Published in Mol Biosyst on August 29, 2007
Cross talk between O-GlcNAcylation and phosphorylation: roles in signaling, transcription, and chronic disease. Annu Rev Biochem (2011) 4.95
Mammalian glycosylation in immunity. Nat Rev Immunol (2008) 2.74
Bittersweet memories: linking metabolism to epigenetics through O-GlcNAcylation. Nat Rev Mol Cell Biol (2012) 2.74
Beta-N-acetylglucosamine (O-GlcNAc) is part of the histone code. Proc Natl Acad Sci U S A (2010) 2.47
Cross-talk between GlcNAcylation and phosphorylation: roles in insulin resistance and glucose toxicity. Am J Physiol Endocrinol Metab (2008) 2.40
AMP-activated protein kinase and p38 MAPK activate O-GlcNAcylation of neuronal proteins during glucose deprivation. J Biol Chem (2008) 1.86
Tandem mass spectrometry identifies many mouse brain O-GlcNAcylated proteins including EGF domain-specific O-GlcNAc transferase targets. Proc Natl Acad Sci U S A (2012) 1.75
A mitotic GlcNAcylation/phosphorylation signaling complex alters the posttranslational state of the cytoskeletal protein vimentin. Mol Biol Cell (2008) 1.64
How does diabetes accelerate Alzheimer disease pathology? Nat Rev Neurol (2010) 1.60
Modulation of transcription factor function by O-GlcNAc modification. Biochim Biophys Acta (2010) 1.55
Protein O-GlcNAcylation: a new signaling paradigm for the cardiovascular system. Am J Physiol Heart Circ Physiol (2008) 1.53
Regulation of calcium/calmodulin-dependent kinase IV by O-GlcNAc modification. J Biol Chem (2009) 1.45
Activation of hexosamine pathway impairs nitric oxide (NO)-dependent arteriolar dilations by increased protein O-GlcNAcylation. Vascul Pharmacol (2011) 1.45
Glycopeptide-specific monoclonal antibodies suggest new roles for O-GlcNAc. Nat Chem Biol (2010) 1.41
Combining high-energy C-trap dissociation and electron transfer dissociation for protein O-GlcNAc modification site assignment. J Proteome Res (2011) 1.41
Mechanisms of disease: the oxidative stress theory of diabetic neuropathy. Rev Endocr Metab Disord (2008) 1.40
O-GlcNAc transferase regulates mitotic chromatin dynamics. J Biol Chem (2010) 1.33
The chemical neurobiology of carbohydrates. Chem Rev (2008) 1.33
O-GlcNAc cycling: implications for neurodegenerative disorders. Int J Biochem Cell Biol (2009) 1.22
Chemical reporters for fluorescent detection and identification of O-GlcNAc-modified proteins reveal glycosylation of the ubiquitin ligase NEDD4-1. Proc Natl Acad Sci U S A (2011) 1.21
The role of protein O-linked beta-N-acetylglucosamine in mediating cardiac stress responses. Biochim Biophys Acta (2009) 1.21
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Intracellular protein glycosylation modulates insulin mediated lifespan in C.elegans. Aging (Albany NY) (2010) 1.14
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Protein O-GlcNAcylation in diabetes and diabetic complications. Expert Rev Proteomics (2013) 1.12
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O-GlcNAc cycling enzymes associate with the translational machinery and modify core ribosomal proteins. Mol Biol Cell (2010) 1.05
Structural and ultrastructural analysis of cerebral cortex, cerebellum, and hypothalamus from diabetic rats. Exp Diabetes Res (2009) 1.05
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Insulin resistance as a key link for the increased risk of cognitive impairment in the metabolic syndrome. Exp Mol Med (2015) 0.93
Detection and analysis of proteins modified by O-linked N-acetylglucosamine. Curr Protoc Protein Sci (2011) 0.93
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Biosynthetic Machinery Involved in Aberrant Glycosylation: Promising Targets for Developing of Drugs Against Cancer. Front Oncol (2015) 0.91
Glucose deprivation-induced increase in protein O-GlcNAcylation in cardiomyocytes is calcium-dependent. J Biol Chem (2012) 0.90
Enrichment of O-GlcNAc modified proteins by the periodate oxidation-hydrazide resin capture approach. J Proteome Res (2010) 0.90
O-GlcNAcylation of AMPA receptor GluA2 is associated with a novel form of long-term depression at hippocampal synapses. J Neurosci (2014) 0.90
Substrate and product analogues as human O-GlcNAc transferase inhibitors. Amino Acids (2010) 0.90
Alpha-synuclein deficiency leads to increased glyoxalase I expression and glycation stress. Cell Mol Life Sci (2010) 0.89
O-GlcNAcylation: a novel post-translational mechanism to alter vascular cellular signaling in health and disease: focus on hypertension. J Am Soc Hypertens (2010) 0.89
O-GlcNAcylation of kinases. Biochem Biophys Res Commun (2012) 0.89
Cardiomyocyte Ogt is essential for postnatal viability. Am J Physiol Heart Circ Physiol (2013) 0.88
Targeted in vivo O-GlcNAc sensors reveal discrete compartment-specific dynamics during signal transduction. J Biol Chem (2010) 0.86
O-GlcNAcylation: The Sweet Side of the Cancer. Front Oncol (2014) 0.86
Protein O-GlcNAcylation: A critical regulator of the cellular response to stress. Curr Signal Transduct Ther (2010) 0.85
Increasing brain protein O-GlcNAc-ylation mitigates breathing defects and mortality of Tau.P301L mice. PLoS One (2013) 0.84
Structure of a bacterial putative acetyltransferase defines the fold of the human O-GlcNAcase C-terminal domain. Open Biol (2013) 0.84
Bisubstrate UDP-peptide conjugates as human O-GlcNAc transferase inhibitors. Biochem J (2014) 0.84
Redox signaling in cardiovascular pathophysiology: A focus on hydrogen peroxide and vascular smooth muscle cells. Redox Biol (2016) 0.81
Elevated O-GlcNAc levels activate epigenetically repressed genes and delay mouse ESC differentiation without affecting naïve to primed cell transition. Stem Cells (2014) 0.80
Glucosamine for osteoarthritis: biological effects, clinical efficacy, and safety on glucose metabolism. Arthritis (2014) 0.80
Increasing O-GlcNAcylation level on organ culture of soleus modulates the calcium activation parameters of muscle fibers. PLoS One (2012) 0.80
Activity Based High-Throughput Screening for Novel O-GlcNAc Transferase Substrates Using a Dynamic Peptide Microarray. PLoS One (2016) 0.79
Biology and biotechnology of hyaluronan. Glycoconj J (2015) 0.79
N-glycomic changes in serum proteins in type 2 diabetes mellitus correlate with complications and with metabolic syndrome parameters. PLoS One (2015) 0.79
O-Linked β-N-acetylglucosamine (O-GlcNAc) Acts as a Glucose Sensor to Epigenetically Regulate the Insulin Gene in Pancreatic Beta Cells. J Biol Chem (2015) 0.78
Synthetic Receptors for the High-Affinity Recognition of O-GlcNAc Derivatives. Angew Chem Int Ed Engl (2016) 0.78
The role of intracellular protein O-glycosylation in cell adhesion and disease. J Biomed Res (2011) 0.77
Glycosylation and other PTMs alterations in neurodegenerative diseases: Current status and future role in neurotrauma. Electrophoresis (2016) 0.77
The Role of the O-GlcNAc Modification in Regulating Eukaryotic Gene Expression. Curr Signal Transduct Ther (2010) 0.76
O-Linked N-Acetylglucosamine (O-GlcNAc) Transferase and O-GlcNAcase Interact with Mi2β Protein at the Aγ-Globin Promoter. J Biol Chem (2016) 0.76
Deficient hippocampal insulin signaling and augmented Tau phosphorylation is related to obesity- and age-induced peripheral insulin resistance: a study in Zucker rats. BMC Neurosci (2014) 0.76
Nucleocytoplasmic human O-GlcNAc transferase is sufficient for O-GlcNAcylation of mitochondrial proteins. Biochem J (2016) 0.75
O-GlcNAcylation of SKN-1 modulates the lifespan and oxidative stress resistance in Caenorhabditis elegans. Sci Rep (2017) 0.75
Oxidative stress induces transient O-GlcNAc elevation and tau dephosphorylation in SH-SY5Y cells. J Cell Mol Med (2016) 0.75
Short-term glucosamine infusion increases islet blood flow in anesthetized rats. Islets (2013) 0.75
An efficient and versatile synthesis of GlcNAcstatins-potent and selective O-GlcNAcase inhibitors built on the tetrahydroimidazo[1,2-a]pyridine scaffold. Tetrahedron (2010) 0.75
Nutrient-driven O-linked N-acetylglucosamine (O-GlcNAc) cycling impacts neurodevelopmental timing and metabolism. J Biol Chem (2017) 0.75
Protein modification by dicarbonyl molecular species in neurodegenerative diseases. J Amino Acids (2011) 0.75
Chemical Methods for Encoding and Decoding of Posttranslational Modifications. Cell Chem Biol (2016) 0.75
O-GlcNAcylation enhances anaplastic thyroid carcinoma malignancy. Oncol Lett (2016) 0.75
Altered expression of O-GlcNAc-modified proteins in a mouse model whose glycemic status is controlled by a low carbohydrate ketogenic diet. Glycoconj J (2013) 0.75
Sustained O-GlcNAcylation reprograms mitochondrial function to regulate energy metabolism. J Biol Chem (2017) 0.75
Interplay between protein glycosylation pathways in Alzheimer's disease. Sci Adv (2017) 0.75
Dynamic O-GlcNAc modification of nucleocytoplasmic proteins in response to stress. A survival response of mammalian cells. J Biol Chem (2004) 3.35
Cell signaling, the essential role of O-GlcNAc! Biochim Biophys Acta (2006) 3.09
Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes. Proc Natl Acad Sci U S A (2002) 3.08
Mapping sites of O-GlcNAc modification using affinity tags for serine and threonine post-translational modifications. Mol Cell Proteomics (2002) 2.88
Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates cytokinesis. Sci Signal (2010) 2.79
Perturbations in O-linked beta-N-acetylglucosamine protein modification cause severe defects in mitotic progression and cytokinesis. J Biol Chem (2005) 2.74
O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease. Proc Natl Acad Sci U S A (2004) 2.67
O-linked beta-N-acetylglucosamine (O-GlcNAc): Extensive crosstalk with phosphorylation to regulate signaling and transcription in response to nutrients and stress. Biochim Biophys Acta (2009) 2.64
O-GlcNAc a sensor of cellular state: the role of nucleocytoplasmic glycosylation in modulating cellular function in response to nutrition and stress. Biochim Biophys Acta (2004) 2.62
Ogt-dependent X-chromosome-linked protein glycosylation is a requisite modification in somatic cell function and embryo viability. Mol Cell Biol (2004) 2.56
Beta-N-acetylglucosamine (O-GlcNAc) is part of the histone code. Proc Natl Acad Sci U S A (2010) 2.47
Cross-talk between GlcNAcylation and phosphorylation: site-specific phosphorylation dynamics in response to globally elevated O-GlcNAc. Proc Natl Acad Sci U S A (2008) 2.45
Cross-talk between GlcNAcylation and phosphorylation: roles in insulin resistance and glucose toxicity. Am J Physiol Endocrinol Metab (2008) 2.40
O-GlcNAc regulates FoxO activation in response to glucose. J Biol Chem (2008) 2.27
The intersections between O-GlcNAcylation and phosphorylation: implications for multiple signaling pathways. J Cell Sci (2010) 2.22
Cardioprotection by N-acetylglucosamine linkage to cellular proteins. Circulation (2008) 2.11
Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation. Nature (2013) 2.08
The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression. Mol Cell Biol (2010) 1.96
Roles of the tetratricopeptide repeat domain in O-GlcNAc transferase targeting and protein substrate specificity. J Biol Chem (2003) 1.96
Dynamic interplay between O-linked N-acetylglucosaminylation and glycogen synthase kinase-3-dependent phosphorylation. Mol Cell Proteomics (2007) 1.92
Dynamic O-glycosylation of nuclear and cytosolic proteins: further characterization of the nucleocytoplasmic beta-N-acetylglucosaminidase, O-GlcNAcase. J Biol Chem (2002) 1.88
O-GlcNAc signalling: implications for cancer cell biology. Nat Rev Cancer (2011) 1.87
AMP-activated protein kinase and p38 MAPK activate O-GlcNAcylation of neuronal proteins during glucose deprivation. J Biol Chem (2008) 1.86
O-GlcNAc cycling: how a single sugar post-translational modification is changing the way we think about signaling networks. J Cell Biochem (2006) 1.79
O-GlcNAc transferase is in a functional complex with protein phosphatase 1 catalytic subunits. J Biol Chem (2004) 1.77
A PGC-1alpha-O-GlcNAc transferase complex regulates FoxO transcription factor activity in response to glucose. J Biol Chem (2008) 1.76
Tandem mass spectrometry identifies many mouse brain O-GlcNAcylated proteins including EGF domain-specific O-GlcNAc transferase targets. Proc Natl Acad Sci U S A (2012) 1.75
Enrichment and site mapping of O-linked N-acetylglucosamine by a combination of chemical/enzymatic tagging, photochemical cleavage, and electron transfer dissociation mass spectrometry. Mol Cell Proteomics (2009) 1.72
The emerging significance of O-GlcNAc in cellular regulation. Chem Rev (2002) 1.65
O-GlcNAc turns twenty: functional implications for post-translational modification of nuclear and cytosolic proteins with a sugar. FEBS Lett (2003) 1.64
A mitotic GlcNAcylation/phosphorylation signaling complex alters the posttranslational state of the cytoskeletal protein vimentin. Mol Biol Cell (2008) 1.64
O-linked beta-N-acetylglucosaminyltransferase substrate specificity is regulated by myosin phosphatase targeting and other interacting proteins. J Biol Chem (2008) 1.64
Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase. J Biol Chem (2002) 1.60
Site-specific interplay between O-GlcNAcylation and phosphorylation in cellular regulation. FEBS Lett (2010) 1.59
Symbol nomenclature for glycan representation. Proteomics (2009) 1.56
Dynamic interplay between O-GlcNAc and O-phosphate: the sweet side of protein regulation. Curr Opin Struct Biol (2003) 1.46
Regulation of calcium/calmodulin-dependent kinase IV by O-GlcNAc modification. J Biol Chem (2009) 1.45
Regulation of the O-linked beta-N-acetylglucosamine transferase by insulin signaling. J Biol Chem (2008) 1.45
Site-specific GlcNAcylation of human erythrocyte proteins: potential biomarker(s) for diabetes. Diabetes (2008) 1.39
dbOGAP - an integrated bioinformatics resource for protein O-GlcNAcylation. BMC Bioinformatics (2011) 1.36
O-GlcNAc: a regulatory post-translational modification. Biochem Biophys Res Commun (2003) 1.35
O-GlcNAc transferase regulates mitotic chromatin dynamics. J Biol Chem (2010) 1.33
O-GlcNAc modification: a nutritional sensor that modulates proteasome function. Trends Cell Biol (2004) 1.33
The transcription factor PDX-1 is post-translationally modified by O-linked N-acetylglucosamine and this modification is correlated with its DNA binding activity and insulin secretion in min6 beta-cells. Arch Biochem Biophys (2003) 1.33
O-linked GlcNAc modification of cardiac myofilament proteins: a novel regulator of myocardial contractile function. Circ Res (2008) 1.32
Posttranslational, reversible O-glycosylation is stimulated by high glucose and mediates plasminogen activator inhibitor-1 gene expression and Sp1 transcriptional activity in glomerular mesangial cells. Endocrinology (2006) 1.32
Quantitative analysis of both protein expression and serine / threonine post-translational modifications through stable isotope labeling with dithiothreitol. Proteomics (2005) 1.30
Regulation of insulin receptor substrate 1 (IRS-1)/AKT kinase-mediated insulin signaling by O-Linked beta-N-acetylglucosamine in 3T3-L1 adipocytes. J Biol Chem (2009) 1.28
Proteomic approaches to analyze the dynamic relationships between nucleocytoplasmic protein glycosylation and phosphorylation. Circ Res (2003) 1.26
Regulation of CK2 by phosphorylation and O-GlcNAcylation revealed by semisynthesis. Nat Chem Biol (2012) 1.24
Dynamic interplay between O-glycosylation and O-phosphorylation of nucleocytoplasmic proteins: a new paradigm for metabolic control of signal transduction and transcription. Prog Nucleic Acid Res Mol Biol (2003) 1.21
Elevation of the post-translational modification of proteins by O-linked N-acetylglucosamine leads to deterioration of the glucose-stimulated insulin secretion in the pancreas of diabetic Goto-Kakizaki rats. Glycobiology (2006) 1.20
Diverse regulation of protein function by O-GlcNAc: a nuclear and cytoplasmic carbohydrate post-translational modification. Curr Opin Chem Biol (2002) 1.19
Evidence of the involvement of O-GlcNAc-modified human RNA polymerase II CTD in transcription in vitro and in vivo. J Biol Chem (2012) 1.18
Characterization of beta-N-acetylglucosaminidase cleavage by caspase-3 during apoptosis. J Biol Chem (2008) 1.17
Glycomics: building upon proteomics to advance glycosciences. Mol Cell Proteomics (2013) 1.12
Protein O-GlcNAcylation in diabetes and diabetic complications. Expert Rev Proteomics (2013) 1.12
Cross-talk between two essential nutrient-sensitive enzymes: O-GlcNAc transferase (OGT) and AMP-activated protein kinase (AMPK). J Biol Chem (2014) 1.09
O-GlcNAc cycling enzymes associate with the translational machinery and modify core ribosomal proteins. Mol Biol Cell (2010) 1.05
O-linked N-acetylglucosamine modification on CCAAT enhancer-binding protein beta: role during adipocyte differentiation. J Biol Chem (2009) 1.04
Localization of the O-GlcNAc transferase and O-GlcNAc-modified proteins in rat cerebellar cortex. Brain Res (2003) 1.02
Identification of O-GlcNAc sites on proteins. Methods Enzymol (2006) 1.02
Increased expression of beta-N-acetylglucosaminidase in erythrocytes from individuals with pre-diabetes and diabetes. Diabetes (2010) 1.01
Modification of RelA by O-linked N-acetylglucosamine links glucose metabolism to NF-κB acetylation and transcription. Proc Natl Acad Sci U S A (2012) 0.98
The dynamic stress-induced "O-GlcNAc-ome" highlights functions for O-GlcNAc in regulating DNA damage/repair and other cellular pathways. Amino Acids (2010) 0.98
Cellular content of UDP-N-acetylhexosamines controls hyaluronan synthase 2 expression and correlates with O-linked N-acetylglucosamine modification of transcription factors YY1 and SP1. J Biol Chem (2011) 0.97
O-GlcNAc modification of nucleocytoplasmic proteins and diabetes. Med Mol Morphol (2005) 0.96
Dynamic nuclear and cytoplasmic glycosylation: enzymes of O-GlcNAc cycling. Biochemistry (2003) 0.95
Detection and analysis of proteins modified by O-linked N-acetylglucosamine. Curr Protoc Mol Biol (2011) 0.94
Detection and analysis of proteins modified by O-linked N-acetylglucosamine. Curr Protoc Protein Sci (2011) 0.93
O-GlcNAcylation of kinases. Biochem Biophys Res Commun (2012) 0.89
The role of O-GlcNAc signaling in the pathogenesis of diabetic retinopathy. Proteomics Clin Appl (2014) 0.88
Two-dimensional gel-based approaches for the assessment of N-Linked and O-GlcNAc glycosylation in human and simian immunodeficiency viruses. Proteomics (2008) 0.85
The E2F-1 associated retinoblastoma-susceptibility gene product is modified by O-GlcNAc. Amino Acids (2010) 0.84
Working group report: the roles of glycans in hemostasis, inflammation and vascular biology. Glycobiology (2008) 0.84
Chemical approaches to study O-GlcNAcylation. Chem Soc Rev (2012) 0.84
Detection and analysis of proteins modified by O-linked N-acetylglucosamine. Curr Protoc Mol Biol (2002) 0.81
Reciprocal keratin 18 Ser48 O-GlcNAcylation and Ser52 phosphorylation using peptide analysis. Biochem Biophys Res Commun (2006) 0.81
Stressing the role of O-GlcNAc: linking cell survival to keratin modification. Nat Cell Biol (2010) 0.79
Morphological changes in diabetic kidney are associated with increased O-GlcNAcylation of cytoskeletal proteins including α-actinin 4. Clin Proteomics (2011) 0.78
Murine platelets are not regulated by O-linked beta-N-acetylglucosamine. Arch Biochem Biophys (2008) 0.78
Comparative Proteomics Reveals Dysregulated Mitochondrial O-GlcNAcylation in Diabetic Hearts. J Proteome Res (2016) 0.76
O-GlcNAcylation of Neuronal Proteins: Roles in Neuronal Functions and in Neurodegeneration. Adv Neurobiol (2014) 0.76
A Quarter Century of Glycobiology. Glycobiology (2015) 0.75
Sweet insights into learning and memory. Nat Chem Biol (2006) 0.75
N-propanoylmannosamine interferes with O-GlcNAc modification of the tyrosine 3-monooxygenase and stimulates dopamine secretion. J Neurosci Res (2008) 0.75