
Prevalence of Titin Truncating Variants in General Population. PLoS One (2015) 0.85
Stressing the giant: a new approach to understanding dilated cardiomyopathy. J Mol Cell Cardiol (2009) 0.84
An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafish. Elife (2015) 0.84
Extensive and modular intrinsically disordered segments in C. elegans TTN-1 and implications in filament binding, elasticity and oblique striation. J Mol Biol (2010) 0.81
Genetics of mechanosensation in the heart. J Cardiovasc Transl Res (2011) 0.81
Titin mutations: the fall of Goliath. Heart Fail Rev (2015) 0.81
Canine candidate genes for dilated cardiomyopathy: annotation of and polymorphic markers for 14 genes. BMC Vet Res (2007) 0.78
Familial dilated cardiomyopathy: Current challenges and future directions. Glob Cardiol Sci Pract (2012) 0.78
Phenotypic heterogeneity of sarcomeric gene mutations: a matter of gain and loss? J Am Coll Cardiol (2009) 0.77
Potential for sexual conflict assessed via testosterone-mediated transcriptional changes in liver and muscle of a songbird. J Exp Biol (2013) 0.76
A new titinopathy: Childhood-juvenile onset Emery-Dreifuss-like phenotype without cardiomyopathy. Neurology (2015) 0.76
Alternative Splicing, Internal Promoter, Nonsense-Mediated Decay, or All Three: Explaining the Distribution of Truncation Variants in Titin. Circ Cardiovasc Genet (2016) 0.75
Genetic Variations Leading to Familial Dilated Cardiomyopathy. Mol Cells (2016) 0.75
Exploration of pathomechanisms triggered by a single-nucleotide polymorphism in titin's I-band: the cardiomyopathy-linked mutation T2580I. Open Biol (2016) 0.75
Titin Truncating Variants in Dilated Cardiomyopathy - Prevalence and Genotype-Phenotype Correlations. PLoS One (2017) 0.75
The genetic background of arrhythmogenic right ventricular cardiomyopathy. J Arrhythm (2016) 0.75
Sudden cardiac death: focus on the genetics of channelopathies and cardiomyopathies. J Biomed Sci (2017) 0.75
Genetic epidemiology of titin-truncating variants in the etiology of dilated cardiomyopathy. Biophys Rev (2017) 0.75
Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomised controlled trial. Lancet (2002) 7.11
The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2009). Hypertens Res (2009) 5.24
The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2014). Hypertens Res (2014) 4.83
The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell (2002) 4.72
Simvastatin attenuates plaque inflammation: evaluation by fluorodeoxyglucose positron emission tomography. J Am Coll Cardiol (2006) 3.43
Transforming growth factor-beta function blocking prevents myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats. Circulation (2002) 3.20
Cytotoxic T lymphocyte-based control of simian immunodeficiency virus replication in a preclinical AIDS vaccine trial. J Exp Med (2004) 2.99
Hypertensive myocardial fibrosis and diastolic dysfunction: another model of inflammation? Hypertension (2004) 2.89
Higher heart rate may predispose to obesity and diabetes mellitus: 20-year prospective study in a general population. Am J Hypertens (2008) 2.54
SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome. Circulation (2007) 2.42
Target blood pressure for treatment of isolated systolic hypertension in the elderly: valsartan in elderly isolated systolic hypertension study. Hypertension (2010) 2.37
A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Cell (2010) 2.27
Alpha B-crystallin mutation in dilated cardiomyopathy. Biochem Biophys Res Commun (2006) 2.27
Intravascular ultrasound evaluation of coronary plaque regression by low density lipoprotein-apheresis in familial hypercholesterolemia: the Low Density Lipoprotein-Apheresis Coronary Morphology and Reserve Trial (LACMART). J Am Coll Cardiol (2002) 2.26
Diabetic vascular complications: pathophysiology, biochemical basis and potential therapeutic strategy. Curr Pharm Des (2005) 2.06
Pioglitazone attenuates atherosclerotic plaque inflammation in patients with impaired glucose tolerance or diabetes a prospective, randomized, comparator-controlled study using serial FDG PET/CT imaging study of carotid artery and ascending aorta. JACC Cardiovasc Imaging (2011) 2.00
Replication of the association between a chromosome 9p21 polymorphism and coronary artery disease in Japanese and Korean populations. J Hum Genet (2008) 1.94
Nebulette mutations are associated with dilated cardiomyopathy and endocardial fibroelastosis. J Am Coll Cardiol (2010) 1.88
Activation of MAPK pathways links LMNA mutations to cardiomyopathy in Emery-Dreifuss muscular dystrophy. J Clin Invest (2007) 1.87
Elevated serum levels of pigment epithelium-derived factor in the metabolic syndrome. J Clin Endocrinol Metab (2006) 1.86
Dilated cardiomyopathy-associated BAG3 mutations impair Z-disc assembly and enhance sensitivity to apoptosis in cardiomyocytes. Hum Mutat (2011) 1.85
Apoptosis induced by inhibition of cyclic AMP response element-binding protein in vascular smooth muscle cells. Circulation (2003) 1.81
Lifelong left ventricular remodeling of hypertrophic cardiomyopathy caused by a founder frameshift deletion mutation in the cardiac Myosin-binding protein C gene among Japanese. J Am Coll Cardiol (2005) 1.80
Role of host angiotensin II type 1 receptor in tumor angiogenesis and growth. J Clin Invest (2003) 1.79
Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy. J Am Coll Cardiol (2004) 1.79
Pulmonary inflammation and emphysema: role of the cytokines IL-18 and IL-13. Am J Respir Crit Care Med (2007) 1.79
Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia. J Biol Chem (2004) 1.75
Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload. Circ Res (2007) 1.74
Electrocardiographic characteristics and SCN5A mutations in idiopathic ventricular fibrillation associated with early repolarization. Circ Arrhythm Electrophysiol (2011) 1.74
Critical role of cyclin D1 nuclear import in cardiomyocyte proliferation. Circ Res (2003) 1.70
Pressure overload-induced transient oxidative stress mediates perivascular inflammation and cardiac fibrosis through angiotensin II. Hypertens Res (2006) 1.70
Long-term clinical outcome after intramuscular implantation of bone marrow mononuclear cells (Therapeutic Angiogenesis by Cell Transplantation [TACT] trial) in patients with chronic limb ischemia. Am Heart J (2008) 1.70
Inhibition of progression and stabilization of plaques by postnatal interferon-gamma function blocking in ApoE-knockout mice. Circ Res (2007) 1.70
Mechanisms for atrial fibrillation in patients with Wolff-Parkinson-White syndrome. J Cardiovasc Electrophysiol (2002) 1.67
Protective and enhancing HLA alleles, HLA-DRB1*0901 and HLA-A*24, for severe forms of dengue virus infection, dengue hemorrhagic fever and dengue shock syndrome. PLoS Negl Trop Dis (2008) 1.65
Prevalence and distribution of sarcomeric gene mutations in Japanese patients with familial hypertrophic cardiomyopathy. Circ J (2011) 1.64
Molecular and functional characterization of novel glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) mutations in sudden infant death syndrome. Circulation (2007) 1.64
Inhibition of eNOS phosphorylation mediates endothelial dysfunction in renal failure: new effect of asymmetric dimethylarginine. Kidney Int (2012) 1.62
Angiogenesis and vasculogenesis are impaired in the precocious-aging klotho mouse. Circulation (2004) 1.61
Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells. Circulation (2007) 1.57
Ultrasound stimulation restores impaired neovascularization-related capacities of human circulating angiogenic cells. Cardiovasc Res (2012) 1.57
Roles of endogenous monocyte chemoattractant protein-1 in ischemia-induced neovascularization. J Am Coll Cardiol (2004) 1.56
Combinations of olmesartan and a calcium channel blocker or a diuretic in elderly hypertensive patients: a randomized, controlled trial. J Hypertens (2014) 1.56
Effect of autologous bone-marrow cell transplantation on ischemic ulcer in patients with Buerger's disease. Circ J (2007) 1.55
Prediction of coronary artery disease in patients undergoing carotid endarterectomy. J Neurosurg (2005) 1.55
Dimethylarginine dimethylaminohydrolase prevents progression of renal dysfunction by inhibiting loss of peritubular capillaries and tubulointerstitial fibrosis in a rat model of chronic kidney disease. J Am Soc Nephrol (2007) 1.54
Incremental value of combining 64-slice computed tomography angiography with stress nuclear myocardial perfusion imaging to improve noninvasive detection of coronary artery disease. J Nucl Cardiol (2009) 1.54
Vascular inflammation evaluated by [18F]-fluorodeoxyglucose positron emission tomography is associated with the metabolic syndrome. J Am Coll Cardiol (2007) 1.53
Novel SCN3B mutation associated with brugada syndrome affects intracellular trafficking and function of Nav1.5. Circ J (2012) 1.52
Prediction of bone mineral density from vitamin D receptor polymorphisms is uncertain in representative samples of Japanese Women. The Japanese Population-based Osteoporosis (JPOS) Study. Int J Epidemiol (2004) 1.52
Enhanced expression of the S100A8/A9 complex in acute myocardial infarction patients. Circ J (2010) 1.51
Evaluation of pharmacogenetic algorithm for warfarin dose requirements in Japanese patients. Circ J (2010) 1.49
Identification of a glutamic acid repeat polymorphism of ALMS1 as a novel genetic risk marker for early-onset myocardial infarction by genome-wide linkage analysis. Circ Cardiovasc Genet (2013) 1.47
Dilated cardiomyopathy-associated FHOD3 variant impairs the ability to induce activation of transcription factor serum response factor. Circ J (2013) 1.47
Tenascin-C regulates recruitment of myofibroblasts during tissue repair after myocardial injury. Am J Pathol (2005) 1.46
How to avoid development of AV block during RF ablation: anatomical and electrophysiological analyses at the time of AV node ablation. Pacing Clin Electrophysiol (2012) 1.45
Comparison of gene expression profiling in pressure and volume overload-induced myocardial hypertrophies in rats. Hypertens Res (2006) 1.45
Large blood pressure variability aggravates arteriolosclerosis and cortical sclerotic changes in the kidney in hypertensive rats. Circ J (2014) 1.45
High-density association study and nomination of susceptibility genes for hypertension in the Japanese National Project. Hum Mol Genet (2007) 1.44
Losartan/hydrochlorothiazide combination vs. high-dose losartan in patients with morning hypertension--a prospective, randomized, open-labeled, parallel-group, multicenter trial. Hypertens Res (2012) 1.43
Low DBP may not be an independent risk for cardiovascular death in revascularized coronary artery disease patients. J Hypertens (2011) 1.42
Identification and functional analysis of a caveolin-3 mutation associated with familial hypertrophic cardiomyopathy. Biochem Biophys Res Commun (2004) 1.39
Pitavastatin regulates helper T-cell differentiation and ameliorates autoimmune myocarditis in mice. Cardiovasc Drugs Ther (2013) 1.38
Cardiac ankyrin repeat protein gene (ANKRD1) mutations in hypertrophic cardiomyopathy. J Am Coll Cardiol (2009) 1.38