Published in Science on June 15, 1962
The multiple molecular structure of the M proteins of group A streptococci. Proc Natl Acad Sci U S A (1965) 2.92
Equilibrium binding of nicotinamide nucleotides to lactate dehydrogenases. Biochem J (1973) 2.77
Symposium on multiple forms of enzymes and control mechanisms. I. Multiple forms of enzymes. Bacteriol Rev (1963) 2.37
Structural adaptations of lactate dehydrogenase isozymes. Proc Natl Acad Sci U S A (1977) 1.88
Sequential expression of chicken actin genes during myogenesis. J Cell Biol (1986) 1.76
Effect of nitrogen dioxide on resistance to respiratory infection. Bacteriol Rev (1966) 1.64
PHYSICAL AND IMMUNOLOGICAL DIFFERENCES AMONG STREPTOKINASES. J Exp Med (1965) 1.61
Evidence for multiple molecular forms of yeast beta-glucosidase in a hybrid yeast. J Bacteriol (1967) 1.58
GENETIC VARIATION AND EVOLUTION OF THE CARBOXYLIC ESTERASES AND CARBONIC ANHYDRASES OF PRIMATE ERYTHROCYTES. Am J Hum Genet (1965) 1.55
Subunit dissociation and recombination of catalase isozymes. Proc Natl Acad Sci U S A (1965) 1.47
Understanding metabolic regulation and its influence on cell physiology. Mol Cell (2013) 1.43
Enzymatically active conformers of mitochondrial malate dehydrogenase. Proc Natl Acad Sci U S A (1966) 1.43
GENETIC EVIDENCE FOR THE SUBUNIT STRUCTURE OF LACTATE DEHYDROGENASE ISOZYMES. Proc Natl Acad Sci U S A (1963) 1.42
Regulation of Staphylococcus aureus lactate dehydrogenase. J Bacteriol (1968) 1.16
The organ-specificity of ferritin in human and horse liver and spleen. Biochem J (1973) 1.12
Lactate dehydrogenase B: a metabolic marker of response to neoadjuvant chemotherapy in breast cancer. Clin Cancer Res (2013) 1.12
Lactate and pyruvate concentrations in exercised ischemic canine muscle: relationship of tissue substrate level to lactate dehydrogenase isozyme pattern. Proc Natl Acad Sci U S A (1966) 1.10
Organ specificity and lactate-dehydrogenase activity. Some properties of human spermatozoal lactate dehydrogenase. Biochem J (1965) 1.09
ORGAN SPECIFICITY AND LACTATE-DEHYDROGENASE ACTIVITY. DIFFERENTIAL INHIBITION BY UREA AND RELATED COMPOUNDS. Biochem J (1965) 1.07
DEVELOPMENTAL CHANGES AND HETEROGENEITY OF LACTIC AND MALIC DEHYDROGENASES OF HUMAN SKELETAL MUSCLES AND OTHER ORGANS. Proc Natl Acad Sci U S A (1963) 1.04
Denervation and disuse atrophy in pigeon breast muscle. An electron microscopic and biochemical study. Am J Pathol (1968) 1.03
Lactic dehydrogenases and muscular dystrophy in the chicken. Proc Natl Acad Sci U S A (1962) 1.02
Lactate dehydrogenase isoenzymes of human semen. Biochem J (1965) 1.02
The enzymes of adenine nucleotide metabolism in developing skeletal muscle. Biochem J (1967) 1.00
Characterization of potato (Solanum tuberosum)lactate dehydrogenase isoenzymes by affinity chromatography and hybridization. Biochem J (1981) 0.96
Factors affecting the reversible dissociation of dehydrogenases. Proc Natl Acad Sci U S A (1965) 0.95
CYTOCHEMICAL LOCALIZATION OF LACTIC DEHYDROGENASE IN WHITE SKELETAL MUSCLE. J Cell Biol (1964) 0.89
Urea and oxalate inhibition of the serum lactate dehydrogenase. J Clin Pathol (1965) 0.89
Permeabilization of animal cells for kinetic studies of intracellular enzymes: in situ behavior of the glycolytic enzymes of erythrocytes. Proc Natl Acad Sci U S A (1980) 0.88
Alpha-hydroxybutyrate dehydrogenase activity in sex-linked muscular dystrophy. J Clin Pathol (1966) 0.88
Changes in the lactate dehydrogenase isoenzyme pattern during differentiation of rabbit bone-marrow erythroid cells. Biochem J (1978) 0.88
Aminoacid sequence of dogfish M4 lactate dehydrogenase. Proc Natl Acad Sci U S A (1973) 0.87
Heterogeneity of liver alcohol dehydrogenase on starch-gel electrophoresis. Biochem J (1965) 0.86
Hypoxia and metabolic adaptation of cancer cells. Oncogenesis (2016) 0.86
Mitochondrial pyruvate transport: a historical perspective and future research directions. Biochem J (2015) 0.85
The determination of lactate dehydrogenase isoenzymes in normal human muscle and other tissues. Biochem J (1967) 0.83
Kinetic analysis of duck epsilon-crystallin, a lens structural protein with lactate dehydrogenase activity. Biochem J (1990) 0.83
Spatial and temporal differentiation of alkaline phosphatase on the intestinal villi of the mouse. J Cell Biol (1967) 0.83
Electrophoretic analysis of hemoglobin and isozymes in individual vertebrate cells. Proc Natl Acad Sci U S A (1970) 0.83
Lactate is always the end product of glycolysis. Front Neurosci (2015) 0.83
Comparative studies of the isozymes of lactic dehydrogenase in rabbit and man. Observations during development and in tissue culture. J Exp Med (1962) 0.82
Some properties of lactate dehydrogenase found in human urine. Biochem J (1967) 0.82
Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation. Elife (2016) 0.82
Identification of lactate dehydrogenase isoenzymes by rapid kinetics. Proc Natl Acad Sci U S A (1972) 0.81
Immunochemical homologies among subunits of trout lactate dehydrogenase isozymes. Proc Natl Acad Sci U S A (1969) 0.80
Enzymatic Kinetic Properties of the Lactate Dehydrogenase Isoenzyme C₄ of the Plateau Pika (Ochotona curzoniae). Int J Mol Sci (2016) 0.79
Lactate dehydrogenase isoenzyme changes during facial development. J Anat (1986) 0.79
Testis-Specific Lactate Dehydrogenase (LDH-C4) in Skeletal Muscle Enhances Apika's Sprint-Running Capacity in Hypoxic Environment. Int J Environ Res Public Health (2015) 0.79
Developmental changes in alcohol-dehydrogenase activity in rat and guinea-pig liver. Biochem J (1967) 0.78
The foetal development of lactate dehydrogenase isoenzymes, glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase from human striated muscle. Biochem J (1969) 0.78
Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network. Dev Biol (2012) 0.78
An atypical distribution of lactate dehydrogenase isoenzymes in the hooded seal (Cystophora cristata) brain may reflect a biochemical adaptation to diving. J Comp Physiol B (2016) 0.78
Phospholipase A2 secretion during intestinal graft ischemia. Dig Dis Sci (1997) 0.78
[Distribution of the isoenzym lactatdehydrogenase in human cartilage (author's transl)]. Arch Orthop Unfallchir (1975) 0.77
Lactate dehydrogenase isozyme patterns in human skeletal muscle. I. Variation of isozyme pattern in the adult. J Neurol Neurosurg Psychiatry (1969) 0.77
Zinc, vanadate and selenate inhibit the tri-iodothyronine-induced expression of fatty acid synthase and malic enzyme in chick-embryo hepatocytes in culture. Biochem J (1994) 0.76
SERUM ENZYME LEVELS IN THE DIAGNOSIS OF ISCHAEMIC HEART DISEASE. J Clin Pathol (1963) 0.76
Leukaemia evoked with 7,8,12-trimethylbenz(a)anthracene in rat. 3. Changes in lymphoid tissues. Br J Cancer (1972) 0.75
Differential lactate and cholesterol synthetic activities in XY and XX Sertoli cells. Sci Rep (2017) 0.75
The Role of Lactate-Mediated Metabolic Coupling between Astrocytes and Neurons in Long-Term Memory Formation. Front Integr Neurosci (2016) 0.75
Effects of pH, ionic strength, and metabolic intermediates on the rates of heat inactivation of lactate dehydrogenase isozymes. Proc Natl Acad Sci U S A (1966) 0.75
Myasthenia gravis: long-term prognostic value of thymus lactate dehydrogenase isoenzyme pattern of hyperplastic thymus and thymoma. J Neurol Neurosurg Psychiatry (1985) 0.75
Exercise Inducible Lactate Dehydrogenase B Regulates Mitochondrial Function in Skeletal Muscle. J Biol Chem (2016) 0.75
Effect of Hypoxia on Ldh-c Expression in Somatic Cells of Plateau Pika. Int J Environ Res Public Health (2016) 0.75
Differentiated rat glial cell strain in tissue culture. Science (1968) 6.49
Fluorescence polarization in homogeneous nucleic acid analysis. Genome Res (1999) 4.59
Establishment of clonal strains of rat pituitary tumor cells that secrete growth hormone. Endocrinology (1968) 4.12
Inhibition of arachidonic acid release from cells as the biochemical action of anti-inflammatory corticosteroids. Proc Natl Acad Sci U S A (1976) 3.62
Altered eicosanoid levels in human colon cancer. J Lab Clin Med (1993) 3.32
Prostaglandin-stimulated bone resorption by rheumatoid synovia. A possible mechanism for bone destruction in rheumatoid arthritis. J Clin Invest (1975) 3.24
Specificities of prostaglandins B 1 , F 1 , and F 2 antigen-antibody reactions. J Biol Chem (1971) 3.08
Detergents in membrane filters. Science (1967) 2.87
Heritability of cellular differentiation: clonal growth and expression of differentiation in retinal pigment cells in vitro. Proc Natl Acad Sci U S A (1966) 2.77
Lactate dehydrogenases: structure and function. Adv Enzymol Relat Areas Mol Biol (1973) 2.58
The comparative enzymology of creatine kinases. I. Isolation and characterization from chicken and rabbit tissues. J Biol Chem (1967) 2.54
A simple method for the quantitation of submicrogram amounts of bacterial endotoxin. Proc Soc Exp Biol Med (1970) 2.53
Tetanus-toxoid emergency boosters: a reappraisal. N Engl J Med (1969) 2.44
Evidence for selection by male mating success in natural populations of Drosophila pseudoobscura. Proc Natl Acad Sci U S A (1979) 2.38
Evidence that the bone resorption-stimulating factor produced by mouse fibrosarcoma cells is prostaglandin E 2 . A new model for the hypercalcemia of cancer. J Exp Med (1972) 2.36
Corticosteroids inhibit prostaglandin production by rheumatiod synovia. Nature (1975) 2.33
Kinetics of Escherichia coli B D-lactate dehydrogenase and evidence for pyruvate-controlled change in conformation. J Biol Chem (1968) 2.27
METABOLISM IN DIABETIC COMA PRODUCED BY ALLOXAN. Science (1945) 2.15
Hydrogen evolution by a chloroplast-ferredoxin-hydrogenase system. Proc Natl Acad Sci U S A (1973) 2.02
Recent application of DNA analysis to issues of paternity. J Forensic Sci (1988) 2.01
Production of both prolactin and growth hormone by clonal strains of rat pituitary tumor cells. Differential effects of hydrocortisone and tissue extracts. J Cell Biol (1970) 2.00
An electrophysiological study of chelonian skeletal muscle. J Physiol (1966) 1.93
Chemical characterization of D-lactate dehydrogenase from Escherichia coli B. J Biol Chem (1968) 1.88
Structure-function relationships in lactate dehydrogenase. Proc Natl Acad Sci U S A (1973) 1.87
Hydrocortisone inhibits prostaglandin production by mouse fibrosarcoma cells. Nature (1975) 1.82
Ryanodine receptor adaptation and Ca2+(-)induced Ca2+ release-dependent Ca2+ oscillations. Biophys J (1996) 1.78
Captopril-induced changes in prostaglandin production: relationship to vascular responses in normal man. J Clin Invest (1980) 1.76
Alpha and beta human transforming growth factors stimulate prostaglandin production and bone resorption in cultured mouse calvaria. Proc Natl Acad Sci U S A (1985) 1.75
Determination of cyclooxygenase products and prostaglandin metabolites using high-pressure liquid chromatography and radioimmunoassay. Anal Biochem (1979) 1.72
Biologically active catecholamines covalentyly bound to glass beads. Proc Natl Acad Sci U S A (1972) 1.68
Stimulation of prostaglandin synthesis by bradykinin and thrombin and their mechanisms of action on MC5-5 fibroblasts. J Biol Chem (1976) 1.68
Accumulation of cyclooxygenase products of arachidonic acid metabolism in gerbil brain during reperfusion after bilateral common carotid artery occlusion. J Neurochem (1980) 1.66
Hypercalcemia and tumor-prostaglandins: the VX2 carcinoma model in the rabbit. Metabolism (1975) 1.60
The effects of 5-Bromodeoxyuridine on the differentiation of chondrocytes in vitro. Dev Biol (1969) 1.60
Prostaglandin production by mouse fibrosarcoma cells in culture: inhibition by indomethacin and aspirin. Biochem Biophys Res Commun (1972) 1.60
An acid phosphatase in the plasma membranes of human astrocytoma showing marked specificity toward phosphotyrosine protein. Proc Natl Acad Sci U S A (1982) 1.58
Prostaglandins in the rheumatic diseases. Ann N Y Acad Sci (1975) 1.58
Prostaglandin synthesis by rheumatoid synovium and its stimulation by colchicine. Prostaglandins (1975) 1.53
The activity of the acidic phosphoproteins from the 80 S rat liver ribosome. J Biol Chem (1982) 1.48
Radioimmunoassay of the leukotrienes of slow reacting substance of anaphylaxis. Proc Natl Acad Sci U S A (1981) 1.45
The serologic specificity of tropocollagen telopeptides. J Exp Med (1967) 1.45
Differentiation in vitro: effects of Sephadex fractions of chick embryo extract. Science (1966) 1.45
Establishment of a clonal strain of hepatoma cells which secrete albumin. J Cell Biol (1969) 1.43
Enzymatically active conformers of mitochondrial malate dehydrogenase. Proc Natl Acad Sci U S A (1966) 1.43
Epidermal growth factor stimulates prostaglandin production and bone resorption in cultured mouse calvaria. Biochem Biophys Res Commun (1978) 1.41
Antibodies to pharmacologically active molecules: specificities and some applications of antiprostaglandins. Pharmacol Rev (1973) 1.40
The serological assessment of a tetanus toxoid field trial. Bull World Health Organ (1971) 1.40
Can academic radiology departments become more efficient and cost less? Radiology (1998) 1.40
Blood components contribute to rise in gerbil brain levels of leukotriene-like immunoreactivity after ischemia and reperfusion. Stroke (1988) 1.39
Epidermal growth factor stimulates prostaglandin biosynthesis by canine kidney (MDCK) cells. Biochem Biophys Res Commun (1977) 1.38
The early primary immune response to absorbed tetanus toxoid in man: A study of the influence of antigen concentration, carrier concentration, and sequence of dosage on the rate, extent, and persistence of the immune response to one and to two doses of toxoid. Bull World Health Organ (1973) 1.35
The comparative enzymology of lactic dehydrogenases. 3. Properties of the H4 and M4 enzymes from a number of vertebrates. J Biol Chem (1967) 1.35
Platelet-dependent stimulation of prostacyclin synthesis by platelet-derived growth factor. Nature (1980) 1.35
Immobilization of hydrogenase on glass beads. Biochem Biophys Res Commun (1976) 1.34
Hyperacute allergic encephalomyelitis: adjuvant effect of pertussis vaccines and extracts. J Immunol (1966) 1.34
Prostaglandins, calcium metabolism and cancer. Fed Proc (1974) 1.33
The comparative enzymology of creatine kinases. II. Physical and chemical properties. J Biol Chem (1967) 1.31
Contribution of prostaglandins to the antihypertensive action of captopril in essential hypertension. Hypertension (1981) 1.31
The soluble protective antigen and the histamine-sensitizing factor of Bordetella pertussis. J Immunol (1965) 1.30
Evidence for parathyroid hormone in nonparathyroid tumors associated with hypercalcemia. Cancer Res (1965) 1.30
The comparative enzymology of lactic dehydrogenases. IV. Function of sulfhydryl groups in lactic dehydrogenases and the sequence around the essential group. J Biol Chem (1965) 1.30
Evidence for the presence of a prostaglandin E 2 -9-keto reductase in rat organs. Biochem Biophys Res Commun (1973) 1.29
Purification and properties of two types of diphosphopyridine nucleotide-linked glycerol 3-phosphate dehydrogenases from chicken breast muscle and chicken liver. J Biol Chem (1969) 1.29
Malate dehydrogenases. II. Purification and properties of Bacillus subtilis, Bacillus stearothermophilus, and Escherichia coli malate dehydrogenases. J Biol Chem (1967) 1.28
Control of growth hormone production by a clonal strain of rat pituitary cells. Stimulation by hydrocortisone. J Cell Biol (1969) 1.28
Association by hydrogen bonding of mononucleotides in aqueous solution. Proc Natl Acad Sci U S A (1972) 1.27
Cyclic 3',5'-adenosine monophosphate in human blood platelets. II. Effect of N6-2'-o-dibutyryl cyclic 3',5'-adenosine monophosphate on platelet function. J Clin Invest (1971) 1.26
Release of prostaglandins and metabolites from guinea-pig lung: inhibition by catecholamines. Prostaglandins (1973) 1.26
Antigenic activity of prostaglandins. Biochem Biophys Res Commun (1970) 1.24
Adjuvant principle of pertussis vaccine in the mouse. Nature (1966) 1.23
Active-passive tetanus immunization. Choice of toxoid, dose of tetanus immune globulin and timing of injections. N Engl J Med (1966) 1.22
Creatine kinase: evidence for a dimeric structure. Biochem Biophys Res Commun (1965) 1.21
Stimulation of prostaglandin biosynthesis by vasoactive substances in methylcholanthrene-transformed mouse BALB/3T3. J Biol Chem (1976) 1.21
Glycyrrhizin inhibits prostaglandin E2 production by activated peritoneal macrophages from rats. Prostaglandins Med (1981) 1.21
Tumor necrosis factor-alpha (cachectin) stimulates bone resorption in mouse calvaria via a prostaglandin-mediated mechanism. Endocrinology (1987) 1.20
Type-specific capsular antigen is associated with virulence in late-onset group B Streptococcal type III disease. Infect Immun (1984) 1.20
Endotoxin-induced hypersensitivity to histamine in mice. I. Contrasting effects of bacterial lipopolysaccharides and the classical histamine-sensitizing factor of Bordetella pertussis. J Bacteriol (1966) 1.19
Efficacy of psychosocial intervention with cancer patients. J Consult Clin Psychol (1980) 1.19
Antibodies to photoproducts of deoxyribonucleic acids irradiated with ultraviolet light. Science (1966) 1.19
Appearance of a brain specific antigen (th S-100 protein) during human foetal development. J Neurochem (1970) 1.18
Prostacyclin and prostaglandin E1 for severe idiopathic pulmonary artery hypertension. Lancet (1980) 1.18
Mydriatic effectiveness of dilute combinations of phenylephrine and tropicamide. Am J Optom Physiol Opt (1982) 1.17
Cyclic 3',5'-adenosine monophosphate in human blood platelets. IV. Regulatory role of cyclic amp in platelet function. Ann N Y Acad Sci (1972) 1.17
Reversible inactivation of dehydrogenases. J Biol Chem (1966) 1.16
Effects of phorbol-12,13-diesters on prostaglandin production and phospholipase activity in canine kidney (MDCK) cells. Biochem Biophys Res Commun (1977) 1.14
Platelet-derived growth factor stimulates bone resorption via a prostaglandin-mediated mechanism. Endocrinology (1982) 1.14
S-100 protein in human acoustic neurinomas. Brain Res (1972) 1.14
Formation of an antibody with serologic specificity for N 6 -( 2 -isopentenyl) adenosine. J Immunol (1972) 1.13
Serologic specificities of methylated base immune systems. Biochemistry (1971) 1.13
Monoclonal antibody and an antibody-toxin conjugate to a cell surface proteoglycan of melanoma cells suppress in vivo tumor growth. Proc Natl Acad Sci U S A (1983) 1.12
Retinoids as well as tumour promoters enhance deacylation of cellular lipids and prostaglandin production in MDCK cells. Nature (1978) 1.11
Nature of multiple molecular forms of enzymes. Ann N Y Acad Sci (1968) 1.11
Highly efficient induction of type C retroviruses by a human tumor in athymic mice. Proc Natl Acad Sci U S A (1980) 1.11
The formation of ternary complexes by diphosphopyridine nucleotide-dependent dehydrogenases. Arch Biochem Biophys (1971) 1.10
Kinetic studies of dogfish liver glutamate dehydrogenase with diphosphopyridine nucleotide and the effect of added salts. J Biol Chem (1967) 1.10
Arachidonic acid metabolism by cells in culture: analyses of culture fluids for cyclooxygenase products by radioimmunoassay before and after separation by high pressure liquid chromatography. Prostaglandins Med (1979) 1.10
Prostaglandin production by methylcholanthrene-transformed mouse BALB/3T3. Requirement for protein synthesis. J Biol Chem (1977) 1.10
Induction of lymphoma in antigenically stimulated athymic mice. Cancer Res (1982) 1.08