Published in Eukaryot Cell on September 14, 2007
Efflux-mediated antifungal drug resistance. Clin Microbiol Rev (2009) 2.44
Stress, drugs, and evolution: the role of cellular signaling in fungal drug resistance. Eukaryot Cell (2008) 1.73
A molecular genetic toolbox for Yarrowia lipolytica. Biotechnol Biofuels (2017) 1.41
Adaptive response and tolerance to weak acids in Saccharomyces cerevisiae: a genome-wide view. OMICS (2010) 1.34
ABC transporters in Saccharomyces cerevisiae and their interactors: new technology advances the biology of the ABCC (MRP) subfamily. Microbiol Mol Biol Rev (2009) 1.34
Fungicide-driven evolution and molecular basis of multidrug resistance in field populations of the grey mould fungus Botrytis cinerea. PLoS Pathog (2009) 1.32
Contribution of CgPDR1-regulated genes in enhanced virulence of azole-resistant Candida glabrata. PLoS One (2011) 1.13
Molecular characterization of propolis-induced cell death in Saccharomyces cerevisiae. Eukaryot Cell (2010) 1.04
Regulation of the CgPdr1 transcription factor from the pathogen Candida glabrata. Eukaryot Cell (2010) 1.01
Multidrug resistance in fungi: regulation of transporter-encoding gene expression. Front Physiol (2014) 0.98
Strategies and molecular tools to fight antimicrobial resistance: resistome, transcriptome, and antimicrobial peptides. Front Microbiol (2013) 0.98
Distinct roles of Candida albicans drug resistance transcription factors TAC1, MRR1, and UPC2 in virulence. Eukaryot Cell (2013) 0.91
Epidemiology and antifungal resistance in invasive Aspergillosis according to primary disease: review of the literature. Eur J Med Res (2011) 0.91
Quantitative transcription dynamic analysis reveals candidate genes and key regulators for ethanol tolerance in Saccharomyces cerevisiae. BMC Microbiol (2010) 0.90
Contributions of Aspergillus fumigatus ATP-binding cassette transporter proteins to drug resistance and virulence. Eukaryot Cell (2013) 0.89
Analysis of promoter function in Aspergillus fumigatus. Eukaryot Cell (2012) 0.88
Stress Response and Pathogenicity of the Necrotrophic Fungal Pathogen Alternaria alternata. Scientifica (Cairo) (2012) 0.86
Two non-target recessive genes confer resistance to the anti-oomycete microtubule inhibitor zoxamide in Phytophthora capsici. PLoS One (2014) 0.86
CZT-1 is a novel transcription factor controlling cell death and natural drug resistance in Neurospora crassa. G3 (Bethesda) (2014) 0.84
Transcription factor CCG-8 as a new regulator in the adaptation to antifungal azole stress. Antimicrob Agents Chemother (2013) 0.83
MFS transporters required for multidrug/multixenobiotic (MD/MX) resistance in the model yeast: understanding their physiological function through post-genomic approaches. Front Physiol (2014) 0.82
Ssz1 restores endoplasmic reticulum-associated protein degradation in cells expressing defective cdc48-ufd1-npl4 complex by upregulating cdc48. Genetics (2009) 0.81
The yeast three-hybrid system as an experimental platform to identify proteins interacting with small signaling molecules in plant cells: potential and limitations. Front Plant Sci (2011) 0.80
Cellular responses required for oxidative stress tolerance, colonization, and lesion formation by the necrotrophic fungus Alternaria alternata in citrus. Curr Microbiol (2010) 0.79
Arv1 lipid transporter function is conserved between pathogenic and nonpathogenic fungi. Fungal Genet Biol (2011) 0.79
Structural and functional study of YER067W, a new protein involved in yeast metabolism control and drug resistance. PLoS One (2010) 0.79
Resistance Assessment for Oxathiapiprolin in Phytophthora capsici and the Detection of a Point Mutation (G769W) in PcORP1 that Confers Resistance. Front Microbiol (2016) 0.79
Is the emergence of fungal resistance to medical triazoles related to their use in the agroecosystems? A mini review. Braz J Microbiol (2016) 0.77
Formulation and Evaluation of Antibacterial Creams and Gels Containing Metal Ions for Topical Application. J Pharm (Cairo) (2016) 0.75
A novel polyamide SL-A92 as a potential fungal resistance blocker: synthesis and bioactivities in Candida albicans. Acta Pharmacol Sin (2010) 0.75
Lysimachia foenum-graecum Herba Extract, a Novel Biopesticide, Inhibits ABC Transporter Genes and Mycelial Growth of Magnaporthe oryzae. Plant Pathol J (2016) 0.75
A Major Facilitator Superfamily Transporter-Mediated Resistance to Oxidative Stress and Fungicides Requires Yap1, Skn7, and MAP Kinases in the Citrus Fungal Pathogen Alternaria alternata. PLoS One (2017) 0.75
Global analysis of protein expression in yeast. Nature (2003) 34.15
Epidemiology of invasive candidiasis: a persistent public health problem. Clin Microbiol Rev (2007) 15.66
Antibacterial resistance worldwide: causes, challenges and responses. Nat Med (2004) 10.46
Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus. Nature (2005) 8.55
Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters. Antimicrob Agents Chemother (1995) 7.44
A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport. Trends Biochem Sci (1993) 7.14
Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus. Antimicrob Agents Chemother (1997) 5.66
Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene. Microbiology (1997) 5.22
Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria. Clin Microbiol Rev (2006) 4.77
The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind. J Biol Chem (2002) 4.52
Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors. Antimicrob Agents Chemother (1996) 4.24
Rare and emerging opportunistic fungal pathogens: concern for resistance beyond Candida albicans and Aspergillus fumigatus. J Clin Microbiol (2004) 4.03
The human ATP-binding cassette (ABC) transporter superfamily. J Lipid Res (2001) 3.95
Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals. Curr Genet (1995) 3.85
Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines. Nature (1985) 3.59
Gametogenesis in yeast is regulated by a transcriptional cascade dependent on Ndt80. Mol Cell (1998) 3.58
YAP1 dependent activation of TRX2 is essential for the response of Saccharomyces cerevisiae to oxidative stress by hydroperoxides. EMBO J (1994) 3.44
Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells. Proc Natl Acad Sci U S A (1986) 3.19
A fungal family of transcriptional regulators: the zinc cluster proteins. Microbiol Mol Biol Rev (2006) 3.05
Nosocomial fungal infections: epidemiology, diagnosis, and treatment. Med Mycol (2007) 3.02
Resistance to antibiotics: are we in the post-antibiotic era? Arch Med Res (2005) 2.98
PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1. J Biol Chem (1994) 2.92
Regulation of yAP-1 nuclear localization in response to oxidative stress. EMBO J (1997) 2.84
Multiple resistance mechanisms among Aspergillus fumigatus mutants with high-level resistance to itraconazole. Antimicrob Agents Chemother (2003) 2.83
Drs2p-related P-type ATPases Dnf1p and Dnf2p are required for phospholipid translocation across the yeast plasma membrane and serve a role in endocytosis. Mol Biol Cell (2003) 2.65
Changing patterns and trends in systemic fungal infections. J Antimicrob Chemother (2005) 2.62
TAC1, transcriptional activator of CDR genes, is a new transcription factor involved in the regulation of Candida albicans ABC transporters CDR1 and CDR2. Eukaryot Cell (2004) 2.61
Mechanisms of azole resistance in clinical isolates of Candida glabrata collected during a hospital survey of antifungal resistance. Antimicrob Agents Chemother (2005) 2.48
Molecular cloning and expression of the Saccharomyces cerevisiae STS1 gene product. A yeast ABC transporter conferring mycotoxin resistance. J Biol Chem (1994) 2.45
ATPase and multidrug transport activities of the overexpressed yeast ABC protein Yor1p. J Biol Chem (1998) 2.39
Genetic analysis of the multidrug transporter. Annu Rev Genet (1995) 2.29
GSH1, which encodes gamma-glutamylcysteine synthetase, is a target gene for yAP-1 transcriptional regulation. Mol Cell Biol (1994) 2.27
Candida albicans gene encoding resistance to benomyl and methotrexate is a multidrug resistance gene. Antimicrob Agents Chemother (1994) 2.23
Genome microarray analysis of transcriptional activation in multidrug resistance yeast mutants. FEBS Lett (2000) 2.22
Antifungal drug resistance of pathogenic fungi. Lancet (2002) 2.20
Gene order evolution and paleopolyploidy in hemiascomycete yeasts. Proc Natl Acad Sci U S A (2002) 2.16
Thiol-based regulatory switches. Annu Rev Genet (2003) 2.14
Role of ATP-binding-cassette transporter genes in high-frequency acquisition of resistance to azole antifungals in Candida glabrata. Antimicrob Agents Chemother (2001) 2.14
A common drug-responsive element mediates the upregulation of the Candida albicans ABC transporters CDR1 and CDR2, two genes involved in antifungal drug resistance. Mol Microbiol (2002) 2.14
The bZip transcription factor Cap1p is involved in multidrug resistance and oxidative stress response in Candida albicans. J Bacteriol (1999) 2.11
Infection by penicillin-resistant staphylococci. Lancet (1948) 2.08
The multidrug resistance gene PDR1 from Saccharomyces cerevisiae. J Biol Chem (1987) 2.02
Antifungal drug resistance in Aspergillus. J Infect (2000) 2.01
Multidrug resistance in Candida albicans: disruption of the BENr gene. Antimicrob Agents Chemother (1995) 1.84
Multidrug resistance: molecular mechanisms and clinical relevance. Cancer Chemother Pharmacol (1997) 1.84
Anticancer drugs, ionophoric peptides, and steroids as substrates of the yeast multidrug transporter Pdr5p. J Biol Chem (1996) 1.79
Sphingolipid functions in Saccharomyces cerevisiae. Biochim Biophys Acta (2002) 1.79
Classification of all putative permeases and other membrane plurispanners of the major facilitator superfamily encoded by the complete genome of Saccharomyces cerevisiae. FEMS Microbiol Rev (1997) 1.77
Transcriptional control of the yeast PDR5 gene by the PDR3 gene product. Mol Cell Biol (1994) 1.77
Azole resistance in Candida glabrata: coordinate upregulation of multidrug transporters and evidence for a Pdr1-like transcription factor. Antimicrob Agents Chemother (2004) 1.76
AP1-mediated multidrug resistance in Saccharomyces cerevisiae requires FLR1 encoding a transporter of the major facilitator superfamily. J Biol Chem (1997) 1.72
Comparison of the susceptibilities of Candida spp. to fluconazole and voriconazole in a 4-year global evaluation using disk diffusion. J Clin Microbiol (2003) 1.70
Candida glabrata PDR1, a transcriptional regulator of a pleiotropic drug resistance network, mediates azole resistance in clinical isolates and petite mutants. Antimicrob Agents Chemother (2006) 1.70
Pdr1 regulates multidrug resistance in Candida glabrata: gene disruption and genome-wide expression studies. Mol Microbiol (2006) 1.67
Increased expression of a novel Aspergillus fumigatus ABC transporter gene, atrF, in the presence of itraconazole in an itraconazole resistant clinical isolate. Fungal Genet Biol (2002) 1.66
PDR3, a new yeast regulatory gene, is homologous to PDR1 and controls the multidrug resistance phenomenon. Mol Gen Genet (1994) 1.63
Molecular and phenotypic characterization of yeast PDR1 mutants that show hyperactive transcription of various ABC multidrug transporter genes. Mol Gen Genet (1997) 1.63
Cloning by gene amplification of two loci conferring multiple drug resistance in Saccharomyces. Genetics (1990) 1.63
Yeast putative transcription factors involved in salt tolerance. FEBS Lett (1998) 1.62
Interaction of the yeast pleiotropic drug resistance genes PDR1 and PDR5. Curr Genet (1992) 1.62
Expression of an ATP-binding cassette transporter-encoding gene (YOR1) is required for oligomycin resistance in Saccharomyces cerevisiae. Mol Cell Biol (1995) 1.61
Yeast multidrug resistance: the PDR network. J Bioenerg Biomembr (1995) 1.61
Yap1p activates gene transcription in an oxidant-specific fashion. Mol Cell Biol (1999) 1.55
Functional expression of Candida albicans drug efflux pump Cdr1p in a Saccharomyces cerevisiae strain deficient in membrane transporters. Antimicrob Agents Chemother (2001) 1.54
Multiple signals from dysfunctional mitochondria activate the pleiotropic drug resistance pathway in Saccharomyces cerevisiae. J Biol Chem (2000) 1.54
Saccharomyces cerevisiae YDR1, which encodes a member of the ATP-binding cassette (ABC) superfamily, is required for multidrug resistance. Curr Genet (1994) 1.52
Tracking down lipid flippases and their biological functions. J Cell Sci (2004) 1.49
The yeast zinc finger regulators Pdr1p and Pdr3p control pleiotropic drug resistance (PDR) as homo- and heterodimers in vivo. Mol Microbiol (2002) 1.49
Functional genomic analysis of fluconazole susceptibility in the pathogenic yeast Candida glabrata: roles of calcium signaling and mitochondria. Antimicrob Agents Chemother (2004) 1.46
Positive autoregulation of the yeast transcription factor Pdr3p, which is involved in control of drug resistance. Mol Cell Biol (1995) 1.45
Identification and characterization of SNQ2, a new multidrug ATP binding cassette transporter of the yeast plasma membrane. J Biol Chem (1995) 1.42
PDR16 and PDR17, two homologous genes of Saccharomyces cerevisiae, affect lipid biosynthesis and resistance to multiple drugs. J Biol Chem (1999) 1.41
The Saccharomyces cerevisiae AP-1 protein discriminates between oxidative stress elicited by the oxidants H2O2 and diamide. J Biol Chem (1997) 1.40
The multidrug resistance transporters of the major facilitator superfamily, 6 years after disclosure of Saccharomyces cerevisiae genome sequence. J Biotechnol (2002) 1.35
Clustered amino acid substitutions in the yeast transcription regulator Pdr3p increase pleiotropic drug resistance and identify a new central regulatory domain. Mol Gen Genet (1997) 1.33
Saccharomyces cerevisiae basic region-leucine zipper protein regulatory networks converge at the ATR1 structural gene. J Biol Chem (1997) 1.32
Regulation of the transcriptional response to oxidative stress in fungi: similarities and differences. Eukaryot Cell (2003) 1.32
Synthesis of mannose-(inositol-P)2-ceramide, the major sphingolipid in Saccharomyces cerevisiae, requires the IPT1 (YDR072c) gene. J Biol Chem (1997) 1.30
Identification and characterization of a Saccharomyces cerevisiae gene, RSB1, involved in sphingoid long-chain base release. J Biol Chem (2002) 1.28
The ergosterol biosynthesis pathway, transporter genes, and azole resistance in Aspergillus fumigatus. Med Mycol (2005) 1.25
CaNdt80 is involved in drug resistance in Candida albicans by regulating CDR1. Antimicrob Agents Chemother (2004) 1.24
The inner membrane protein Mdm33 controls mitochondrial morphology in yeast. J Cell Biol (2003) 1.22
Mutations in the yeast PDR3, PDR4, PDR7 and PDR9 pleiotropic (multiple) drug resistance loci affect the transcript level of an ATP binding cassette transporter encoding gene, PDR5. Genetics (1994) 1.22
New insights into the pleiotropic drug resistance network from genome-wide characterization of the YRR1 transcription factor regulation system. Mol Cell Biol (2002) 1.20
In-vivo selection of an azole-resistant petite mutant of Candida glabrata. J Med Microbiol (2000) 1.19
Transcriptional control of multidrug resistance in the yeast Saccharomyces. Prog Nucleic Acid Res Mol Biol (2003) 1.19
Drug-induced regulation of the MDR1 promoter in Candida albicans. Antimicrob Agents Chemother (2005) 1.18
Regulation of transcription factor Pdr1p function by an Hsp70 protein in Saccharomyces cerevisiae. Mol Cell Biol (1998) 1.17
The yeast multidrug resistance pump, Pdr5p, confers reduced drug resistance in erg mutants of Saccharomyces cerevisiae. Microbiology (1999) 1.16
Identification of promoter elements responsible for the regulation of MDR1 from Candida albicans, a major facilitator transporter involved in azole resistance. Microbiology (2006) 1.16
Genes encoding multiple drug resistance-like proteins in Aspergillus fumigatus and Aspergillus flavus. Gene (1997) 1.15
The multidrug resistance-associated protein (MRP) subfamily (Yrs1/Yor1) of Saccharomyces cerevisiae is important for the tolerance to a broad range of organic anions. J Biol Chem (1996) 1.14
Yeast ATP-binding cassette transporters: cellular cleaning pumps. Methods Enzymol (2005) 1.12
Conservation of eukaryotic sterol homeostasis: new insights from studies in budding yeast. Biochim Biophys Acta (2000) 1.11
Saccharomyces cerevisiae multidrug resistance gene expression inversely correlates with the status of the F(0) component of the mitochondrial ATPase. J Biol Chem (2001) 1.11
Loss of function mutation in the yeast multiple drug resistance gene PDR5 causes a reduction in chloramphenicol efflux. Antimicrob Agents Chemother (1994) 1.10
The central role of PDR1 in the foundation of yeast drug resistance. J Biol Chem (2006) 1.10
Transcriptional regulation of MDR1, encoding a drug efflux determinant, in fluconazole-resistant Candida albicans strains through an Mcm1p binding site. Eukaryot Cell (2006) 1.10
ERG6 and PDR5 regulate small lipophilic drug accumulation in yeast cells via distinct mechanisms. FEBS Lett (2002) 1.09
A nuclear receptor-like pathway regulating multidrug resistance in fungi. Nature (2008) 3.00
The response to heat shock and oxidative stress in Saccharomyces cerevisiae. Genetics (2011) 2.16
New insights into the pleiotropic drug resistance network from genome-wide characterization of the YRR1 transcription factor regulation system. Mol Cell Biol (2002) 1.20
Oxidant-specific folding of Yap1p regulates both transcriptional activation and nuclear localization. J Biol Chem (2005) 1.12
Differential roles of transcriptional mediator subunits in regulation of multidrug resistance gene expression in Saccharomyces cerevisiae. Mol Biol Cell (2010) 1.03
Evidence for the bifunctional nature of mitochondrial phosphatidylserine decarboxylase: role in Pdr3-dependent retrograde regulation of PDR5 expression. Mol Cell Biol (2008) 1.02
Long chain base tolerance in Saccharomyces cerevisiae is induced by retrograde signals from the mitochondria. J Biol Chem (2006) 1.02
Regulation of the CgPdr1 transcription factor from the pathogen Candida glabrata. Eukaryot Cell (2010) 1.01
Transcriptional regulation by Lge1p requires a function independent of its role in histone H2B ubiquitination. J Biol Chem (2004) 1.01
Compartment-specific synthesis of phosphatidylethanolamine is required for normal heavy metal resistance. Mol Biol Cell (2009) 0.99
Coordinate control of lipid composition and drug transport activities is required for normal multidrug resistance in fungi. Biochim Biophys Acta (2008) 0.97
Differential regulation of ceramide synthase components LAC1 and LAG1 in Saccharomyces cerevisiae. Eukaryot Cell (2004) 0.96
Compensatory activation of the multidrug transporters Pdr5p, Snq2p, and Yor1p by Pdr1p in Saccharomyces cerevisiae. FEBS Lett (2008) 0.93
Negative transcriptional regulation of multidrug resistance gene expression by an Hsp70 protein. J Biol Chem (2007) 0.90
Identification of interdependent signals required for anterograde traffic of the ATP-binding cassette transporter protein Yor1p. J Biol Chem (2002) 0.90
Contributions of Aspergillus fumigatus ATP-binding cassette transporter proteins to drug resistance and virulence. Eukaryot Cell (2013) 0.89
Proteolytic degradation of the Yap1 transcription factor is regulated by subcellular localization and the E3 ubiquitin ligase Not4. J Biol Chem (2012) 0.89
Analysis of promoter function in Aspergillus fumigatus. Eukaryot Cell (2012) 0.88
YBP1 and its homologue YBP2/YBH1 influence oxidative-stress tolerance by nonidentical mechanisms in Saccharomyces cerevisiae. Eukaryot Cell (2004) 0.88
Regulation of yeast nutrient permease endocytosis by ATP-binding cassette transporters and a seven-transmembrane protein, RSB1. J Biol Chem (2010) 0.87
Differential oxidant tolerance determined by the key transcription factor Yap1 is controlled by levels of the Yap1-binding protein, Ybp1. J Biol Chem (2011) 0.86
Vacuolar import of phosphatidylcholine requires the ATP-binding cassette transporter Ybt1. Traffic (2011) 0.84
Targeted gene deletion in Aspergillus fumigatus using microbial machinery and a recyclable marker. J Microbiol Methods (2013) 0.78
Functional analysis of an ATP-binding cassette transporter protein from Aspergillus fumigatus by heterologous expression in Saccharomyces cerevisiae. Fungal Genet Biol (2013) 0.77
Redox sensing and histidine oxidation: no longer PerR-fect strangers. Nat Chem Biol (2006) 0.77