Published in Am J Respir Cell Mol Biol on January 01, 2002
Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. J Clin Invest (2004) 6.32
Animal models of acute lung injury. Am J Physiol Lung Cell Mol Physiol (2008) 6.10
Antioxidants enhance mammalian proteasome expression through the Keap1-Nrf2 signaling pathway. Mol Cell Biol (2003) 2.19
Nrf2-regulated PPAR{gamma} expression is critical to protection against acute lung injury in mice. Am J Respir Crit Care Med (2010) 2.02
Oxidants and the pathogenesis of lung diseases. J Allergy Clin Immunol (2008) 1.91
The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism. Front Oncol (2012) 1.64
Disruption of Nrf2 impairs the resolution of hyperoxia-induced acute lung injury and inflammation in mice. J Immunol (2009) 1.53
Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2. Pharmacol Rev (2012) 1.45
Genetic and pharmacologic evidence links oxidative stress to ventilator-induced lung injury in mice. Am J Respir Crit Care Med (2007) 1.41
Nrf2-mediated transcriptional induction of antioxidant response in mouse embryos exposed to ethanol in vivo: implications for the prevention of fetal alcohol spectrum disorders. Antioxid Redox Signal (2008) 1.38
Recent advances in genetic predisposition to clinical acute lung injury. Am J Physiol Lung Cell Mol Physiol (2009) 1.34
Cigarette smoke impairs clearance of apoptotic cells through oxidant-dependent activation of RhoA. Am J Respir Crit Care Med (2009) 1.31
The Keap1-Nrf2 system prevents onset of diabetes mellitus. Mol Cell Biol (2013) 1.30
Conditional deletion of Nrf2 in airway epithelium exacerbates acute lung injury and impairs the resolution of inflammation. Am J Respir Cell Mol Biol (2011) 1.19
The early responses of VEGF and its receptors during acute lung injury: implication of VEGF in alveolar epithelial cell survival. Crit Care (2006) 1.17
Hyperoxia-induced signal transduction pathways in pulmonary epithelial cells. Free Radic Biol Med (2007) 1.16
NRF2 cysteine residues are critical for oxidant/electrophile-sensing, Kelch-like ECH-associated protein-1-dependent ubiquitination-proteasomal degradation, and transcription activation. Mol Pharmacol (2009) 1.14
Genetic basis of murine responses to hyperoxia-induced lung injury. Immunogenetics (2006) 1.13
The triterpenoid CDDO-imidazolide confers potent protection against hyperoxic acute lung injury in mice. Am J Respir Crit Care Med (2009) 1.05
Inflammation and immune-related candidate gene associations with acute lung injury susceptibility and severity: a validation study. PLoS One (2012) 1.04
EGFR-activated signaling and actin remodeling regulate cyclic stretch-induced NRF2-ARE activation. Am J Respir Cell Mol Biol (2006) 1.02
Targeted deletion of nrf2 impairs lung development and oxidant injury in neonatal mice. Antioxid Redox Signal (2012) 1.02
Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo. Am J Physiol Lung Cell Mol Physiol (2013) 1.01
Redox regulation of T-cell function: from molecular mechanisms to significance in human health and disease. Antioxid Redox Signal (2012) 1.01
The genetic contribution to heart rate and heart rate variability in quiescent mice. Am J Physiol Heart Circ Physiol (2008) 0.96
Anti-human tissue factor antibody ameliorated intestinal ischemia reperfusion-induced acute lung injury in human tissue factor knock-in mice. PLoS One (2008) 0.96
The antioxidant response element and oxidative stress modifiers in airway diseases. Curr Mol Med (2008) 0.94
Genomic structure and variation of nuclear factor (erythroid-derived 2)-like 2. Oxid Med Cell Longev (2013) 0.93
Nrf2 and cardiovascular defense. Oxid Med Cell Longev (2013) 0.91
Manipulation of gene expression by oxygen: a primer from bedside to bench. Pediatr Res (2009) 0.90
Nrf2-mediated liver protection by sauchinone, an antioxidant lignan, from acetaminophen toxicity through the PKCδ-GSK3β pathway. Br J Pharmacol (2011) 0.89
PI3K-AKT Signaling via Nrf2 Protects against Hyperoxia-Induced Acute Lung Injury, but Promotes Inflammation Post-Injury Independent of Nrf2 in Mice. PLoS One (2015) 0.89
Loss of Nrf2 accelerates ionizing radiation-induced bone loss by upregulating RANKL. Free Radic Biol Med (2012) 0.88
Thioredoxin reductase inhibition elicits Nrf2-mediated responses in Clara cells: implications for oxidant-induced lung injury. Antioxid Redox Signal (2012) 0.88
Genetic polymorphisms associated with acute lung injury. Pharmacogenomics (2009) 0.88
Genetic analysis of tissue glutathione concentrations and redox balance. Free Radic Biol Med (2014) 0.85
Association of Nrf2 polymorphism haplotypes with acute lung injury phenotypes in inbred strains of mice. Antioxid Redox Signal (2014) 0.84
The NRF2 activation and antioxidative response are not impaired overall during hyperoxia-induced lung epithelial cell death. Oxid Med Cell Longev (2013) 0.83
Quantitative trait analysis of the development of pulmonary tolerance to inhaled zinc oxide in mice. Respir Res (2005) 0.82
Noblesse oblige: NRF2 functions in the airways. Am J Respir Cell Mol Biol (2014) 0.82
Cardiac physiologic and genetic predictors of hyperoxia-induced acute lung injury in mice. Am J Respir Cell Mol Biol (2011) 0.81
Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications. Physiol Rev (2016) 0.81
Nrf2 is a protective factor against oxidative stresses induced by diesel exhaust particle in allergic asthma. Oxid Med Cell Longev (2013) 0.80
Common variants of NFE2L2 gene predisposes to acute respiratory distress syndrome in patients with severe sepsis. Crit Care (2015) 0.79
Hyperoxia promotes polarization of the immune response in ovalbumin-induced airway inflammation, leading to a TH17 cell phenotype. Immun Inflamm Dis (2015) 0.78
Redox signaling regulated by electrophiles and reactive sulfur species. J Clin Biochem Nutr (2016) 0.78
Genetic polymorphism of the Nrf2 promoter region is associated with vitiligo risk in Han Chinese populations. J Cell Mol Med (2016) 0.76
Genetic epidemiology of acute lung injury: choosing the right candidate genes is the first step. Crit Care (2004) 0.76
Age and Sex of Mice Markedly Affect Survival Times Associated with Hyperoxic Acute Lung Injury. PLoS One (2015) 0.76
NRF2 Is a Key Target for Prevention of Noise-Induced Hearing Loss by Reducing Oxidative Damage of Cochlea. Sci Rep (2016) 0.76
The influence of Nrf2 on cardiac responses to environmental stressors. Oxid Med Cell Longev (2013) 0.75
Multiple-laboratory comparison of microarray platforms. Nat Methods (2005) 11.74
Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. J Clin Invest (2004) 6.32
Role of NRF2 in protection against hyperoxic lung injury in mice. Am J Respir Cell Mol Biol (2002) 5.57
Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers. Proc Natl Acad Sci U S A (2004) 5.54
Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res (2002) 5.43
Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis. J Clin Invest (2006) 4.41
Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice. J Exp Med (2005) 4.31
Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival. J Biol Chem (2002) 4.14
The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice. J Cell Biol (2009) 3.49
Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. Proc Natl Acad Sci U S A (2002) 3.18
Nrf2 defends the lung from oxidative stress. Antioxid Redox Signal (2006) 2.96
Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity. Biochem Biophys Res Commun (2005) 2.85
Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter. Mol Cell Biol (2002) 2.82
Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis. Nucleic Acids Res (2010) 2.80
Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes. Mol Cancer Ther (2007) 2.71
Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury. FASEB J (2007) 2.65
A genome-wide association study on African-ancestry populations for asthma. J Allergy Clin Immunol (2009) 2.53
Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice. Proc Natl Acad Sci U S A (2008) 2.53
The transcription factor NRF2 protects against pulmonary fibrosis. FASEB J (2004) 2.43
Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide. Biochem Biophys Res Commun (2006) 2.37
A role for immune complexes in enhanced respiratory syncytial virus disease. J Exp Med (2002) 2.34
When NRF2 talks, who's listening? Antioxid Redox Signal (2010) 2.32
Antioxidants enhance mammalian proteasome expression through the Keap1-Nrf2 signaling pathway. Mol Cell Biol (2003) 2.19
Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults. Mutat Res (2007) 2.10
Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha. Nucleic Acids Res (2012) 2.07
Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole. Cancer Res (2006) 2.05
The role of Keap1 in cellular protective responses. Chem Res Toxicol (2005) 2.03
Nrf2-regulated PPAR{gamma} expression is critical to protection against acute lung injury in mice. Am J Respir Crit Care Med (2010) 2.02
Genetic influence on daily wheel running activity level. Physiol Genomics (2004) 1.98
Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proc Natl Acad Sci U S A (2008) 1.97
Oxidants and the pathogenesis of lung diseases. J Allergy Clin Immunol (2008) 1.91
Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast. Carcinogenesis (2007) 1.91
Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide. Eur J Pharmacol (2009) 1.90
Targeting NRF2 signaling for cancer chemoprevention. Toxicol Appl Pharmacol (2009) 1.88
Glutathione peroxidase 2, the major cigarette smoke-inducible isoform of GPX in lungs, is regulated by Nrf2. Am J Respir Cell Mol Biol (2006) 1.86
NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis. Mol Cell Biol (2007) 1.86
Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice. Carcinogenesis (2009) 1.85
Identification of polymorphic antioxidant response elements in the human genome. Hum Mol Genet (2007) 1.79
Gene expression profiling of NRF2-mediated protection against oxidative injury. Free Radic Biol Med (2005) 1.76
Role of Nrf2 in protection against intracerebral hemorrhage injury in mice. Free Radic Biol Med (2007) 1.73
NADPH oxidase and ERK signaling regulates hyperoxia-induced Nrf2-ARE transcriptional response in pulmonary epithelial cells. J Biol Chem (2004) 1.73
Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate treatment. Int J Cancer (2007) 1.67
Ozone and pulmonary innate immunity. Proc Am Thorac Soc (2007) 1.61
Nrf2: control of sensitivity to carcinogens. Arch Toxicol (2011) 1.61
Nrf2 protects against airway disorders. Toxicol Appl Pharmacol (2009) 1.60
Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils. Antioxid Redox Signal (2007) 1.60
The glutathione-S-transferase Mu 1 null genotype modulates ozone-induced airway inflammation in human subjects. J Allergy Clin Immunol (2009) 1.57
Global gene expression analysis of Anopheles gambiae responses to microbial challenge. Insect Biochem Mol Biol (2005) 1.55
In vivo modulation of the Parkinsonian phenotype by Nrf2. Neurotoxicology (2006) 1.54
Ozone enhances markers of innate immunity and antigen presentation on airway monocytes in healthy individuals. J Allergy Clin Immunol (2007) 1.54
Antiviral activity of Nrf2 in a murine model of respiratory syncytial virus disease. Am J Respir Crit Care Med (2008) 1.53
Disruption of Nrf2 impairs the resolution of hyperoxia-induced acute lung injury and inflammation in mice. J Immunol (2009) 1.53
Protection against inhaled oxidants through scavenging of oxidized lipids by macrophage receptors MARCO and SR-AI/II. J Clin Invest (2007) 1.52
Genetic or pharmacologic amplification of nrf2 signaling inhibits acute inflammatory liver injury in mice. Toxicol Sci (2008) 1.52
Regulation of notch1 signaling by nrf2: implications for tissue regeneration. Sci Signal (2010) 1.50
Atopic asthmatic subjects but not atopic subjects without asthma have enhanced inflammatory response to ozone. J Allergy Clin Immunol (2010) 1.50
Influence of genetic background on daily running-wheel activity differs with aging. Physiol Genomics (2005) 1.47
MEKK1 plays a critical role in activating the transcription factor C/EBP-beta-dependent gene expression in response to IFN-gamma. Proc Natl Acad Sci U S A (2002) 1.47
Chemoprevention through the Keap1-Nrf2 signaling pathway by phase 2 enzyme inducers. Mutat Res (2004) 1.47
Protective interventions to prevent aflatoxin-induced carcinogenesis in developing countries. Annu Rev Public Health (2008) 1.46
Transgenic expression of aflatoxin aldehyde reductase (AKR7A1) modulates aflatoxin B1 metabolism but not hepatic carcinogenesis in the rat. Toxicol Sci (2009) 1.45
Genetic dissection of the Nrf2-dependent redox signaling-regulated transcriptional programs of cell proliferation and cytoprotection. Physiol Genomics (2007) 1.45
Specific mutations of hepatitis B virus in plasma predict liver cancer development. Proc Natl Acad Sci U S A (2004) 1.45
Quantitative trait loci for physical activity traits in mice. Physiol Genomics (2008) 1.45
Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage. J Cell Biol (2012) 1.44
Hyperoxia stimulates an Nrf2-ARE transcriptional response via ROS-EGFR-PI3K-Akt/ERK MAP kinase signaling in pulmonary epithelial cells. Antioxid Redox Signal (2006) 1.44
Genetic and pharmacologic evidence links oxidative stress to ventilator-induced lung injury in mice. Am J Respir Crit Care Med (2007) 1.41
Bioavailability of Sulforaphane from two broccoli sprout beverages: results of a short-term, cross-over clinical trial in Qidong, China. Cancer Prev Res (Phila) (2011) 1.37
Signal transduction pathways of tumor necrosis factor--mediated lung injury induced by ozone in mice. Am J Respir Crit Care Med (2007) 1.37
Deficiency in Nrf2-GSH signaling impairs type II cell growth and enhances sensitivity to oxidants. Am J Respir Cell Mol Biol (2007) 1.36
Disruption of the transcription factor Nrf2 promotes pro-oxidative dendritic cells that stimulate Th2-like immunoresponsiveness upon activation by ambient particulate matter. J Immunol (2008) 1.36
The cysteine-rich region of respiratory syncytial virus attachment protein inhibits innate immunity elicited by the virus and endotoxin. Proc Natl Acad Sci U S A (2005) 1.36
Nrf2 regulates an adaptive response protecting against oxidative damage following diquat-mediated formation of superoxide anion. Arch Biochem Biophys (2006) 1.33
Common and divergent immune response signaling pathways discovered in peripheral blood mononuclear cell gene expression patterns in presymptomatic and clinically apparent malaria. Infect Immun (2006) 1.33
Oxidative stress and antioxidants in the pathogenesis of pulmonary fibrosis: a potential role for Nrf2. Antioxid Redox Signal (2008) 1.30
The Keap1-Nrf2 system prevents onset of diabetes mellitus. Mol Cell Biol (2013) 1.30
The flavanol (-)-epicatechin prevents stroke damage through the Nrf2/HO1 pathway. J Cereb Blood Flow Metab (2010) 1.29
Genetic mutations associated with cigarette smoking in pancreatic cancer. Cancer Res (2009) 1.28
Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genes. Carcinogenesis (2005) 1.28
Divergent responses of chondrocytes and endothelial cells to shear stress: cross-talk among COX-2, the phase 2 response, and apoptosis. Proc Natl Acad Sci U S A (2005) 1.28
Wolbachia infections in Anopheles gambiae cells: transcriptomic characterization of a novel host-symbiont interaction. PLoS Pathog (2011) 1.27
Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs. Free Radic Biol Med (2008) 1.27
The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells. Mol Biol Cell (2011) 1.26
Nrf2 deficiency prevents reductive stress-induced hypertrophic cardiomyopathy. Cardiovasc Res (2013) 1.25
Comparative airway inflammatory response of normal volunteers to ozone and lipopolysaccharide challenge. Inhal Toxicol (2010) 1.24
Genetic mechanisms of susceptibility to oxidative lung injury in mice. Free Radic Biol Med (2006) 1.23
Synergism between rhinovirus infection and oxidant pollutant exposure enhances airway epithelial cell cytokine production. Environ Health Perspect (2002) 1.23
Interactive effects of nrf2 genotype and oltipraz on benzo[a]pyrene-DNA adducts and tumor yield in mice. Carcinogenesis (2003) 1.22
Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors. J Biol Chem (2004) 1.21
Toll-like receptor 4 in butylated hydroxytoluene-induced mouse pulmonary inflammation and tumorigenesis. J Natl Cancer Inst (2005) 1.21
Homocysteine and cognitive function in a population-based study of older adults. J Am Geriatr Soc (2005) 1.21