Published in Arthritis Res Ther on November 05, 2012
Cartilage damage in osteoarthritis and rheumatoid arthritis-two unequal siblings. Nat Rev Rheumatol (2015) 1.03
How citrullination invaded rheumatoid arthritis research. Arthritis Res Ther (2014) 0.80
A novel role for protein arginine deiminase 4 in pluripotency: the emerging role of citrullinated histone H1 in cellular programming. Bioessays (2014) 0.80
Association of cross-reactive antibodies targeting peptidyl-arginine deiminase 3 and 4 with rheumatoid arthritis-associated interstitial lung disease. PLoS One (2014) 0.79
Focal adhesion kinase is required for synovial fibroblast invasion, but not murine inflammatory arthritis. Arthritis Res Ther (2014) 0.78
Tumor necrosis factor alpha, citrullination, and peptidylarginine deiminase 4 in lung and joint inflammation. Arthritis Res Ther (2016) 0.76
Rheumatoid arthritis antigens homocitrulline and citrulline are generated by local myeloperoxidase and peptidyl arginine deiminases 2, 3 and 4 in rheumatoid nodule and synovial tissue. Arthritis Res Ther (2016) 0.75
Spontaneous Secretion of the Citrullination Enzyme PAD2 and Cell Surface Exposure of PAD4 by Neutrophils. Front Immunol (2017) 0.75
Joint inflammation related citrullination of functional arginines in extracellular proteins. Sci Rep (2017) 0.75
Fibronectins: multifunctional modular glycoproteins. J Cell Biol (1982) 8.05
Fibronectin: purification, immunochemical properties, and biological activities. Methods Enzymol (1982) 4.45
Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis. Immunol Rev (2010) 2.71
Synovial fibroblasts spread rheumatoid arthritis to unaffected joints. Nat Med (2009) 2.55
Peptidyl arginine deiminase type 2 (PAD-2) and PAD-4 but not PAD-1, PAD-3, and PAD-6 are expressed in rheumatoid arthritis synovium in close association with tissue inflammation. Arthritis Rheum (2007) 2.40
Smoking increases peptidylarginine deiminase 2 enzyme expression in human lungs and increases citrullination in BAL cells. Ann Rheum Dis (2008) 2.27
Citrullination is an inflammation-dependent process. Ann Rheum Dis (2006) 2.25
N-α-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis. J Immunol (2011) 2.18
Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice. J Exp Med (2008) 2.17
A colorimetric 96-well microtiter plate assay for the determination of enzymatically formed citrulline. Anal Biochem (2000) 2.15
Immune complexes containing citrullinated fibrinogen costimulate macrophages via Toll-like receptor 4 and Fcγ receptor. Arthritis Rheum (2011) 2.11
Protein unfolding by peptidylarginine deiminase. Substrate specificity and structural relationships of the natural substrates trichohyalin and filaggrin. J Biol Chem (1996) 2.05
Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severity. Arthritis Res Ther (2005) 2.03
Synovial fluid is a site of citrullination of autoantigens in inflammatory arthritis. Arthritis Rheum (2008) 1.86
Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion. J Cell Biol (2008) 1.79
Increased PADI4 expression in blood and tissues of patients with malignant tumors. BMC Cancer (2009) 1.78
Localization of peptidylarginine deiminase 4 (PADI4) and citrullinated protein in synovial tissue of rheumatoid arthritis. Rheumatology (Oxford) (2004) 1.68
Myelin in multiple sclerosis is developmentally immature. J Clin Invest (1994) 1.52
The distribution of fibronectin in the pannus in rheumatoid arthritis. Br J Exp Pathol (1981) 1.41
Anti-cyclic citrullinated peptide antibodies from rheumatoid arthritis patients activate complement via both the classical and alternative pathways. Arthritis Rheum (2009) 1.40
Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation. J Exp Med (2008) 1.34
Transgenic and knockout analyses of the role of TNF in immune regulation and disease pathogenesis. J Inflamm (1997) 1.30
Citrullination of fibronectin in rheumatoid arthritis synovial tissue. Rheumatology (Oxford) (2005) 1.24
Cellular invasion into matrix beads: localization of beta 1 integrins and fibronectin to the invadopodia. J Cell Sci (1991) 1.23
Prognostic factors of 10-year radiographic outcome in early rheumatoid arthritis: a prospective study. Arthritis Res Ther (2008) 1.22
Citrullination of CXCL12 differentially reduces CXCR4 and CXCR7 binding with loss of inflammatory and anti-HIV-1 activity via CXCR4. J Immunol (2009) 1.15
Extended binding site on fibronectin for the functional upstream domain of protein F1 of Streptococcus pyogenes. J Biol Chem (2010) 1.11
Model of fibronectin tertiary structure based on studies of interactions between fragments. Biochemistry (1986) 1.06
Functional characterization of adherent synovial fluid cells in rheumatoid arthritis: destructive potential in vitro and in vivo. Arthritis Rheum (2003) 1.02
Mapping the heparin-binding site on the 13-14F3 fragment of fibronectin. J Biol Chem (2002) 1.00
Integrins and their ligands in rheumatoid arthritis. Arthritis Res Ther (2011) 0.97
Local administration of glucocorticoids decreases synovial citrullination in rheumatoid arthritis. Arthritis Res Ther (2012) 0.97
Fibronectin on the surface of articular cartilage in rheumatoid arthritis. Arthritis Rheum (1984) 0.96
Detection of citrullinated proteins in synovial fluids derived from patients with rheumatoid arthritis by proteomics-based analysis. Ann Clin Biochem (2008) 0.95
Telopeptides of type II collagen upregulate proteinases and damage cartilage but are less effective than highly active fibronectin fragments. Inflamm Res (2009) 0.89
Formation of invadopodia-like structures by synovial cells promotes cartilage breakdown in collagen-induced arthritis: involvement of the protein tyrosine kinase Src. Arthritis Rheum (2011) 0.89
Anti-citrullinated fibronectin antibodies in rheumatoid arthritis are associated with human leukocyte antigen-DRB1 shared epitope alleles. Arthritis Res Ther (2012) 0.87
Autoimmunity to citrullinated type II collagen in rheumatoid arthritis. Mod Rheumatol (2006) 0.84
Pathogenic importance of fibronectin in the superficial region of articular cartilage as a local factor for the induction of pannus extension on rheumatoid articular cartilage. Ann Rheum Dis (1992) 0.83
Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis. Cell (2005) 7.41
Calpain-mediated proteolysis of talin regulates adhesion dynamics. Nat Cell Biol (2004) 4.29
Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis. Cell (2009) 3.46
Resolution of inflammation by retrograde chemotaxis of neutrophils in transgenic zebrafish. J Leukoc Biol (2006) 3.21
Differential regulation of protrusion and polarity by PI3K during neutrophil motility in live zebrafish. Dev Cell (2010) 3.19
Dichotomous role of the macrophage in early Mycobacterium marinum infection of the zebrafish. Cell Host Microbe (2007) 3.09
Regulating cell migration: calpains make the cut. J Cell Sci (2005) 3.03
Lyn is a redox sensor that mediates leukocyte wound attraction in vivo. Nature (2011) 2.54
Polymerization of type I and III collagens is dependent on fibronectin and enhanced by integrins alpha 11beta 1 and alpha 2beta 1. J Biol Chem (2002) 2.26
Spatiotemporal photolabeling of neutrophil trafficking during inflammation in live zebrafish. J Leukoc Biol (2011) 2.22
Live imaging of neutrophil motility in a zebrafish model of WHIM syndrome. Blood (2010) 2.15
Peptidylarginine deiminase 4 contributes to tumor necrosis factor α-induced inflammatory arthritis. Arthritis Rheumatol (2014) 2.14
Characterization of a membrane-based gradient generator for use in cell-signaling studies. Lab Chip (2006) 2.11
FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion. J Cell Biol (2009) 1.97
Fibronectin regulates latent transforming growth factor-beta (TGF beta) by controlling matrix assembly of latent TGF beta-binding protein-1. J Biol Chem (2005) 1.82
Fibronectin fibrillogenesis regulates three-dimensional neovessel formation. Genes Dev (2008) 1.81
Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion. J Cell Biol (2008) 1.79
Regulation of focal complex composition and disassembly by the calcium-dependent protease calpain. J Cell Sci (2002) 1.79
Regulation of adhesion dynamics by calpain-mediated proteolysis of focal adhesion kinase (FAK). J Biol Chem (2010) 1.75
TRPM7 regulates cell adhesion by controlling the calcium-dependent protease calpain. J Biol Chem (2006) 1.75
RACK1 regulates integrin-mediated adhesion, protrusion, and chemotactic cell migration via its Src-binding site. Mol Biol Cell (2003) 1.65
Progressive neurodegeneration in patients with primary immunodeficiency disease on IVIG treatment. Clin Immunol (2002) 1.64
ADAMTS1 mediates the release of antiangiogenic polypeptides from TSP1 and 2. EMBO J (2006) 1.59
Live imaging of chronic inflammation caused by mutation of zebrafish Hai1. J Cell Sci (2007) 1.59
A platform for assessing chemotactic migration within a spatiotemporally defined 3D microenvironment. Lab Chip (2008) 1.58
Neutrophil dysfunction in a family with a SAPHO syndrome-like phenotype. Arthritis Rheum (2008) 1.58
The F-BAR protein PSTPIP1 controls extracellular matrix degradation and filopodia formation in macrophages. Blood (2014) 1.57
Fibrillin assembly requires fibronectin. Mol Biol Cell (2008) 1.53
Tyrosine phosphorylation of type Igamma phosphatidylinositol phosphate kinase by Src regulates an integrin-talin switch. J Cell Biol (2003) 1.49
Pseudomonas aeruginosa Type III secretion system interacts with phagocytes to modulate systemic infection of zebrafish embryos. Cell Microbiol (2009) 1.45
Filopodial calcium transients regulate growth cone motility and guidance through local activation of calpain. Neuron (2003) 1.42
Early redox, Src family kinase, and calcium signaling integrate wound responses and tissue regeneration in zebrafish. J Cell Biol (2012) 1.41
Rapid prototyping of arrayed microfluidic systems in polystyrene for cell-based assays. Anal Chem (2011) 1.39
Talin1 regulates TCR-mediated LFA-1 function. J Immunol (2006) 1.39
Characterization of zebrafish larval inflammatory macrophages. Dev Comp Immunol (2009) 1.37
Differential interactions of thrombospondin-1, -2, and -4 with CD47 and effects on cGMP signaling and ischemic injury responses. J Biol Chem (2008) 1.34
Cell polarization mechanisms during directed cell migration. Nat Cell Biol (2005) 1.33
Structure of the calcium-rich signature domain of human thrombospondin-2. Nat Struct Mol Biol (2005) 1.33
Alpha4beta1 integrin mediates selective endothelial cell responses to thrombospondins 1 and 2 in vitro and modulates angiogenesis in vivo. Circ Res (2003) 1.32
Proteolysis of cortactin by calpain regulates membrane protrusion during cell migration. Mol Biol Cell (2005) 1.30
Interactions of thrombospondins with alpha4beta1 integrin and CD47 differentially modulate T cell behavior. J Cell Biol (2002) 1.29
Interaction of alpha9beta1 integrin with thrombospondin-1 promotes angiogenesis. Circ Res (2007) 1.28
Type Igamma PIP kinase is a novel uropod component that regulates rear retraction during neutrophil chemotaxis. Mol Biol Cell (2007) 1.27
The N-terminal 70-kDa fragment of fibronectin binds to cell surface fibronectin assembly sites in the absence of intact fibronectin. Matrix Biol (2006) 1.26
Roles of integrin activation in eosinophil function and the eosinophilic inflammation of asthma. J Leukoc Biol (2007) 1.25
Calpain-mediated proteolysis of paxillin negatively regulates focal adhesion dynamics and cell migration. J Biol Chem (2011) 1.23
Cyclin G2 is a centrosome-associated nucleocytoplasmic shuttling protein that influences microtubule stability and induces a p53-dependent cell cycle arrest. Exp Cell Res (2006) 1.22
An arrayed high-content chemotaxis assay for patient diagnosis. Integr Biol (Camb) (2010) 1.22
Identification of novel beta1 integrin binding sites in the type 1 and type 2 repeats of thrombospondin-1. J Biol Chem (2004) 1.19
Regulation of integrin function by CD47 ligands. Differential effects on alpha vbeta 3 and alpha 4beta1 integrin-mediated adhesion. J Biol Chem (2002) 1.18
TNF-alpha promotes a stop signal that inhibits neutrophil polarization and migration via a p38 MAPK pathway. J Leukoc Biol (2005) 1.17
Enhancement of thrombogenesis by plasma fibronectin cross-linked to fibrin and assembled in platelet thrombi. Blood (2006) 1.15
Calpain proteases in cell adhesion and motility. Int Rev Cytol (2005) 1.14
Asymmetric localization of calpain 2 during neutrophil chemotaxis. Mol Biol Cell (2006) 1.14
Recognition of the N-terminal modules of thrombospondin-1 and thrombospondin-2 by alpha6beta1 integrin. J Biol Chem (2003) 1.13
A polymorphism in thrombospondin-1 associated with familial premature coronary artery disease alters Ca2+ binding. J Biol Chem (2004) 1.12
Extended binding site on fibronectin for the functional upstream domain of protein F1 of Streptococcus pyogenes. J Biol Chem (2010) 1.11
Microfluidic kit-on-a-lid: a versatile platform for neutrophil chemotaxis assays. Blood (2012) 1.11
Natural killer T-cell autoreactivity leads to a specialized activation state. Blood (2008) 1.11
Dual roles for Rac2 in neutrophil motility and active retention in zebrafish hematopoietic tissue. Dev Cell (2011) 1.11
Fibronectin binds and enhances the activity of bone morphogenetic protein 1. J Biol Chem (2009) 1.11
α(M)β(2) integrin-mediated adhesion and motility of IL-5-stimulated eosinophils on periostin. Am J Respir Cell Mol Biol (2013) 1.10
Rational design of a ligand-controlled protein conformational switch. Proc Natl Acad Sci U S A (2013) 1.08
Fibronectin's central cell-binding domain supports focal adhesion formation and Rho signal transduction. J Biol Chem (2005) 1.07
Innate immune response to Streptococcus iniae infection in zebrafish larvae. Infect Immun (2012) 1.05
Thrombospondin 1 binding to calreticulin-LRP1 signals resistance to anoikis. FASEB J (2008) 1.05
Up-regulation and activation of eosinophil integrins in blood and airway after segmental lung antigen challenge. J Immunol (2008) 1.05
Plasma fibronectin supports hemostasis and regulates thrombosis. J Clin Invest (2014) 1.05
Distinct signalling mechanisms mediate neutrophil attraction to bacterial infection and tissue injury. Cell Microbiol (2012) 1.04
RACK1 regulates Src activity and modulates paxillin dynamics during cell migration. Exp Cell Res (2007) 1.03
Hax1 regulates neutrophil adhesion and motility through RhoA. J Cell Biol (2011) 1.02
Assembly of exogenous fibronectin by fibronectin-null cells is dependent on the adhesive substrate. J Biol Chem (2004) 1.02
Epidermal growth factor-like repeats of thrombospondins activate phospholipase Cgamma and increase epithelial cell migration through indirect epidermal growth factor receptor activation. J Biol Chem (2009) 1.02
Display of cell surface sites for fibronectin assembly is modulated by cell adherence to (1)F3 and C-terminal modules of fibronectin. PLoS One (2009) 1.02
Interactions among the three structural motifs of the C-terminal region of human thrombospondin-2. Biochemistry (2003) 1.02
Differential engagement of modules 1 and 4 of vascular cell adhesion molecule-1 (CD106) by integrins alpha4beta1 (CD49d/29) and alphaMbeta2 (CD11b/18) of eosinophils. J Biol Chem (2006) 1.02
Trimeric assembly of the C-terminal region of thrombospondin-1 or thrombospondin-2 is necessary for cell spreading and fascin spike organisation. J Cell Sci (2002) 1.01
Dissection of the hyperadhesive phenotype of airway eosinophils in asthma. Am J Respir Cell Mol Biol (2006) 1.00
The ENTH domain protein Clint1 is required for epidermal homeostasis in zebrafish. Development (2009) 1.00
The PCH family member proline-serine-threonine phosphatase-interacting protein 1 targets to the leukocyte uropod and regulates directed cell migration. Mol Biol Cell (2008) 1.00
Immunochemical analysis of the structure of the signature domains of thrombospondin-1 and thrombospondin-2 in low calcium concentrations. J Biol Chem (2007) 0.99
Actin-binding protein-1 interacts with WASp-interacting protein to regulate growth factor-induced dorsal ruffle formation. Mol Biol Cell (2009) 0.98
Localized bacterial infection induces systemic activation of neutrophils through Cxcr2 signaling in zebrafish. J Leukoc Biol (2013) 0.98
Zebrafish Entrapment By Restriction Array (ZEBRA) device: a low-cost, agarose-free zebrafish mounting technique for automated imaging. Lab Chip (2013) 0.98
The von Willebrand factor-reducing activity of thrombospondin-1 is located in the calcium-binding/C-terminal sequence and requires a free thiol at position 974. Blood (2002) 0.97
Spatiotemporal regulation of Src and its substrates at invadosomes. Eur J Cell Biol (2012) 0.97
Actions of the functional upstream domain of protein F1 of Streptococcus pyogenes on the conformation of fibronectin. Biophys Chem (2004) 0.97
Modulation of neutrophil function by a secreted mucinase of Escherichia coli O157:H7. PLoS Pathog (2009) 0.97
Biophysical characterization, including disulfide bond assignments, of the anti-angiogenic type 1 domains of human thrombospondin-1. Biochemistry (2002) 0.97
The counteradhesive proteins, thrombospondin 1 and SPARC/osteonectin, open the tyrosine phosphorylation-responsive paracellular pathway in pulmonary vascular endothelia. Microvasc Res (2008) 0.96