PubRank

Sankar Ghosh

Author PubWeight™ 187.07‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Shared principles in NF-kappaB signaling. Cell 2008 20.96
2 Signaling to NF-kappaB. Genes Dev 2004 19.78
3 Crosstalk in NF-κB signaling pathways. Nat Immunol 2011 6.05
4 The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1. Mol Cell 2002 5.84
5 NF-κB, the first quarter-century: remarkable progress and outstanding questions. Genes Dev 2012 5.77
6 TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev 2005 5.56
7 A toll-like receptor that prevents infection by uropathogenic bacteria. Science 2004 5.26
8 TLR11 activation of dendritic cells by a protozoan profilin-like protein. Science 2005 4.86
9 The NF-kappaB family of transcription factors and its regulation. Cold Spring Harb Perspect Biol 2009 4.61
10 TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature 2011 4.16
11 NF-κB, inflammation, and metabolic disease. Cell Metab 2011 4.00
12 PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation. Science 2005 3.74
13 Recognition and signaling by toll-like receptors. Annu Rev Cell Dev Biol 2006 3.44
14 Mitochondria in innate immune responses. Nat Rev Immunol 2011 3.31
15 Antigen-receptor signaling to nuclear factor kappa B. Immunity 2006 3.07
16 Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy. J Clin Invest 2007 2.99
17 Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo. Nat Med 2004 2.94
18 A mouse model of Salmonella typhi infection. Cell 2012 2.83
19 Negative regulation of toll-like receptor-mediated signaling by Tollip. J Biol Chem 2001 2.78
20 The MAGUK family protein CARD11 is essential for lymphocyte activation. Immunity 2003 2.67
21 NF-κB in immunobiology. Cell Res 2011 2.61
22 Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease. Proc Natl Acad Sci U S A 2007 2.43
23 Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor. Immunity 2009 2.35
24 NF-kappa B activation in human breast cancer specimens and its role in cell proliferation and apoptosis. Proc Natl Acad Sci U S A 2004 2.33
25 Regulatory T cells: recommendations to simplify the nomenclature. Nat Immunol 2013 2.13
26 Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. Genes Dev 2003 2.10
27 T regulatory cells maintain intestinal homeostasis by suppressing γδ T cells. Immunity 2010 2.02
28 Antineuroinflammatory effect of NF-kappaB essential modifier-binding domain peptides in the adoptive transfer model of experimental allergic encephalomyelitis. J Immunol 2004 1.84
29 IkappaBbeta acts to inhibit and activate gene expression during the inflammatory response. Nature 2010 1.68
30 Characterization of the Ikappa B-kinase NEMO binding domain. J Biol Chem 2002 1.65
31 Repression of gene expression by unphosphorylated NF-kappaB p65 through epigenetic mechanisms. Genes Dev 2008 1.64
32 RelB forms transcriptionally inactive complexes with RelA/p65. J Biol Chem 2003 1.63
33 The kinase PDK1 integrates T cell antigen receptor and CD28 coreceptor signaling to induce NF-kappaB and activate T cells. Nat Immunol 2009 1.55
34 NF-κB: roles and regulation in different CD4(+) T-cell subsets. Immunol Rev 2013 1.45
35 Noncanonical NF-kappaB signaling in dendritic cells is required for indoleamine 2,3-dioxygenase (IDO) induction and immune regulation. Blood 2007 1.42
36 Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii. Immunity 2012 1.40
37 Combined action of nucleic acid-sensing Toll-like receptors and TLR11/TLR12 heterodimers imparts resistance to Toxoplasma gondii in mice. Cell Host Microbe 2013 1.35
38 X-ray crystal structure of an IkappaBbeta x NF-kappaB p65 homodimer complex. J Biol Chem 2003 1.35
39 Involvement of phosphatidylinositol 3-kinase-mediated up-regulation of I kappa B alpha in anti-inflammatory effect of gemfibrozil in microglia. J Immunol 2007 1.35
40 RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1. J Biol Chem 2009 1.30
41 Amelioration of acute inflammation by systemic administration of a cell-permeable peptide inhibitor of NF-kappaB activation. Arthritis Rheum 2005 1.27
42 CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis. J Cell Biol 2006 1.25
43 Role of nuclear factor-kappaB in the immune system and bone. Immunol Rev 2005 1.21
44 Constitutively active NF-kappaB triggers systemic TNFalpha-dependent inflammation and localized TNFalpha-independent inflammatory disease. Genes Dev 2010 1.21
45 Regulating inducible transcription through controlled localization. Sci STKE 2005 1.20
46 Phosphorylation of serine 68 in the IkappaB kinase (IKK)-binding domain of NEMO interferes with the structure of the IKK complex and tumor necrosis factor-alpha-induced NF-kappaB activity. J Biol Chem 2007 1.19
47 Inhibition of nuclear factor kappa B (NF-B): an emerging theme in anti-inflammatory therapies. Mol Interv 2002 1.16
48 Cytosolic, nuclear and nucleolar localization signals determine subcellular distribution and activity of the NF-kappaB inducing kinase NIK. J Cell Sci 2004 1.16
49 A novel ubiquitin-like domain in IkappaB kinase beta is required for functional activity of the kinase. J Biol Chem 2004 1.16
50 Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex. Biochem J 2008 1.15
51 Subversion of innate immune responses by Brucella through the targeted degradation of the TLR signaling adapter, MAL. J Immunol 2009 1.15
52 Tumor necrosis factor-alpha induces nuclear factor-kappaB-dependent TRPC1 expression in endothelial cells. J Biol Chem 2003 1.14
53 NF-kappaB, an evolutionarily conserved mediator of immune and inflammatory responses. Adv Exp Med Biol 2005 1.10
54 Helix-loop-helix proteins regulate pre-TCR and TCR signaling through modulation of Rel/NF-kappaB activities. Immunity 2002 1.10
55 Dimerization of the I kappa B kinase-binding domain of NEMO is required for tumor necrosis factor alpha-induced NF-kappa B activity. Mol Cell Biol 2006 1.10
56 SnapShot: NF-kappaB signaling pathways. Cell 2006 1.06
57 Differential role of the transcription factor NF-kappaB in selection and survival of CD4+ and CD8+ thymocytes. Immunity 2008 1.04
58 Local treatment with the selective IkappaB kinase beta inhibitor NEMO-binding domain peptide ameliorates synovial inflammation. Arthritis Res Ther 2006 1.04
59 Lipopolysaccharide induces CXCL2/macrophage inflammatory protein-2 gene expression in enterocytes via NF-kappaB activation: independence from endogenous TNF-alpha and platelet-activating factor. Immunology 2006 1.00
60 Inhibition of NF-kappaB activation reduces the tissue effects of transgenic IL-13. J Immunol 2007 1.00
61 Structure-based analysis of Toxoplasma gondii profilin: a parasite-specific motif is required for recognition by Toll-like receptor 11. J Mol Biol 2010 0.98
62 Testing NF-κB-based therapy in hemiparkinsonian monkeys. J Neuroimmune Pharmacol 2012 0.98
63 Differential phosphorylation of the signal-responsive domain of I kappa B alpha and I kappa B beta by I kappa B kinases. J Biol Chem 2003 0.97
64 NFkappaB activates in vivo the synthesis of inducible Cox-2 in the brain. J Cereb Blood Flow Metab 2005 0.96
65 The interferon-inducible p202a protein modulates NF-kappaB activity by inhibiting the binding to DNA of p50/p65 heterodimers and p65 homodimers while enhancing the binding of p50 homodimers. J Biol Chem 2003 0.94
66 Activation of NF-kappaB promotes the transition of large, CD43+ pre-B cells to small, CD43- pre-B cells. Int Immunol 2005 0.92
67 The Two Faces of NF-κB Signaling in Cancer Development and Therapy. Cancer Cell 2011 0.88
68 Elevated levels of select gangliosides in T cells from renal cell carcinoma patients is associated with T cell dysfunction. J Immunol 2009 0.87
69 Regulation of IkappaBbeta expression in testis. Mol Biol Cell 2002 0.87
70 Cell-intrinsic NF-κB activation is critical for the development of natural regulatory T cells in mice. PLoS One 2011 0.87
71 CD8+ T cell apoptosis induced by Escherichia coli heat-labile enterotoxin B subunit occurs via a novel pathway involving NF-kappaB-dependent caspase activation. Eur J Immunol 2002 0.87
72 NF-kappaB is dispensable for normal lymphocyte development in bone marrow but required for protection of progenitors from TNFalpha. Int Immunol 2006 0.86
73 The kinase PDK1 is essential for B-cell receptor mediated survival signaling. PLoS One 2013 0.85
74 Selective inhibition of NF-kappaB in dendritic cells by the NEMO-binding domain peptide blocks maturation and prevents T cell proliferation and polarization. Eur J Immunol 2005 0.84
75 'PPAR'ting ways with inflammation. Nat Immunol 2005 0.84
76 Regulation of fibroblast growth factor-inducible 14 (Fn14) expression levels via ligand-independent lysosomal degradation. J Biol Chem 2014 0.82
77 Critical role for IL-1β in DNA damage-induced mucositis. Proc Natl Acad Sci U S A 2014 0.81
78 A role for NF-κB activity in skin hyperplasia and the development of keratoacanthomata in mice. PLoS One 2013 0.81
79 Transition from heterotypic to homotypic PDK1 homodimerization is essential for TCR-mediated NF-κB activation. J Immunol 2013 0.80
80 Toll-like receptor 11 (TLR11) prevents Salmonella penetration into the murine Peyer patches. J Biol Chem 2012 0.80
81 TNF-alpha induction of GM2 expression on renal cell carcinomas promotes T cell dysfunction. J Immunol 2007 0.80
82 Keeping cartographers busy. Nat Cell Biol 2004 0.75
83 Direct activation of protein kinases by ubiquitin. J Mol Cell Biol 2009 0.75