Published in Nat Struct Mol Biol on October 07, 2007
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Inactivation of the KcsA potassium channel explored with heterotetramers. J Gen Physiol (2010) 0.89
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External Ba2+ block of the two-pore domain potassium channel TREK-1 defines conformational transition in its selectivity filter. J Biol Chem (2011) 0.88
Kir4.1 K+ channels are regulated by external cations. Channels (Austin) (2011) 0.88
Gating in CNGA1 channels. Pflugers Arch (2009) 0.88
The pathway and spatial scale for MscS inactivation. J Gen Physiol (2011) 0.88
An electrostatic interaction between TEA and an introduced pore aromatic drives spring-in-the-door inactivation in Shaker potassium channels. J Gen Physiol (2009) 0.88
Modular strategy for the semisynthesis of a K+ channel: investigating interactions of the pore helix. ACS Chem Biol (2009) 0.87
Dynamics transitions at the outer vestibule of the KcsA potassium channel during gating. Proc Natl Acad Sci U S A (2014) 0.87
Voltage-dependent inactivation gating at the selectivity filter of the MthK K+ channel. J Gen Physiol (2010) 0.86
The analysis of desensitizing CNGA1 channels reveals molecular interactions essential for normal gating. J Gen Physiol (2009) 0.86
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Hydrogen bonds as molecular timers for slow inactivation in voltage-gated potassium channels. Elife (2013) 0.86
Voltage clamp fluorimetry reveals a novel outer pore instability in a mammalian voltage-gated potassium channel. J Gen Physiol (2008) 0.85
Control of voltage-gated K+ channel permeability to NMDG+ by a residue at the outer pore. J Gen Physiol (2009) 0.85
Mechanism of Cd2+ coordination during slow inactivation in potassium channels. Structure (2012) 0.85
Altered and dynamic ion selectivity of K+ channels in cell development and excitability. Trends Pharmacol Sci (2014) 0.83
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Pore helices play a dynamic role as integrators of domain motion during Kv11.1 channel inactivation gating. J Biol Chem (2013) 0.83
Individual Ion Binding Sites in the K(+) Channel Play Distinct Roles in C-type Inactivation and in Recovery from Inactivation. Structure (2016) 0.82
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Modulation of Kir1.1 inactivation by extracellular Ca and Mg. Biophys J (2011) 0.82
Probing the energy landscape of activation gating of the bacterial potassium channel KcsA. PLoS Comput Biol (2013) 0.81
Amino acid substitutions in the pore helix of GluR6 control inhibition by membrane fatty acids. J Gen Physiol (2008) 0.81
A molecular switch driving inactivation in the cardiac K+ channel HERG. PLoS One (2012) 0.81
Aromatic-aromatic interactions between residues in KCa3.1 pore helix and S5 transmembrane segment control the channel gating process. J Gen Physiol (2014) 0.81
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Energetics of Multi-Ion Conduction Pathways in Potassium Ion Channels. J Chem Theory Comput (2013) 0.80
Structures of KcsA in complex with symmetrical quaternary ammonium compounds reveal a hydrophobic binding site. Biochemistry (2014) 0.80
Ion-binding properties of a K+ channel selectivity filter in different conformations. Proc Natl Acad Sci U S A (2015) 0.80
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Pore helix-S6 interactions are critical in governing current amplitudes of KCNQ3 K+ channels. Biophys J (2012) 0.79
Arrhythmogenic effects of mutated L-type Ca(2+)-channels on an optogenetically paced muscular pump in Caenorhabditis elegans. Sci Rep (2015) 0.78
Navigating Membrane Protein Structure, Dynamics, and Energy Landscapes Using Spin Labeling and EPR Spectroscopy. Methods Enzymol (2015) 0.78
Energetics of double-ion occupancy in the gramicidin A channel. J Phys Chem B (2010) 0.78
Initial steps of inactivation at the K+ channel selectivity filter. Proc Natl Acad Sci U S A (2014) 0.78
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Multi-ion free energy landscapes underscore the microscopic mechanism of ion selectivity in the KcsA channel. Biochim Biophys Acta (2016) 0.77
The "structurally minimal" isoform KChIP2d modulates recovery of K(v)4.3 N-terminal deletion mutant Δ2-39. Channels (Austin) (2011) 0.77
Artificial modulation of the gating behavior of a K+ channel in a KvAP-DNA chimera. PLoS One (2011) 0.77
A structural, functional, and computational analysis suggests pore flexibility as the base for the poor selectivity of CNG channels. Proc Natl Acad Sci U S A (2015) 0.77
Structure of the pore-helix of the hERG K(+) channel. Eur Biophys J (2009) 0.77
Hysteresis in voltage-gated channels. Channels (Austin) (2016) 0.76
Potassium-dependent activation of Kir4.2 K⁺ channels. J Physiol (2011) 0.76
Residues at the outer mouth of Kir1.1 determine K-dependent gating. Biophys J (2012) 0.76
Designer and natural peptide toxin blockers of the KcsA potassium channel identified by phage display. Proc Natl Acad Sci U S A (2015) 0.75
Discovery and characterisation of a novel toxin from Dendroaspis angusticeps, named Tx7335, that activates the potassium channel KcsA. Sci Rep (2016) 0.75
It's spring-time for slow inactivation. J Gen Physiol (2009) 0.75
Atomic mutagenesis in ion channels with engineered stoichiometry. Elife (2016) 0.75
Exploring the Dynamics of the TWIK-1 Channel. Biophys J (2016) 0.75
Molecular determinants of gating at the potassium-channel selectivity filter. Nat Struct Mol Biol (2006) 4.64
Physical principles underlying the transduction of bilayer deformation forces during mechanosensitive channel gating. Nat Struct Biol (2002) 4.53
Open channel structure of MscL and the gating mechanism of mechanosensitive channels. Nature (2002) 4.42
Control of ion selectivity in potassium channels by electrostatic and dynamic properties of carbonyl ligands. Nature (2004) 4.37
Molecular architecture of the KvAP voltage-dependent K+ channel in a lipid bilayer. Science (2004) 3.59
Closing in on the resting state of the Shaker K(+) channel. Neuron (2007) 3.49
Structural mechanism of C-type inactivation in K(+) channels. Nature (2010) 3.30
Mechanism of voltage gating in potassium channels. Science (2012) 3.24
Calculation of absolute protein-ligand binding free energy from computer simulations. Proc Natl Acad Sci U S A (2005) 3.21
Gating charge displacement in voltage-gated ion channels involves limited transmembrane movement. Nature (2005) 2.98
Absolute binding free energy calculations using molecular dynamics simulations with restraining potentials. Biophys J (2006) 2.88
Two atomic constraints unambiguously position the S4 segment relative to S1 and S2 segments in the closed state of Shaker K channel. Proc Natl Acad Sci U S A (2007) 2.85
Computations of standard binding free energies with molecular dynamics simulations. J Phys Chem B (2009) 2.80
Importance of hydration and dynamics on the selectivity of the KcsA and NaK channels. J Gen Physiol (2007) 2.79
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The free energy landscapes governing conformational changes in a glutamate receptor ligand-binding domain. Structure (2007) 2.45
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Control of ion selectivity in LeuT: two Na+ binding sites with two different mechanisms. J Mol Biol (2008) 2.27
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A structural mechanism for MscS gating in lipid bilayers. Science (2008) 2.24
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Finding transition pathways using the string method with swarms of trajectories. J Phys Chem B (2008) 2.17
Absolute hydration free energy scale for alkali and halide ions established from simulations with a polarizable force field. J Phys Chem B (2006) 2.15
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The hidden energetics of ligand binding and activation in a glutamate receptor. Nat Struct Mol Biol (2011) 2.10
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Calculation of the gating charge for the Kv1.2 voltage-activated potassium channel. Biophys J (2010) 1.87
Polarizable empirical force field for the primary and secondary alcohol series based on the classical Drude model. J Chem Theory Comput (2007) 1.86
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Multidomain assembled states of Hck tyrosine kinase in solution. Proc Natl Acad Sci U S A (2010) 1.79
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Simulating Monovalent and Divalent Ions in Aqueous Solution Using a Drude Polarizable Force Field. J Chem Theory Comput (2010) 1.39
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Protein conformational dynamics in the mechanism of HIV-1 protease catalysis. Proc Natl Acad Sci U S A (2011) 1.25
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