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Biochem J
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2007
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Functional mapping of a trypanosome centromere by chromosome fragmentation identifies a 16-kb GC-rich transcriptional "strand-switch" domain as a major feature.
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Genome Res
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2005
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Functional characterisation of the iron superoxide dismutase gene repertoire in Trypanosoma brucei.
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Free Radic Biol Med
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RNA interference identifies two hydroperoxide metabolizing enzymes that are essential to the bloodstream form of the african trypanosome.
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J Biol Chem
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2003
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Crystal structures of Λ-[Ru(phen)₂dppz]²⁺ with oligonucleotides containing TA/TA and AT/AT steps show two intercalation modes.
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Nat Chem
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Design and synthesis of bioactive adamantane spiro heterocycles.
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Curr Top Med Chem
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12
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Trypanosoma cruzi expresses a plant-like ascorbate-dependent hemoperoxidase localized to the endoplasmic reticulum.
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Proc Natl Acad Sci U S A
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2002
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1.20
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13
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Ruthenium polypyridyl chemistry; from basic research to applications and back again.
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2006
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The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin.
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J Biol Chem
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2002
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1.16
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15
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Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs.
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Bioorg Med Chem
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2008
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16
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Bioluminescence imaging of chronic Trypanosoma cruzi infections reveals tissue-specific parasite dynamics and heart disease in the absence of locally persistent infection.
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Cell Microbiol
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2014
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Structure determination of an intercalating ruthenium dipyridophenazine complex which kinks DNA by semiintercalation of a tetraazaphenanthrene ligand.
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Proc Natl Acad Sci U S A
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2011
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1.13
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Genome Biol
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2007
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1.13
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19
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pTcINDEX: a stable tetracycline-regulated expression vector for Trypanosoma cruzi.
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BMC Biotechnol
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2006
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1.11
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20
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Multiple splice variants encode a novel adenylyl cyclase of possible plastid origin expressed in the sexual stage of the malaria parasite Plasmodium falciparum.
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J Biol Chem
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2003
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1.10
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21
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Benznidazole-resistance in Trypanosoma cruzi is a readily acquired trait that can arise independently in a single population.
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J Infect Dis
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2012
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1.07
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The suppression of galactose metabolism in Trypanosoma cruzi epimastigotes causes changes in cell surface molecular architecture and cell morphology.
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Mol Biochem Parasitol
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2006
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1.05
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23
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TcGPXII, a glutathione-dependent Trypanosoma cruzi peroxidase with substrate specificity restricted to fatty acid and phospholipid hydroperoxides, is localized to the endoplasmic reticulum.
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Biochem J
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2002
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1.04
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Peroxiredoxins play a major role in protecting Trypanosoma cruzi against macrophage- and endogenously-derived peroxynitrite.
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Biochem J
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2008
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1.01
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25
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The Trypanosoma cruzi metacyclic-specific protein Met-III associates with the nucleolus and contains independent amino and carboxyl terminal targeting elements.
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Int J Parasitol
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2006
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1.01
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Deletion of the Trypanosoma brucei superoxide dismutase gene sodb1 increases sensitivity to nifurtimox and benznidazole.
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Antimicrob Agents Chemother
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2006
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Highly sensitive in vivo imaging of Trypanosoma brucei expressing "red-shifted" luciferase.
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PLoS Negl Trop Dis
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Validation of spermidine synthase as a drug target in African trypanosomes.
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Biochem J
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Vitamin C biosynthesis in trypanosomes: a role for the glycosome.
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Proc Natl Acad Sci U S A
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Photooxidation of guanine by a ruthenium dipyridophenazine complex intercalated in a double-stranded polynucleotide monitored directly by picosecond visible and infrared transient absorption spectroscopy.
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Chemistry
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2008
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[Ru(TAP)2(dppz)]2+: a DNA intercalating complex, which luminesces strongly in water and undergoes photo-induced proton-coupled electron transfer with guanosine-5'-monophosphate.
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Dalton Trans
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2004
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Recent advances in the development of 1,8-naphthalimide based DNA targeting binders, anticancer and fluorescent cellular imaging agents.
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Chem Soc Rev
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2013
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Monitoring the effect of ultrafast deactivation of the electronic excited states of DNA bases and polynucleotides following 267 nm laser excitation using picosecond time-resolved infrared spectroscopy.
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Chem Commun (Camb)
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2005
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Centromere-associated topoisomerase activity in bloodstream form Trypanosoma brucei.
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Nucleic Acids Res
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2010
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Femtosecond electron-transfer reactions in mono- and polynucleotides and in DNA.
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J Am Chem Soc
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X-ray crystal structure of rac-[Ru(phen)2dppz]2+ with d(ATGCAT)2 shows enantiomer orientations and water ordering.
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J Am Chem Soc
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2013
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Purine nucleotide cyclases in the malaria parasite.
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Trends Parasitol
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Design and synthesis of bioactive 1,2-annulated adamantane derivatives.
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Org Biomol Chem
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Novel lipophilic acetohydroxamic acid derivatives based on conformationally constrained spiro carbocyclic 2,6-diketopiperazine scaffolds with potent trypanocidal activity.
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J Med Chem
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2011
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40
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Genetic dissection of drug resistance in trypanosomes.
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The role of glutathione peroxidases in trypanosomatids.
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Biol Chem
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Versatile solution phase triangular silver nanoplates for highly sensitive plasmon resonance sensing.
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ACS Nano
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Magnetic nanoparticle assemblies on denatured DNA show unusual magnetic relaxivity and potential applications for MRI.
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Chem Commun (Camb)
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2004
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0.85
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Ordered DNA wrapping switches on luminescence in single-walled nanotube dispersions.
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Genetic techniques in Trypanosoma cruzi.
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Picosecond transient infrared study of the ultrafast deactivation processes of electronically excited B-DNA and Z-DNA forms of [poly(dG-dC)]2.
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Angew Chem Int Ed Engl
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The amino terminal domain of a novel WD repeat protein from Trypanosoma cruzi contains a non-canonical mitochondrial targeting signal.
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Int J Parasitol
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Chiral highly luminescent CdS quantum dots.
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Chem Commun (Camb)
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2007
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Reduction of dipyrido-[3,2-a:2',3'-c]-phenazine (dppz) by photolysis in ethanol solution.
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Chem Commun (Camb)
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2005
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A comparative picosecond transient infrared study of 1-methylcytosine and 5'-dCMP that sheds further light on the excited states of cytosine derivatives.
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J Am Chem Soc
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2011
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ps-TRIR covers all the bases--recent advances in the use of transient IR for the detection of short-lived species in nucleic acids.
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The terminal step in vitamin C biosynthesis in Trypanosoma cruzi is mediated by a FMN-dependent galactonolactone oxidase.
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Biochem J
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2007
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Centromere-associated repeat arrays on Trypanosoma brucei chromosomes are much more extensive than predicted.
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BMC Genomics
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Preparation of saline-stable, silica-coated triangular silver nanoplates of use for optical sensing.
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J Colloid Interface Sci
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Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines.
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Bioorg Med Chem
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2009
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New oxapolycyclic cage amines with NMDA receptor antagonist and trypanocidal activities.
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Bioorg Med Chem
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2009
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Excited state dependent electron transfer of a rhenium-dipyridophenazine complex intercalated between the base pairs of DNA: a time-resolved UV-visible and IR absorption investigation into the photophysics of fac-[Re(CO)3(F2dppz)(py)]+ bound to either [poly(dA-dT)]2 or [poly(dG-dC)]2.
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Photochem Photobiol Sci
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Enhanced third-order optical nonlinearity of silver nanoparticles with a tunable surface plasmon resonance.
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Ultrafast IR spectroscopy of the short-lived transients formed by UV excitation of cytosine derivatives.
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Chem Commun (Camb)
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2007
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Design, synthesis, and trypanocidal activity of new aminoadamantane derivatives.
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J Med Chem
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Evidence that transport of iron from the lysosome to the cytosol in African trypanosomes is mediated by a mucolipin orthologue.
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Mol Microbiol
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The photophysics of fac-[Re(CO)3(dppz)(py)]+ in CH3CN: a comparative picosecond flash photolysis, transient infrared, transient resonance Raman and density functional theoretical study.
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Photochem Photobiol Sci
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2003
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0.78
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63
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A study of the pH dependence of electronically excited guanosine compounds by picosecond time-resolved infrared spectroscopy.
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Photochem Photobiol Sci
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Solvent dependent photophysics of fac-[Re(CO)(3)(11,12-X(2)dppz)(py)](+)(X = H, F or Me).
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Photochem Photobiol Sci
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2007
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0.78
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65
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Ultrafast IR spectroscopy of polymeric cytosine nucleic acids reveal the long-lived species is due to a localised state.
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Phys Chem Chem Phys
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2012
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66
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Controlled dehydration of a ruthenium complex-DNA crystal induces reversible DNA kinking.
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J Am Chem Soc
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Picosecond infrared probing of the vibrational spectra of transients formed upon UV excitation of stacked G-tetrad structures.
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Chem Commun (Camb)
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2007
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Study of picosecond processes of an intercalated dipyridophenazine Cr(III) complex bound to defined sequence DNAs using transient absorption and time-resolved infrared methods.
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Design and synthesis of Trypanosoma brucei active 1-alkyloxy and 1-benzyloxyadamantano 2-guanylhydrazones.
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Supramolecular approach to enantioselective DNA recognition using enantiomerically resolved cationic 4-amino-1,8-naphthalimide-based Tröger's bases.
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Understanding the DNA binding of novel non-symmetrical guanidinium/2-aminoimidazolinium derivatives.
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Org Biomol Chem
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Design and synthesis of bioactive adamantanaminoalcohols and adamantanamines.
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Huprines as a new family of dual acting trypanocidal-antiplasmodial agents.
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Bioorg Med Chem
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Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines.
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Targeting of photooxidative damage on single-stranded DNA representing the bcr-abl chimeric gene using oligonucleotide-conjugates containing [Ru(phen)3](2+)-like photosensitiser groups.
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Photochem Photobiol Sci
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Synthesis, spectroscopic and biological studies of a fluorescent Pt(II) (terpy) based 1,8-naphthalimide conjugate as a DNA targeting agent.
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Etching-resistant silver nanoprisms by epitaxial deposition of a protecting layer of gold at the edges.
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Langmuir
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Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities.
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An E/Z conformational behaviour study on the trypanocidal action of lipophilic spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acids.
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Tetrahedron Lett
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Structural insights into the catalytic mechanism of Trypanosoma cruzi GPXI (glutathione peroxidase-like enzyme I).
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Biochem J
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Microwave induced preparation of a-axis oriented double-ended needle-shaped ZnO microparticles.
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Synthesis and photophysical evaluation of a pyridinium 4-amino-1,8-naphthalimide derivative that upon intercalation displays preference for AT-rich double-stranded DNA.
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Org Biomol Chem
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The effect of the 4-amino functionality on the photophysical and DNA binding properties of alkyl-pyridinium derived 1,8-naphthalimides.
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Org Biomol Chem
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Unusual photophysical switching in a Ru(II) diimine DNA probe caused by amide functionalisation.
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Efficient quenching of TGA-capped CdTe quantum dot emission by a surface-coordinated europium(III) cyclen complex.
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Photophysical studies of CdTe quantum dots in the presence of a zinc cationic porphyrin.
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Photochem Photobiol Sci
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Photophysical study of a family of [Ru(phen)2(Me n dpq)]2+ complexes in different solvents and DNA: a specific water effect promoted by methyl substitution.
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Long-lived excited states in i-motif DNA studied by picosecond time-resolved IR spectroscopy.
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Chem Commun (Camb)
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Natural and artificial photosynthesis: general discussion.
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Photochem Photobiol Sci
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Photochem Photobiol Sci
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Influence of polystyrenesulfonate on electron transfer quenching of ruthenium trisbipyridine luminescence by viologens: non-covalent assembly and covalent tethering of the ruthenium complex.
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Phys Chem Chem Phys
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Synthesis of N3- and 2-NH2-substituted 6,7-diphenylpterins and their use as intermediates for the preparation of oligonucleotide conjugates designed to target photooxidative damage on single-stranded DNA representing the bcr-abl chimeric gene.
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Org Biomol Chem
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2004
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The influence of loops on the binding of the [Ru(phen)dppz] light-switch compound to i-motif DNA structures revealed by time-resolved spectroscopy.
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