Published in J Neurosci Res on March 01, 2008
An oligovascular niche: cerebral endothelial cells promote the survival and proliferation of oligodendrocyte precursor cells. J Neurosci (2009) 1.62
The developing oligodendrocyte: key cellular target in brain injury in the premature infant. Int J Dev Neurosci (2011) 1.46
Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons. Cell Death Differ (2010) 1.15
12/15-Lipoxygenase targets neuronal mitochondria under oxidative stress. J Neurochem (2009) 1.13
Regulated necrosis: disease relevance and therapeutic opportunities. Nat Rev Drug Discov (2016) 1.09
Astrocytes protect oligodendrocyte precursor cells via MEK/ERK and PI3K/Akt signaling. J Neurosci Res (2010) 1.08
Edaravone, a free radical scavenger, protects components of the neurovascular unit against oxidative stress in vitro. Brain Res (2009) 1.06
Inhibition of 12/15-lipoxygenase as therapeutic strategy to treat stroke. Ann Neurol (2012) 1.05
Mammalian lipoxygenases and their biological relevance. Biochim Biophys Acta (2014) 1.04
Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase. J Med Chem (2011) 1.03
Increased nuclear apoptosis-inducing factor after transient focal ischemia: a 12/15-lipoxygenase-dependent organelle damage pathway. J Cereb Blood Flow Metab (2010) 1.02
Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1. J Med Chem (2010) 1.01
Reactive oxygen species and inhibitors of inflammatory enzymes, NADPH oxidase, and iNOS in experimental models of Parkinson's disease. Mediators Inflamm (2012) 1.00
Pathophysiology of glia in perinatal white matter injury. Glia (2014) 1.00
Inflammatory hyperalgesia induces essential bioactive lipid production in the spinal cord. J Neurochem (2010) 0.97
Role of 12/15-lipoxygenase in nitrosative stress and peripheral prediabetic and diabetic neuropathies. Free Radic Biol Med (2010) 0.93
Proteasome inhibitor-induced apoptosis is mediated by positive feedback amplification of PKCdelta proteolytic activation and mitochondrial translocation. J Cell Mol Med (2008) 0.92
Suppression of vaccine immunity by inflammatory monocytes. J Immunol (2012) 0.91
Akt and mTOR mediate programmed necrosis in neurons. Cell Death Dis (2014) 0.90
Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase. J Med Chem (2014) 0.89
Lipoxygenase: an emerging target for stroke therapy. CNS Neurol Disord Drug Targets (2013) 0.88
Following experimental stroke, the recovering brain is vulnerable to lipoxygenase-dependent semaphorin signaling. FASEB J (2012) 0.83
Pseudoperoxidase investigations of hydroperoxides and inhibitors with human lipoxygenases. Bioorg Med Chem (2013) 0.82
Emerging targets in lipid-based therapy. Biochem Pharmacol (2012) 0.81
Therapies targeting lipid peroxidation in traumatic brain injury. Brain Res (2016) 0.80
Gene-environment interaction models to unmask susceptibility mechanisms in Parkinson's disease. J Vis Exp (2014) 0.80
The potential of 12/15-lipoxygenase inhibitors in stroke therapy. Future Med Chem (2014) 0.79
STAT-dependent upregulation of 12/15-lipoxygenase contributes to neuronal injury after stroke. J Cereb Blood Flow Metab (2015) 0.78
12/15-lipoxygenase expression is increased in oligodendrocytes and microglia of periventricular leukomalacia. Dev Neurosci (2013) 0.77
Differential contribution of lipoxygenase isozymes to nigrostriatal vulnerability. Neuroscience (2012) 0.77
Prolonged Effects of Silver Nanoparticles on p53/p21 Pathway-Mediated Proliferation, DNA Damage Response, and Methylation Parameters in HT22 Hippocampal Neuronal Cells. Mol Neurobiol (2016) 0.77
Structural optimization and biological evaluation of 1,5-disubstituted pyrazole-3-carboxamines as potent inhibitors of human 5-lipoxygenase. Acta Pharm Sin B (2016) 0.77
A potent and selective inhibitor targeting human and murine 12/15-LOX. Bioorg Med Chem (2016) 0.76
Human 15-LOX-1 active site mutations alter inhibitor binding and decrease potency. Bioorg Med Chem (2016) 0.75
Insulin-like growth factor I reduces lipid oxidation and foam cell formation via downregulation of 12/15-lipoxygenase. Atherosclerosis (2014) 0.75
Activity-Based Probes for 15-Lipoxygenase-1. Angew Chem Int Ed Engl (2016) 0.75
Design of a novel thiophene inhibitor of 15-lipoxygenase-1 with both anti-inflammatory and neuroprotective properties. Eur J Med Chem (2016) 0.75
Increased 12/15-Lipoxygenase Leads to Widespread Brain Injury Following Global Cerebral Ischemia. Transl Stroke Res (2016) 0.75
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature (2006) 15.69
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12/15-lipoxygenase is increased in Alzheimer's disease: possible involvement in brain oxidative stress. Am J Pathol (2004) 1.71
Neuroprotective properties of the natural vitamin E alpha-tocotrienol. Stroke (2005) 1.56
Baicalein and 12/15-lipoxygenase in the ischemic brain. Stroke (2006) 1.50
Peroxynitrite-induced neuronal apoptosis is mediated by intracellular zinc release and 12-lipoxygenase activation. J Neurosci (2004) 1.45
Oxygenation of biological membranes by the pure reticulocyte lipoxygenase. J Biol Chem (1990) 1.37
Novel human lipoxygenase inhibitors discovered using virtual screening with homology models. J Med Chem (2006) 1.36
Structure-activity relationship studies of nordihydroguaiaretic acid inhibitors toward soybean, 12-human, and 15-human lipoxygenase. J Med Chem (2002) 1.25
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In vitro model of oxidative stress in cortical neurons. Methods Enzymol (2002) 1.12
12-Lipoxygenase plays a key role in cell death caused by glutathione depletion and arachidonic acid in rat oligodendrocytes. Eur J Neurosci (2004) 1.11
Blockade of 12-lipoxygenase expression protects cortical neurons from apoptosis induced by beta-amyloid peptide. Cell Death Differ (2004) 1.11
Glutathione depletion and oxidative stress. Parkinsonism Relat Disord (2002) 1.11
Proteasome inhibition protects HT22 neuronal cells from oxidative glutamate toxicity. J Neurochem (2005) 1.05
Maturation-dependent oligodendrocyte apoptosis caused by hyperoxia. J Neurosci Res (2006) 1.00
Arachidonate 12-lipoxygenase isozymes. Adv Exp Med Biol (1999) 0.89
Update of the stroke therapy academic industry roundtable preclinical recommendations. Stroke (2009) 6.79
The science of stroke: mechanisms in search of treatments. Neuron (2010) 6.14
Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway. Proc Natl Acad Sci U S A (2003) 5.11
Role of matrix metalloproteinases in delayed cortical responses after stroke. Nat Med (2006) 5.10
Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain. Nat Med (2008) 3.83
The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS. J Neurosci (2002) 3.55
Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator. Nat Med (2003) 3.10
Nitrosative and oxidative injury to premyelinating oligodendrocytes in periventricular leukomalacia. J Neuropathol Exp Neurol (2003) 2.65
A pilot study of normobaric oxygen therapy in acute ischemic stroke. Stroke (2005) 2.58
Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue. Nat Methods (2010) 2.37
Involvement of matrix metalloproteinase in thrombolysis-associated hemorrhagic transformation after embolic focal ischemia in rats. Stroke (2002) 2.30
Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytes. Proc Natl Acad Sci U S A (2005) 2.30
Increased brain expression of matrix metalloproteinase-9 after ischemic and hemorrhagic human stroke. Stroke (2006) 2.27
Effects of neuroglobin overexpression on acute brain injury and long-term outcomes after focal cerebral ischemia. Stroke (2008) 2.25
Upper limb ischemic preconditioning prevents recurrent stroke in intracranial arterial stenosis. Neurology (2012) 2.19
Mechanisms of hemorrhagic transformation after tissue plasminogen activator reperfusion therapy for ischemic stroke. Stroke (2004) 2.13
Extension of the thrombolytic time window with minocycline in experimental stroke. Stroke (2008) 2.10
Neuroprotection via matrix-trophic coupling between cerebral endothelial cells and neurons. Proc Natl Acad Sci U S A (2008) 2.06
Correlation between brain reorganization, ischemic damage, and neurologic status after transient focal cerebral ischemia in rats: a functional magnetic resonance imaging study. J Neurosci (2003) 2.05
Glutamate receptor-mediated oligodendrocyte toxicity in periventricular leukomalacia: a protective role for topiramate. J Neurosci (2004) 1.99
Cortical spreading depression activates and upregulates MMP-9. J Clin Invest (2004) 1.93
Normobaric hyperoxia improves cerebral blood flow and oxygenation, and inhibits peri-infarct depolarizations in experimental focal ischaemia. Brain (2007) 1.92
Cell-cell signaling in the neurovascular unit. Neurochem Res (2007) 1.92
Stimulus-induced changes in blood flow and 2-deoxyglucose uptake dissociate in ipsilateral somatosensory cortex. J Neurosci (2008) 1.89
Involvement of matrix metalloproteinase in neuroblast cell migration from the subventricular zone after stroke. J Neurosci (2006) 1.85
Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recovery after stroke. FEBS J (2009) 1.82
The glutamate transporter GLT1a is expressed in excitatory axon terminals of mature hippocampal neurons. J Neurosci (2004) 1.82
The neurotoxicity of tissue plasminogen activator? J Cereb Blood Flow Metab (2004) 1.80
Multiphasic roles for matrix metalloproteinases after stroke. Curr Opin Pharmacol (2008) 1.79
Tissue plasminogen activator promotes matrix metalloproteinase-9 upregulation after focal cerebral ischemia. Stroke (2005) 1.77
Normobaric hyperoxia reduces MRI diffusion abnormalities and infarct size in experimental stroke. Neurology (2002) 1.67
Developmentally regulated role for Ras-GRFs in coupling NMDA glutamate receptors to Ras, Erk and CREB. EMBO J (2004) 1.65
An oligovascular niche: cerebral endothelial cells promote the survival and proliferation of oligodendrocyte precursor cells. J Neurosci (2009) 1.62
Fingolimod provides long-term protection in rodent models of cerebral ischemia. Ann Neurol (2010) 1.62
Beyond NMDA and AMPA glutamate receptors: emerging mechanisms for ionic imbalance and cell death in stroke. Trends Pharmacol Sci (2008) 1.62
Green tea polyphenol (-)-epigallocatechin gallate reduces neuronal cell damage and up-regulation of MMP-9 activity in hippocampal CA1 and CA2 areas following transient global cerebral ischemia. J Neurosci Res (2009) 1.60
Pulse oximetry: review of a potential aid in endodontic diagnosis. J Endod (2009) 1.60
Effects of normobaric hyperoxia in a rat model of focal cerebral ischemia-reperfusion. J Cereb Blood Flow Metab (2002) 1.59
OCT methods for capillary velocimetry. Biomed Opt Express (2012) 1.57
Role of matrix metalloproteinases in delayed neuronal damage after transient global cerebral ischemia. J Neurosci (2004) 1.56
Astrocytic induction of matrix metalloproteinase-9 and edema in brain hemorrhage. J Cereb Blood Flow Metab (2006) 1.56
Junctional complexes of the blood-brain barrier: permeability changes in neuroinflammation. Prog Neurobiol (2002) 1.55
Expression of a variant form of the glutamate transporter GLT1 in neuronal cultures and in neurons and astrocytes in the rat brain. J Neurosci (2002) 1.54
Calcium-permeable AMPA/kainate receptors mediate toxicity and preconditioning by oxygen-glucose deprivation in oligodendrocyte precursors. Proc Natl Acad Sci U S A (2003) 1.54
Apoptotic surge of potassium currents is mediated by p38 phosphorylation of Kv2.1. Proc Natl Acad Sci U S A (2007) 1.52
Proliferation of epithelial cell rests, formation of apical cysts, and regression of apical cysts after periapical wound healing. J Endod (2007) 1.51
Baicalein and 12/15-lipoxygenase in the ischemic brain. Stroke (2006) 1.50
Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models. J Am Chem Soc (2014) 1.49
Selective inhibition of 12-lipoxygenase protects islets and beta cells from inflammatory cytokine-mediated beta cell dysfunction. Diabetologia (2014) 1.49
Experimental model of warfarin-associated intracerebral hemorrhage. Stroke (2008) 1.48
Granulocyte colony-stimulating factor enhances angiogenesis after focal cerebral ischemia. Brain Res (2005) 1.47
Neurovascular proteases in brain injury, hemorrhage and remodeling after stroke. Stroke (2007) 1.47
The developing oligodendrocyte: key cellular target in brain injury in the premature infant. Int J Dev Neurosci (2011) 1.46
Peroxynitrite-induced neuronal apoptosis is mediated by intracellular zinc release and 12-lipoxygenase activation. J Neurosci (2004) 1.45
Annexin A2 combined with low-dose tPA improves thrombolytic therapy in a rat model of focal embolic stroke. J Cereb Blood Flow Metab (2010) 1.44
Hemoglobin-induced cytotoxicity in rat cerebral cortical neurons: caspase activation and oxidative stress. Stroke (2002) 1.43
Somatic mutations in epidermal growth factor receptor signaling pathway genes in non-small cell lung cancers. J Thorac Oncol (2010) 1.43
Glutathione peroxidase-catalase cooperativity is required for resistance to hydrogen peroxide by mature rat oligodendrocytes. J Neurosci (2004) 1.42
Normobaric hyperoxia extends the reperfusion window in focal cerebral ischemia. Ann Neurol (2005) 1.42
Triggers and mediators of hemorrhagic transformation in cerebral ischemia. Mol Neurobiol (2003) 1.40
Biphasic actions of HMGB1 signaling in inflammation and recovery after stroke. Ann N Y Acad Sci (2010) 1.39
Relaxation-compensated fast multislice amide proton transfer (APT) imaging of acute ischemic stroke. Magn Reson Med (2008) 1.39
Association between pH-weighted endogenous amide proton chemical exchange saturation transfer MRI and tissue lactic acidosis during acute ischemic stroke. J Cereb Blood Flow Metab (2011) 1.36
Novel human lipoxygenase inhibitors discovered using virtual screening with homology models. J Med Chem (2006) 1.36
Oxidative stress and matrix metalloproteinase-9 in acute ischemic stroke: the Biomarker Evaluation for Antioxidant Therapies in Stroke (BEAT-Stroke) study. Stroke (2007) 1.35
Novel role of vitamin k in preventing oxidative injury to developing oligodendrocytes and neurons. J Neurosci (2003) 1.33
Role of metabotropic glutamate receptors in oligodendrocyte excitotoxicity and oxidative stress. Proc Natl Acad Sci U S A (2004) 1.33
Essential role for ERK mitogen-activated protein kinase in matrix metalloproteinase-9 regulation in rat cortical astrocytes. Glia (2003) 1.32
Tumor necrosis factor alpha mediates lipopolysaccharide-induced microglial toxicity to developing oligodendrocytes when astrocytes are present. J Neurosci (2008) 1.32
Hyperoxia causes maturation-dependent cell death in the developing white matter. J Neurosci (2008) 1.30
High-mobility group box 1 promotes metalloproteinase-9 upregulation through Toll-like receptor 4 after cerebral ischemia. Stroke (2010) 1.30
Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases. Bioorg Med Chem (2006) 1.29
Dysfunctional cell-cell signaling in the neurovascular unit as a paradigm for central nervous system disease. Stroke (2008) 1.29
Inhibition of reactive astrocytes with fluorocitrate retards neurovascular remodeling and recovery after focal cerebral ischemia in mice. J Cereb Blood Flow Metab (2009) 1.27
Acute plasmalemma permeability and protracted clearance of injured cells after controlled cortical impact in mice. J Cereb Blood Flow Metab (2007) 1.27
Fukutin is required for maintenance of muscle integrity, cortical histiogenesis and normal eye development. Hum Mol Genet (2003) 1.27
Plasma and brain matrix metalloproteinase-9 after acute focal cerebral ischemia in rats. Stroke (2009) 1.26
Effects of neuroglobin overexpression on mitochondrial function and oxidative stress following hypoxia/reoxygenation in cultured neurons. J Neurosci Res (2009) 1.25
Protecting against cerebrovascular injury: contributions of 12/15-lipoxygenase to edema formation after transient focal ischemia. Stroke (2008) 1.25
Structure-activity relationship studies of nordihydroguaiaretic acid inhibitors toward soybean, 12-human, and 15-human lipoxygenase. J Med Chem (2002) 1.25
Astrocytic high-mobility group box 1 promotes endothelial progenitor cell-mediated neurovascular remodeling during stroke recovery. Proc Natl Acad Sci U S A (2012) 1.24
TNF alpha and Fas mediate tissue damage and functional outcome after traumatic brain injury in mice. J Cereb Blood Flow Metab (2007) 1.23
Cellular and subcellular mRNA localization of glutamate transporter isoforms GLT1a and GLT1b in rat brain by in situ hybridization. J Comp Neurol (2005) 1.22
Induction of caspase-mediated cell death by matrix metalloproteinases in cerebral endothelial cells after hypoxia-reoxygenation. J Cereb Blood Flow Metab (2004) 1.21
DEK over expression as an independent biomarker for poor prognosis in colorectal cancer. BMC Cancer (2013) 1.20
Infarct prediction and treatment assessment with MRI-based algorithms in experimental stroke models. J Cereb Blood Flow Metab (2006) 1.20
Protective effects of statins involving both eNOS and tPA in focal cerebral ischemia. J Cereb Blood Flow Metab (2005) 1.18