Published in Development on September 26, 2007
miR-212 and miR-132 are required for epithelial stromal interactions necessary for mouse mammary gland development. Nat Genet (2010) 4.06
Hormone action in the mammary gland. Cold Spring Harb Perspect Biol (2010) 2.10
Genetic mosaic analysis reveals FGF receptor 2 function in terminal end buds during mammary gland branching morphogenesis. Dev Biol (2008) 1.97
Discoidin domain receptor tyrosine kinases: new players in cancer progression. Cancer Metastasis Rev (2012) 1.96
A role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathway. Cell Stem Cell (2013) 1.86
The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage. PLoS One (2009) 1.83
Wnt5a regulates directional cell migration and cell proliferation via Ror2-mediated noncanonical pathway in mammalian palate development. Development (2008) 1.74
Mammary gland development. Wiley Interdiscip Rev Dev Biol (2013) 1.64
Integrated morphodynamic signalling of the mammary gland. Nat Rev Mol Cell Biol (2011) 1.50
Molecular mechanisms guiding embryonic mammary gland development. Cold Spring Harb Perspect Biol (2010) 1.37
MMTV-Wnt1 and -DeltaN89beta-catenin induce canonical signaling in distinct progenitors and differentially activate Hedgehog signaling within mammary tumors. PLoS One (2009) 1.33
Cell-matrix interactions in mammary gland development and breast cancer. Cold Spring Harb Perspect Biol (2010) 1.30
Discoidin domain receptor functions in physiological and pathological conditions. Int Rev Cell Mol Biol (2014) 1.29
Loss of TGF-beta or Wnt5a results in an increase in Wnt/beta-catenin activity and redirects mammary tumour phenotype. Breast Cancer Res (2009) 1.29
Discoidin domain receptors: unique receptor tyrosine kinases in collagen-mediated signaling. J Biol Chem (2013) 1.27
A t-butyloxycarbonyl-modified Wnt5a-derived hexapeptide functions as a potent antagonist of Wnt5a-dependent melanoma cell invasion. Proc Natl Acad Sci U S A (2009) 1.25
Key signaling nodes in mammary gland development and cancer: β-catenin. Breast Cancer Res (2010) 1.24
The role of Wnt5a in prostate gland development. Dev Biol (2009) 1.14
SLIT/ROBO1 signaling suppresses mammary branching morphogenesis by limiting basal cell number. Dev Cell (2011) 1.14
Wnt5a exhibits layer-specific expression in adult skin, is upregulated in psoriasis, and synergizes with type 1 interferon. PLoS One (2009) 1.09
Morphogenesis of the developing mammary gland: stage-dependent impact of adipocytes. Dev Biol (2010) 1.08
Wnt and mammary stem cells: hormones cannot fly wingless. Curr Opin Pharmacol (2010) 1.08
Wnt-5a-induced phosphorylation of DARPP-32 inhibits breast cancer cell migration in a CREB-dependent manner. J Biol Chem (2009) 1.07
Wnt signaling in mammary glands: plastic cell fates and combinatorial signaling. Cold Spring Harb Perspect Biol (2012) 1.05
Paracrine WNT5A Signaling Inhibits Expansion of Tumor-Initiating Cells. Cancer Res (2015) 1.04
Discoidin domain receptors in disease. Matrix Biol (2013) 1.01
Dvl2-dependent activation of Daam1 and RhoA regulates Wnt5a-induced breast cancer cell migration. PLoS One (2012) 1.01
WNT5A selectively inhibits mouse ventral prostate development. Dev Biol (2008) 1.00
Co-opted JNK/SAPK signaling in Wnt/beta-catenin-induced tumorigenesis. Neoplasia (2008) 1.00
The control of branching morphogenesis. Open Biol (2013) 1.00
Wnt to build a tube: contributions of Wnt signaling to epithelial tubulogenesis. Dev Dyn (2010) 1.00
WWOX at the crossroads of cancer, metabolic syndrome related traits and CNS pathologies. Biochim Biophys Acta (2014) 0.98
Wnt5a as an effector of TGFβ in mammary development and cancer. J Mammary Gland Biol Neoplasia (2011) 0.96
TGFbeta promotes Wnt expression during cataract development. Exp Eye Res (2008) 0.95
Drugging a stem cell compartment using Wnt3a protein as a therapeutic. PLoS One (2014) 0.95
Wnt/β-catenin Signaling in Normal and Cancer Stem Cells. Cancers (Basel) (2011) 0.94
Wnt signaling in breast organogenesis. Organogenesis (2008) 0.94
R-spondin1 is a novel hormone mediator for mammary stem cell self-renewal. Genes Dev (2014) 0.93
Choreographing metastasis to the tune of LTBP. J Mammary Gland Biol Neoplasia (2011) 0.90
TGF-β-activated kinase 1 (TAK1) signaling regulates TGF-β-induced WNT-5A expression in airway smooth muscle cells via Sp1 and β-catenin. PLoS One (2014) 0.89
Mammary branch initiation and extension are inhibited by separate pathways downstream of TGFβ in culture. Exp Cell Res (2011) 0.89
Conditional Wwox deletion in mouse mammary gland by means of two Cre recombinase approaches. PLoS One (2012) 0.89
Both canonical and non-canonical Wnt signaling independently promote stem cell growth in mammospheres. PLoS One (2014) 0.88
WNT-5A: signaling and functions in health and disease. Cell Mol Life Sci (2015) 0.86
Tyrosine kinase discoidin domain receptors DDR1 and DDR2 are coordinately deregulated in triple-negative breast cancer. Breast Cancer Res Treat (2015) 0.85
Neuropilin-2 promotes branching morphogenesis in the mouse mammary gland. Development (2011) 0.84
Separate and distinctive roles for Wnt5a in tongue, lingual tissue and taste papilla development. Dev Biol (2011) 0.83
Reprogramming during epithelial to mesenchymal transition under the control of TGFβ. Cell Adh Migr (2014) 0.83
Gpr177 deficiency impairs mammary development and prohibits Wnt-induced tumorigenesis. PLoS One (2013) 0.82
PIAS1 regulates breast tumorigenesis through selective epigenetic gene silencing. PLoS One (2014) 0.81
Discoidin domain receptor 1 (DDR1) kinase as target for structure-based drug discovery. Drug Discov Today (2014) 0.81
WNT5A signaling impairs breast cancer cell migration and invasion via mechanisms independent of the epithelial-mesenchymal transition. J Exp Clin Cancer Res (2016) 0.80
Ror2 regulates branching, differentiation, and actin-cytoskeletal dynamics within the mammary epithelium. J Cell Biol (2015) 0.80
Misexpression of wingless-related MMTV integration site 5A in mouse mammary gland inhibits the milk ejection response and regulates connexin43 phosphorylation. Biol Reprod (2011) 0.79
Mammary Development and Breast Cancer: A Wnt Perspective. Cancers (Basel) (2016) 0.77
WNT5a in tongue and fungiform Papilla development. Ann N Y Acad Sci (2009) 0.76
Links between transforming growth factor-beta and canonical Wnt signaling yield new insights into breast cancer susceptibility, suppression and tumor heterogeneity. Breast Cancer Res (2009) 0.76
miR-2478 inhibits TGFβ1 expression by targeting the transcriptional activation region downstream of the TGFβ1 promoter in dairy goats. Sci Rep (2017) 0.75
Ltbp1L is focally induced in embryonic mammary mesenchyme, demarcates the ductal luminal lineage and is upregulated during involution. Breast Cancer Res (2013) 0.75
Modulation of Mammary Gland Development and Milk Production by Growth Hormone Expression in GH Transgenic Goats. Front Physiol (2016) 0.75
Diverse regulation of mammary epithelial growth and branching morphogenesis through noncanonical Wnt signaling. Proc Natl Acad Sci U S A (2017) 0.75
Wnt5a suppresses tumor formation and redirects tumor phenotype in MMTV-Wnt1 tumors. PLoS One (2014) 0.75
Paracrine WNT5A signaling in healthy and neoplastic mammary tissue. Mol Cell Oncol (2015) 0.75
Multiple Roles of WNT5A in Breast Cancer. Med Sci Monit (2016) 0.75
Wnt5a Signaling in Normal and Cancer Stem Cells. Stem Cells Int (2017) 0.75
Intraflagellar transport is essential for endochondral bone formation. Development (2006) 2.90
Conditional Kif3a ablation causes abnormal hedgehog signaling topography, growth plate dysfunction, and excessive bone and cartilage formation during mouse skeletogenesis. Development (2007) 1.97
TGF-beta promotes Th17 cell development through inhibition of SOCS3. J Immunol (2009) 1.66
Transforming growth factor-beta signaling mediates hypoxia-induced pulmonary arterial remodeling and inhibition of alveolar development in newborn mouse lung. Am J Physiol Lung Cell Mol Physiol (2008) 1.45
Development of the post-natal growth plate requires intraflagellar transport proteins. Dev Biol (2007) 1.44
TGF-β2 suppresses macrophage cytokine production and mucosal inflammatory responses in the developing intestine. Gastroenterology (2010) 1.44
Deletion of Tgfbr2 in Prx1-cre expressing mesenchyme results in defects in development of the long bones and joints. Dev Biol (2007) 1.42
TGFbeta2 mediates the effects of hedgehog on hypertrophic differentiation and PTHrP expression. Development (2002) 1.37
Primary cilia are decreased in breast cancer: analysis of a collection of human breast cancer cell lines and tissues. J Histochem Cytochem (2010) 1.31
Loss of TGF-beta or Wnt5a results in an increase in Wnt/beta-catenin activity and redirects mammary tumour phenotype. Breast Cancer Res (2009) 1.29
Dominant negative mutation of the TGF-beta receptor blocks hypoxia-induced pulmonary vascular remodeling. J Appl Physiol (1985) (2005) 1.25
Disruption of PCP signaling causes limb morphogenesis and skeletal defects and may underlie Robinow syndrome and brachydactyly type B. Hum Mol Genet (2010) 1.07
Molecular profiling of the developing mouse axial skeleton: a role for Tgfbr2 in the development of the intervertebral disc. BMC Dev Biol (2010) 1.07
Cilia involvement in patterning and maintenance of the skeleton. Curr Top Dev Biol (2008) 1.06
Tgfbr2 is required for development of the skull vault. Dev Biol (2009) 1.04
C-type natriuretic peptide regulates endochondral bone growth through p38 MAP kinase-dependent and -independent pathways. BMC Dev Biol (2007) 1.03
WNT5A inhibits metastasis and alters splicing of Cd44 in breast cancer cells. PLoS One (2013) 1.02
Tgfbr2 regulates the maintenance of boundaries in the axial skeleton. Dev Biol (2006) 1.01
Co-ordination of TGF-beta and FGF signaling pathways in bone organ cultures. Mech Dev (2004) 0.98
TGF-beta, c-Cbl, and PDGFR-alpha the in mammary stroma. Dev Biol (2005) 0.96
PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development. EMBO J (2010) 0.96
Chondrocyte-specific regulatory activity of Runx2 is essential for survival and skeletal development. Cells Tissues Organs (2011) 0.95
Runx2 regulates endochondral ossification through control of chondrocyte proliferation and differentiation. J Bone Miner Res (2014) 0.93
Ift88 regulates Hedgehog signaling, Sfrp5 expression, and β-catenin activity in post-natal growth plate. J Orthop Res (2012) 0.90
Expression patterns of matrix metalloproteinases and vascular endothelial growth factor during epiphyseal ossification. J Bone Miner Res (2005) 0.88
Unique and redundant roles of Smad3 in TGF-beta-mediated regulation of long bone development in organ culture. Dev Dyn (2004) 0.88
Role for primary cilia in the regulation of mouse ovarian function. Dev Dyn (2008) 0.84
Altered responsiveness to TGF-β results in reduced Papss2 expression and alterations in the biomechanical properties of mouse articular cartilage. Arthritis Res Ther (2012) 0.81
PDGF mediates TGFβ-induced migration during development of the spinous process. Dev Biol (2012) 0.79
Inhibiting breast cancer progression by exploiting TGFbeta signaling. Curr Drug Targets (2010) 0.79
Misexpression of wingless-related MMTV integration site 5A in mouse mammary gland inhibits the milk ejection response and regulates connexin43 phosphorylation. Biol Reprod (2011) 0.79
Transforming growth factor-beta signaling helps specify tumor type in DMBA and hormone-induced mammary cancers. Differentiation (2006) 0.77