PubRank

Ernst Hafen

Author PubWeight™ 122.16‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev 2004 7.51
2 Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol Cell 2003 6.76
3 Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands. Proc Natl Acad Sci U S A 2005 5.34
4 Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in Drosophila. Curr Biol 2002 5.12
5 Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry. Genome Biol 2004 4.91
6 The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. J Biol 2003 4.85
7 Long-lived Drosophila with overexpressed dFOXO in adult fat body. Science 2004 4.70
8 Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control. Trends Cell Biol 2003 4.67
9 Rheb is an essential regulator of S6K in controlling cell growth in Drosophila. Nat Cell Biol 2003 4.20
10 The DrosDel collection: a set of P-element insertions for generating custom chromosomal aberrations in Drosophila melanogaster. Genetics 2004 3.71
11 Dietary restriction in long-lived dwarf flies. Science 2002 3.71
12 The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila. Genes Dev 2004 3.59
13 A high-quality catalog of the Drosophila melanogaster proteome. Nat Biotechnol 2007 3.34
14 The DrosDel deletion collection: a Drosophila genomewide chromosomal deficiency resource. Genetics 2007 3.08
15 Drosophila egg-laying site selection as a system to study simple decision-making processes. Science 2008 2.50
16 The WW domain protein Kibra acts upstream of Hippo in Drosophila. Dev Cell 2010 2.34
17 dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1. Nat Cell Biol 2002 2.31
18 Identification and functional characterization of N-terminally acetylated proteins in Drosophila melanogaster. PLoS Biol 2009 2.25
19 Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB. Science 2002 2.05
20 A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity. Mol Cell Proteomics 2005 1.95
21 Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs. PLoS One 2008 1.95
22 Model for the regulation of size in the wing imaginal disc of Drosophila. Mech Dev 2006 1.76
23 Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance. J Biol 2008 1.65
24 The Drosophila insulin/IGF receptor controls growth and size by modulating PtdInsP(3) levels. Development 2002 1.60
25 Exploring the effects of mechanical feedback on epithelial topology. Development 2010 1.59
26 A universal method for automated gene mapping. Genome Biol 2005 1.50
27 Overgrowth caused by misexpression of a microRNA with dispensable wild-type function. Dev Biol 2006 1.43
28 Knockout of 'metal-responsive transcription factor' MTF-1 in Drosophila by homologous recombination reveals its central role in heavy metal homeostasis. EMBO J 2003 1.33
29 Substrate-dependent control of MAPK phosphorylation in vivo. Mol Syst Biol 2011 1.26
30 The Drosophila mitochondrial ribosomal protein mRpL12 is required for Cyclin D/Cdk4-driven growth. EMBO J 2005 1.25
31 The Drosophila SH2B family adaptor Lnk acts in parallel to chico in the insulin signaling pathway. PLoS Genet 2009 1.17
32 Diet-dependent effects of the Drosophila Mnk1/Mnk2 homolog Lk6 on growth via eIF4E. Curr Biol 2005 1.14
33 Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of rapamycin interaction proteome. Mol Syst Biol 2011 1.12
34 The Drosophila melanogaster PeptideAtlas facilitates the use of peptide data for improved fly proteomics and genome annotation. BMC Bioinformatics 2009 1.06
35 Biochemical membrane lipidomics during Drosophila development. Dev Cell 2012 1.02
36 Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk. PLoS Genet 2010 1.01
37 The Drosophila dual-specificity ERK phosphatase DMKP3 cooperates with the ERK tyrosine phosphatase PTP-ER. Development 2003 1.00
38 A combined proteomic and genetic analysis identifies a role for the lipid desaturase Desat1 in starvation-induced autophagy in Drosophila. Autophagy 2009 1.00
39 MK2-dependent p38b signalling protects Drosophila hindgut enterocytes against JNK-induced apoptosis under chronic stress. PLoS Genet 2011 1.00
40 Maternal-effect loci involved in Drosophila oogenesis and embryogenesis: P element-induced mutations on the third chromosome. Int J Dev Biol 2002 1.00
41 High-resolution SNP mapping by denaturing HPLC. Proc Natl Acad Sci U S A 2002 0.97
42 A proteome catalog of Drosophila melanogaster: an essential resource for targeted quantitative proteomics. Fly (Austin) 2007 0.94
43 Susi, a negative regulator of Drosophila PI3-kinase. Dev Cell 2005 0.92
44 Bunched, the Drosophila homolog of the mammalian tumor suppressor TSC-22, promotes cellular growth. BMC Dev Biol 2008 0.92
45 An efficient method to generate chromosomal rearrangements by targeted DNA double-strand breaks in Drosophila melanogaster. Genome Res 2004 0.92
46 Playing a part in research? University students' attitudes to direct-to-consumer genomics. Public Health Genomics 2014 0.92
47 The lack of autophagy triggers precocious activation of Notch signaling during Drosophila oogenesis. BMC Dev Biol 2012 0.90
48 Madm (Mlf1 adapter molecule) cooperates with Bunched A to promote growth in Drosophila. J Biol 2010 0.90
49 Bernard Lerer: recipient of the 2014 inaugural Werner Kalow Responsible Innovation Prize in Global Omics and Personalized Medicine (Pacific Rim Association for Clinical Pharmacogenetics). OMICS 2014 0.89
50 The hemolymph proteome of fed and starved Drosophila larvae. PLoS One 2013 0.88
51 Drosophila cbl is essential for control of cell death and cell differentiation during eye development. PLoS One 2008 0.88
52 SOCS36E specifically interferes with Sevenless signaling during Drosophila eye development. Dev Biol 2008 0.88
53 Csk differentially regulates Src64 during distinct morphological events in Drosophila germ cells. Development 2006 0.85
54 Targeted expression of the class II phosphoinositide 3-kinase in Drosophila melanogaster reveals lipid kinase-dependent effects on patterning and interactions with receptor signaling pathways. Mol Cell Biol 2004 0.84
55 The Drosophila homolog of human tumor suppressor TSC-22 promotes cellular growth, proliferation, and survival. Proc Natl Acad Sci U S A 2008 0.84
56 The Cdi/TESK1 kinase is required for Sevenless signaling and epithelial organization in the Drosophila eye. J Cell Sci 2006 0.81
57 Nutrient restriction enhances the proliferative potential of cells lacking the tumor suppressor PTEN in mitotic tissues. Elife 2013 0.81
58 The nuclear receptor DHR3 modulates dS6 kinase-dependent growth in Drosophila. PLoS Genet 2010 0.81
59 A reverse genetic screen in Drosophila using a deletion-inducing mutagen. Genome Biol 2004 0.80
60 Use of anionic denaturing detergents to purify insoluble proteins after overexpression. BMC Biotechnol 2012 0.79
61 The RNA-binding proteins FMR1, rasputin and caprin act together with the UBA protein lingerer to restrict tissue growth in Drosophila melanogaster. PLoS Genet 2013 0.79
62 The Lnk/SH2B adaptor provides a fail-safe mechanism to establish the Insulin receptor-Chico interaction. Cell Commun Signal 2013 0.79
63 Local requirement of the Drosophila insulin binding protein imp-L2 in coordinating developmental progression with nutritional conditions. Dev Biol 2013 0.78