Published in J Nat Prod on October 31, 2007
Bacterial diterpene synthases: new opportunities for mechanistic enzymology and engineered biosynthesis. Curr Opin Chem Biol (2012) 1.15
Biosynthetic potential-based strain prioritization for natural product discovery: a showcase for diterpenoid-producing actinomycetes. J Nat Prod (2014) 1.02
Diterpene production in Mycobacterium tuberculosis. FEBS J (2010) 0.87
Exploration of geosmin synthase from Streptomyces peucetius ATCC 27952 by deletion of doxorubicin biosynthetic gene cluster. J Ind Microbiol Biotechnol (2009) 0.78
Characterization of an orphan diterpenoid biosynthetic operon from Salinispora arenicola. J Nat Prod (2014) 0.77
Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis. Nat Biotechnol (2003) 7.84
An alternative menaquinone biosynthetic pathway operating in microorganisms. Science (2008) 2.46
Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism. Proc Natl Acad Sci U S A (2010) 2.29
Diversity of the biosynthesis of the isoprene units. Nat Prod Rep (2003) 2.05
Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol. Proc Natl Acad Sci U S A (2008) 1.88
Geosmin biosynthesis in Streptomyces avermitilis. Molecular cloning, expression, and mechanistic study of the germacradienol/geosmin synthase. J Antibiot (Tokyo) (2006) 1.84
Specificity and affinity of natural product cyclopentapeptide inhibitors against A. fumigatus, human, and bacterial chitinases. Chem Biol (2005) 1.80
ACAT2 is localized to hepatocytes and is the major cholesterol-esterifying enzyme in human liver. Circulation (2004) 1.76
A gene cluster for biosynthesis of the sesquiterpenoid antibiotic pentalenolactone in Streptomyces avermitilis. Biochemistry (2006) 1.67
Reveromycin A biosynthesis uses RevG and RevJ for stereospecific spiroacetal formation. Nat Chem Biol (2011) 1.62
Mycobacterium tuberculosis H37Rv3377c encodes the diterpene cyclase for producing the halimane skeleton. Chem Commun (Camb) (2005) 1.56
Cytochrome p450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3(2). Biochem Biophys Res Commun (2003) 1.52
Functional analysis of eubacterial diterpene cyclases responsible for biosynthesis of a diterpene antibiotic, terpentecin. J Biol Chem (2002) 1.48
Atpenins, potent and specific inhibitors of mitochondrial complex II (succinate-ubiquinone oxidoreductase). Proc Natl Acad Sci U S A (2003) 1.44
Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites. ACS Synth Biol (2013) 1.40
Structural and computational analysis of the quinone-binding site of complex II (succinate-ubiquinone oxidoreductase): a mechanism of electron transfer and proton conduction during ubiquinone reduction. J Biol Chem (2005) 1.38
Massadine, a novel geranylgeranyltransferase type I inhibitor from the marine sponge Stylissa aff. massa. Org Lett (2003) 1.34
Mechanistic studies of HPP epoxidase: configuration of the substrate governs its enzymatic fate. Angew Chem Int Ed Engl (2002) 1.28
The onchocerciasis chronicle: from the beginning to the end? Trends Parasitol (2012) 1.28
Biosynthesis of a natural polyketide-isoprenoid hybrid compound, furaquinocin A: identification and heterologous expression of the gene cluster. J Bacteriol (2006) 1.22
Chemical biology of natural indolocarbazole products: 30 years since the discovery of staurosporine. J Antibiot (Tokyo) (2009) 1.22
High-resolution structures of a chitinase complexed with natural product cyclopentapeptide inhibitors: mimicry of carbohydrate substrate. Proc Natl Acad Sci U S A (2002) 1.20
Identification of ACAT1- and ACAT2-specific inhibitors using a novel, cell-based fluorescence assay: individual ACAT uniqueness. J Lipid Res (2003) 1.17
Cellulose complementing factor (Ccp) is a new member of the cellulose synthase complex (terminal complex) in Acetobacter xylinum. J Biosci Bioeng (2013) 1.15
A comparative analysis of the sugar phosphate cyclase superfamily involved in primary and secondary metabolism. Chembiochem (2007) 1.15
Hyper-inducible expression system for streptomycetes. Proc Natl Acad Sci U S A (2004) 1.14
Isoapoptolidin: structure and activity of the ring-expanded isomer of apoptolidin. Org Lett (2002) 1.14
Isolation of new actinomycete strains for the screening of new bioactive compounds. J Gen Appl Microbiol (2003) 1.14
Mechanism by which the lectin actinohivin blocks HIV infection of target cells. Proc Natl Acad Sci U S A (2009) 1.12
Fusicoccins are biosynthesized by an unusual chimera diterpene synthase in fungi. Proc Natl Acad Sci U S A (2007) 1.12
Studies on a new biosynthetic pathway for menaquinone. J Am Chem Soc (2008) 1.12
Oxaline, a fungal alkaloid, arrests the cell cycle in M phase by inhibition of tubulin polymerization. Biochim Biophys Acta (2004) 1.12
Pentalenolactone biosynthesis. Molecular cloning and assignment of biochemical function to PtlH, a non-heme iron dioxygenase of Streptomyces avermitilis. J Am Chem Soc (2006) 1.10
Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase complexed with cofactors: implications of a flexible loop movement upon substrate binding. J Biochem (2002) 1.10
Lariatins, antimycobacterial peptides produced by Rhodococcus sp. K01-B0171, have a lasso structure. J Am Chem Soc (2006) 1.09
Genome mining of the Streptomyces avermitilis genome and development of genome-minimized hosts for heterologous expression of biosynthetic gene clusters. J Ind Microbiol Biotechnol (2013) 1.07
Guadinomines, Type III secretion system inhibitors, produced by Streptomyces sp. K01-0509. I: taxonomy, fermentation, isolation and biological properties. J Antibiot (Tokyo) (2008) 1.07
Pentalenolactone biosynthesis. Molecular cloning and assignment of biochemical function to PtlI, a cytochrome P450 of Streptomyces avermitilis. J Am Chem Soc (2006) 1.07
Enhancement of metabolites productivity of Penicillium pinophilum FKI-5653, by co-culture with Trichoderma harzianum FKI-5655. J Antibiot (Tokyo) (2011) 1.07
Pyripyropene A, an acyl-coenzyme A:cholesterol acyltransferase 2-selective inhibitor, attenuates hypercholesterolemia and atherosclerosis in murine models of hyperlipidemia. Arterioscler Thromb Vasc Biol (2011) 1.06
Functional analysis of eubacterial ent-copalyl diphosphate synthase and pimara-9(11),15-diene synthase with unique primary sequences. J Biochem (2006) 1.05
In vitro and in vivo antimalarial activity of puberulic acid and its new analogs, viticolins A-C, produced by Penicillium sp. FKI-4410. J Antibiot (Tokyo) (2010) 1.05
Chiral alcohol production by NADH-dependent phenylacetaldehyde reductase coupled with in situ regeneration of NADH. Eur J Biochem (2002) 1.04
Avenolide, a Streptomyces hormone controlling antibiotic production in Streptomyces avermitilis. Proc Natl Acad Sci U S A (2011) 1.04
Stereochemical analysis of isopentenyl diphosphate isomerase type II from Staphylococcus aureus using chemically synthesized (S)- and (R)-[2-2H]isopentenyl diphosphates. Org Lett (2005) 1.03
Toward a structure-activity relationship for apoptolidin: selective functionalization of the hydroxyl group array. Org Lett (2003) 1.03
Facile synthetic access to and biological evaluation of the macrocyclic core of apoptolidin. Org Lett (2003) 1.02
Maklamicin, an antibacterial polyketide from an endophytic Micromonospora sp. J Nat Prod (2011) 1.02
Promising lead compounds for novel antiprotozoals. J Antibiot (Tokyo) (2010) 1.01
Structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase in a quaternary complex with a magnesium ion, NADPH and the antimalarial drug fosmidomycin. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 1.01
Nonomuraea maheshkhaliensis sp. nov., a novel actinomycete isolated from mangrove rhizosphere mud. J Gen Appl Microbiol (2007) 1.00
A new antibiotic, antimycin Ag, produced by Streptomyces sp. K01-0031. J Antibiot (Tokyo) (2005) 0.99
Crystal structure of the non-heme iron dioxygenase PtlH in pentalenolactone biosynthesis. J Biol Chem (2007) 0.99
Molecular mechanisms of anti-inflammatory action of erythromycin in human bronchial epithelial cells: possible role in the signaling pathway that regulates nuclear factor-kappaB activation. Antimicrob Agents Chemother (2004) 0.99
fldA is an essential gene required in the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis. FEBS Lett (2005) 0.98
Isolation and identification of three new 5-alkenyl-3,3(2H)-furanones from two streptomyces species using a genomic screening approach. J Antibiot (Tokyo) (2006) 0.98
A concise stereoselective route to the indoline spiroaminal framework of neoxaline and oxaline. Org Lett (2005) 0.97
Reconstitution of biosynthetic machinery for indole-diterpene paxilline in Aspergillus oryzae. J Am Chem Soc (2013) 0.97
Enzymatic properties of futalosine hydrolase, an enzyme essential to a newly identified menaquinone biosynthetic pathway. Biosci Biotechnol Biochem (2009) 0.97
Structure of thioviridamide, a novel apoptosis inducer from Streptomyces olivoviridis. J Antibiot (Tokyo) (2006) 0.96
Identification of diterpene biosynthetic gene clusters and functional analysis of labdane-related diterpene cyclases in Phomopsis amygdali. Biosci Biotechnol Biochem (2008) 0.96
A relationship between the mevalonate pathway and isoprenoid production in actinomycetes. J Antibiot (Tokyo) (2003) 0.96
Pentalenolactone biosynthesis: Molecular cloning and assignment of biochemical function to PtlF, a short-chain dehydrogenase from Streptomyces avermitilis, and identification of a new biosynthetic intermediate. Arch Biochem Biophys (2006) 0.96
Bottromycin derivatives: efficient chemical modifications of the ester moiety and evaluation of anti-MRSA and anti-VRE activities. Bioorg Med Chem Lett (2010) 0.95
Selectivity of microbial acyl-CoA: cholesterol acyltransferase inhibitors toward isozymes. J Antibiot (Tokyo) (2007) 0.95
EM703 improves bleomycin-induced pulmonary fibrosis in mice by the inhibition of TGF-beta signaling in lung fibroblasts. Respir Res (2006) 0.95
Menaquinone biosynthesis: formation of aminofutalosine requires a unique radical SAM enzyme. J Am Chem Soc (2013) 0.95
Novel mitochondrial complex II isolated from Trypanosoma cruzi is composed of 12 peptides including a heterodimeric Ip subunit. J Biol Chem (2009) 0.94
Cloning of the gene cluster responsible for the biosynthesis of brasilicardin A, a unique diterpenoid. J Antibiot (Tokyo) (2008) 0.94
Structure determination and total synthesis of bottromycin A2: a potent antibiotic against MRSA and VRE. Angew Chem Int Ed Engl (2009) 0.93
Actinohivin, a novel anti-human immunodeficiency virus protein from an actinomycete, inhibits viral entry to cells by binding high-mannose type sugar chains of gp120. Biochem Biophys Res Commun (2004) 0.93
Avermectin Biosynthesis. Chem Rev (1997) 0.93
Antiatherogenic activity of fungal beauveriolides, inhibitors of lipid droplet accumulation in macrophages. Proc Natl Acad Sci U S A (2004) 0.93
Presence of copalyl diphosphate synthase gene in an actinomycete possessing the mevalonate pathway. J Antibiot (Tokyo) (2004) 0.93
Structures of grixazone A and B, A-factor-dependent yellow pigments produced under phosphate depletion by Streptomyces griseus. J Antibiot (Tokyo) (2004) 0.92
Aranorosin circumvents arbekacin-resistance in MRSA by inhibiting the bifunctional enzyme AAC(6')/APH(2″). J Antibiot (Tokyo) (2012) 0.92
Correlation of F0F1-ATPase inhibition and antiproliferative activity of apoptolidin analogues. Org Lett (2006) 0.92
In vitro antimalarial activity of biflavonoids from Wikstroemia indica. Planta Med (2004) 0.92
Nosokomycins, new antibiotics discovered in an in vivo-mimic infection model using silkworm larvae. I: Fermentation, isolation and biological properties. J Antibiot (Tokyo) (2010) 0.92
Terpenoids Produced by Actinomycetes: Napyradiomycins from Streptomyces antimycoticus NT17. J Nat Prod (2008) 0.91
Fungal malformins inhibit bleomycin-induced G2 checkpoint in Jurkat cells. Biol Pharm Bull (2007) 0.91
Bacillus subtilis ypgA gene is fni, a nonessential gene encoding type 2 isopentenyl diphosphate isomerase. Biosci Biotechnol Biochem (2004) 0.91
Diversity of the early step of the futalosine pathway. Antimicrob Agents Chemother (2010) 0.91
Potential therapeutics for obesity and atherosclerosis: inhibitors of neutral lipid metabolism from microorganisms. Pharmacol Ther (2007) 0.91