Published in Development on July 01, 2011
VEGF/neuropilin-2 regulation of Bmi-1 and consequent repression of IGF-IR define a novel mechanism of aggressive prostate cancer. Cancer Discov (2012) 1.06
RORα suppresses breast tumor invasion by inducing SEMA3F expression. Cancer Res (2012) 1.04
Neuropilin-2 regulates α6β1 integrin in the formation of focal adhesions and signaling. J Cell Sci (2012) 0.98
Neuropilins: expression and roles in the epithelium. Int J Exp Pathol (2012) 0.98
Enhancing integrin function by VEGF/neuropilin signaling: implications for tumor biology. Cell Adh Migr (2012) 0.88
Lymphangiogenesis and metastasis--a closer look at the neuropilin/semaphorin3 axis. Microvasc Res (2014) 0.78
Promotion of metastasis of thyroid cancer cells via NRP-2-mediated induction. Oncol Lett (2016) 0.75
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J Cell Biol (2003) 12.96
Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell (1998) 10.32
Cre-mediated gene deletion in the mammary gland. Nucleic Acids Res (1997) 4.89
Neuropilin is a semaphorin III receptor. Cell (1997) 4.88
Neuropilin is a receptor for the axonal chemorepellent Semaphorin III. Cell (1997) 4.77
Collective epithelial migration and cell rearrangements drive mammary branching morphogenesis. Dev Cell (2008) 4.18
The fallacy of epithelial mesenchymal transition in neoplasia. Cancer Res (2005) 3.65
ERbeta impedes prostate cancer EMT by destabilizing HIF-1alpha and inhibiting VEGF-mediated snail nuclear localization: implications for Gleason grading. Cancer Cell (2010) 3.25
Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cells. Cancer Res (2001) 2.85
Tube or not tube: remodeling epithelial tissues by branching morphogenesis. Dev Cell (2003) 2.70
Branching morphogenesis of the Drosophila tracheal system. Annu Rev Cell Dev Biol (2003) 2.50
Neuropilin-2 is required in vivo for selective axon guidance responses to secreted semaphorins. Neuron (2000) 2.25
Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4. Cancer Res (2002) 2.20
Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells. PLoS Biol (2009) 2.16
Tissue remodelling through branching morphogenesis. Nat Rev Mol Cell Biol (2009) 2.06
Candidate regulators of mammary branching morphogenesis identified by genome-wide transcript analysis. Dev Dyn (2006) 2.03
Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells. Cancer Res (2003) 1.95
Wnt5a is required for proper mammary gland development and TGF-beta-mediated inhibition of ductal growth. Development (2007) 1.85
Mammary epithelial-specific disruption of focal adhesion kinase retards tumor formation and metastasis in a transgenic mouse model of human breast cancer. Am J Pathol (2008) 1.82
Neuropilin-2 regulates the development of selective cranial and sensory nerves and hippocampal mossy fiber projections. Neuron (2000) 1.76
Neuropilin-1 promotes human glioma progression through potentiating the activity of the HGF/SF autocrine pathway. Oncogene (2007) 1.71
Semaphorin 3B (SEMA3B) induces apoptosis in lung and breast cancer, whereas VEGF165 antagonizes this effect. Proc Natl Acad Sci U S A (2004) 1.53
Neuropilins in tumor biology. Clin Cancer Res (2009) 1.44
The interaction of Neuropilin-1 and Neuropilin-2 with tyrosine-kinase receptors for VEGF. Adv Exp Med Biol (2002) 1.43
Selective requirements for NRP1 ligands during neurovascular patterning. Development (2007) 1.41
Comparative mechanisms of branching morphogenesis in diverse systems. J Mammary Gland Biol Neoplasia (2006) 1.39
A peptide corresponding to the neuropilin-1-binding site on VEGF(165) induces apoptosis of neuropilin-1-expressing breast tumour cells. Br J Cancer (2005) 1.39
Molecular mechanisms guiding embryonic mammary gland development. Cold Spring Harb Perspect Biol (2010) 1.37
Interactions of multiple heparin binding growth factors with neuropilin-1 and potentiation of the activity of fibroblast growth factor-2. J Biol Chem (2005) 1.36
Neuropilin-1 and neuropilin-2 act as coreceptors, potentiating proangiogenic activity. Blood (2007) 1.32
Vascular endothelial growth factor induces branching morphogenesis/tubulogenesis in renal epithelial cells in a neuropilin-dependent fashion. Mol Cell Biol (2005) 1.29
Mammary epithelial-specific deletion of the focal adhesion kinase gene leads to severe lobulo-alveolar hypoplasia and secretory immaturity of the murine mammary gland. J Biol Chem (2007) 1.26
Hepatocyte growth factor-mediated cell invasion in pancreatic cancer cells is dependent on neuropilin-1. Cancer Res (2007) 1.26
Regulation of beta 4-integrin expression by epigenetic modifications in the mammary gland and during the epithelial-to-mesenchymal transition. J Cell Sci (2009) 1.25
Migration-promoting role of VEGF-C and VEGF-C binding receptors in human breast cancer cells. Br J Cancer (2007) 1.24
Aberrant sensory innervation of the olfactory bulb in neuropilin-2 mutant mice. J Neurosci (2002) 1.21
Residues within the first subdomain of the FERM-like domain in focal adhesion kinase are important in its regulation. J Biol Chem (2004) 1.17
Metabolic stress induces the lysosomal degradation of neuropilin-1 but not neuropilin-2. J Biol Chem (2008) 1.14
Neuropilin-2 expression in breast cancer: correlation with lymph node metastasis, poor prognosis, and regulation of CXCR4 expression. BMC Cancer (2009) 1.12
Neuropilins: a versatile partner of extracellular molecules that regulate development and disease. Front Biosci (2008) 1.07
Vascular endothelial growth factor-A stimulates Snail expression in breast tumor cells: implications for tumor progression. Exp Cell Res (2008) 1.03
Roles of neuropilins in neuronal development, angiogenesis, and cancers. World J Surg (2005) 0.98
Involvement of axonal guidance proteins and their signaling partners in the developing mouse mammary gland. J Cell Physiol (2006) 0.97
Inactivation of VEGF in mammary gland epithelium severely compromises mammary gland development and function. FASEB J (2007) 0.96
ERbeta impedes prostate cancer EMT by destabilizing HIF-1alpha and inhibiting VEGF-mediated snail nuclear localization: implications for Gleason grading. Cancer Cell (2010) 3.25
Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition. J Cell Biol (2005) 2.88
VEGF targets the tumour cell. Nat Rev Cancer (2013) 2.71
Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma. J Clin Invest (2005) 2.61
IAP regulation of metastasis. Cancer Cell (2010) 2.47
Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4. Cancer Res (2002) 2.20
Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids. Mol Biol Cell (2003) 2.11
The epithelial-mesenchymal transition (EMT) and colorectal cancer progression. Cancer Biol Ther (2005) 2.10
Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells. Cancer Res (2003) 1.95
Functional analysis of the contribution of RhoA and RhoC GTPases to invasive breast carcinoma. Cancer Res (2004) 1.83
IMP3 is a novel biomarker for triple negative invasive mammary carcinoma associated with a more aggressive phenotype. Hum Pathol (2009) 1.80
Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells. J Cell Biol (2002) 1.66
Hypoxia stimulates carcinoma invasion by stabilizing microtubules and promoting the Rab11 trafficking of the alpha6beta4 integrin. Cancer Res (2005) 1.61
Regulated splicing of the α6 integrin cytoplasmic domain determines the fate of breast cancer stem cells. Cell Rep (2014) 1.58
Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression. Cancer Metastasis Rev (2005) 1.58
Proteases, extracellular matrix, and cancer: a workshop of the path B study section. Am J Pathol (2004) 1.52
Transcriptional regulation of VEGF-A by the unfolded protein response pathway. PLoS One (2010) 1.52
Altered localization of p120 catenin during epithelial to mesenchymal transition of colon carcinoma is prognostic for aggressive disease. Cancer Res (2005) 1.49
miR-10b targets Tiam1: implications for Rac activation and carcinoma migration. J Biol Chem (2010) 1.41
Analysis of integrin beta4 expression in human breast cancer: association with basal-like tumors and prognostic significance. Clin Cancer Res (2008) 1.40
Flt-1-dependent survival characterizes the epithelial-mesenchymal transition of colonic organoids. Curr Biol (2003) 1.36
GLI1 regulates a novel neuropilin-2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation. EMBO Mol Med (2013) 1.33
Protein kinase C-alpha phosphorylation of specific serines in the connecting segment of the beta 4 integrin regulates the dynamics of type II hemidesmosomes. Mol Cell Biol (2004) 1.31
Regulation of beta 4-integrin expression by epigenetic modifications in the mammary gland and during the epithelial-to-mesenchymal transition. J Cell Sci (2009) 1.25
A role for ADAM12 in breast tumor progression and stromal cell apoptosis. Cancer Res (2005) 1.24
ADAM12 induces actin cytoskeleton and extracellular matrix reorganization during early adipocyte differentiation by regulating beta1 integrin function. J Cell Sci (2003) 1.21
The epithelial-mesenchymal transition of colon carcinoma involves expression of IL-8 and CXCR-1-mediated chemotaxis. Exp Cell Res (2004) 1.16
ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA. J Biol Chem (2002) 1.16
Role of JNK in mammary gland development and breast cancer. Cancer Res (2011) 1.14
The alpha6beta4 integrin maintains the survival of human breast carcinoma cells in vivo. Cancer Res (2005) 1.14
Metabolic stress induces the lysosomal degradation of neuropilin-1 but not neuropilin-2. J Biol Chem (2008) 1.14
IMP3, a new biomarker to predict progression of cervical intraepithelial neoplasia into invasive cancer. Am J Surg Pathol (2011) 1.13
The Met receptor and alpha 6 beta 4 integrin can function independently to promote carcinoma invasion. J Biol Chem (2004) 1.06
VEGF/neuropilin-2 regulation of Bmi-1 and consequent repression of IGF-IR define a novel mechanism of aggressive prostate cancer. Cancer Discov (2012) 1.06
The alpha6beta4 integrin can regulate ErbB-3 expression: implications for alpha6beta4 signaling and function. Cancer Res (2007) 1.04
Intrinsic signaling functions of the beta4 integrin intracellular domain. J Biol Chem (2007) 1.00
Use of RNA interference to inhibit integrin (alpha6beta4)-mediated invasion and migration of breast carcinoma cells. Clin Exp Metastasis (2003) 0.99
ADAM12 produced by tumor cells rather than stromal cells accelerates breast tumor progression. Mol Cancer Res (2011) 0.99
Neuropilin-2 regulates α6β1 integrin in the formation of focal adhesions and signaling. J Cell Sci (2012) 0.98
Contributions of the alpha6 integrins to breast carcinoma survival and progression. Mol Cells (2004) 0.97
Paternal RLIM/Rnf12 is a survival factor for milk-producing alveolar cells. Cell (2012) 0.97
Insulin receptor substrate-2 regulates aerobic glycolysis in mouse mammary tumor cells via glucose transporter 1. J Biol Chem (2008) 0.95
Estrogen and progesterone regulate radiation-induced p53 activity in mammary epithelium through TGF-beta-dependent pathways. Oncogene (2005) 0.95
Estrogen receptor β sustains epithelial differentiation by regulating prolyl hydroxylase 2 transcription. Proc Natl Acad Sci U S A (2013) 0.93
Epithelial-mesenchymal transition and colorectal cancer: gaining insights into tumor progression using LIM 1863 cells. Cells Tissues Organs (2007) 0.93
Hypoxia-induced vascular endothelial growth factor transcription and protection from apoptosis are dependent on alpha6beta1 integrin in breast carcinoma cells. Cancer Res (2004) 0.91
Integrin β4 regulates SPARC protein to promote invasion. J Biol Chem (2012) 0.91
IMP3 protein promotes chemoresistance in breast cancer cells by regulating breast cancer resistance protein (ABCG2) expression. J Biol Chem (2013) 0.91
Malignant transformation of human cells by constitutive expression of platelet-derived growth factor-BB. J Biol Chem (2005) 0.90
Id2 complexes with the SNAG domain of Snai1 inhibiting Snai1-mediated repression of integrin β4. Mol Cell Biol (2013) 0.89
RKIP phosphorylation and STAT3 activation is inhibited by oxaliplatin and camptothecin and are associated with poor prognosis in stage II colon cancer patients. BMC Cancer (2013) 0.88
Enhancing integrin function by VEGF/neuropilin signaling: implications for tumor biology. Cell Adh Migr (2012) 0.88
Effects of β4 integrin expression on microRNA patterns in breast cancer. Biol Open (2012) 0.85
Ras stimulation of E2F activity and a consequent E2F regulation of integrin alpha6beta4 promote the invasion of breast carcinoma cells. Cancer Res (2006) 0.85
Expression microarray analysis identifies novel epithelial-derived protein markers in eosinophilic esophagitis. Mod Pathol (2013) 0.84
Calretinin expression in high-grade invasive ductal carcinoma of the breast is associated with basal-like subtype and unfavorable prognosis. Hum Pathol (2013) 0.81
Total Survivin and acetylated Survivin correlate with distinct molecular subtypes of breast cancer. Hum Pathol (2011) 0.78
Intra-operative microwave ablation of liver malignancies with tumour permittivity feedback control: a prospective ablate and resect study. HPB (Oxford) (2013) 0.77
Expression of the beta 4 integrin subunit induces monocytic differentiation of 32D/v-Abl cells. Blood (2002) 0.76
Cadherin 17 is a sensitive and specific marker for metanephric adenoma. Am J Surg Pathol (2015) 0.75
Monochorionic twins discordant for mosaic trisomy 14. Am J Med Genet A (2014) 0.75
Human Papillomavirus Genotyping of Incidental Malignant and Premalignant Lesions on Hemorrhoidectomy Specimens. Am J Surg Pathol (2017) 0.75