Published in Proc Natl Acad Sci U S A on May 01, 2012
Shear stress-initiated signaling and its regulation of endothelial function. Arterioscler Thromb Vasc Biol (2014) 1.12
Molecular imaging of inflammation in atherosclerosis. Theranostics (2013) 1.08
Circulating Bmp10 acts through endothelial Alk1 to mediate flow-dependent arterial quiescence. Development (2013) 0.94
Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow. Nature (2016) 0.90
Endothelial Msx1 transduces hemodynamic changes into an arteriogenic remodeling response. J Cell Biol (2015) 0.83
Cells gain traction in 3D. Proc Natl Acad Sci U S A (2012) 0.81
Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia. J Cell Biol (2016) 0.80
The BMP Pathway Participates in Human Naive CD4+ T Cell Activation and Homeostasis. PLoS One (2015) 0.80
Integrated Regional Cardiac Hemodynamic Imaging and RNA Sequencing Reveal Corresponding Heterogeneity of Ventricular Wall Shear Stress and Endocardial Transcriptome. J Am Heart Assoc (2016) 0.75
Blood flow boosts BMP signaling to keep vessels in shape. J Cell Biol (2016) 0.75
Cardiovascular disease: A turbulent path to plaque formation. Nature (2016) 0.75
Secreted miR-27a Induced by Cyclic Stretch Modulates the Proliferation of Endothelial Cells in Hypertension via GRK6. Sci Rep (2017) 0.75
Blood Brothers: Hemodynamics and Cell-Matrix Interactions in Endothelial Function. Antioxid Redox Signal (2016) 0.75
BMP-SMAD signalling output is highly regionalized in cardiovascular and lymphatic endothelial networks. BMC Dev Biol (2016) 0.75
Regulators and effectors of bone morphogenetic protein signalling in the cardiovascular system. J Physiol (2015) 0.75
Dickkopf-3 Upregulates VEGF in Cultured Human Endothelial Cells by Activating Activin Receptor-Like Kinase 1 (ALK1) Pathway. Front Pharmacol (2017) 0.75
VAMP3 and SNAP23 mediate the disturbed flow-induced endothelial microRNA secretion and smooth muscle hyperplasia. Proc Natl Acad Sci U S A (2017) 0.75
Endothelial cells respond to the direction of mechanical stimuli through SMAD signaling to regulate coronary artery size. Development (2017) 0.75
Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives. Physiol Rev (2011) 5.51
Mechanotransduction in vascular physiology and atherogenesis. Nat Rev Mol Cell Biol (2009) 4.58
Bone morphogenetic protein expression in human atherosclerotic lesions. J Clin Invest (1993) 4.54
A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Arterioscler Thromb Vasc Biol (1995) 4.43
Laminar shear stress: mechanisms by which endothelial cells transduce an atheroprotective force. Arterioscler Thromb Vasc Biol (1998) 4.19
Oscillatory shear stress stimulates adhesion molecule expression in cultured human endothelium. Circ Res (1998) 2.37
Hemodynamic shear stresses in mouse aortas: implications for atherogenesis. Arterioscler Thromb Vasc Biol (2006) 2.34
Hemodynamic forces are complex regulators of endothelial gene expression. FASEB J (1995) 2.23
Vascular endothelium responds to fluid shear stress gradients. Arterioscler Thromb (1992) 2.21
Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress stimulates an inflammatory response. J Biol Chem (2003) 2.03
Transforming growth factor-betas and vascular disorders. Arterioscler Thromb Vasc Biol (2006) 1.99
Connexin43 is highly localized to sites of disturbed flow in rat aortic endothelium but connexin37 and connexin40 are more uniformly distributed. Circ Res (1998) 1.90
Spatial and temporal regulation of gap junction connexin43 in vascular endothelial cells exposed to controlled disturbed flows in vitro. Proc Natl Acad Sci U S A (1999) 1.75
Regulation of endothelial cell cycle by laminar versus oscillatory flow: distinct modes of interactions of AMP-activated protein kinase and Akt pathways. Circ Res (2007) 1.48
Effects of disturbed flow on endothelial cells. J Biomech Eng (1998) 1.44
Molecular and mechanical bases of focal lipid accumulation in arterial wall. Prog Biophys Mol Biol (2003) 1.24
Rapid endothelial turnover in atherosclerosis-prone areas coincides with stem cell repair in apolipoprotein E-deficient mice. Circulation (2008) 1.23
Histone deacetylase 3 is critical in endothelial survival and atherosclerosis development in response to disturbed flow. Circulation (2009) 1.21
BMP-4 induction of arrest and differentiation of osteoblast-like cells via p21 CIP1 and p27 KIP1 regulation. Mol Endocrinol (2009) 1.02
Effects of different types of fluid shear stress on endothelial cell proliferation and survival. J Cell Physiol (2007) 0.99
Spatial hemodynamics, the endothelium, and focal atherogenesis: a cell cycle link? Circ Res (2000) 0.94
Preferential activation of SMAD1/5/8 on the fibrosa endothelium in calcified human aortic valves--association with low BMP antagonists and SMAD6. PLoS One (2011) 0.93
Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives. Physiol Rev (2011) 5.51
Visualizing the mechanical activation of Src. Nature (2005) 4.63
An extracellular matrix microarray for probing cellular differentiation. Nat Methods (2005) 4.35
Molecular basis of the effects of shear stress on vascular endothelial cells. J Biomech (2005) 3.77
Stem cell fate dictated solely by altered nanotube dimension. Proc Natl Acad Sci U S A (2009) 3.73
Role of integrins in endothelial mechanosensing of shear stress. Circ Res (2002) 2.85
Cooperative effects of Rho and mechanical stretch on stress fiber organization. Proc Natl Acad Sci U S A (2005) 2.78
Activation of Rac1 by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression. EMBO J (2002) 2.46
A positive feedback mechanism governs the polarity and motion of motile cilia. Nature (2007) 2.44
Flow-Dependent Regulation of Kruppel-Like Factor 2 Is Mediated by MicroRNA-92a. Circulation (2011) 2.29
Effects of cell tension on the small GTPase Rac. J Cell Biol (2002) 2.24
Fluorescence proteins, live-cell imaging, and mechanobiology: seeing is believing. Annu Rev Biomed Eng (2008) 2.16
PKCδ signalling regulates SR-A and CD36 expression and foam cell formation. Cardiovasc Res (2012) 2.12
Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression. Mol Cell (2003) 2.09
Biochemistry and biomechanics of cell motility. Annu Rev Biomed Eng (2005) 2.08
Regulation of vascular smooth muscle cell turnover by endothelial cell-secreted microRNA-126: role of shear stress. Circ Res (2013) 2.04
Molecular basis of the effects of mechanical stretch on vascular smooth muscle cells. J Biomech (2006) 2.02
The role of the dynamics of focal adhesion kinase in the mechanotaxis of endothelial cells. Proc Natl Acad Sci U S A (2002) 2.01
Determination of hierarchical relationship of Src and Rac at subcellular locations with FRET biosensors. Proc Natl Acad Sci U S A (2008) 1.97
Klotho is a target gene of PPAR-gamma. Kidney Int (2008) 1.96
High glucose impairs early and late endothelial progenitor cells by modifying nitric oxide-related but not oxidative stress-mediated mechanisms. Diabetes (2007) 1.86
MicroRNA-19a mediates the suppressive effect of laminar flow on cyclin D1 expression in human umbilical vein endothelial cells. Proc Natl Acad Sci U S A (2010) 1.80
Live Cells Exert 3-Dimensional Traction Forces on Their Substrata. Cell Mol Bioeng (2009) 1.80
Rho mediates the shear-enhancement of endothelial cell migration and traction force generation. Biophys J (2004) 1.77
MicroRNA-21 targets peroxisome proliferators-activated receptor-alpha in an autoregulatory loop to modulate flow-induced endothelial inflammation. Proc Natl Acad Sci U S A (2011) 1.77
Combinatorial signaling microenvironments for studying stem cell fate. Stem Cells Dev (2008) 1.76
Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow. Proc Natl Acad Sci U S A (2009) 1.74
Role of microRNA-23b in flow-regulation of Rb phosphorylation and endothelial cell growth. Proc Natl Acad Sci U S A (2010) 1.73
Shear stress, SIRT1, and vascular homeostasis. Proc Natl Acad Sci U S A (2010) 1.68
Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis. Circulation (2013) 1.60
Shear stress regulation of Krüppel-like factor 2 expression is flow pattern-specific. Biochem Biophys Res Commun (2006) 1.57
Regulation of endothelial cell cycle by laminar versus oscillatory flow: distinct modes of interactions of AMP-activated protein kinase and Akt pathways. Circ Res (2007) 1.48
Localization and characterization of a novel secreted protein SCUBE1 in human platelets. Cardiovasc Res (2006) 1.48
Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout mice. Proc Natl Acad Sci U S A (2008) 1.48
Defining long-term maintenance conditions of human embryonic stem cells with arrayed cellular microenvironment technology. Stem Cells Dev (2009) 1.46
Shear stress increases ICAM-1 and decreases VCAM-1 and E-selectin expressions induced by tumor necrosis factor-[alpha] in endothelial cells. Arterioscler Thromb Vasc Biol (2003) 1.45
Endotoxin induces toll-like receptor 4 expression in vascular smooth muscle cells via NADPH oxidase activation and mitogen-activated protein kinase signaling pathways. Arterioscler Thromb Vasc Biol (2006) 1.45
Off-pump technique in coronary artery bypass grafting in elderly patients. ANZ J Surg (2003) 1.45
Suppression of pro-inflammatory adhesion molecules by PPAR-delta in human vascular endothelial cells. Arterioscler Thromb Vasc Biol (2007) 1.45
microRNA: a master regulator of cellular processes for bioengineering systems. Annu Rev Biomed Eng (2010) 1.44
Long-term human pluripotent stem cell self-renewal on synthetic polymer surfaces. Biomaterials (2010) 1.42
Integrins regulate VE-cadherin and catenins: dependence of this regulation on Src, but not on Ras. Proc Natl Acad Sci U S A (2006) 1.39
Comparisons of mechanical versus phase-array intracardiac echocardiography-assisted transseptal puncture in patients with dilated left atrium undergoing percutaneous transvenous mitral commissurotomy. J Chin Med Assoc (2010) 1.39
Effects of flow patterns on the localization and expression of VE-cadherin at vascular endothelial cell junctions: in vivo and in vitro investigations. J Vasc Res (2005) 1.37
Genomic analysis of smooth muscle cells in 3-dimensional collagen matrix. FASEB J (2002) 1.33
The role of human antigen R, an RNA-binding protein, in mediating the stabilization of toll-like receptor 4 mRNA induced by endotoxin: a novel mechanism involved in vascular inflammation. Arterioscler Thromb Vasc Biol (2006) 1.33
Ruptured congenital sinus of valsalva aneurysms. J Card Surg (2004) 1.32
Integrin activation and internalization on soft ECM as a mechanism of induction of stem cell differentiation by ECM elasticity. Proc Natl Acad Sci U S A (2011) 1.31
Flow activation of AMP-activated protein kinase in vascular endothelium leads to Krüppel-like factor 2 expression. Arterioscler Thromb Vasc Biol (2009) 1.30
The spatiotemporal pattern of Src activation at lipid rafts revealed by diffusion-corrected FRET imaging. PLoS Comput Biol (2008) 1.27
Regulation of stretch-induced JNK activation by stress fiber orientation. Cell Signal (2006) 1.27
Shear stress inhibits adhesion molecule expression in vascular endothelial cells induced by coculture with smooth muscle cells. Blood (2002) 1.27
Overexpression of proline oxidase induces proline-dependent and mitochondria-mediated apoptosis. Mol Cell Biochem (2006) 1.27
Vascular endothelial function and circulating endothelial progenitor cells in patients with cardiac syndrome X. Heart (2007) 1.26
Vascular endothelial responses to altered shear stress: pathologic implications for atherosclerosis. Ann Med (2009) 1.26
Spherically symmetric mesenchymal stromal cell bodies inherent with endogenous extracellular matrices for cellular cardiomyoplasty. Stem Cells (2009) 1.25
Overexpression of HO-1 protects against TNF-alpha-mediated airway inflammation by down-regulation of TNFR1-dependent oxidative stress. Am J Pathol (2009) 1.25
Phosphatidylinositol 3-kinase/Akt pathway is involved in transforming growth factor-beta1-induced phenotypic modulation of 10T1/2 cells to smooth muscle cells. Cell Signal (2005) 1.25
Differential regulation of Rho GTPases by beta1 and beta3 integrins: the role of an extracellular domain of integrin in intracellular signaling. J Cell Sci (2002) 1.24
In vivo knee moments and shear after total knee arthroplasty. J Biomech (2007) 1.24
Analysis of the effect of disturbed flow on monocytic adhesion to endothelial cells. J Biomech (2003) 1.23
Tumor cell cycle arrest induced by shear stress: Roles of integrins and Smad. Proc Natl Acad Sci U S A (2008) 1.23
Roles of cell confluency and fluid shear in 3-dimensional intracellular forces in endothelial cells. Proc Natl Acad Sci U S A (2012) 1.22
Laminar flow activates peroxisome proliferator-activated receptor-gamma in vascular endothelial cells. Circulation (2004) 1.22
Functional consequences of PRODH missense mutations. Am J Hum Genet (2005) 1.21
Shear stress activation of SREBP1 in endothelial cells is mediated by integrins. Arterioscler Thromb Vasc Biol (2002) 1.20
Mechanical stimuli and nutrients regulate rapamycin-sensitive signaling through distinct mechanisms in skeletal muscle. J Cell Biochem (2006) 1.20
Ginkgo biloba extract inhibits tumor necrosis factor-alpha-induced reactive oxygen species generation, transcription factor activation, and cell adhesion molecule expression in human aortic endothelial cells. Arterioscler Thromb Vasc Biol (2003) 1.18
Extracorporeal membrane oxygenation for refractory cardiogenic shock after cardiac surgery: predictors of early mortality and outcome from 51 adult patients. Eur J Cardiothorac Surg (2009) 1.17
Interplay between integrins and FLK-1 in shear stress-induced signaling. Am J Physiol Cell Physiol (2002) 1.17
Bioengineered cardiac patch constructed from multilayered mesenchymal stem cells for myocardial repair. Biomaterials (2008) 1.17
Chondrogenesis of human mesenchymal stem cells encapsulated in alginate beads. J Biomed Mater Res A (2003) 1.16
Usefulness of multidetector-row computed tomography in evaluating adult cor triatriatum. Tex Heart Inst J (2008) 1.15
Anisotropic rheology and directional mechanotransduction in vascular endothelial cells. Proc Natl Acad Sci U S A (2008) 1.14
Mechanisms of induction of endothelial cell E-selectin expression by smooth muscle cells and its inhibition by shear stress. Blood (2007) 1.13
Oxidative stress is involved in the development of experimental abdominal aortic aneurysm: a study of the transcription profile with complementary DNA microarray. J Vasc Surg (2002) 1.12
Role of histone deacetylases in transcription factor regulation and cell cycle modulation in endothelial cells in response to disturbed flow. Proc Natl Acad Sci U S A (2012) 1.11
Cell adhesion molecule Echinoid associates with unconventional myosin VI/Jaguar motor to regulate cell morphology during dorsal closure in Drosophila. Dev Biol (2007) 1.11
Rho-ROCK-LIMK-cofilin pathway regulates shear stress activation of sterol regulatory element binding proteins. Circ Res (2003) 1.11
Synergistic roles of platelet-derived growth factor-BB and interleukin-1beta in phenotypic modulation of human aortic smooth muscle cells. Proc Natl Acad Sci U S A (2006) 1.11