Published in Dev Cell on September 01, 2007
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Induction of diabetes in aged C57B6 mice results in severe nephropathy: an association with oxidative stress, endoplasmic reticulum stress, and inflammation. Am J Pathol (2010) 1.34
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Cigarette smoke induces endoplasmic reticulum stress and the unfolded protein response in normal and malignant human lung cells. BMC Cancer (2008) 1.28
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ATF6beta is a host cellular target of the Toxoplasma gondii virulence factor ROP18. J Exp Med (2011) 1.21
Coronavirus infection modulates the unfolded protein response and mediates sustained translational repression. J Virol (2008) 1.19
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CDK5 and MEKK1 mediate pro-apoptotic signalling following endoplasmic reticulum stress in an autosomal dominant retinitis pigmentosa model. Nat Cell Biol (2012) 1.17
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Endoplasmic reticulum stress and the unfolded protein responses in retinal degeneration. Exp Eye Res (2014) 1.14
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Deficiency of suppressor enhancer Lin12 1 like (SEL1L) in mice leads to systemic endoplasmic reticulum stress and embryonic lethality. J Biol Chem (2010) 1.14
The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in β-cells. Diabetes Obes Metab (2010) 1.14
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Stress signaling in the methionine-choline-deficient model of murine fatty liver disease. Gastroenterology (2010) 1.13
Protein misfolding induces hypoxic preconditioning via a subset of the unfolded protein response machinery. Mol Cell Biol (2010) 1.12
Mutations in the unfolded protein response regulator ATF6 cause the cone dysfunction disorder achromatopsia. Nat Genet (2015) 1.12
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The endoplasmic reticulum stress sensor, ATF6α, protects against neurotoxin-induced dopaminergic neuronal death. J Biol Chem (2010) 1.09
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Selective activation of the transcription factor ATF6 mediates endoplasmic reticulum proliferation triggered by a membrane protein. Proc Natl Acad Sci U S A (2011) 1.07
The cell stress machinery and retinal degeneration. FEBS Lett (2013) 1.07
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DangER: protein ovERload. Targeting protein degradation to treat myeloma. Haematologica (2012) 1.06
Despite increased ATF4 binding at the C/EBP-ATF composite site following activation of the unfolded protein response, system A transporter 2 (SNAT2) transcription activity is repressed in HepG2 cells. J Biol Chem (2008) 1.06
Hyperactivity of the Ero1α oxidase elicits endoplasmic reticulum stress but no broad antioxidant response. J Biol Chem (2012) 1.06
MicroRNA-30c-2* limits expression of proadaptive factor XBP1 in the unfolded protein response. J Cell Biol (2012) 1.05
Monitoring and manipulating mammalian unfolded protein response. Methods Enzymol (2011) 1.05
Transcriptional regulation of the Ufm1 conjugation system in response to disturbance of the endoplasmic reticulum homeostasis and inhibition of vesicle trafficking. PLoS One (2012) 1.05
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Cell type-specific transcriptomics of hypothalamic energy-sensing neuron responses to weight-loss. Elife (2015) 1.05
Acute ablation of PERK results in ER dysfunctions followed by reduced insulin secretion and cell proliferation. BMC Cell Biol (2009) 1.04
C/EBP homologous protein (CHOP) contributes to suppression of metabolic genes during endoplasmic reticulum stress in the liver. J Biol Chem (2012) 1.04
AATF mediates an antiapoptotic effect of the unfolded protein response through transcriptional regulation of AKT1. Cell Death Differ (2009) 1.03
RNA surveillance is required for endoplasmic reticulum homeostasis. Proc Natl Acad Sci U S A (2012) 1.03
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IRE1alpha controls cyclin A1 expression and promotes cell proliferation through XBP-1. Cell Stress Chaperones (2009) 1.01
A modified UPR stress sensing system reveals a novel tissue distribution of IRE1/XBP1 activity during normal Drosophila development. Cell Stress Chaperones (2012) 1.00
Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins. PLoS Biol (2006) 6.45
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes Dev (2002) 6.37
A time-dependent phase shift in the mammalian unfolded protein response. Dev Cell (2003) 4.99
XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum. J Cell Biol (2004) 4.03
XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. Cancer Res (2004) 3.24
The Rab8 GTPase regulates apical protein localization in intestinal cells. Nature (2007) 3.01
Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation. J Cell Biol (2006) 2.76
Tumor necrosis factor alpha (TNFalpha) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFalpha. J Biol Chem (2005) 2.71
Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT3 mutant AML in first relapse. Blood (2011) 2.66
pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response. J Cell Biol (2006) 2.62
Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II. J Biochem (2004) 2.62
Impaired flow-dependent control of vascular tone and remodeling in P2X4-deficient mice. Nat Med (2005) 2.59
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ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum. Cell Struct Funct (2008) 2.42
Hepatitis C virus subgenomic replicons induce endoplasmic reticulum stress activating an intracellular signaling pathway. J Virol (2002) 2.39
Assessment of individual radionuclide distributions from the Fukushima nuclear accident covering central-east Japan. Proc Natl Acad Sci U S A (2011) 2.29
Hepatitis C virus suppresses the IRE1-XBP1 pathway of the unfolded protein response. J Biol Chem (2004) 2.29
Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis. J Hepatol (2003) 2.28
Usefulness of mitral annular velocity in predicting exercise tolerance in patients with impaired left ventricular systolic function. Am J Cardiol (2006) 2.14
Elevated levels of serum advanced glycation end products in patients with non-alcoholic steatohepatitis. J Gastroenterol Hepatol (2007) 1.85
Homozygous deletion scanning of the lung cancer genome at a 100-kb resolution. Genes Chromosomes Cancer (2007) 1.77
Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow. Proc Natl Acad Sci U S A (2009) 1.74
Suppressive function of androgen receptor in bone resorption. Proc Natl Acad Sci U S A (2003) 1.72
Induction of liver steatosis and lipid droplet formation in ATF6alpha-knockout mice burdened with pharmacological endoplasmic reticulum stress. Mol Biol Cell (2010) 1.70
The anti-apoptotic role of the unfolded protein response in Bcr-Abl-positive leukemia cells. Leuk Res (2009) 1.69
Inspection of safety and accuracy of D2 lymph node dissection in laparoscopy-assisted distal gastrectomy. World J Surg (2008) 1.68
Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP. J Biol Chem (2002) 1.68
Involvement of Propionibacterium acnes in the augmentation of lipogenesis in hamster sebaceous glands in vivo and in vitro. J Invest Dermatol (2009) 1.67
Noroviruses distinguish between type 1 and type 2 histo-blood group antigens for binding. J Virol (2008) 1.65
Regulation of endocytic recycling by C. elegans Rab35 and its regulator RME-4, a coated-pit protein. EMBO J (2008) 1.65
Augmentation of lipogenesis by 15-deoxy-Delta12,14-prostaglandin J2 in hamster sebaceous glands: identification of cytochrome P-450-mediated 15-deoxy-Delta12,14-prostaglandin J2 production. J Invest Dermatol (2005) 1.64
Harmonin mutations cause mechanotransduction defects in cochlear hair cells. Neuron (2009) 1.63
Role of disulfide bridges formed in the luminal domain of ATF6 in sensing endoplasmic reticulum stress. Mol Cell Biol (2006) 1.60
Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis. Circulation (2013) 1.60
A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6. J Biol Chem (2003) 1.57
A comparison of the defective granulopoiesis in childhood cyclic neutropenia and in severe congenital neutropenia. Haematologica (2005) 1.53
Deletion of Atf6α impairs astroglial activation and enhances neuronal death following brain ischemia in mice. J Neurochem (2015) 1.48
Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity. Curr Biol (2002) 1.47
Reduction of disulfide bridges in the lumenal domain of ATF6 in response to glucose starvation. Cell Struct Funct (2006) 1.47
C1galt1-deficient mice exhibit thrombocytopenia due to abnormal terminal differentiation of megakaryocytes. Blood (2013) 1.45
A thrombospondin-dependent pathway for a protective ER stress response. Cell (2012) 1.45
An HLA-A24-restricted cytotoxic T lymphocyte epitope of a tumor-associated protein, survivin. Clin Cancer Res (2002) 1.45
Premature ovarian failure in androgen receptor-deficient mice. Proc Natl Acad Sci U S A (2005) 1.44
TDAG8 is a proton-sensing and psychosine-sensitive G-protein-coupled receptor. J Biol Chem (2004) 1.42
Comparison of clinical effectiveness between surgical and endovascular treatment for thrombotic obstruction in hemodialysis access. J Vasc Access (2011) 1.41
Activation of the FGF2-FGFR1 autocrine pathway: a novel mechanism of acquired resistance to gefitinib in NSCLC. Mol Cancer Res (2013) 1.40
Unconventional splicing of XBP1 mRNA occurs in the cytoplasm during the mammalian unfolded protein response. J Cell Sci (2009) 1.39
Involvement of proton-sensing TDAG8 in extracellular acidification-induced inhibition of proinflammatory cytokine production in peritoneal macrophages. J Immunol (2009) 1.39
ATF6 modulates SREBP2-mediated lipogenesis. EMBO J (2004) 1.36
A catalog of genes homozygously deleted in human lung cancer and the candidacy of PTPRD as a tumor suppressor gene. Genes Chromosomes Cancer (2010) 1.33
The endoplasmic reticulum stress response is stimulated through the continuous activation of transcription factors ATF6 and XBP1 in Ins2+/Akita pancreatic beta cells. Genes Cells (2004) 1.32
Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice. J Clin Invest (2012) 1.31
p53 regulates Toll-like receptor 3 expression and function in human epithelial cell lines. Mol Cell Biol (2008) 1.29
Distributions of beta+ decayed nuclei generated in the CH2 and H2O targets by the target nuclear fragment reaction using therapeutic MONO and SOBP proton beam. Med Phys (2005) 1.29
Divergent movement of adjacent whiskers. J Neurophysiol (2002) 1.29
Activation of mammalian unfolded protein response is compatible with the quality control system operating in the endoplasmic reticulum. Mol Biol Cell (2004) 1.29
A novel strategy for mammalian cell surface glycome profiling using lectin microarray. Glycobiology (2007) 1.27
CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases. Adv Drug Deliv Rev (2009) 1.27
Polylactosamine on glycoproteins influences basal levels of lymphocyte and macrophage activation. Proc Natl Acad Sci U S A (2007) 1.27
Rab11 is required for synchronous secretion of chondroitin proteoglycans after fertilization in Caenorhabditis elegans. J Cell Sci (2008) 1.27
Synergistic effect between proteasome and autophagosome in the clearance of polyubiquitinated TDP-43. J Neurosci Res (2010) 1.26
Defective function of GABA-containing synaptic vesicles in mice lacking the AP-3B clathrin adaptor. J Cell Biol (2004) 1.22
Dysfunction of the unfolded protein response during global brain ischemia and reperfusion. J Cereb Blood Flow Metab (2003) 1.21
Cellular function of calcium-independent phospholipase A2. Biol Pharm Bull (2004) 1.20
Androgen receptor gene knockout male mice exhibit impaired cardiac growth and exacerbation of angiotensin II-induced cardiac fibrosis. J Biol Chem (2005) 1.20
Beta-hydroxybutyrate, a cerebral function improving agent, protects rat brain against ischemic damage caused by permanent and transient focal cerebral ischemia. Jpn J Pharmacol (2002) 1.20
Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers. Mol Cell Biol (2002) 1.17
Alg14 recruits Alg13 to the cytoplasmic face of the endoplasmic reticulum to form a novel bipartite UDP-N-acetylglucosamine transferase required for the second step of N-linked glycosylation. J Biol Chem (2005) 1.16
Three-dimensional nanometry of vesicle transport in living cells using dual-focus imaging optics. Biochem Biophys Res Commun (2007) 1.11
A potent immunogenic general cancer vaccine that targets survivin, an inhibitor of apoptosis proteins. Clin Cancer Res (2005) 1.10
A role for the unfolded protein response in optimizing antibody secretion. Mol Immunol (2004) 1.10
The fusion oncoprotein PML-RARalpha induces endoplasmic reticulum (ER)-associated degradation of N-CoR and ER stress. J Biol Chem (2003) 1.10