Published in Exp Eye Res on August 26, 2008
Aging and age-related diseases of the ocular lens and vitreous body. Invest Ophthalmol Vis Sci (2013) 1.08
The lens as a model for fibrotic disease. Philos Trans R Soc Lond B Biol Sci (2011) 0.97
Wnt3a promotes epithelial-mesenchymal transition, migration, and proliferation of lens epithelial cells. Mol Vis (2012) 0.95
Development and use of the lens epithelial explant system to study lens differentiation and cataractogenesis. Prog Retin Eye Res (2009) 0.85
Biology-Driven Gene-Gene Interaction Analysis of Age-Related Cataract in the eMERGE Network. Genet Epidemiol (2015) 0.83
Targeted deletion of the murine Lgr4 gene decreases lens epithelial cell resistance to oxidative stress and induces age-related cataract formation. PLoS One (2015) 0.79
Effects of transforming growth factor β2 and connective tissue growth factor on induction of epithelial mesenchymal transition and extracellular matrix synthesis in human lens epithelial cells. Int J Ophthalmol (2013) 0.79
Lenticular cytoprotection, part 2: link between glycogen synthase kinase-3β, epithelial to mesenchymal transition, and mitochondrial depolarization. Mol Vis (2014) 0.78
β-Catenin/CBP-Dependent Signaling Regulates TGF-β-Induced Epithelial to Mesenchymal Transition of Lens Epithelial Cells. Invest Ophthalmol Vis Sci (2016) 0.76
The Zeb proteins δEF1 and Sip1 may have distinct functions in lens cells following cataract surgery. Invest Ophthalmol Vis Sci (2014) 0.76
The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol (2004) 24.63
Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature (2003) 20.48
Wnt signalling in stem cells and cancer. Nature (2005) 19.26
Convergence of Wnt, beta-catenin, and cadherin pathways. Science (2004) 13.13
Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. PLoS Biol (2006) 7.36
TGF-beta-induced EMT: mechanisms and implications for fibrotic lung disease. Am J Physiol Lung Cell Mol Physiol (2007) 5.24
TGF-beta signaling in cancer--a double-edged sword. Trends Cell Biol (2001) 4.87
Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions. J Biol Chem (2003) 4.55
Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin. Cells Tissues Organs (2005) 3.10
Smad3 is key to TGF-beta-mediated epithelial-to-mesenchymal transition, fibrosis, tumor suppression and metastasis. Cytokine Growth Factor Rev (2005) 2.69
Transforming growth factor-beta signaling during epithelial-mesenchymal transformation: implications for embryogenesis and tumor metastasis. Cells Tissues Organs (2005) 2.64
Growth factor regulation of lens development. Dev Biol (2005) 2.46
Hierarchical model of gene regulation by transforming growth factor beta. Proc Natl Acad Sci U S A (2003) 2.37
Smad3 signaling is required for epithelial-mesenchymal transition of lens epithelium after injury. Am J Pathol (2004) 2.17
Smad3-dependent nuclear translocation of beta-catenin is required for TGF-beta1-induced proliferation of bone marrow-derived adult human mesenchymal stem cells. Genes Dev (2006) 2.15
Cooperation between snail and LEF-1 transcription factors is essential for TGF-beta1-induced epithelial-mesenchymal transition. Mol Biol Cell (2006) 2.06
Type I transforming growth factor beta receptor binds to and activates phosphatidylinositol 3-kinase. J Biol Chem (2005) 2.04
Induction of cataract-like changes in rat lens epithelial explants by transforming growth factor beta. Invest Ophthalmol Vis Sci (1994) 1.92
Wnts as ligands: processing, secretion and reception. Oncogene (2006) 1.90
Wnt5a is required for proper mammary gland development and TGF-beta-mediated inhibition of ductal growth. Development (2007) 1.85
Transcriptional cooperation between the transforming growth factor-beta and Wnt pathways in mammary and intestinal tumorigenesis. Cancer Res (2007) 1.81
The duality of beta-catenin function: a requirement in lens morphogenesis and signaling suppression of lens fate in periocular ectoderm. Dev Biol (2005) 1.74
Planar cell polarity signaling in vertebrates. Bioessays (2007) 1.62
Cataract induction in lenses cultured with transforming growth factor-beta. Invest Ophthalmol Vis Sci (1995) 1.57
FGF-induced lens cell proliferation and differentiation is dependent on MAPK (ERK1/2) signalling. Development (2001) 1.49
Wnt-7a modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. J Biol Chem (2007) 1.47
Planar cell polarity and vertebrate organogenesis. Semin Cell Dev Biol (2006) 1.43
Posterior capsule opacification: a cell biological perspective. Exp Eye Res (2002) 1.42
Lens-specific expression of transforming growth factor beta1 in transgenic mice causes anterior subcapsular cataracts. J Clin Invest (1998) 1.40
A role for Wnt/beta-catenin signaling in lens epithelial differentiation. Dev Biol (2003) 1.39
TGF-beta 1 induces lens cells to accumulate alpha-smooth muscle actin, a marker for subcapsular cataracts. Curr Eye Res (1994) 1.34
TGF-beta2-induced matrix modification and cell transdifferentiation in the human lens capsular bag. Invest Ophthalmol Vis Sci (2002) 1.33
TGFbeta induces morphological and molecular changes similar to human anterior subcapsular cataract. Br J Ophthalmol (2002) 1.25
Abnormal lens morphogenesis and ectopic lens formation in the absence of beta-catenin function. Genesis (2007) 1.22
Smad translocation and growth suppression in lens epithelial cells by endogenous TGFbeta2 during wound repair. Exp Eye Res (2001) 1.20
Adverse clinical consequences of neodymium:YAG laser treatment of posterior capsule opacification. J Cataract Refract Surg (2004) 1.16
TGFbeta-Smad signalling in postoperative human lens epithelial cells. Br J Ophthalmol (2002) 1.14
The surgical management of cataract: barriers, best practices and outcomes. Int Ophthalmol (2007) 1.12
Differential cataractogenic potency of TGF-beta1, -beta2, and -beta3 and their expression in the postnatal rat eye. Invest Ophthalmol Vis Sci (1998) 1.04
Lens-specific expression of TGF-beta induces anterior subcapsular cataract formation in the absence of Smad3. Invest Ophthalmol Vis Sci (2006) 1.03
Relationship between posterior capsule opacification and intraocular lens biocompatibility. Prog Retin Eye Res (2004) 1.03
Inhibition of transforming growth factor-beta-induced cataractous changes in lens explants by ocular media and alpha 2-macroglobulin. Invest Ophthalmol Vis Sci (1996) 1.02
Aberrant lens fiber differentiation in anterior subcapsular cataract formation: a process dependent on reduced levels of Pax6. Invest Ophthalmol Vis Sci (2004) 1.02
Cross-talk between the TGFbeta and Wnt signaling pathways in murine embryonic maxillary mesenchymal cells. FEBS Lett (2005) 1.01
Tgfbeta receptor expression in lens: implications for differentiation and cataractogenesis. Exp Eye Res (2001) 0.95
Lithium stabilizes the polarized lens epithelial phenotype and inhibits proliferation, migration, and epithelial mesenchymal transition. J Pathol (2006) 0.92
Deregulation of lens epithelial cell proliferation and differentiation during the development of TGFbeta-induced anterior subcapsular cataract. Dev Neurosci (2004) 0.91
Identification of three novel Smad binding proteins involved in cell polarity. FEBS Lett (2003) 0.90
Growth factor regulation of lens development. Dev Biol (2005) 2.46
Induction of cataract-like changes in rat lens epithelial explants by transforming growth factor beta. Invest Ophthalmol Vis Sci (1994) 1.92
Transforming growth factor-beta-induced epithelial-mesenchymal transition in the lens: a model for cataract formation. Cells Tissues Organs (2005) 1.85
Cataract induction in lenses cultured with transforming growth factor-beta. Invest Ophthalmol Vis Sci (1995) 1.57
Cell division, cell elongation and distribution of alpha-, beta- and gamma-crystallins in the rat lens. J Embryol Exp Morphol (1978) 1.53
FGF-induced lens cell proliferation and differentiation is dependent on MAPK (ERK1/2) signalling. Development (2001) 1.49
Lens-specific expression of transforming growth factor beta1 in transgenic mice causes anterior subcapsular cataracts. J Clin Invest (1998) 1.40
Lens development. Eye (Lond) (1999) 1.38
TGF-beta 1 induces lens cells to accumulate alpha-smooth muscle actin, a marker for subcapsular cataracts. Curr Eye Res (1994) 1.34
Cell division, cell elongation and the co-ordination of crystallin gene expression during lens morphogenesis in the rat. J Embryol Exp Morphol (1978) 1.33
Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development. Genes Dev (1997) 1.30
Smad translocation and growth suppression in lens epithelial cells by endogenous TGFbeta2 during wound repair. Exp Eye Res (2001) 1.20
Understanding the role of growth factors in embryonic development: insights from the lens. Philos Trans R Soc Lond B Biol Sci (2011) 1.20
Acidic and basic FGF in ocular media and lens: implications for lens polarity and growth patterns. Development (1993) 1.18
TGFbeta-Smad signalling in postoperative human lens epithelial cells. Br J Ophthalmol (2002) 1.14
Induction of the eye lens. Differentiation (1980) 1.12
Requirement for TGFbeta receptor signaling during terminal lens fiber differentiation. Development (2001) 1.11
Patterning the optic neuroepithelium by FGF signaling and Ras activation. Development (2001) 1.09
Cell specialization in the small intestinal epithelium of adult Xenopus laevis: structural aspects. J Anat (1978) 1.08
Neural retinas promote cell division and fibre differentiation in lens epithelial explants. Curr Eye Res (1984) 1.07
A role for Wnt/planar cell polarity signaling during lens fiber cell differentiation? Semin Cell Dev Biol (2006) 1.06
Spatio-temporal distribution of acidic and basic FGF indicates a role for FGF in rat lens morphogenesis. Dev Dyn (1993) 1.05
Spatial and temporal expression of Wnt and Dickkopf genes during murine lens development. Gene Expr Patterns (2004) 1.04
Differential cataractogenic potency of TGF-beta1, -beta2, and -beta3 and their expression in the postnatal rat eye. Invest Ophthalmol Vis Sci (1998) 1.04
Evidence that fibroblast growth factor promotes lens fibre differentiation. Curr Eye Res (1987) 1.03
Inhibition of transforming growth factor-beta-induced cataractous changes in lens explants by ocular media and alpha 2-macroglobulin. Invest Ophthalmol Vis Sci (1996) 1.02
Estrogen protects lenses against cataract induced by transforming growth factor-beta (TGFbeta). J Exp Med (1997) 1.00
Induction of lens fibre differentiation by acidic and basic fibroblast growth factor (FGF). Growth Factors (1989) 1.00
Structural analysis of lens epithelial explants induced to differentiate into fibres by fibroblast growth factor (FGF). Exp Eye Res (1989) 1.00
Spatial and temporal expression of p57(KIP2) during murine lens development. Mech Dev (1999) 0.99
Localization of acidic fibroblast growth factor, basic fibroblast growth factor, and heparan sulphate proteoglycan in rat lens: implications for lens polarity and growth patterns. Invest Ophthalmol Vis Sci (1993) 0.99
Intravitreal injection of TGFbeta induces cataract in rats. Invest Ophthalmol Vis Sci (1999) 0.97
Induction and maintenance of differentiation of rat lens epithelium by FGF-2, insulin and IGF-1. Exp Eye Res (1998) 0.95
Tgfbeta receptor expression in lens: implications for differentiation and cataractogenesis. Exp Eye Res (2001) 0.95
Onset of fibre differentiation in cultured rat lens epithelium under the influence of neural retina-conditioned medium. Exp Eye Res (1984) 0.93
Rise and fall of crystallin gene messenger levels during fibroblast growth factor induced terminal differentiation of lens cells. Dev Biol (1992) 0.93
Lithium stabilizes the polarized lens epithelial phenotype and inhibits proliferation, migration, and epithelial mesenchymal transition. J Pathol (2006) 0.92
Differential expression of fibroblast growth factor receptors during rat lens morphogenesis and growth. Invest Ophthalmol Vis Sci (1997) 0.91
Deregulation of lens epithelial cell proliferation and differentiation during the development of TGFbeta-induced anterior subcapsular cataract. Dev Neurosci (2004) 0.91
Differential effects of aqueous and vitreous on fiber differentiation and extracellular matrix accumulation in lens epithelial explants. Invest Ophthalmol Vis Sci (1995) 0.89
Effects of differences in mitotic activity, stage of cell cycle, and degree of specialization of donor cells on nuclear transplantation in Xenopus laevis. Dev Biol (1975) 0.89
The role of fibroblast growth factor in eye lens development. Ann N Y Acad Sci (1991) 0.89
Ubiquitin-dependent pathway is up-regulated in differentiating lens cells. Exp Eye Res (1999) 0.89
IGF-1 enhancement of FGF-induced lens fiber differentiation in rats of different ages. Invest Ophthalmol Vis Sci (1993) 0.88
The roles of laminin and fibronectin in the development of the lens capsule. Curr Eye Res (1991) 0.88
IGF enhancement of FGF-induced fibre differentiation and DNA synthesis in lens explants. Exp Eye Res (1996) 0.88
Susceptibility to TGFbeta2-induced cataract increases with aging in the rat. Invest Ophthalmol Vis Sci (2000) 0.87
Expression of FGF-1 and FGF-2 mRNA during lens morphogenesis, differentiation and growth. Curr Eye Res (1997) 0.87
FGF receptor-1 (flg) expression is correlated with fibre differentiation during rat lens morphogenesis and growth. Dev Dyn (1996) 0.86
Expression of Crim1 during murine ocular development. Mech Dev (2000) 0.85
Cell specialization in the small intestinal epithelium of adult Xenopus laevis: functional aspects. J Anat (1978) 0.84
Distribution of acidic and basic fibroblast growth factors (FGF) in the foetal rat eye: implications for lens development. Growth Factors (1992) 0.84
Nuclear transplantation from specialized and unspecialized gut epithelial cells of adult Xenopus laevis. J Exp Zool (1974) 0.84
Proliferation of lens epithelial explants in culture increases with age of donor rat. Curr Eye Res (1984) 0.83
The effects of insulin and basic fibroblast growth factor on fibre differentiation in rat lens epithelial explants. Growth Factors (1991) 0.80
Lens tropomodulin: developmental expression during differentiation. Exp Eye Res (1996) 0.80
The spatial relationship between presumptive lens and optic vesicle/cup during early eye morphogenesis in the rat. Exp Eye Res (1981) 0.80
Cytoplasmic processes interconnect lens placode and optic vesicle during eye morphogenesis. Exp Eye Res (1980) 0.80
Age of rats affects response of lens epithelial explants to fibroblast growth factor. Exp Eye Res (1992) 0.80
Beta- and gamma-crystallin synthesis in rat lens epithelium explanted with neural retinal. Differentiation (1980) 0.79
Chromosome localization and characterization of the mouse and human zinc finger protein 265 gene. Cytogenet Cell Genet (2000) 0.79
The age of rats affects the response of lens epithelial explants to fibroblast growth factor. An ultrastructural analysis. Invest Ophthalmol Vis Sci (1992) 0.79
Binding of FGF-1 and FGF-2 to heparan sulphate proteoglycans of the mammalian lens capsule. Growth Factors (1997) 0.79
A morphometric analysis of the development of the rat lens capsule. Curr Eye Res (1989) 0.79
Age-related changes in fibre differentiation of rat lens epithelial explants exposed to fibroblast growth factor. Exp Eye Res (1990) 0.78
Inhibition of FGF-induced alphaA-crystallin promoter activity in lens epithelial explants by TGFbeta. Invest Ophthalmol Vis Sci (2000) 0.78
Peter Bishop Lecture: growth factors in lens development and cataract: key roles for fibroblast growth factor and TGF-beta. Clin Experiment Ophthalmol (2000) 0.78
Nuclear pyknosis during lens fibre differentiation in epithelial explants. Curr Eye Res (1986) 0.78
Functional analysis of the actin-binding protein, tropomyosin 1, in neuroblastoma. Br J Cancer (2003) 0.78
A light microscope study of the lens of the tryptophan deficient rat. Exp Eye Res (1979) 0.77
A lens fibre differentiation factor from calf neural retina. Exp Cell Res (1986) 0.77
Influence of neural retina on lens fibre differentiation in rats. Aust N Z J Ophthalmol (1985) 0.76
Analysis of an inductive interaction between lens and neural retina in rats of different ages. Exp Eye Res (1986) 0.76
Age-related changes in fibre differentiation of rat lens epithelial cells in vitro. Exp Eye Res (1988) 0.76
Localization of the extracellular Ca(2+)-sensing receptor in the human placenta. Placenta (2002) 0.76
An enzyme-linked immunosorbent assay for the quantitation of DNA. J Immunol Methods (1989) 0.75