Published in Glycobiology on November 09, 2006
The hexosamine signaling pathway: O-GlcNAc cycling in feast or famine. Biochim Biophys Acta (2009) 2.66
Cross-talk between GlcNAcylation and phosphorylation: roles in insulin resistance and glucose toxicity. Am J Physiol Endocrinol Metab (2008) 2.40
Modulation of transcription factor function by O-GlcNAc modification. Biochim Biophys Acta (2010) 1.55
Glucosamine protects neonatal cardiomyocytes from ischemia-reperfusion injury via increased protein O-GlcNAc and increased mitochondrial Bcl-2. Am J Physiol Cell Physiol (2008) 1.47
Urea impairs β cell glycolysis and insulin secretion in chronic kidney disease. J Clin Invest (2016) 1.39
Elevation of global O-GlcNAc levels in 3T3-L1 adipocytes by selective inhibition of O-GlcNAcase does not induce insulin resistance. J Biol Chem (2008) 1.28
Snapin mediates incretin action and augments glucose-dependent insulin secretion. Cell Metab (2011) 1.27
Cracking the O-GlcNAc code in metabolism. Trends Endocrinol Metab (2013) 1.21
Protein O-GlcNAcylation in diabetes and diabetic complications. Expert Rev Proteomics (2013) 1.12
Aging leads to increased levels of protein O-linked N-acetylglucosamine in heart, aorta, brain and skeletal muscle in Brown-Norway rats. Biogerontology (2008) 1.12
Elevation of Global O-GlcNAc in rodents using a selective O-GlcNAcase inhibitor does not cause insulin resistance or perturb glucohomeostasis. Chem Biol (2010) 1.03
Cell-penetrant, nanomolar O-GlcNAcase inhibitors selective against lysosomal hexosaminidases. Chem Biol (2010) 1.00
Conditional knock-out reveals a requirement for O-linked N-Acetylglucosaminase (O-GlcNAcase) in metabolic homeostasis. J Biol Chem (2015) 0.97
Hexosamine flux, the O-GlcNAc modification, and the development of insulin resistance in adipocytes. Mol Cell Endocrinol (2009) 0.96
Interaction of diet and diabetes on cardiovascular function in rats. Am J Physiol Heart Circ Physiol (2008) 0.96
O-linked-N-acetylglucosamine cycling and insulin signaling are required for the glucose stress response in Caenorhabditis elegans. Genetics (2011) 0.95
Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1. Proc Natl Acad Sci U S A (2012) 0.92
Natural history of β-cell adaptation and failure in type 2 diabetes. Mol Aspects Med (2014) 0.91
Role of transcription factor modifications in the pathogenesis of insulin resistance. Exp Diabetes Res (2011) 0.82
Pleiotropic and age-dependent effects of decreased protein modification by O-linked N-acetylglucosamine on pancreatic β-cell function and vascularization. J Biol Chem (2011) 0.81
Increased O-GlcNAc causes disrupted lens fiber cell differentiation and cataracts. Biochem Biophys Res Commun (2009) 0.81
Change in long-spacing collagen in Descemet's membrane of diabetic Goto-Kakizaki rats and its suppression by antidiabetic agents. Exp Diabetes Res (2008) 0.81
O-GlcNAc and aging: C. elegans as a genetic model to test O-GlcNAc roles in type II diabetic insulin resistance. Aging (Albany NY) (2010) 0.79
Substrate specificity provides insights into the sugar donor recognition mechanism of O-GlcNAc transferase (OGT). PLoS One (2013) 0.79
Morphological changes in diabetic kidney are associated with increased O-GlcNAcylation of cytoskeletal proteins including α-actinin 4. Clin Proteomics (2011) 0.78
Prkar1a in the regulation of insulin secretion. Horm Metab Res (2012) 0.78
Protein O-GlcNAcylation: emerging mechanisms and functions. Nat Rev Mol Cell Biol (2017) 0.78
The Role of the O-GlcNAc Modification in Regulating Eukaryotic Gene Expression. Curr Signal Transduct Ther (2010) 0.76
RNA-guided RNA cleavage by a CRISPR RNA-Cas protein complex. Cell (2009) 11.12
Comprehensive analysis of NAC family genes in Oryza sativa and Arabidopsis thaliana. DNA Res (2003) 4.01
Dynamic O-GlcNAc modification of nucleocytoplasmic proteins in response to stress. A survival response of mammalian cells. J Biol Chem (2004) 3.35
Cell signaling, the essential role of O-GlcNAc! Biochim Biophys Acta (2006) 3.09
Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes. Proc Natl Acad Sci U S A (2002) 3.08
O-mannosyl phosphorylation of alpha-dystroglycan is required for laminin binding. Science (2010) 2.98
Mapping sites of O-GlcNAc modification using affinity tags for serine and threonine post-translational modifications. Mol Cell Proteomics (2002) 2.88
EphA-Ephrin-A-mediated beta cell communication regulates insulin secretion from pancreatic islets. Cell (2007) 2.81
Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates cytokinesis. Sci Signal (2010) 2.79
Perturbations in O-linked beta-N-acetylglucosamine protein modification cause severe defects in mitotic progression and cytokinesis. J Biol Chem (2005) 2.74
O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease. Proc Natl Acad Sci U S A (2004) 2.67
O-linked beta-N-acetylglucosamine (O-GlcNAc): Extensive crosstalk with phosphorylation to regulate signaling and transcription in response to nutrients and stress. Biochim Biophys Acta (2009) 2.64
O-GlcNAc a sensor of cellular state: the role of nucleocytoplasmic glycosylation in modulating cellular function in response to nutrition and stress. Biochim Biophys Acta (2004) 2.62
Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling. Nat Med (2002) 2.61
Ogt-dependent X-chromosome-linked protein glycosylation is a requisite modification in somatic cell function and embryo viability. Mol Cell Biol (2004) 2.56
Beta-N-acetylglucosamine (O-GlcNAc) is part of the histone code. Proc Natl Acad Sci U S A (2010) 2.47
Cross-talk between GlcNAcylation and phosphorylation: site-specific phosphorylation dynamics in response to globally elevated O-GlcNAc. Proc Natl Acad Sci U S A (2008) 2.45
Cross-talk between GlcNAcylation and phosphorylation: roles in insulin resistance and glucose toxicity. Am J Physiol Endocrinol Metab (2008) 2.40
Secretory granules are recaptured largely intact after stimulated exocytosis in cultured endocrine cells. Proc Natl Acad Sci U S A (2003) 2.36
O-GlcNAc regulates FoxO activation in response to glucose. J Biol Chem (2008) 2.27
The intersections between O-GlcNAcylation and phosphorylation: implications for multiple signaling pathways. J Cell Sci (2010) 2.22
Cardioprotection by N-acetylglucosamine linkage to cellular proteins. Circulation (2008) 2.11
A CUL-2 ubiquitin ligase containing three FEM proteins degrades TRA-1 to regulate C. elegans sex determination. Dev Cell (2007) 2.11
Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation. Nature (2013) 2.08
Redundant roles of Sox17 and Sox18 in postnatal angiogenesis in mice. J Cell Sci (2006) 2.05
Sinoatrial node dysfunction and early unexpected death of mice with a defect of klotho gene expression. Circulation (2004) 2.00
Recognition of a ubiquitous self antigen by prostate cancer-infiltrating CD8+ T lymphocytes. Science (2008) 1.99
Dynamic developmental elaboration of N-linked glycan complexity in the Drosophila melanogaster embryo. J Biol Chem (2007) 1.99
The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression. Mol Cell Biol (2010) 1.96
Roles of the tetratricopeptide repeat domain in O-GlcNAc transferase targeting and protein substrate specificity. J Biol Chem (2003) 1.96
Dynamic interplay between O-linked N-acetylglucosaminylation and glycogen synthase kinase-3-dependent phosphorylation. Mol Cell Proteomics (2007) 1.92
Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation. Nat Chem Biol (2012) 1.89
Dynamic O-glycosylation of nuclear and cytosolic proteins: further characterization of the nucleocytoplasmic beta-N-acetylglucosaminidase, O-GlcNAcase. J Biol Chem (2002) 1.88
O-GlcNAc signalling: implications for cancer cell biology. Nat Rev Cancer (2011) 1.87
O-GlcNAc modification in diabetes and Alzheimer's disease. Mol Biosyst (2007) 1.86
AMP-activated protein kinase and p38 MAPK activate O-GlcNAcylation of neuronal proteins during glucose deprivation. J Biol Chem (2008) 1.86
Ubiquitin-like small archaeal modifier proteins (SAMPs) in Haloferax volcanii. Nature (2010) 1.80
O-GlcNAc cycling: how a single sugar post-translational modification is changing the way we think about signaling networks. J Cell Biochem (2006) 1.79
O-GlcNAc transferase is in a functional complex with protein phosphatase 1 catalytic subunits. J Biol Chem (2004) 1.77
A PGC-1alpha-O-GlcNAc transferase complex regulates FoxO transcription factor activity in response to glucose. J Biol Chem (2008) 1.76
Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation. J Clin Invest (2005) 1.75
Tandem mass spectrometry identifies many mouse brain O-GlcNAcylated proteins including EGF domain-specific O-GlcNAc transferase targets. Proc Natl Acad Sci U S A (2012) 1.75
Enrichment and site mapping of O-linked N-acetylglucosamine by a combination of chemical/enzymatic tagging, photochemical cleavage, and electron transfer dissociation mass spectrometry. Mol Cell Proteomics (2009) 1.72
Imaging analysis reveals mechanistic differences between first- and second-phase insulin exocytosis. J Cell Biol (2007) 1.67
The emerging significance of O-GlcNAc in cellular regulation. Chem Rev (2002) 1.65
O-linked beta-N-acetylglucosaminyltransferase substrate specificity is regulated by myosin phosphatase targeting and other interacting proteins. J Biol Chem (2008) 1.64
A mitotic GlcNAcylation/phosphorylation signaling complex alters the posttranslational state of the cytoskeletal protein vimentin. Mol Biol Cell (2008) 1.64
O-GlcNAc turns twenty: functional implications for post-translational modification of nuclear and cytosolic proteins with a sugar. FEBS Lett (2003) 1.64
Critical role of O-Linked β-N-acetylglucosamine transferase in prostate cancer invasion, angiogenesis, and metastasis. J Biol Chem (2012) 1.63
Imaging exocytosis of single insulin secretory granules with evanescent wave microscopy: distinct behavior of granule motion in biphasic insulin release. J Biol Chem (2001) 1.61
Inhibition of miR-92a enhances fracture healing via promoting angiogenesis in a model of stabilized fracture in young mice. J Bone Miner Res (2014) 1.60
Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase. J Biol Chem (2002) 1.60
Site-specific interplay between O-GlcNAcylation and phosphorylation in cellular regulation. FEBS Lett (2010) 1.59
Symbol nomenclature for glycan representation. Proteomics (2009) 1.56
Isolation and characterization of a rice dwarf mutant with a defect in brassinosteroid biosynthesis. Plant Physiol (2002) 1.51
A clinical comparative study of the direct anterior with mini-posterior approach: two consecutive series. J Arthroplasty (2008) 1.50
Long-term suppressive effect of octreotide on progression of metastatic gastrinoma with multiple endocrine neoplasia type 1: seven-year follow up. Intern Med (2010) 1.48
Dynamic interplay between O-GlcNAc and O-phosphate: the sweet side of protein regulation. Curr Opin Struct Biol (2003) 1.46
Regulation of calcium/calmodulin-dependent kinase IV by O-GlcNAc modification. J Biol Chem (2009) 1.45
Regulation of the O-linked beta-N-acetylglucosamine transferase by insulin signaling. J Biol Chem (2008) 1.45
Site of docking and fusion of insulin secretory granules in live MIN6 beta cells analyzed by TAT-conjugated anti-syntaxin 1 antibody and total internal reflection fluorescence microscopy. J Biol Chem (2003) 1.43
Site mapping and characterization of O-glycan structures on alpha-dystroglycan isolated from rabbit skeletal muscle. J Biol Chem (2010) 1.43
Exosome-like vesicles with dipeptidyl peptidase IV in human saliva. Biol Pharm Bull (2008) 1.42
Glycopeptide-specific monoclonal antibodies suggest new roles for O-GlcNAc. Nat Chem Biol (2010) 1.41
Impact of uremia, diabetes, and peritoneal dialysis itself on the pathogenesis of peritoneal sclerosis: a quantitative study of peritoneal membrane morphology. Clin J Am Soc Nephrol (2008) 1.41
Safety and efficacy of autologous progenitor cell transplantation for therapeutic angiogenesis in patients with critical limb ischemia. Circ J (2007) 1.41
Combining high-energy C-trap dissociation and electron transfer dissociation for protein O-GlcNAc modification site assignment. J Proteome Res (2011) 1.41
Site-specific GlcNAcylation of human erythrocyte proteins: potential biomarker(s) for diabetes. Diabetes (2008) 1.39
The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance. J Clin Invest (2013) 1.39
In vivo modulation of O-GlcNAc levels regulates hippocampal synaptic plasticity through interplay with phosphorylation. J Biol Chem (2008) 1.39
Relationships between Causes of Fever of Unknown Origin and Inflammatory Markers: A Multicenter Collaborative Retrospective Study. Intern Med (2015) 1.38
dbOGAP - an integrated bioinformatics resource for protein O-GlcNAcylation. BMC Bioinformatics (2011) 1.36
O-GlcNAc: a regulatory post-translational modification. Biochem Biophys Res Commun (2003) 1.35
O-GlcNAc transferase regulates mitotic chromatin dynamics. J Biol Chem (2010) 1.33
Optimal distance of malignant negative margin in excision of nonsmall cell lung cancer: a multicenter prospective study. Ann Thorac Surg (2004) 1.33
O-GlcNAc modification: a nutritional sensor that modulates proteasome function. Trends Cell Biol (2004) 1.33
The transcription factor PDX-1 is post-translationally modified by O-linked N-acetylglucosamine and this modification is correlated with its DNA binding activity and insulin secretion in min6 beta-cells. Arch Biochem Biophys (2003) 1.33
O-linked GlcNAc modification of cardiac myofilament proteins: a novel regulator of myocardial contractile function. Circ Res (2008) 1.32
Posttranslational, reversible O-glycosylation is stimulated by high glucose and mediates plasminogen activator inhibitor-1 gene expression and Sp1 transcriptional activity in glomerular mesangial cells. Endocrinology (2006) 1.32
Glycomic analyses of mouse models of congenital muscular dystrophy. J Biol Chem (2011) 1.32
O-GlcNAc modifications regulate cell survival and epiboly during zebrafish development. BMC Dev Biol (2009) 1.31
Hyper-O-GlcNAcylation is anti-apoptotic and maintains constitutive NF-κB activity in pancreatic cancer cells. J Biol Chem (2013) 1.31
Quantitative analysis of both protein expression and serine / threonine post-translational modifications through stable isotope labeling with dithiothreitol. Proteomics (2005) 1.30
O-GlcNAc in cancer biology. Amino Acids (2013) 1.28
Regulation of insulin receptor substrate 1 (IRS-1)/AKT kinase-mediated insulin signaling by O-Linked beta-N-acetylglucosamine in 3T3-L1 adipocytes. J Biol Chem (2009) 1.28
Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25. Nat Commun (2011) 1.27
Targeted disruption of mouse ortholog of the human MYH9 responsible for macrothrombocytopenia with different organ involvement: hematological, nephrological, and otological studies of heterozygous KO mice. Biochem Biophys Res Commun (2004) 1.27