Human ovarian surface epithelial cells immortalized with hTERT maintain functional pRb and p53 expression.

PubWeight™: 0.96‹?› | Rank: Top 15%

🔗 View Article (PMID 17877616)

Published in Cell Prolif on October 01, 2007

Authors

N F Li1, S Broad, Y J Lu, J S Yang, R Watson, T Hagemann, G Wilbanks, I Jacobs, F Balkwill, D Dafou, S A Gayther

Author Affiliations

1: Centre for Translational Oncology, Barts and the London, Queen Mary's School of Medicine and Dentistry, Charterhouse Square, London, UK. n.f.li@qmul.ac.uk

Articles citing this

Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: establishing a reversible immune evasion mechanism in human cancer. Blood (2012) 1.60

Senescent fibroblasts promote neoplastic transformation of partially transformed ovarian epithelial cells in a three-dimensional model of early stage ovarian cancer. Neoplasia (2010) 1.33

Organotypic culture model of pancreatic cancer demonstrates that stromal cells modulate E-cadherin, beta-catenin, and Ezrin expression in tumor cells. Am J Pathol (2009) 1.22

Vaccinia virus induces programmed necrosis in ovarian cancer cells. Mol Ther (2013) 1.01

Microcell-mediated chromosome transfer identifies EPB41L3 as a functional suppressor of epithelial ovarian cancers. Neoplasia (2010) 0.99

Modeling High-Grade Serous Carcinoma: How Converging Insights into Pathogenesis and Genetics are Driving Better Experimental Platforms. Front Oncol (2013) 0.91

Sequential genetic change at the TP53 and chemokine receptor CXCR4 locus during transformation of human ovarian surface epithelium. Oncogene (2012) 0.87

p21 Promotes oncolytic adenoviral activity in ovarian cancer and is a potential biomarker. Mol Cancer (2010) 0.87

Genetic determinants of FOXM1 overexpression in epithelial ovarian cancer and functional contribution to cell cycle progression. Oncotarget (2015) 0.83

Inflammatory cytokine tumor necrosis factor alpha confers precancerous phenotype in an organoid model of normal human ovarian surface epithelial cells. Neoplasia (2009) 0.83

Oncolytic virotherapy for ovarian cancer. Oncolytic Virother (2012) 0.77

Overexpression of miRNA-221 promotes cell proliferation by targeting the apoptotic protease activating factor-1 and indicates a poor prognosis in ovarian cancer. Int J Oncol (2017) 0.75

Articles by these authors

Kinetic PCR analysis: real-time monitoring of DNA amplification reactions. Biotechnology (N Y) (1993) 22.41

The twisted circular form of polyoma viral DNA. Proc Natl Acad Sci U S A (1965) 20.04

Detection of specific polymerase chain reaction product by utilizing the 5'----3' exonuclease activity of Thermus aquaticus DNA polymerase. Proc Natl Acad Sci U S A (1991) 16.94

Towards sustainability in world fisheries. Nature (2002) 15.14

Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium. Am J Hum Genet (1998) 15.09

Guidelines for the welfare and use of animals in cancer research. Br J Cancer (2010) 6.97

Characterization of a cis-Golgi matrix protein, GM130. J Cell Biol (1995) 6.22

Management of women who test positive for high-risk types of human papillomavirus: the HART study. Lancet (2003) 5.39

Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis. Nat Med (1999) 4.41

Early and late helix-coil transitions in closed circular DNA. The number of superhelical turns in polyoma DNA. J Mol Biol (1968) 4.04

One hundred questions of importance to the conservation of global biological diversity. Conserv Biol (2009) 3.95

Methadone maintenance in general practice: patients, workload, and outcomes. BMJ (1994) 3.71

Fine mapping of the latency-related gene of herpes simplex virus type 1: alternative splicing produces distinct latency-related RNAs containing open reading frames. J Virol (1988) 3.51

Differences between respondents and nonrespondents in a multicenter community-based study vary by gender ethnicity. The Atherosclerosis Risk in Communities (ARIC) Study Investigators. J Clin Epidemiol (1996) 3.49

Cdc2 kinase directly phosphorylates the cis-Golgi matrix protein GM130 and is required for Golgi fragmentation in mitosis. Cell (1998) 3.36

Milk-borne Scarlet Fever and Tonsillitis. Br Med J (1937) 3.20

Supporting problem drug users: improving methadone maintenance in general practice. Br J Gen Pract (1995) 3.15

GRASP55, a second mammalian GRASP protein involved in the stacking of Golgi cisternae in a cell-free system. EMBO J (1999) 3.14

Human DNA sequence homologous to the transforming gene (mos) of Moloney murine sarcoma virus. Proc Natl Acad Sci U S A (1982) 3.14

New tumor markers: CA125 and beyond. Int J Gynecol Cancer (2005) 2.92

Partitioning of the Golgi apparatus during mitosis in living HeLa cells. J Cell Biol (1997) 2.90

Risk models for familial ovarian and breast cancer. Genet Epidemiol (2000) 2.75

Kin recognition between medial Golgi enzymes in HeLa cells. EMBO J (1994) 2.62

The Philadelphia story: the 22q11.2 deletion: report on 250 patients. Genet Couns (1999) 2.58

Mutation analysis of BRCA1 and BRCA2 in a male breast cancer population. Am J Hum Genet (1997) 2.53

Diabetes management in a health maintenance organization. Efficacy of care management using cluster visits. Diabetes Care (1999) 2.52

Barrett's metaplasia. Lancet (2000) 2.47

Familial gastric cancer: overview and guidelines for management. J Med Genet (1999) 2.38

Fusion of splicing factor genes PSF and NonO (p54nrb) to the TFE3 gene in papillary renal cell carcinoma. Oncogene (1997) 2.32

Localization of organelle proteins by isotope tagging (LOPIT). Mol Cell Proteomics (2004) 2.31

Europe and America forge health links. BMJ (1996) 2.24

Phase I study of bryostatin 1: assessment of interleukin 6 and tumor necrosis factor alpha induction in vivo. The Cancer Research Campaign Phase I Committee. J Natl Cancer Inst (1993) 2.22

Seven novel methylation guide small nucleolar RNAs are processed from a common polycistronic transcript by Rat1p and RNase III in yeast. Mol Cell Biol (1999) 2.20

Effects of caffeine, ephedrine and their combination on time to exhaustion during high-intensity exercise. Eur J Appl Physiol Occup Physiol (1998) 2.16

Conservation. High value and long life--double jeopardy for tunas and billfishes. Science (2011) 2.14

Factors affecting visualization of postmenopausal ovaries: descriptive study from the multicenter United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). Ultrasound Obstet Gynecol (2013) 2.11

Reassembly of Golgi stacks from mitotic Golgi fragments in a cell-free system. J Cell Biol (1995) 2.10

The presence of ribonucleotides in mature closed-circular mitochondrial DNA. Proc Natl Acad Sci U S A (1973) 2.05

Dementia in older people: an update. Intern Med J (2014) 2.03

Levels of matrix metalloproteases in bladder cancer correlate with tumor grade and invasion. Cancer Res (1993) 1.97

A polymorphic stop codon in BRCA2. Nat Genet (1996) 1.95

Fine mapping of the major latency-related RNA of herpes simplex virus type 1 in humans. J Gen Virol (1988) 1.89

Isolation of a matrix that binds medial Golgi enzymes. J Cell Biol (1994) 1.87

Effect of caffeine and ephedrine ingestion on anaerobic exercise performance. Med Sci Sports Exerc (2001) 1.86

Matrix metalloprotease 2 (MMP-2) and matrix metalloprotease 9 (MMP-9) type IV collagenases in colorectal cancer. Cancer Res (1996) 1.84

Dietary intake patterns and sociodemographic factors in the atherosclerosis risk in communities study. ARIC Study Investigators. Prev Med (1994) 1.83

A category-ratio perceived exertion scale: relationship to blood and muscle lactates and heart rate. Med Sci Sports Exerc (1983) 1.83

Onset of blood lactate accumulation and marathon running performance. Int J Sports Med (1981) 1.70

Transverse-momentum and pseudorapidity distributions of charged hadrons in pp collisions at square root of s = 7 TeV. Phys Rev Lett (2010) 1.67

The CryIA(c) receptor purified from Manduca sexta displays multiple specificities. J Biol Chem (1995) 1.67

Phase I and pharmacokinetic study of PKC412, an inhibitor of protein kinase C. J Clin Oncol (2001) 1.62

Frequently occurring germ-line mutations of the BRCA1 gene in ovarian cancer families from Russia. Am J Hum Genet (1997) 1.62

Genetic intra-tumour heterogeneity in epithelial ovarian cancer and its implications for molecular diagnosis of tumours. J Pathol (2007) 1.61

Cyclin A1 directly interacts with B-myb and cyclin A1/cdk2 phosphorylate B-myb at functionally important serine and threonine residues: tissue-specific regulation of B-myb function. Blood (2001) 1.60

Levels of filaggrin degradation products are influenced by both filaggrin genotype and atopic dermatitis severity. Allergy (2011) 1.59

Sorting by COP I-coated vesicles under interphase and mitotic conditions. J Cell Biol (1996) 1.58

Study of the mass and spin-parity of the Higgs boson candidate via its decays to Z boson pairs. Phys Rev Lett (2013) 1.56

Validating genetic risk associations for ovarian cancer through the international Ovarian Cancer Association Consortium. Br J Cancer (2009) 1.54

EU adopts tougher safeguards on genetic modification. BMJ (1999) 1.53

Interferon affects both G1 and S+G2 in cells stimulated from quiescence to growth. Nature (1978) 1.52

Randomised controlled trial of effect of Baby Check on use of health services in first 6 months of life. BMJ (1999) 1.51

Hormone replacement therapy may alleviate sleep apnea in menopausal women: a pilot study. Menopause (1999) 1.50

Reversed polarity of Na(+) -K(+) -ATPase: mislocation to apical plasma membranes in polycystic kidney disease epithelia. Am J Physiol (1991) 1.49

Frontal lobe neglect in monkeys. Neurology (1995) 1.48

Differentiation of a Vero cell adapted porcine epidemic diarrhea virus from Korean field strains by restriction fragment length polymorphism analysis of ORF 3. Vaccine (2003) 1.47

Somatic and germline mutations of the BRCA2 gene in sporadic ovarian cancer. Cancer Res (1996) 1.47

Kinetics of fetal cellular and cell-free DNA in the maternal circulation during and after pregnancy: implications for noninvasive prenatal diagnosis. Transfusion (2001) 1.46

Sulfated carbohydrate compounds prevent microbial adherence by sexually transmitted disease pathogens. Antimicrob Agents Chemother (1997) 1.46

Contribution of BRCA1 mutations to ovarian cancer. N Engl J Med (1997) 1.44

Pinworm control and risk factors of pinworm infection among primary-school children in Taiwan. Am J Trop Med Hyg (2001) 1.43

Pityriasis rubra pilaris treated with acitretin and narrow-band ultraviolet B (Re-TL-01) Br J Dermatol (2000) 1.43

Can postmenopausal hormone replacement improve plasma lipids in women with diabetes? The Atherosclerosis Risk in Communities Study Investigators. Diabetes Care (1996) 1.40

Putative association of a TLR9 promoter polymorphism with atopic eczema. Allergy (2007) 1.39

Clinical and laboratory evaluation of cytomegalovirus-induced mononucleosis in previously healthy individuals. Report of 82 cases. Medicine (Baltimore) (1986) 1.38

Lentiviral vectors for gene therapy of cystic fibrosis. Hum Gene Ther (1997) 1.38

Kinetic roughening of ion-sputtered Pd(001) surface: beyond the Kuramoto-Sivashinsky model. Phys Rev Lett (2004) 1.38

Blood lactate response to the Canadian Aerobic Fitness Test (CAFT). Can J Sport Sci (1992) 1.38

Velocity specificity of training in bodybuilders. Can J Sport Sci (1992) 1.38

Gain of 1q is associated with adverse outcome in favorable histology Wilms' tumors. Am J Pathol (2001) 1.38

Progesterone receptor variation and risk of ovarian cancer is limited to the invasive endometrioid subtype: results from the Ovarian Cancer Association Consortium pooled analysis. Br J Cancer (2008) 1.38

Health ministers to help orphan drugs. BMJ (1995) 1.36

Large outbreak of food poisoning caused by Salmonella typhimurium definitive type 49 in mayonnaise. BMJ (1989) 1.34

Age-related left ventricular function in the mouse: analysis based on in vivo pressure-volume relationships. Am J Physiol (1999) 1.33

The Drosophila GMII gene encodes a Golgi alpha-mannosidase II. J Cell Sci (1999) 1.32

Up for Mischief? IL-17/Th17 in the tumour microenvironment. Oncogene (2010) 1.32

The role of the membrane-spanning domain and stalk region of N-acetylglucosaminyltransferase I in retention, kin recognition and structural maintenance of the Golgi apparatus in HeLa cells. J Cell Sci (1996) 1.32

Increase in signal intensities on T1-weighted magnetic resonance images in asymptomatic manganese-exposed workers. Neurotoxicology (1999) 1.31

A role for mitogen-activated protein kinase activation by integrins in the pathogenesis of psoriasis. J Clin Invest (2001) 1.31

Ion channels formed in planar lipid bilayers by Bacillus thuringiensis toxins in the presence of Manduca sexta midgut receptors. FEBS Lett (1997) 1.30

Targeted antigen delivery to antigen-presenting cells including dendritic cells by engineered Fas-mediated apoptosis. Nat Biotechnol (2000) 1.29

Changes in onset of blood lactate accumulation (OBLA) and muscle enzymes after training at OBLA. Eur J Appl Physiol Occup Physiol (1982) 1.29

Blood lactate. Implications for training and sports performance. Sports Med (1986) 1.27

Hair follicle stem cells: their location, role in hair cycle, and involvement in skin tumor formation. J Invest Dermatol (1993) 1.26

beta1 integrins regulate keratinocyte adhesion and differentiation by distinct mechanisms. Mol Biol Cell (2000) 1.26

Reproducibility of allergen-induced early and late asthmatic responses. J Allergy Clin Immunol (1995) 1.25

The p24 family member p23 is required for early embryonic development. Curr Biol (2000) 1.24

Locating high-affinity fatty acid-binding sites on albumin by x-ray crystallography and NMR spectroscopy. Proc Natl Acad Sci U S A (2005) 1.24

Outcome of risk-reducing salpingo-oophorectomy in BRCA carriers and women of unknown mutation status. BJOG (2011) 1.23

Measurement of the electron charge asymmetry in inclusive W production in pp collisions at sqrt[s]=7  TeV. Phys Rev Lett (2012) 1.23