Published in Science on December 07, 1984
Platelet factor 4 is chemotactic for neutrophils and monocytes. Proc Natl Acad Sci U S A (1981) 3.03
Amphiphilic secondary structure: design of peptide hormones. Science (1984) 2.71
Secondary structures of proteins and peptides in amphiphilic environments. (A review). Proc Natl Acad Sci U S A (1983) 2.26
Kinetics and mechanism of hemolysis induced by melittin and by a synthetic melittin analogue. Biophys J (1982) 2.03
The interaction of hemoglobin with the cytoplasmic domain of band 3 of the human erythrocyte membrane. J Biol Chem (1984) 1.83
Identification of a mutant human insulin predicted to contain a serine-for-phenylalanine substitution. Proc Natl Acad Sci U S A (1983) 1.67
Peptides with affinity for membranes. Annu Rev Biophys Biophys Chem (1987) 1.63
Design and characterization of peptides with amphiphilic beta-strand structures. J Cell Biochem (1985) 1.51
The mechanism of activation of lecithin:cholesterol acyltransferase by apolipoprotein A-I and an amphiphilic peptide. J Biol Chem (1980) 1.50
Idealization of the hydrophobic segment of the alkaline phosphatase signal peptide. Nature (1986) 1.34
The carboxyl-terminal tridecapeptide of platelet factor 4 is a potent chemotactic agent for monocytes. Biochem Biophys Res Commun (1982) 1.28
Purification and characterization of the principal inhibitor of calcium oxalate monohydrate crystal growth in human urine. J Biol Chem (1983) 1.22
Semisynthesis and biological activity of porcine [LeuB24]insulin and [LeuB25]insulin. Proc Natl Acad Sci U S A (1980) 1.16
Binding of amphiphilic peptides to phospholipid/cholesterol unilamellar vesicles: a model for protein--cholesterol interaction. Proc Natl Acad Sci U S A (1981) 1.15
Sulfhydryl group reactivity of adenosine 3',5'-monophosphate dependent protein kinase from bovine heart: a probe of holoenzyme structure. Biochemistry (1978) 1.15
An antipeptide antibody that specifically inhibits insulin receptor autophosphorylation and protein kinase activity. Proc Natl Acad Sci U S A (1985) 1.11
Design, synthesis, and characterization of a model peptide having potent calcitonin-like biological activity: implications for calcitonin structure/activity. Biochemistry (1985) 1.09
pH dependence of the hydrolysis of O-acetyl-L-mandelate catalyzed by carboxypeptidase A. A critical examination. J Am Chem Soc (1966) 1.06
Purification and characterization of a calcium oxalate monohydrate crystal growth inhibitor from human kidney tissue culture medium. J Biol Chem (1981) 1.05
Modification of the catalytic subunit of bovine heart cAMP-dependent protein kinase with affinity labels related to peptide substrates. J Biol Chem (1982) 1.04
Chain length-function correlation of amphiphilic peptides. Synthesis and surface properties of a tetratetracontapeptide segment of apolipoprotein A-I. J Biol Chem (1980) 1.04
[LeuB24]insulin and [AlaB24]insulin: altered structures and cellular processing of B24-substituted insulin analogs. Proc Natl Acad Sci U S A (1982) 1.04
Protein kinase C phosphorylates the synthetic peptide Arg-Arg-Lys-Ala-Ser-Gly-Pro-Pro-Val in the presence of phospholipid plus either Ca2+ or a phorbol ester tumor promoter. Biochem Biophys Res Commun (1984) 1.04
pH dependence of the nitrotyrosine-248 and arsanilazotyrosine-248 carboxypeptidase A catalyzed hydrolysis of O-(trans-p-chlorocinnamoyl)-L-beta-phenyllactate. J Am Chem Soc (1976) 1.03
Magnetic resonance and kinetic studies of the manganese(II) ion and substrate complexes of the catalytic subunit of adenosine 3',5'-monophosphate dependent protein kinase from bovine heart. Biochemistry (1979) 1.02
Mechanism of action of carboxypeptidase A in ester hydrolysis. Proc Natl Acad Sci U S A (1976) 1.01
pPH dependence and competitive product inhibition of the carboxypeptidase A catalyzed hydrolysis of O-(trans-cinnamoyl)-L-beta-phenyllactate. J Am Chem Soc (1969) 1.01
Structural characterization of beta-endorphin through the design, synthesis, and study of model peptides. Mol Pharmacol (1982) 0.99
Surface properties of an amphiphilic peptide hormone and of its analog: corticotropin-releasing factor and sauvagine. Proc Natl Acad Sci U S A (1983) 0.99
Modification of the active site of alkaline phosphatase by site-directed mutagenesis. Science (1986) 0.99
Phosphorylation of histone catalyzed by a bovine brain protein kinase. J Biol Chem (1976) 0.98
Magnetic resonance measurements of intersubstrate distances at the active site of protein kinase using substitution-inert cobalt(III) and chromium(III) complexes of adenosine 5'-(beta, gamma-methylenetriphosphate). Biochemistry (1980) 0.98
NMR studies of the backbone protons and secondary structure of pentapeptide and heptapeptide substrates bound to bovine heart protein kinase. Biochemistry (1984) 0.96
Biological properties of two models of calcitonin gene related peptide with idealized amphiphilic alpha-helices of different lengths. Biochemistry (1988) 0.95
A chemically synthesized Antennapedia homeo domain binds to a specific DNA sequence. Science (1988) 0.95
Mechanistic studies of cAMP-dependent protein kinase action. CRC Crit Rev Biochem (1984) 0.95
The pH dependence of the pepsin-catalyzed hydrolysis of N-acetyl-L-phenylalanyl-L-3,5-dibromotyrosine. J Am Chem Soc (1967) 0.95
The structural characterization of beta-endorphin and related peptide hormones and neurotransmitters. Pharmacol Rev (1986) 0.94
Nuclear magnetic resonance studies of the conformation and kinetics of the peptide-substrate at the active site of bovine heart protein kinase. Biochemistry (1981) 0.94
Magnetic resonance studies of the effect of the regulatory subunit on metal and substrate binding to the catalytic subunit of bovine heart protein kinase. J Biol Chem (1980) 0.93
Introduction of guest peptides into Escherichia coli alkaline phosphatase. Excision and purification of a dynorphin analogue from an active chimeric protein. J Biol Chem (1990) 0.93
Identification of amino acid residues involved in substrate recognition by the catalytic subunit of bovine cyclic AMP dependent protein kinase: peptide-based affinity labels. Biochemistry (1988) 0.92
Effect of D2O on the carboxypeptidase-catalyzed hydrolysis of O-(trans-cinnamoyl)-L-beta-phenyllactate and N-(N-benzoylglycyl)-L-phenylalanine. Proc Natl Acad Sci U S A (1969) 0.92
Structure-function analysis of proteins through the design, synthesis, and study of peptide models. Methods Enzymol (1987) 0.91
Biological and physical properties of a beta-endorphin analog containing only D-amino acids in the amphiphilic helical segment 13-31. J Biol Chem (1984) 0.90
Chemical mutation of enzyme active sites. Science (1984) 0.90
The hydrolysis of O-hippuryglycolate catalyzed by carboxypeptidase A. Evidence for possible allosteric effects. Biochem Biophys Res Commun (1965) 0.89
Use of site-directed mutagenesis to elucidate the role of arginine-166 in the catalytic mechanism of alkaline phosphatase. Proc Natl Acad Sci U S A (1988) 0.89
Isolation and characterization of calcium oxalate crystal growth inhibitors from human urine. Biochem Biophys Res Commun (1978) 0.89
Cyclic AMP-dependent ATPase activity of bovine heart protein kinase. Proc Natl Acad Sci U S A (1979) 0.88
A method for probing the affinity of peptides for amphiphilic surfaces. Anal Biochem (1985) 0.87
Studies of the mechanism of action and regulation of cAMP-dependent protein kinase. Arch Biochem Biophys (1980) 0.86
Synapsin I is a highly surface-active molecule. J Biol Chem (1991) 0.86
A kinetic study of interactions of (Rp)- and (Sp)-adenosine cyclic 3',5'-phosphorothioates with type II bovine cardiac muscle adenosine cyclic 3',5'-phosphate dependent protein kinase. Biochemistry (1982) 0.85
Design and synthesis of the pseudo-EF hand in calbindin D9K: effect of amino acid substitutions in the alpha-helical regions. Proteins (1991) 0.84
Design of an effective mechanism-based inactivator for a zinc protease. Proc Natl Acad Sci U S A (1990) 0.84
Studies on the solid-phase synthesis of bovine pancreatic trypsin inhibitor (Kunitz) and the characterization of the synthetic material. J Org Chem (1976) 0.84
Photoaffinity labeling the substance P receptor using a derivative of substance P containing p-benzoylphenylalanine. Biochemistry (1991) 0.83
Probing the peptide binding site of the cAMP-dependent protein kinase by using a peptide-based photoaffinity label. Proc Natl Acad Sci U S A (1988) 0.83
A search for an intermediate in carboxypeptidase A catalyzed ester hydrolyses. J Am Chem Soc (1970) 0.83
New reagents for the introduction of the thiomethyl group at sulfhydryl residues of proteins with concomitant spectrophotometric titration of the sulfhydryls: methyl 3-nitro-2-pyridyl disulfide and methyl 2-pyridyl disulfide. Anal Biochem (1982) 0.83
The chemical modification of enzymatic specificity. Annu Rev Biochem (1985) 0.83
A functional decaisoleucine-containing signal sequence. Construction by cassette mutagenesis. J Biol Chem (1988) 0.83
Characterization of amphiphilic secondary structures in neuropeptide Y through the design, synthesis, and study of model peptides. J Biol Chem (1989) 0.82
A comparative analysis of single- and multiple-residue substitutions in the alkaline phosphatase signal peptide. Biopolymers (1990) 0.82
Reaction of a six-membered cyclic sulfonate ester, -(2-hydroxy-3,5-dinitrophenyl)ethanesulfonic acid sultone, with the active site of papain. J Am Chem Soc (1973) 0.82
Signal peptide subsegments are not always functionally interchangeable. M13 procoat hydrophobic core fails to transport alkaline phosphatase in Escherichia coli. J Biol Chem (1989) 0.81
Purification of recombinant pp60v-src protein tyrosine kinase and phosphorylation of peptides with different secondary structure preference. Biochemistry (1989) 0.81
Affinity chromatographic purification of papain. Int J Pept Protein Res (1979) 0.81
Mechanistic studies of carboxypeptidase Y. Kinetic detection of an acyl-enzyme intermediate in trimethylacetate esterase action. J Am Chem Soc (1976) 0.81
Role of enzyme-peptide substrate backbone hydrogen bonding in determining protein kinase substrate specificities. Biochemistry (1987) 0.81
Synthesis and biological evaluation of pNPY fragments. Int J Pept Protein Res (1988) 0.81
The design of peptides and proteins. Ann N Y Acad Sci (1986) 0.80
The use of N-methylated peptides and depsipeptides to probe the binding of heptapeptide substrates to cAMP-dependent protein kinase. J Biol Chem (1985) 0.80
Amphiphilic cationic peptides mediate cell adhesion to plastic surfaces. J Cell Physiol (1985) 0.80
Use of NMR and EPR to study cAMP-dependent protein kinase. Methods Enzymol (1983) 0.80
Development of helix-based vasoactive intestinal peptide analogues: identification of residues required for receptor interaction. Biochemistry (1988) 0.80
Opioid receptor selectivity of peptide models of beta-endorphin. Int J Pept Protein Res (1989) 0.79
Ionic inhibition of catalytic phosphorylation of histone by bovine brain protein kinase. J Biol Chem (1977) 0.79
Design of biologically active peptides with non-peptidic structural elements. Biological and physical properties of a synthetic analogue of beta-endorphin with unnatural amino acids in the region 6-12. J Biol Chem (1986) 0.79
Studies on the interactions of spin-labeled substrates with chymotrypsin and with cycloamyloses. J Am Chem Soc (1975) 0.79
Inactivation of phosphofructokinase by dialdehyde-ATP. Arch Biochem Biophys (1979) 0.79
Multiple forms of carboxypeptidase Y from Saccharomyces cerevisiae. Kinetic demonstration of effects of carbohydrate residues on the catalytic mechanism of a glycoenzyme. J Biol Chem (1978) 0.79
Heterogeneity of glucagon receptors of rat hepatocytes: a synthetic peptide probe for the high affinity site. Biochem Biophys Res Commun (1984) 0.79
Semisynthetic enzymes: design of flavin-dependent oxidoreductases. Biotechnol Genet Eng Rev (1987) 0.78
Distinguishing among protein kinases by substrate specificities. Biochemistry (1987) 0.78
Nuclear magnetic resonance studies of the conformation of tetraamminecobalt (III)--ATP bound at the active site of bovine heart protein kinase. Biochemistry (1979) 0.78
Specificity of bovine heart protein kinase for the delta-stereoisomer of the metal--ATP complex. FEBS Lett (1979) 0.78
Flavopapain: synthesis and properties of semi-synthetic enzymes. Biochem Biophys Res Commun (1977) 0.78
Characterization of an amphiphilic helical structure in beta-endorphin through the design, synthesis, and study of model peptides. J Biol Chem (1983) 0.78
Inactivation of the catalytic subunit of bovine cAMP-dependent protein kinase by a peptide-based affinity inactivator. Biopolymers (1990) 0.78
Inhibition of the pepsin catalyzed hydrolysis of diphenyl sulfite by N-acetyl-L-phenyl-alanine, 3,5-dibromo-L-tryosine and N-acetyl-L-phenylalanyl-3,5-dibromo-L-tyrosine. Arch Biochem Biophys (1968) 0.77
Nuclear Overhauser effect studies of the conformations of tetraamminecobalt(III)-adenosine 5'-triphosphate free and bound to bovine heart protein kinase. Biochemistry (1983) 0.77
Synthesis, purification, and characterization of the A and B diastereomers of gamma-32P-labeled adenosine 5'-O-(2-thiotriphosphate). J Biol Chem (1980) 0.77
Synthesis and structural stability of helichrome as an artificial hemeproteins. Biopolymers (1990) 0.77
Design and biological activity of analogs of growth hormone releasing factor with potential amphiphilic helical carboxyl termini. Proc Natl Acad Sci U S A (1986) 0.77
Stereochemical and kinetic studies on the action of the catalytic subunit of bovine cardiac muscle adenosine 3',5'-monophosphate dependent protein kinase using metal ion complexes of ATP beta S. Biochemistry (1980) 0.77
NMR studies of the mechanism of action and regulation of protein kinase. Curr Top Cell Regul (1985) 0.77
On the action of carboxypeptidase A on ester substrates in alkaline solution. Biochem Biophys Res Commun (1972) 0.77
Use of directed mutagenesis to probe the role of tyrosine 198 in the catalytic mechanism of carboxypeptidase A. J Biol Chem (1987) 0.76