Published in Annu Rev Public Health on January 01, 2008
Global burden of aflatoxin-induced hepatocellular carcinoma: a risk assessment. Environ Health Perspect (2010) 3.35
Nrf2: friend or foe for chemoprevention? Carcinogenesis (2009) 2.72
Mycotoxins and human disease: a largely ignored global health issue. Carcinogenesis (2009) 2.38
Advances in chemical carcinogenesis: a historical review and prospective. Cancer Res (2008) 1.83
Chemical biology of mutagenesis and DNA repair: cellular responses to DNA alkylation. Carcinogenesis (2009) 1.73
Aflatoxin exposure and viral hepatitis in the etiology of liver cirrhosis in the Gambia, West Africa. Environ Health Perspect (2008) 1.22
Disparities in liver cancer incidence by nativity, acculturation, and socioeconomic status in California Hispanics and Asians. Cancer Epidemiol Biomarkers Prev (2010) 1.10
Contribution of gut bacteria to liver pathobiology. Gastroenterol Res Pract (2010) 1.07
Health economic impacts and cost-effectiveness of aflatoxin-reduction strategies in Africa: case studies in biocontrol and post-harvest interventions. Food Addit Contam Part A Chem Anal Control Expo Risk Assess (2010) 1.07
Costs and efficacy of public health interventions to reduce aflatoxin-induced human disease. Food Addit Contam Part A Chem Anal Control Expo Risk Assess (2010) 0.98
Aflatoxin B1-DNA adduct formation and mutagenicity in livers of neonatal male and female B6C3F1 mice. Toxicol Sci (2011) 0.96
Aflatoxin regulations in a network of global maize trade. PLoS One (2012) 0.95
Risk factors for hepatocellular carcinoma in India. J Clin Exp Hepatol (2014) 0.85
Global risk assessment of aflatoxins in maize and peanuts: are regulatory standards adequately protective? Toxicol Sci (2013) 0.83
Sulforaphane-mediated reduction of aflatoxin B₁-N⁷-guanine in rat liver DNA: impacts of strain and sex. Toxicol Sci (2011) 0.82
Occurrence of aflatoxins in selected processed foods from Pakistan. Int J Mol Sci (2012) 0.82
Evaluating the technical feasibility of aflatoxin risk reduction strategies in Africa. Food Addit Contam Part A Chem Anal Control Expo Risk Assess (2010) 0.81
Aflatoxins, hepatocellular carcinoma and public health. World J Gastroenterol (2013) 0.81
Perspective: time to face the fungal threat. Nature (2014) 0.80
A single neonatal exposure to aflatoxin b1 induces prolonged genetic damage in two loci of mouse liver. Toxicol Sci (2012) 0.80
Aflatoxin regulations and global pistachio trade: insights from social network analysis. PLoS One (2014) 0.78
Deciphering the Anti-Aflatoxinogenic Properties of Eugenol Using a Large-Scale q-PCR Approach. Toxins (Basel) (2016) 0.78
Dew inspired breathing-based detection of genetic point mutation visualized by naked eye. Sci Rep (2014) 0.77
Prenatal exposure of mice to the human liver carcinogen aflatoxin B1 reveals a critical window of susceptibility to genetic change. Int J Cancer (2014) 0.77
Molecular characteristics of Hepatitis B and chronic liver disease in a cohort of HB carriers from Bamako, Mali. BMC Infect Dis (2015) 0.75
The role of plant processing for the cancer preventive potential of Ethiopian kale (Brassica carinata). Food Nutr Res (2017) 0.75
Aflatoxin B1 inhibits the type 1 interferon response pathway via STAT1 suggesting another mechanism of hepatocellular carcinoma. Infect Agent Cancer (2017) 0.75
Distinct response of the hepatic transcriptome to Aflatoxin B1 induced hepatocellular carcinogenesis and resistance in rats. Sci Rep (2016) 0.75
Biomonitoring Human Albumin Adducts: The Past, the Present, and the Future. Chem Res Toxicol (2016) 0.75
Global geographical overlap of aflatoxin and hepatitis C: controlling risk factors for liver cancer worldwide. Food Addit Contam Part A Chem Anal Control Expo Risk Assess (2013) 0.75
DNA Sequence Modulates Geometrical Isomerism of the trans-8,9- Dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl-formamido)- 9-hydroxy Aflatoxin B1 Adduct. Chem Res Toxicol (2015) 0.75
Therapeutic properties of green tea against environmental insults. J Nutr Biochem (2016) 0.75
Intervention trial with calcium montmorillonite clay in a south Texas population exposed to aflatoxin. Food Addit Contam Part A Chem Anal Control Expo Risk Assess (2016) 0.75
Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. J Clin Invest (2004) 6.32
Genetic variation and cancer: improving the environment for publication of association studies. Cancer Epidemiol Biomarkers Prev (2004) 6.24
Role of NRF2 in protection against hyperoxic lung injury in mice. Am J Respir Cell Mol Biol (2002) 5.57
Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers. Proc Natl Acad Sci U S A (2004) 5.54
Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res (2002) 5.43
Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis. J Clin Invest (2006) 4.41
Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice. J Exp Med (2005) 4.31
Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival. J Biol Chem (2002) 4.14
The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice. J Cell Biol (2009) 3.49
Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. Proc Natl Acad Sci U S A (2002) 3.18
Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity. Biochem Biophys Res Commun (2005) 2.85
Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter. Mol Cell Biol (2002) 2.82
Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis. Nucleic Acids Res (2010) 2.80
A systematic review and meta-analysis of the risk of increasing adiposity on Barrett's esophagus. Am J Gastroenterol (2007) 2.79
Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes. Mol Cancer Ther (2007) 2.71
Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice. Proc Natl Acad Sci U S A (2008) 2.53
Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide. Biochem Biophys Res Commun (2006) 2.37
When NRF2 talks, who's listening? Antioxid Redox Signal (2010) 2.32
Antioxidants enhance mammalian proteasome expression through the Keap1-Nrf2 signaling pathway. Mol Cell Biol (2003) 2.19
Preventable exposures associated with human cancers. J Natl Cancer Inst (2011) 2.14
Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults. Mutat Res (2007) 2.10
Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole. Cancer Res (2006) 2.05
The role of Keap1 in cellular protective responses. Chem Res Toxicol (2005) 2.03
Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proc Natl Acad Sci U S A (2008) 1.97
Postweaning exposure to aflatoxin results in impaired child growth: a longitudinal study in Benin, West Africa. Environ Health Perspect (2004) 1.97
Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast. Carcinogenesis (2007) 1.91
Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide. Eur J Pharmacol (2009) 1.90
Targeting NRF2 signaling for cancer chemoprevention. Toxicol Appl Pharmacol (2009) 1.88
Glutathione peroxidase 2, the major cigarette smoke-inducible isoform of GPX in lungs, is regulated by Nrf2. Am J Respir Cell Mol Biol (2006) 1.86
NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis. Mol Cell Biol (2007) 1.86
Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice. Carcinogenesis (2009) 1.85
Role of Nrf2 in protection against intracerebral hemorrhage injury in mice. Free Radic Biol Med (2007) 1.73
Linkage analysis of susceptibility to hyperoxia. Nrf2 is a candidate gene. Am J Respir Cell Mol Biol (2002) 1.73
Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate treatment. Int J Cancer (2007) 1.67
Nrf2: control of sensitivity to carcinogens. Arch Toxicol (2011) 1.61
Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils. Antioxid Redox Signal (2007) 1.60
In vivo modulation of the Parkinsonian phenotype by Nrf2. Neurotoxicology (2006) 1.54
A million africans a year dying from cancer by 2030: what can cancer research and control offer to the continent? Int J Cancer (2011) 1.54
Disruption of Nrf2 impairs the resolution of hyperoxia-induced acute lung injury and inflammation in mice. J Immunol (2009) 1.53
Modification of immune function through exposure to dietary aflatoxin in Gambian children. Environ Health Perspect (2003) 1.53
Genetic or pharmacologic amplification of nrf2 signaling inhibits acute inflammatory liver injury in mice. Toxicol Sci (2008) 1.52
Regulation of notch1 signaling by nrf2: implications for tissue regeneration. Sci Signal (2010) 1.50
Chemoprevention through the Keap1-Nrf2 signaling pathway by phase 2 enzyme inducers. Mutat Res (2004) 1.47
Transgenic expression of aflatoxin aldehyde reductase (AKR7A1) modulates aflatoxin B1 metabolism but not hepatic carcinogenesis in the rat. Toxicol Sci (2009) 1.45
Specific mutations of hepatitis B virus in plasma predict liver cancer development. Proc Natl Acad Sci U S A (2004) 1.45
Genetic dissection of the Nrf2-dependent redox signaling-regulated transcriptional programs of cell proliferation and cytoprotection. Physiol Genomics (2007) 1.45
Human exposure monitoring and evaluation in the Arctic: the importance of understanding exposures to the development of public health policy. Environ Health Perspect (2004) 1.45
Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage. J Cell Biol (2012) 1.44
Genetic and pharmacologic evidence links oxidative stress to ventilator-induced lung injury in mice. Am J Respir Crit Care Med (2007) 1.41
Bioavailability of Sulforaphane from two broccoli sprout beverages: results of a short-term, cross-over clinical trial in Qidong, China. Cancer Prev Res (Phila) (2011) 1.37
Deficiency in Nrf2-GSH signaling impairs type II cell growth and enhances sensitivity to oxidants. Am J Respir Cell Mol Biol (2007) 1.36
Disruption of the transcription factor Nrf2 promotes pro-oxidative dendritic cells that stimulate Th2-like immunoresponsiveness upon activation by ambient particulate matter. J Immunol (2008) 1.36
Nrf2 regulates an adaptive response protecting against oxidative damage following diquat-mediated formation of superoxide anion. Arch Biochem Biophys (2006) 1.33
Liver cancer in low and middle income countries. BMJ (2003) 1.33
The role of aflatoxins and hepatitis viruses in the etiopathogenesis of hepatocellular carcinoma: A basis for primary prevention in Guinea-Conakry, West Africa. J Gastroenterol Hepatol (2002) 1.32
The Keap1-Nrf2 system prevents onset of diabetes mellitus. Mol Cell Biol (2013) 1.30
Risk of mortality and cancer incidence in Barrett's esophagus. Cancer Epidemiol Biomarkers Prev (2007) 1.29
The flavanol (-)-epicatechin prevents stroke damage through the Nrf2/HO1 pathway. J Cereb Blood Flow Metab (2010) 1.29
Genetic mutations associated with cigarette smoking in pancreatic cancer. Cancer Res (2009) 1.28
Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genes. Carcinogenesis (2005) 1.28
Divergent responses of chondrocytes and endothelial cells to shear stress: cross-talk among COX-2, the phase 2 response, and apoptosis. Proc Natl Acad Sci U S A (2005) 1.28
Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs. Free Radic Biol Med (2008) 1.27
The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells. Mol Biol Cell (2011) 1.26
Nrf2 deficiency prevents reductive stress-induced hypertrophic cardiomyopathy. Cardiovasc Res (2013) 1.25
Aflatoxin exposure in utero causes growth faltering in Gambian infants. Int J Epidemiol (2007) 1.25
Interactive effects of nrf2 genotype and oltipraz on benzo[a]pyrene-DNA adducts and tumor yield in mice. Carcinogenesis (2003) 1.22
Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors. J Biol Chem (2004) 1.21
Aflatoxin and hepatitis B virus biomarkers: a paradigm for complex environmental exposures and cancer risk. Cancer Biomark (2005) 1.20
Validation of the multiple sensor mechanism of the Keap1-Nrf2 system. Free Radic Biol Med (2012) 1.18
Vitamin D and vitamin D analogs as cancer chemopreventive agents. Nutr Rev (2003) 1.16
Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles. Breast Cancer Res Treat (2011) 1.15
Role of increased expression of the proteasome in the protective effects of sulforaphane against hydrogen peroxide-mediated cytotoxicity in murine neuroblastoma cells. Free Radic Biol Med (2007) 1.15
Reduced aflatoxin exposure presages decline in liver cancer mortality in an endemic region of China. Cancer Prev Res (Phila) (2013) 1.14
Inhibition of estrogen signaling activates the NRF2 pathway in breast cancer. Breast Cancer Res Treat (2010) 1.14
Urinary deoxynivalenol is correlated with cereal intake in individuals from the United kingdom. Environ Health Perspect (2008) 1.13
Chemopreventive promise of targeting the Nrf2 pathway. Drug News Perspect (2007) 1.13
Immunotoxicity of aflatoxin B1: impairment of the cell-mediated response to vaccine antigen and modulation of cytokine expression. Toxicol Appl Pharmacol (2008) 1.13
Tissue inhibitor of metalloproteinase-3 (TIMP-3) gene is methylated in the development of esophageal adenocarcinoma: loss of expression correlates with poor prognosis. Int J Cancer (2005) 1.13
NF-E2-related factor 2 regulates the stress response to UVA-1-oxidized phospholipids in skin cells. FASEB J (2009) 1.13
A plea on behalf of expert evaluation and the experts involved. Int J Epidemiol (2010) 1.12
Hepatocellular carcinoma and polymorphisms in carcinogen-metabolizing and DNA repair enzymes in a population with aflatoxin exposure and hepatitis B virus endemicity. Cancer Epidemiol Biomarkers Prev (2005) 1.12
The NRF2-heme oxygenase-1 system modulates cyclosporin A-induced epithelial-mesenchymal transition and renal fibrosis. Free Radic Biol Med (2010) 1.12
Notes from the field: "green" chemoprevention as frugal medicine. Cancer Prev Res (Phila) (2012) 1.11
Role of metabolism and viruses in aflatoxin-induced liver cancer. Toxicol Appl Pharmacol (2005) 1.11
Quantification of aflatoxin-B1-N7-Guanine in human urine by high-performance liquid chromatography and isotope dilution tandem mass spectrometry. Chem Res Toxicol (2006) 1.10
The transcriptional response to a peroxisome proliferator-activated receptor alpha agonist includes increased expression of proteome maintenance genes. J Biol Chem (2004) 1.10
Innate immunity against bacterial infection following hyperoxia exposure is impaired in NRF2-deficient mice. J Immunol (2009) 1.09
NewGeneris: a European study on maternal diet during pregnancy and child health. Cancer Epidemiol Biomarkers Prev (2009) 1.09
Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of Parkinson's disease. Antioxid Redox Signal (2012) 1.09
Genetic variation in XPD predicts treatment outcome and risk of acute myeloid leukemia following chemotherapy. Blood (2004) 1.09
Nrf2 is a critical modulator of the innate immune response in a model of uveitis. Free Radic Biol Med (2009) 1.08
Risk factors, DNA damage, and disease progression in Barrett's esophagus. Cancer Epidemiol Biomarkers Prev (2005) 1.06
A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin. Cancer Res (2008) 1.06
The triterpenoid CDDO-imidazolide confers potent protection against hyperoxic acute lung injury in mice. Am J Respir Crit Care Med (2009) 1.05
New player on an old field; the keap1/Nrf2 pathway as a target for treatment of type 2 diabetes and metabolic syndrome. Curr Diabetes Rev (2013) 1.05
Evaluation of data quality at the Gambia national cancer registry. Int J Cancer (2012) 1.02
An intron splice acceptor polymorphism in hMSH2 and risk of leukemia after treatment with chemotherapeutic alkylating agents. Clin Cancer Res (2003) 1.02
Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo. Am J Physiol Lung Cell Mol Physiol (2013) 1.01
Induction of 26S proteasome subunit PSMB5 by the bifunctional inducer 3-methylcholanthrene through the Nrf2-ARE, but not the AhR/Arnt-XRE, pathway. Biochem Biophys Res Commun (2006) 1.01
p16 expression in Barrett's esophagus and esophageal adenocarcinoma: association with genetic and epigenetic alterations. Cancer Lett (2005) 1.00