Residues within a conserved amino acid motif of domains 1 and 4 of VCAM-1 are required for binding to VLA-4.

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Published in J Cell Biol on April 01, 1994

Authors

R H Vonderheide1, T F Tedder, T A Springer, D E Staunton

Author Affiliations

1: Center for Blood Research, Dana-Farber Cancer Institute, Boston, Massachusetts.

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CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice. Immunity (1996) 2.28

Structural homology of a macrophage differentiation antigen and an antigen involved in T-cell-mediated killing. Nature (1982) 2.26

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Intercellular adhesion molecule 3, a third adhesion counter-receptor for lymphocyte function-associated molecule 1 on resting lymphocytes. J Exp Med (1992) 2.24

Influence of receptor lateral mobility on adhesion strengthening between membranes containing LFA-3 and CD2. J Cell Biol (1991) 2.24

LFA-1 and Lyt-2,3, molecules associated with T lymphocyte-mediated killing; and Mac-1, an LFA-1 homologue associated with complement receptor function. Immunol Rev (1982) 2.23

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Domains in plexins: links to integrins and transcription factors. Trends Biochem Sci (1999) 2.23

Regulated expression of the Mac-1, LFA-1, p150,95 glycoprotein family during leukocyte differentiation. J Immunol (1986) 2.21

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Cerebral protection in homozygous null ICAM-1 mice after middle cerebral artery occlusion. Role of neutrophil adhesion in the pathogenesis of stroke. J Clin Invest (1996) 2.19