Roles of integrin activation in eosinophil function and the eosinophilic inflammation of asthma.

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Published in J Leukoc Biol on October 10, 2007

Authors

Steven R Barthel1, Mats W Johansson, Dawn M McNamee, Deane F Mosher

Author Affiliations

1: Department of Biomolecular, University of Wisconsin-Madison, 4285A Medical Sciences Center, 1300 University Avenue, Madison, WI 53706-1532, USA.

Associated clinical trials:

Phenotyping Circulating and Lung Resident Eosinophils in Severe Asthma (P-CLESA) (P-CLESA) | NCT04463836

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Integrins: bidirectional, allosteric signaling machines. Cell (2002) 36.25

Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. Clin Chem (1993) 27.24

Asthma. N Engl J Med (2001) 8.73

Crystal structure of the extracellular segment of integrin alpha Vbeta3. Science (2001) 8.12

Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics. Nature (2004) 5.87

Asthma. From bronchoconstriction to airways inflammation and remodeling. Am J Respir Crit Care Med (2000) 5.82

Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med (1999) 4.75

Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18). Cell (1995) 4.73

Podosomes: adhesion hot-spots of invasive cells. Trends Cell Biol (2003) 4.51

The eosinophilic leukocyte: structure and function. Adv Immunol (1986) 4.08

Non-eosinophilic asthma: importance and possible mechanisms. Thorax (2002) 3.53

RANTES and macrophage inflammatory protein 1 alpha induce the migration and activation of normal human eosinophil granulocytes. J Exp Med (1992) 3.25

Heterogeneity of airway inflammation in persistent asthma : evidence of neutrophilic inflammation and increased sputum interleukin-8. Chest (2001) 3.19

Two conformations of the integrin A-domain (I-domain): a pathway for activation? Structure (1995) 3.15

CC chemokines in allergic inflammation. Immunol Today (1994) 2.85

Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules. J Exp Med (1991) 2.76

Activated conformations of very late activation integrins detected by a group of antibodies (HUTS) specific for a novel regulatory region (355-425) of the common beta 1 chain. J Biol Chem (1996) 2.72

Evidence for the increase in asthma worldwide. Ciba Found Symp (1997) 2.57

A monoclonal antibody against an activation epitope on mouse integrin chain beta 1 blocks adhesion of lymphocytes to the endothelial integrin alpha 6 beta 1. Proc Natl Acad Sci U S A (1993) 2.40

Monocyte chemotactic protein 3 is a most effective basophil- and eosinophil-activating chemokine. J Exp Med (1994) 2.29

The eosinophil and the pathophysiology of asthma. J Allergy Clin Immunol (1986) 2.29

CD4+ T lymphocytes migrating in three-dimensional collagen lattices lack focal adhesions and utilize beta1 integrin-independent strategies for polarization, interaction with collagen fibers and locomotion. Eur J Immunol (1998) 2.28

Identification by immunofluorescence of eosinophil granule major basic protein in lung tissues of patients with bronchial asthma. Lancet (1982) 2.21

Monoclonal antibody 9EG7 defines a novel beta 1 integrin epitope induced by soluble ligand and manganese, but inhibited by calcium. J Biol Chem (1995) 2.21

Role of vascular cell adhesion molecule 1/very late activation antigen 4 and intercellular adhesion molecule 1/lymphocyte function-associated antigen 1 interactions in antigen-induced eosinophil and T cell recruitment into the tissue. J Exp Med (1994) 2.13

Angiotensin II stimulates endothelial vascular cell adhesion molecule-1 via nuclear factor-kappaB activation induced by intracellular oxidative stress. Arterioscler Thromb Vasc Biol (2000) 2.07

Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthma. J Exp Med (2002) 2.04

Integrin structures and conformational signaling. Curr Opin Cell Biol (2006) 2.03

IL-4 acts synergistically with IL-1 beta to promote lymphocyte adhesion to microvascular endothelium by induction of vascular cell adhesion molecule-1. J Immunol (1990) 1.97

IL-5 enhances the in vitro adhesion of human eosinophils, but not neutrophils, in a leucocyte integrin (CD11/18)-dependent manner. Immunology (1990) 1.85

A novel T cell-regulated mechanism modulating allergen-induced airways hyperreactivity in BALB/c mice independently of IL-4 and IL-5. J Immunol (1998) 1.81

The integrin alpha9beta1 mediates adhesion to activated endothelial cells and transendothelial neutrophil migration through interaction with vascular cell adhesion molecule-1. J Cell Biol (1999) 1.79

Gene structure, chromosomal location, and basis for alternative mRNA splicing of the human VCAM1 gene. Proc Natl Acad Sci U S A (1991) 1.79

Pharmacology of the eosinophil. Pharmacol Rev (1999) 1.73

Studies on the adhesive interaction between purified human eosinophils and cultured vascular endothelial cells. J Immunol (1988) 1.68

Human eosinophil adherence to vascular endothelium mediated by binding to vascular cell adhesion molecule 1 and endothelial leukocyte adhesion molecule 1. Proc Natl Acad Sci U S A (1991) 1.67

L-selectin and very late antigen-4 integrin promote eosinophil rolling at physiological shear rates in vivo. J Immunol (1994) 1.66

Blockade of inflammation and airway hyperresponsiveness in immune-sensitized mice by dominant-negative phosphoinositide 3-kinase-TAT. J Exp Med (2003) 1.64

Comparison of airway and blood eosinophil function after in vivo antigen challenge. J Immunol (1992) 1.63

Alpha 4-integrins mediate antigen-induced late bronchial responses and prolonged airway hyperresponsiveness in sheep. J Clin Invest (1994) 1.58

Conformational changes in tertiary structure near the ligand binding site of an integrin I domain. Proc Natl Acad Sci U S A (1999) 1.54

A monoclonal antibody recognizing very late activation antigen-4 inhibits eosinophil accumulation in vivo. J Exp Med (1993) 1.53

Real time analysis of the affinity regulation of alpha 4-integrin. The physiologically activated receptor is intermediate in affinity between resting and Mn(2+) or antibody activation. J Biol Chem (2001) 1.51

Decreased expression of membrane IL-5 receptor alpha on human eosinophils: I. Loss of membrane IL-5 receptor alpha on airway eosinophils and increased soluble IL-5 receptor alpha in the airway after allergen challenge. J Immunol (2002) 1.46

The role of eosinophils in the pathogenesis of asthma. Trends Mol Med (2005) 1.44

Residues within a conserved amino acid motif of domains 1 and 4 of VCAM-1 are required for binding to VLA-4. J Cell Biol (1994) 1.43

CD4 T-lymphocyte activation in asthma is accompanied by increased serum concentrations of interleukin-5. Effect of glucocorticoid therapy. Am Rev Respir Dis (1993) 1.43

Integrins in regulation of tissue development and function. J Pathol (2003) 1.42

CD11b/CD18 (Mac-1) is required for degranulation of human eosinophils induced by human recombinant granulocyte-macrophage colony-stimulating factor and platelet-activating factor. J Immunol (1994) 1.40

The contribution of LFA-1 (CD11a/CD18) and MAC-1 (CD11b/CD18) to the in vivo migration of polymorphonuclear leucocytes to inflammatory reactions in the rat. Immunology (1992) 1.39

Eosinophil transendothelial migration induced by cytokines. III. Effect of the chemokine RANTES. J Immunol (1994) 1.38

The Mac-1 and p150,95 beta 2 integrins bind denatured proteins to mediate leukocyte cell-substrate adhesion. Exp Cell Res (1992) 1.38

Integrin activation by dithiothreitol or Mn2+ induces a ligand-occupied conformation and exposure of a novel NH2-terminal regulatory site on the beta1 integrin chain. J Biol Chem (1998) 1.37

Eosinophils: biology and role in disease. Adv Immunol (1995) 1.37

Blockade of CD49d (alpha4 integrin) on intrapulmonary but not circulating leukocytes inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma. J Clin Invest (1997) 1.36

Interactions between human eosinophils and schistosomula of Schistosoma mansoni. II. The mechanism of irreversible eosinophil adherence. J Exp Med (1979) 1.34

Dual inhibition of VLA-4 and LFA-1 maximally inhibits cutaneous delayed-type hypersensitivity-induced inflammation. Am J Pathol (1993) 1.33

Cloning of an alternate form of vascular cell adhesion molecule-1 (VCAM1). J Biol Chem (1991) 1.32

Migration inhibitory factor up-regulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 via Src, PI3 kinase, and NFkappaB. Blood (2005) 1.32

Evidence that monoclonal antibodies directed against the integrin beta subunit plexin/semaphorin/integrin domain stimulate function by inducing receptor extension. J Biol Chem (2004) 1.29

Cell adhesion and migration properties of beta 2-integrin negative polymorphonuclear granulocytes on defined extracellular matrix molecules. Relevance for leukocyte extravasation. J Biol Chem (2001) 1.28

At least 2 distinct pathways generating reactive oxygen species mediate vascular cell adhesion molecule-1 induction by advanced glycation end products. Arterioscler Thromb Vasc Biol (2005) 1.27

Differential regulation of beta 1 and beta 2 integrin avidity by chemoattractants in eosinophils. Proc Natl Acad Sci U S A (1996) 1.26

A molecular basis for integrin alphaMbeta 2 ligand binding promiscuity. J Biol Chem (2002) 1.25

Mechanisms of acute eosinophil mobilization from the bone marrow stimulated by interleukin 5: the role of specific adhesion molecules and phosphatidylinositol 3-kinase. J Exp Med (1998) 1.25

Arrangement of domains, and amino acid residues required for binding of vascular cell adhesion molecule-1 to its counter-receptor VLA-4 (alpha 4 beta 1). J Cell Biol (1994) 1.23

Freezing adhesion molecules in a state of high-avidity binding blocks eosinophil migration. J Exp Med (1993) 1.23

Eosinophil trafficking to sites of allergic inflammation. Immunol Rev (2001) 1.22

Antibody to very late activation antigen 4 prevents antigen-induced bronchial hyperreactivity and cellular infiltration in the guinea pig airways. J Exp Med (1994) 1.22

Stimulation of eosinophil adherence to human vascular endothelial cells in vitro by platelet-activating factor. J Immunol (1988) 1.21

Ablation of eosinophils leads to a reduction of allergen-induced pulmonary pathology. Am J Physiol Lung Cell Mol Physiol (2002) 1.20

Allergy and asthma. J Allergy Clin Immunol (2005) 1.20

A research method to induce and examine a mild exacerbation of asthma by withdrawal of inhaled corticosteroid. Clin Exp Allergy (1992) 1.16

The role of the leukocyte adhesion molecules VLA-4, LFA-1, and Mac-1 in allergic airway responses in the rat. Am J Respir Crit Care Med (1994) 1.15

Altered adhesion molecule expression and endothelial cell activation accompany the recruitment of human granulocytes to the lung after segmental antigen challenge. Am J Respir Cell Mol Biol (1992) 1.13

The effects of an anti-CD11a mAb, efalizumab, on allergen-induced airway responses and airway inflammation in subjects with atopic asthma. J Allergy Clin Immunol (2003) 1.13

Selective, tight-binding inhibitors of integrin alpha4beta1 that inhibit allergic airway responses. J Med Chem (1999) 1.12

Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC-zeta-GATA signaling pathways. J Biol Chem (2002) 1.12

Structure/function studies on vascular cell adhesion molecule-1. J Biol Chem (1992) 1.11

Beta 1 integrin-mediated lymphocyte adherence to extracellular matrix is enhanced by phorbol ester treatment. Eur J Immunol (1991) 1.11

A small-molecule, tight-binding inhibitor of the integrin alpha(4)beta(1) blocks antigen-induced airway responses and inflammation in experimental asthma in sheep. Am J Respir Crit Care Med (2000) 1.09

Identification of a key integrin-binding sequence in VCAM-1 homologous to the LDV active site in fibronectin. J Cell Sci (1994) 1.09

Regulation of conformation and ligand binding function of integrin alpha5beta1 by the beta1 cytoplasmic domain. J Biol Chem (1996) 1.08

Eosinophil function. N Engl J Med (1981) 1.07

Eosinophil transendothelial migration induced by cytokines. II. Potentiation of eosinophil transendothelial migration by eosinophil-active cytokines. J Immunol (1994) 1.07

alphadbeta2 integrin is expressed on human eosinophils and functions as an alternative ligand for vascular cell adhesion molecule 1 (VCAM-1). J Exp Med (1998) 1.06

Monoclonal antibodies as probes of integrin priming and activation. Biochem Soc Trans (2004) 1.05

Integrin alphaDbeta2, an adhesion receptor up-regulated on macrophage foam cells, exhibits multiligand-binding properties. Blood (2005) 1.04

IL-5 and IL-5 receptor in asthma. Mem Inst Oswaldo Cruz (1997) 1.04

Eosinophil adhesion to vascular cell adhesion molecule-1 activates superoxide anion generation. J Immunol (1995) 1.04

Future research directions in asthma: an NHLBI Working Group report. Am J Respir Crit Care Med (2004) 1.04

Characterization of a late phase pulmonary response after antigen challenge in allergic sheep. Am Rev Respir Dis (1983) 1.03

The rise of the phoenix: the expanding role of the eosinophil in health and disease. Allergy (2005) 1.03

A surrogate method for assessment of beta(2)-integrin-dependent adhesion of human eosinophils to ICAM-1. J Immunol Methods (2000) 1.02

Differential engagement of modules 1 and 4 of vascular cell adhesion molecule-1 (CD106) by integrins alpha4beta1 (CD49d/29) and alphaMbeta2 (CD11b/18) of eosinophils. J Biol Chem (2006) 1.02

Leukocyte trafficking in alveoli and airway passages. Respir Res (2000) 1.02

Blood and bronchoalveolar eosinophils in allergic subjects after segmental antigen challenge: surface phenotype, density heterogeneity, and prostanoid production. J Allergy Clin Immunol (1994) 1.01

Blockade of CD49d inhibits allergic airway pathologies independent of effects on leukocyte recruitment. Am J Physiol Lung Cell Mol Physiol (2001) 1.01

The intercellular adhesion molecule (ICAM) family of proteins. New members and novel functions. Immunol Res (1998) 1.00

Dissection of the hyperadhesive phenotype of airway eosinophils in asthma. Am J Respir Cell Mol Biol (2006) 1.00

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