Published in Endocrinology on August 23, 2007
Central nervous system inflammation induces muscle atrophy via activation of the hypothalamic-pituitary-adrenal axis. J Exp Med (2011) 1.15
Metformin induces apoptosis and cell cycle arrest mediated by oxidative stress, AMPK and FOXO3a in MCF-7 breast cancer cells. PLoS One (2014) 1.10
Pathophysiology of anorexia in the cancer cachexia syndrome. J Cachexia Sarcopenia Muscle (2015) 0.93
Metformin increases phagocytosis and acidifies lysosomal/endosomal compartments in AMPK-dependent manner in rat primary microglia. Naunyn Schmiedebergs Arch Pharmacol (2009) 0.92
Concern Inhibition of hypothalamic Foxo1 expression reduced food intake in diet-induced obesity rats. J Physiol (2009) 0.91
Prenatal androgenization of female mice programs an increase in firing activity of gonadotropin-releasing hormone (GnRH) neurons that is reversed by metformin treatment in adulthood. Endocrinology (2010) 0.88
Intracerebroventricular injection of metformin induces anorexia in rats. Diabetes Metab J (2012) 0.83
Glucose regulates amyloid β production via AMPK. J Neural Transm (Vienna) (2015) 0.76
In vitro and in vivo targeting of bladder carcinoma with metformin in combination with cisplatin. Oncol Lett (2015) 0.75
Neuroimmune mechanisms of behavioral alterations in a syngeneic murine model of human papilloma virus-related head and neck cancer. Psychoneuroendocrinology (2017) 0.75
New insight for metformin against bladder cancer. Genes Environ (2017) 0.75
Retraction Note: Diacerhein attenuates the inflammatory response and improves survival in a model of severe sepsis. Crit Care (2016) 0.75
Retracted Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes (2007) 5.67
Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology (2005) 4.35
Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity. J Neurosci (2009) 3.22
Retracted Gut microbiota is a key modulator of insulin resistance in TLR 2 knockout mice. PLoS Biol (2011) 3.02
IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKbeta and ER stress inhibition. PLoS Biol (2010) 2.21
High- or low-salt diet from weaning to adulthood: effect on body weight, food intake and energy balance in rats. Nutr Metab Cardiovasc Dis (2005) 2.15
S-nitrosation of the insulin receptor, insulin receptor substrate 1, and protein kinase B/Akt: a novel mechanism of insulin resistance. Diabetes (2005) 1.91
Metformin amplifies chemotherapy-induced AMPK activation and antitumoral growth. Clin Cancer Res (2011) 1.88
TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys. Cell Metab (2013) 1.74
High-fat diet induces apoptosis of hypothalamic neurons. PLoS One (2009) 1.73
Retracted A central role for neuronal AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in high-protein diet-induced weight loss. Diabetes (2007) 1.59
Retracted Exercise improves insulin and leptin sensitivity in hypothalamus of Wistar rats. Diabetes (2006) 1.57
Reversal of diet-induced insulin resistance with a single bout of exercise in the rat: the role of PTP1B and IRS-1 serine phosphorylation. J Physiol (2006) 1.56
Retracted Physical exercise reduces circulating lipopolysaccharide and TLR4 activation and improves insulin signaling in tissues of DIO rats. Diabetes (2011) 1.50
Cross-talk between the insulin and leptin signaling systems in rat hypothalamus. Obes Res (2005) 1.48
Unsaturated fatty acids revert diet-induced hypothalamic inflammation in obesity. PLoS One (2012) 1.47
Interleukin-10 is a protective factor against diet-induced insulin resistance in liver. J Hepatol (2008) 1.47
Inhibition of toll-like receptor 2 expression improves insulin sensitivity and signaling in muscle and white adipose tissue of mice fed a high-fat diet. J Endocrinol (2008) 1.41
Western diet modulates insulin signaling, c-Jun N-terminal kinase activity, and insulin receptor substrate-1ser307 phosphorylation in a tissue-specific fashion. Endocrinology (2004) 1.39
Acute physical exercise reverses S-nitrosation of the insulin receptor, insulin receptor substrate 1 and protein kinase B/Akt in diet-induced obese Wistar rats. J Physiol (2007) 1.38
Fatty acid synthase inhibition with Orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model. Int J Cancer (2008) 1.25
Mutual paracrine effects of oral squamous cell carcinoma cells and normal oral fibroblasts: induction of fibroblast to myofibroblast transdifferentiation and modulation of tumor cell proliferation. Oral Oncol (2007) 1.23
Overexpression of HOXB7 homeobox gene in oral cancer induces cellular proliferation and is associated with poor prognosis. Int J Oncol (2010) 1.22
Novel signal transduction pathway for luteinizing hormone and its interaction with insulin: activation of Janus kinase/signal transducer and activator of transcription and phosphoinositol 3-kinase/Akt pathways. Endocrinology (2003) 1.18
Diet-induced inflammation of the hypothalamus in obesity. Neuroimmunomodulation (2008) 1.18
Inhibition of UCP2 expression reverses diet-induced diabetes mellitus by effects on both insulin secretion and action. FASEB J (2007) 1.17
Retracted Inflammation of the hypothalamus leads to defective pancreatic islet function. J Biol Chem (2011) 1.16
The multi-faceted cross-talk between the insulin and angiotensin II signaling systems. Diabetes Metab Res Rev (2006) 1.16
Concern Acute exercise reduces hepatic glucose production through inhibition of the Foxo1/HNF-4alpha pathway in insulin resistant mice. J Physiol (2010) 1.15
Obesity-induced increase in tumor necrosis factor-α leads to development of colon cancer in mice. Gastroenterology (2012) 1.14
Infliximab reverses steatosis and improves insulin signal transduction in liver of rats fed a high-fat diet. J Endocrinol (2007) 1.13
Targeted disruption of iNOS prevents LPS-induced S-nitrosation of IRbeta/IRS-1 and Akt and insulin resistance in muscle of mice. Am J Physiol Endocrinol Metab (2006) 1.13
Amelioration of diet-induced diabetes mellitus by removal of visceral fat. J Endocrinol (2006) 1.12
TNF-alpha acts in the hypothalamus inhibiting food intake and increasing the respiratory quotient--effects on leptin and insulin signaling pathways. Peptides (2007) 1.10
Endurance training improves responsiveness to insulin and modulates insulin signal transduction through the phosphatidylinositol 3-kinase/Akt-1 pathway. Eur J Endocrinol (2002) 1.10
Infliximab restores glucose homeostasis in an animal model of diet-induced obesity and diabetes. Endocrinology (2007) 1.09
Retracted EGFR tyrosine kinase inhibitor (PD153035) improves glucose tolerance and insulin action in high-fat diet-fed mice. Diabetes (2009) 1.08
Cold exposure induces tissue-specific modulation of the insulin-signalling pathway in Rattus norvegicus. J Physiol (2003) 1.07
Hepatocyte growth factor plays a key role in insulin resistance-associated compensatory mechanisms. Endocrinology (2012) 1.06
Central exercise action increases the AMPK and mTOR response to leptin. PLoS One (2008) 1.05
AdipoR1 mediates the anorexigenic and insulin/leptin-like actions of adiponectin in the hypothalamus. FEBS Lett (2008) 1.04
Interaction between leptin and insulin signaling pathways differentially affects JAK-STAT and PI 3-kinase-mediated signaling in rat liver. Biol Chem (2003) 1.03
Antineoplastic effect of rapamycin is potentiated by inhibition of IRS-1 signaling in prostate cancer cells xenografts. J Cancer Res Clin Oncol (2008) 1.03
Participation of prolactin receptors and phosphatidylinositol 3-kinase and MAP kinase pathways in the increase in pancreatic islet mass and sensitivity to glucose during pregnancy. J Endocrinol (2004) 1.02