Published in Neuron on October 04, 2007
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Sensing voltage across lipid membranes. Nature (2008) 2.66
The voltage-gated proton channel Hv1 has two pores, each controlled by one voltage sensor. Neuron (2008) 2.26
Dynamics of the Kv1.2 voltage-gated K+ channel in a membrane environment. Biophys J (2007) 2.10
Structure of the full-length Shaker potassium channel Kv1.2 by normal-mode-based X-ray crystallographic refinement. Proc Natl Acad Sci U S A (2010) 2.02
Disulfide locking a sodium channel voltage sensor reveals ion pair formation during activation. Proc Natl Acad Sci U S A (2008) 2.02
A shaker K+ channel with a miniature engineered voltage sensor. Cell (2010) 2.00
Calculation of the gating charge for the Kv1.2 voltage-activated potassium channel. Biophys J (2010) 1.87
RNA editing underlies temperature adaptation in K+ channels from polar octopuses. Science (2012) 1.87
Sequential formation of ion pairs during activation of a sodium channel voltage sensor. Proc Natl Acad Sci U S A (2009) 1.79
An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations. J Gen Physiol (2012) 1.72
Structural basis for gating charge movement in the voltage sensor of a sodium channel. Proc Natl Acad Sci U S A (2011) 1.68
The membrane potential and its representation by a constant electric field in computer simulations. Biophys J (2008) 1.68
Structural dynamics of an isolated voltage-sensor domain in a lipid bilayer. Structure (2008) 1.64
A molecular framework for temperature-dependent gating of ion channels. Cell (2014) 1.64
Genetically encoded fluorescent sensors of membrane potential. Brain Cell Biol (2008) 1.57
Crystal structure of a fibroblast growth factor homologous factor (FHF) defines a conserved surface on FHFs for binding and modulation of voltage-gated sodium channels. J Biol Chem (2009) 1.56
Conformational changes and slow dynamics through microsecond polarized atomistic molecular simulation of an integral Kv1.2 ion channel. PLoS Comput Biol (2009) 1.51
Intermediate states of the Kv1.2 voltage sensor from atomistic molecular dynamics simulations. Proc Natl Acad Sci U S A (2011) 1.49
Allosteric substrate switching in a voltage-sensing lipid phosphatase. Nat Chem Biol (2016) 1.47
Tracking a complete voltage-sensor cycle with metal-ion bridges. Proc Natl Acad Sci U S A (2012) 1.46
A specialized molecular motion opens the Hv1 voltage-gated proton channel. Nat Struct Mol Biol (2015) 1.45
A multiscale model linking ion-channel molecular dynamics and electrostatics to the cardiac action potential. Proc Natl Acad Sci U S A (2009) 1.43
Extent of voltage sensor movement during gating of shaker K+ channels. Neuron (2008) 1.42
Gating charge interactions with the S1 segment during activation of a Na+ channel voltage sensor. Proc Natl Acad Sci U S A (2011) 1.40
In search of a consensus model of the resting state of a voltage-sensing domain. Neuron (2011) 1.36
Strong cooperativity between subunits in voltage-gated proton channels. Nat Struct Mol Biol (2009) 1.36
Mapping the receptor site for alpha-scorpion toxins on a Na+ channel voltage sensor. Proc Natl Acad Sci U S A (2011) 1.36
Gating pore currents in DIIS4 mutations of NaV1.4 associated with periodic paralysis: saturation of ion flux and implications for disease pathogenesis. J Gen Physiol (2008) 1.35
Zinc inhibition of monomeric and dimeric proton channels suggests cooperative gating. J Physiol (2010) 1.29
Kv channel gating requires a compatible S4-S5 linker and bottom part of S6, constrained by non-interacting residues. J Gen Physiol (2008) 1.28
Lipoelectric modification of ion channel voltage gating by polyunsaturated fatty acids. Biophys J (2008) 1.26
Pore-opening mechanism of the nicotinic acetylcholine receptor evinced by proton transfer. Nat Struct Mol Biol (2008) 1.23
Lipid-dependent gating of a voltage-gated potassium channel. Nat Commun (2011) 1.22
Intermediate state trapping of a voltage sensor. J Gen Physiol (2012) 1.20
The S4-S5 linker of KCNQ1 channels forms a structural scaffold with the S6 segment controlling gate closure. J Biol Chem (2010) 1.19
The activated state of a sodium channel voltage sensor in a membrane environment. Proc Natl Acad Sci U S A (2010) 1.18
Mg2+ enhances voltage sensor/gate coupling in BK channels. J Gen Physiol (2008) 1.18
Long-term inactivation particle for voltage-gated sodium channels. J Physiol (2010) 1.17
Molecular dynamics simulation of Kv channel voltage sensor helix in a lipid membrane with applied electric field. Biophys J (2008) 1.13
Fluorescence applications in molecular neurobiology. Neuron (2010) 1.13
PIP2 controls voltage-sensor movement and pore opening of Kv channels through the S4-S5 linker. Proc Natl Acad Sci U S A (2012) 1.13
APBSmem: a graphical interface for electrostatic calculations at the membrane. PLoS One (2010) 1.12
3₁₀-helix conformation facilitates the transition of a voltage sensor S4 segment toward the down state. Biophys J (2011) 1.11
Monitoring protein interactions and dynamics with solvatochromic fluorophores. Trends Biotechnol (2009) 1.10
Dynamic coupling of voltage sensor and gate involved in closed-state inactivation of kv4.2 channels. J Gen Physiol (2009) 1.10
Molecular recognition and self-assembly special feature: Calix[4]arene-based conical-shaped ligands for voltage-dependent potassium channels. Proc Natl Acad Sci U S A (2009) 1.09
Conformational changes associated with proton-dependent gating of ASIC1a. J Biol Chem (2009) 1.09
Water wires in atomistic models of the Hv1 proton channel. Biochim Biophys Acta (2011) 1.07
Down-state model of the voltage-sensing domain of a potassium channel. Biophys J (2010) 1.06
Molecular template for a voltage sensor in a novel K+ channel. III. Functional reconstitution of a sensorless pore module from a prokaryotic Kv channel. J Gen Physiol (2008) 1.06
Gating charge immobilization in Kv4.2 channels: the basis of closed-state inactivation. J Gen Physiol (2008) 1.05
Structure-function map of the receptor site for β-scorpion toxins in domain II of voltage-gated sodium channels. J Biol Chem (2011) 1.05
Models of voltage-dependent conformational changes in NaChBac channels. Biophys J (2008) 1.05
R1 in the Shaker S4 occupies the gating charge transfer center in the resting state. J Gen Physiol (2011) 1.04
Molecular dynamics investigation of the ω-current in the Kv1.2 voltage sensor domains. Biophys J (2012) 1.03
Initial response of the potassium channel voltage sensor to a transmembrane potential. J Am Chem Soc (2009) 1.03
Coarse grained model for exploring voltage dependent ion channels. Biochim Biophys Acta (2011) 1.02
Biophysical characterization of the fluorescent protein voltage probe VSFP2.3 based on the voltage-sensing domain of Ci-VSP. Eur Biophys J (2010) 1.02
Fluorescence-tracking of activation gating in human ERG channels reveals rapid S4 movement and slow pore opening. PLoS One (2010) 1.02
Modeling and simulation of ion channels. Chem Rev (2012) 1.02
Realistic simulation of the activation of voltage-gated ion channels. Proc Natl Acad Sci U S A (2012) 1.02
Atomic constraints between the voltage sensor and the pore domain in a voltage-gated K+ channel of known structure. J Gen Physiol (2008) 1.02
Hydrophobic plug functions as a gate in voltage-gated proton channels. Proc Natl Acad Sci U S A (2013) 1.01
Structural changes during HCN channel gating defined by high affinity metal bridges. J Gen Physiol (2012) 1.00
Effect of sensor domain mutations on the properties of voltage-gated ion channels: molecular dynamics studies of the potassium channel Kv1.2. Biophys J (2010) 1.00
The gating charge pathway of an epilepsy-associated potassium channel accommodates chemical ligands. Cell Res (2013) 1.00
Exploring conformational states of the bacterial voltage-gated sodium channel NavAb via molecular dynamics simulations. Proc Natl Acad Sci U S A (2012) 1.00
Elucidation of the molecular basis of selective recognition uncovers the interaction site for the core domain of scorpion alpha-toxins on sodium channels. J Biol Chem (2011) 1.00
Molecular mechanism of voltage sensing in voltage-gated proton channels. J Gen Physiol (2013) 0.99
Nano-positioning system for structural analysis of functional homomeric proteins in multiple conformations. Structure (2012) 0.99
Voltage-dependent conformational changes in connexin channels. Biochim Biophys Acta (2011) 0.99
An extracellular Cu2+ binding site in the voltage sensor of BK and Shaker potassium channels. J Gen Physiol (2008) 0.98
Membrane bending is critical for the stability of voltage sensor segments in the membrane. J Gen Physiol (2012) 0.97
Common molecular determinants of tarantula huwentoxin-IV inhibition of Na+ channel voltage sensors in domains II and IV. J Biol Chem (2011) 0.97
Constant electric field simulations of the membrane potential illustrated with simple systems. Biochim Biophys Acta (2011) 0.96
Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels. J Gen Physiol (2012) 0.95
Functional analysis of the Kv1.1 N255D mutation associated with autosomal dominant hypomagnesemia. J Biol Chem (2009) 0.94
Double mutant cycle analysis identified a critical leucine residue in the IIS4S5 linker for the activation of the Ca(V)2.3 calcium channel. J Biol Chem (2011) 0.94
Voltage-dependent gating of HERG potassium channels. Front Pharmacol (2012) 0.93
Interactions of H562 in the S5 helix with T618 and S621 in the pore helix are important determinants of hERG1 potassium channel structure and function. Biophys J (2009) 0.92
Structural refinement of the hERG1 pore and voltage-sensing domains with ROSETTA-membrane and molecular dynamics simulations. Proteins (2010) 0.92
Dual effect of phosphatidylinositol (4,5)-bisphosphate PIP(2) on Shaker K(+) [corrected] channels. J Biol Chem (2012) 0.91
Voltage-Controlled Enzymes: The New JanusBifrons. Front Pharmacol (2012) 0.91
Multi-scale electrophysiology modeling: from atom to organ. J Gen Physiol (2010) 0.90
Working model for the structural basis for KCNE1 modulation of the KCNQ1 potassium channel. Curr Opin Struct Biol (2011) 0.90
Being flexible: the voltage-controllable activation gate of kv channels. Front Pharmacol (2012) 0.89
Relative motion of transmembrane segments S0 and S4 during voltage sensor activation in the human BK(Ca) channel. J Gen Physiol (2010) 0.89
Coupling between residues on S4 and S1 defines the voltage-sensor resting conformation in NaChBac. Biophys J (2010) 0.89
Transfer of ion binding site from ether-a-go-go to Shaker: Mg2+ binds to resting state to modulate channel opening. J Gen Physiol (2010) 0.89
Molecular dynamics simulations of voltage-gated cation channels: insights on voltage-sensor domain function and modulation. Front Pharmacol (2012) 0.87
Independent and cooperative motions of the Kv1.2 channel: voltage sensing and gating. Biophys J (2010) 0.87
Coarse-grained simulations of the gating current in the voltage-activated Kv1.2 channel. Proc Natl Acad Sci U S A (2014) 0.87
Optically detected structural change in the N-terminal region of the voltage-sensor domain. Biophys J (2013) 0.87
Unlocking the mechanisms of HCN channel gating with locked-open and locked-closed channels. J Gen Physiol (2012) 0.87
The Voltage-Sensing Domain of K(v)7.2 Channels as a Molecular Target for Epilepsy-Causing Mutations and Anticonvulsants. Front Pharmacol (2011) 0.87
A novel mechanism for fine-tuning open-state stability in a voltage-gated potassium channel. Nat Commun (2013) 0.87
A homology model of the pore domain of a voltage-gated calcium channel is consistent with available SCAM data. J Gen Physiol (2010) 0.86
Coupling of S4 helix translocation and S6 gating analyzed by molecular-dynamics simulations of mutated Kv channels. Biophys J (2009) 0.86
Structural interactions between lipids, water and S1-S4 voltage-sensing domains. J Mol Biol (2012) 0.86
Subunit counting in membrane-bound proteins. Nat Methods (2007) 5.75
Molecular determinants of gating at the potassium-channel selectivity filter. Nat Struct Mol Biol (2006) 4.64
Control of ion selectivity in potassium channels by electrostatic and dynamic properties of carbonyl ligands. Nature (2004) 4.37
Analysis of a RanGTP-regulated gradient in mitotic somatic cells. Nature (2006) 3.47
Remote control of neuronal activity with a light-gated glutamate receptor. Neuron (2007) 3.45
Allosteric control of an ionotropic glutamate receptor with an optical switch. Nat Chem Biol (2005) 3.23
Calculation of absolute protein-ligand binding free energy from computer simulations. Proc Natl Acad Sci U S A (2005) 3.21
Molecular imaging of hydrogen peroxide produced for cell signaling. Nat Chem Biol (2007) 3.19
In vivo performance of genetically encoded indicators of neural activity in flies. J Neurosci (2005) 3.11
How does voltage open an ion channel? Annu Rev Cell Dev Biol (2006) 3.05
Gating charge displacement in voltage-gated ion channels involves limited transmembrane movement. Nature (2005) 2.98
Voltage-sensing arginines in a potassium channel permeate and occlude cation-selective pores. Neuron (2005) 2.94
Absolute binding free energy calculations using molecular dynamics simulations with restraining potentials. Biophys J (2006) 2.88
Two atomic constraints unambiguously position the S4 segment relative to S1 and S2 segments in the closed state of Shaker K channel. Proc Natl Acad Sci U S A (2007) 2.85
Computations of standard binding free energies with molecular dynamics simulations. J Phys Chem B (2009) 2.80
Importance of hydration and dynamics on the selectivity of the KcsA and NaK channels. J Gen Physiol (2007) 2.79
Voltage-gated ion channels and gating modifier toxins. Toxicon (2006) 2.77
Overview of molecular relationships in the voltage-gated ion channel superfamily. Pharmacol Rev (2005) 2.73
Functional architecture of olfactory ionotropic glutamate receptors. Neuron (2011) 2.67
Energetics of ion conduction through the gramicidin channel. Proc Natl Acad Sci U S A (2003) 2.67
Subunit organization and functional transitions in Ci-VSP. Nat Struct Mol Biol (2007) 2.64
Structural basis for the coupling between activation and inactivation gates in K(+) channels. Nature (2010) 2.63
Ion permeation and selectivity of OmpF porin: a theoretical study based on molecular dynamics, Brownian dynamics, and continuum electrodiffusion theory. J Mol Biol (2002) 2.61
Optogenetic dissection of a behavioural module in the vertebrate spinal cord. Nature (2009) 2.61
Scanless two-photon excitation of channelrhodopsin-2. Nat Methods (2010) 2.60
Molecular driving forces determining potassium channel slow inactivation. Nat Struct Mol Biol (2007) 2.56
A gate in the selectivity filter of potassium channels. Structure (2005) 2.50
The free energy landscapes governing conformational changes in a glutamate receptor ligand-binding domain. Structure (2007) 2.45
Ion selectivity in potassium channels. Biophys Chem (2006) 2.28
Control of ion selectivity in LeuT: two Na+ binding sites with two different mechanisms. J Mol Biol (2008) 2.27
The voltage-gated proton channel Hv1 has two pores, each controlled by one voltage sensor. Neuron (2008) 2.26
A microscopic view of ion conduction through the K+ channel. Proc Natl Acad Sci U S A (2003) 2.24
Ions and counterions in a biological channel: a molecular dynamics simulation of OmpF porin from Escherichia coli in an explicit membrane with 1 M KCl aqueous salt solution. J Mol Biol (2002) 2.23
Finding transition pathways using the string method with swarms of trajectories. J Phys Chem B (2008) 2.17
Optical lock-in detection imaging microscopy for contrast-enhanced imaging in living cells. Proc Natl Acad Sci U S A (2008) 2.15
Absolute hydration free energy scale for alkali and halide ions established from simulations with a polarizable force field. J Phys Chem B (2006) 2.15
Boronate-based fluorescent probes for imaging cellular hydrogen peroxide. J Am Chem Soc (2005) 2.11
The hidden energetics of ligand binding and activation in a glutamate receptor. Nat Struct Mol Biol (2011) 2.10
Dynamics of the Kv1.2 voltage-gated K+ channel in a membrane environment. Biophys J (2007) 2.10
The twisted ion-permeation pathway of a resting voltage-sensing domain. Nature (2006) 2.10
A gating hinge in Na+ channels; a molecular switch for electrical signaling. Neuron (2004) 2.08
A selective, cell-permeable optical probe for hydrogen peroxide in living cells. J Am Chem Soc (2004) 2.08
Optical switches for remote and noninvasive control of cell signaling. Science (2008) 2.02
Disulfide locking a sodium channel voltage sensor reveals ion pair formation during activation. Proc Natl Acad Sci U S A (2008) 2.02
Modeling the structure of agitoxin in complex with the Shaker K+ channel: a computational approach based on experimental distance restraints extracted from thermodynamic mutant cycles. Biophys J (2002) 1.98
The orientation and molecular movement of a k(+) channel voltage-sensing domain. Neuron (2003) 1.96
Conformational switch between slow and fast gating modes: allosteric regulation of voltage sensor mobility in the EAG K+ channel. Neuron (2002) 1.95
Molecular mechanism of H+ conduction in the single-file water chain of the gramicidin channel. Biophys J (2002) 1.94
Autoinhibitory control of the CaV1.2 channel by its proteolytically processed distal C-terminal domain. J Physiol (2006) 1.92
Ion permeation through the alpha-hemolysin channel: theoretical studies based on Brownian dynamics and Poisson-Nernst-Plank electrodiffusion theory. Biophys J (2004) 1.91
Magnetic forces enable rapid endothelialization of synthetic vascular grafts. Circulation (2006) 1.90
The cooperative voltage sensor motion that gates a potassium channel. J Gen Physiol (2005) 1.89
Calculation of the gating charge for the Kv1.2 voltage-activated potassium channel. Biophys J (2010) 1.87
Polarizable empirical force field for the primary and secondary alcohol series based on the classical Drude model. J Chem Theory Comput (2007) 1.86
Structural rearrangements in single ion channels detected optically in living cells. Proc Natl Acad Sci U S A (2002) 1.85
Structural and molecular basis of the assembly of the TRPP2/PKD1 complex. Proc Natl Acad Sci U S A (2009) 1.84
The structure of a receptor with two associating transmembrane domains on the cell surface: integrin alphaIIbbeta3. Mol Cell (2009) 1.82
Multidomain assembled states of Hck tyrosine kinase in solution. Proc Natl Acad Sci U S A (2010) 1.79
Sequential formation of ion pairs during activation of a sodium channel voltage sensor. Proc Natl Acad Sci U S A (2009) 1.79
Polarizable empirical force field for aromatic compounds based on the classical drude oscillator. J Phys Chem B (2007) 1.77
Emergence of patterned activity in the developing zebrafish spinal cord. Curr Biol (2011) 1.76
Filtering of visual information in the tectum by an identified neural circuit. Science (2010) 1.73
An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations. J Gen Physiol (2012) 1.72
A selective turn-on fluorescent sensor for imaging copper in living cells. J Am Chem Soc (2006) 1.72
Mapping the conformational transition in Src activation by cumulating the information from multiple molecular dynamics trajectories. Proc Natl Acad Sci U S A (2009) 1.70
Challenges of endovascular tube graft repair of thoracic aortic aneurysm: midterm follow-up and lessons learned. J Vasc Surg (2003) 1.68
Force field bias in protein folding simulations. Biophys J (2009) 1.67
Computation of binding free energy with molecular dynamics and grand canonical Monte Carlo simulations. J Chem Phys (2008) 1.66
Protein-protein interactions governing septin heteropentamer assembly and septin filament organization in Saccharomyces cerevisiae. Mol Biol Cell (2004) 1.63
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Mechanisms of photoswitch conjugation and light activation of an ionotropic glutamate receptor. Proc Natl Acad Sci U S A (2007) 1.62
PBEQ-Solver for online visualization of electrostatic potential of biomolecules. Nucleic Acids Res (2008) 1.61
Structural basis of two-stage voltage-dependent activation in K+ channels. Proc Natl Acad Sci U S A (2003) 1.61
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How far will you go to sense voltage? Neuron (2005) 1.61
Rules of engagement for NMDA receptor subunits. Proc Natl Acad Sci U S A (2008) 1.60
Electrochemical coupling in the voltage-dependent phosphatase Ci-VSP. Nat Chem Biol (2010) 1.59
Structure and function of the voltage sensor of sodium channels probed by a beta-scorpion toxin. J Biol Chem (2006) 1.58
Understanding the dielectric properties of liquid amides from a polarizable force field. J Phys Chem B (2008) 1.57
Stoichiometry of the KCNQ1 - KCNE1 ion channel complex. Proc Natl Acad Sci U S A (2010) 1.54
Molecular models of voltage sensing. J Gen Physiol (2002) 1.53
LiGluR restores visual responses in rodent models of inherited blindness. Mol Ther (2011) 1.53
The N-terminal end of the catalytic domain of SRC kinase Hck is a conformational switch implicated in long-range allosteric regulation. Structure (2005) 1.53
Molecular basis of proton blockage in aquaporins. Structure (2004) 1.51
All optical interface for parallel, remote, and spatiotemporal control of neuronal activity. Nano Lett (2007) 1.49
Electrostatics of the intracellular vestibule of K+ channels. J Mol Biol (2005) 1.48
Optical control of metabotropic glutamate receptors. Nat Neurosci (2013) 1.45
Free energy landscape of A-DNA to B-DNA conversion in aqueous solution. J Am Chem Soc (2005) 1.44
Src kinase conformational activation: thermodynamics, pathways, and mechanisms. PLoS Comput Biol (2008) 1.43
Simulated x-ray scattering of protein solutions using explicit-solvent models. J Chem Phys (2009) 1.43
Structural determinants of proton blockage in aquaporins. J Mol Biol (2004) 1.43
The ionization state and the conformation of Glu-71 in the KcsA K(+) channel. Biophys J (2002) 1.41
High-performance scalable molecular dynamics simulations of a polarizable force field based on classical Drude oscillators in NAMD. J Phys Chem Lett (2011) 1.41
Gating charge interactions with the S1 segment during activation of a Na+ channel voltage sensor. Proc Natl Acad Sci U S A (2011) 1.40
The opening of the two pores of the Hv1 voltage-gated proton channel is tuned by cooperativity. Nat Struct Mol Biol (2009) 1.40
Heterogeneity in synaptic transmission along a Drosophila larval motor axon. Nat Neurosci (2005) 1.40