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B N Ames

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Rank Title Journal Year PubWeight™‹?›
1 Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutat Res 1975 17.12
2 Positive selection for loss of tetracycline resistance. J Bacteriol 1980 15.79
3 Positive control of a regulon for defenses against oxidative stress and some heat-shock proteins in Salmonella typhimurium. Cell 1985 12.51
4 Revised methods for the Salmonella mutagenicity test. Mutat Res 1983 11.60
5 Bilirubin is an antioxidant of possible physiological importance. Science 1987 11.26
6 The free radical theory of aging matures. Physiol Rev 1998 9.83
7 Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. Science 1983 9.38
8 Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection. Proc Natl Acad Sci U S A 1973 9.09
9 Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals. Proc Natl Acad Sci U S A 1975 8.66
10 An improved bacterial test system for the detection and classification of mutagens and carcinogens. Proc Natl Acad Sci U S A 1973 8.45
11 Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis. Proc Natl Acad Sci U S A 1981 8.45
12 Procedure for identifying nonsense mutations. J Bacteriol 1968 8.16
13 Localized mutagenesis of any specific small region of the bacterial chromosome. Proc Natl Acad Sci U S A 1971 7.98
14 A Series of Histidineless Mutants of Neurospora Crassa. Genetics 1952 7.20
15 Classification of aminotransferase (C gene) mutants in the histidine operon. J Mol Biol 1966 6.92
16 Oxidative damage and mitochondrial decay in aging. Proc Natl Acad Sci U S A 1994 6.84
17 Complete analysis of cellular nucleotides by two-dimensional thin layer chromatography. J Biol Chem 1982 6.69
18 Frameshift mutagenesis in Salmonella. Cold Spring Harb Symp Quant Biol 1966 6.53
19 Compounds which serve as the sole source of carbon or nitrogen for Salmonella typhimurium LT-2. J Bacteriol 1969 5.99
20 Iron uptake in Salmonella typhimurium: utilization of exogenous siderochromes as iron carriers. J Bacteriol 1972 5.77
21 Transcriptional regulator of oxidative stress-inducible genes: direct activation by oxidation. Science 1990 5.53
22 Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc Natl Acad Sci U S A 1988 5.52
23 Detection of carcinogens as mutagens: bacterial tester strains with R factor plasmids. Proc Natl Acad Sci U S A 1975 5.51
24 Hydrogen peroxide-inducible proteins in Salmonella typhimurium overlap with heat shock and other stress proteins. Proc Natl Acad Sci U S A 1986 5.29
25 Transport of antibiotics and metabolite analogs by systems under cyclic AMP control: positive selection of Salmonella typhimurium cya and crp mutants. J Bacteriol 1978 4.91
26 Oxygen radicals and human disease. Ann Intern Med 1987 4.57
27 Iron transport in Salmonella typhimurium: mutants blocked in the biosynthesis of enterobactin. J Bacteriol 1970 4.44
28 Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci U S A 1997 4.38
29 Histidine regulatory mutants in Salmonella typhimurium II. Histidine regulatory mutants having altered histidyl-tRNA synthetase. J Mol Biol 1966 4.15
30 Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine. Proc Natl Acad Sci U S A 1990 4.06
31 Ascorbate is an outstanding antioxidant in human blood plasma. Proc Natl Acad Sci U S A 1989 4.02
32 Oxidative decay of DNA. J Biol Chem 1997 3.94
33 Histidine regulatory mutants in Salmonella typhimurium 3. A class of regulatory mutants deficient in tRNA for histidine. J Mol Biol 1966 3.80
34 OxyR, a positive regulator of hydrogen peroxide-inducible genes in Escherichia coli and Salmonella typhimurium, is homologous to a family of bacterial regulatory proteins. Proc Natl Acad Sci U S A 1989 3.77
35 An alkyl hydroperoxide reductase from Salmonella typhimurium involved in the defense of DNA against oxidative damage. Purification and properties. J Biol Chem 1989 3.74
36 AppppA, heat-shock stress, and cell oxidation. Proc Natl Acad Sci U S A 1983 3.68
37 Carcinogens as frameshift mutagens: metabolites and derivatives of 2-acetylaminofluorene and other aromatic amine carcinogens. Proc Natl Acad Sci U S A 1972 3.61
38 Histidine regulation in Salmonella typhimurium. XI. The percentage of transfer RNA His charged in vivo and its relation to the repression of the histidine operon. J Mol Biol 1972 3.60
39 [Mutant tRNA His ineffective in repression and lacking two pseudouridine modifications]. Nat New Biol 1972 3.57
40 Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals: discussion. Proc Natl Acad Sci U S A 1976 3.46
41 The leader mRNA of the histidine attenuator region resembles tRNAHis: possible general regulatory implications. Proc Natl Acad Sci U S A 1983 3.43
42 Antioxidant defenses and lipid peroxidation in human blood plasma. Proc Natl Acad Sci U S A 1988 3.42
43 Epoxides of carcinogenic polycyclic hydrocarbons are frameshift mutagens. Science 1972 3.42
44 Adenosine 3':5'-cyclic monophosphate concentration in the bacterial host regulates the viral decision between lysogeny and lysis. Proc Natl Acad Sci U S A 1971 3.39
45 Positive selection of mutants with deletions of the gal-chl region of the Salmonella chromosome as a screening procedure for mutagens that cause deletions. J Bacteriol 1975 3.37
46 An alkyl hydroperoxide reductase induced by oxidative stress in Salmonella typhimurium and Escherichia coli: genetic characterization and cloning of ahp. J Bacteriol 1989 3.37
47 Antioxidant activity of albumin-bound bilirubin. Proc Natl Acad Sci U S A 1987 3.35
48 AppppA and related adenylylated nucleotides are synthesized as a consequence of oxidation stress. Cell 1984 3.25
49 Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning? Free Radic Biol Med 2005 3.13
50 Regulation of nonspecific acid phosphatase in Salmonella: phoN and phoP genes. J Bacteriol 1979 3.09
51 Guanosine 5'-diphosphate 3'-diphosphate (ppGpp): positive effector for histidine operon transcription and general signal for amino-acid deficiency. Proc Natl Acad Sci U S A 1975 3.05
52 Urinary 8-hydroxy-2'-deoxyguanosine as a biological marker of in vivo oxidative DNA damage. Proc Natl Acad Sci U S A 1989 2.92
53 gamma-tocopherol, the major form of vitamin E in the US diet, deserves more attention. Am J Clin Nutr 2001 2.91
54 Bacterial defenses against oxidative stress. Trends Genet 1990 2.89
55 Oxidative DNA damage and senescence of human diploid fibroblast cells. Proc Natl Acad Sci U S A 1995 2.89
56 Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein assay. Anal Biochem 1983 2.85
57 Thymine glycol and thymidine glycol in human and rat urine: a possible assay for oxidative DNA damage. Proc Natl Acad Sci U S A 1984 2.82
58 Regulation of two phosphatases and a cyclic phosphodiesterase of Salmonella typhimurium. J Bacteriol 1977 2.68
59 A new Salmonella tester strain (TA102) with A X T base pairs at the site of mutation detects oxidative mutagens. Proc Natl Acad Sci U S A 1982 2.67
60 Oxidative damage to DNA: relation to species metabolic rate and life span. Proc Natl Acad Sci U S A 1988 2.62
61 Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells. Proc Natl Acad Sci U S A 1994 2.55
62 Hair dyes are mutagenic: identification of a variety of mutagenic ingredients. Proc Natl Acad Sci U S A 1975 2.55
63 Identification and molecular analysis of oxyR-regulated promoters important for the bacterial adaptation to oxidative stress. J Mol Biol 1989 2.52
64 Spontaneous mutagenesis and oxidative damage to DNA in Salmonella typhimurium. Proc Natl Acad Sci U S A 1987 2.51
65 Mode of action of the herbicide, 3-amino-1,2,4-triazole(amitrole): inhibition of an enzyme of histidine biosynthesis. Arch Biochem Biophys 1965 2.46
66 Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication. Biochem J 1998 2.41
67 Biosynthesis of pseudouridine in transfer ribonucleic acid. J Biol Chem 1974 2.36
68 Effect of the alpha-hydrazino analogue of histidine on histidine transport and arginine biosynthesis. J Biol Chem 1966 2.35
69 Pleiotropy of hisT mutants blocked in pseudouridine synthesis in tRNA: leucine and isoleucine-valine operons. Proc Natl Acad Sci U S A 1974 2.31
70 Histidine regulatory mutants in Salmonella typhimurium. IV. A positive selection for polar histidine-requiring mutants from histidine operator constitutive mutants. J Mol Biol 1967 2.30
71 Complete analysis of tRNA-modified nucleosides by high-performance liquid chromatography: the 29 modified nucleosides of Salmonella typhimurium and Escherichia coli tRNA. Anal Biochem 1983 2.29
72 gamma-tocopherol and its major metabolite, in contrast to alpha-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells. Proc Natl Acad Sci U S A 2000 2.29
73 Illicit transport: the oligopeptide permease. Proc Natl Acad Sci U S A 1973 2.22
74 Identifying environmental chemicals causing mutations and cancer. Science 1979 2.22
75 Ranking possible carcinogenic hazards. Science 1987 2.06
76 Chronological supplement to the Carcinogenic Potency Database: standardized results of animal bioassays published through December 1982. Environ Health Perspect 1986 2.06
77 Antioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brain. Proc Natl Acad Sci U S A 1988 2.04
78 Histidine regulation in Salmonella typhimurium. IX. Histidine transfer ribonucleic acid of the regulatory mutants. J Biol Chem 1972 2.04
79 Transfer RNA and the control of the histidine operon. Cold Spring Harb Symp Quant Biol 1966 2.02
80 DNA oxidation matters: the HPLC-electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine. Proc Natl Acad Sci U S A 1998 2.01
81 Endogenous oxidative damage of deoxycytidine in DNA. Proc Natl Acad Sci U S A 1992 1.98
82 Alkyl hydroperoxide reductase from Salmonella typhimurium. Sequence and homology to thioredoxin reductase and other flavoprotein disulfide oxidoreductases. J Biol Chem 1990 1.95
83 Gamma-tocopherol prevents airway eosinophilia and mucous cell hyperplasia in experimentally induced allergic rhinitis and asthma. Clin Exp Allergy 2007 1.93
84 gamma-tocopherol traps mutagenic electrophiles such as NO(X) and complements alpha-tocopherol: physiological implications. Proc Natl Acad Sci U S A 1997 1.91
85 A modified nucleotide in tRNA as a possible regulator of aerobiosis: synthesis of cis-2-methyl-thioribosylzeatin in the tRNA of Salmonella. Cell 1984 1.90
86 Immobilization stress causes oxidative damage to lipid, protein, and DNA in the brain of rats. FASEB J 1996 1.83
87 Hydroxymethyluracil DNA glycosylase in mammalian cells. Proc Natl Acad Sci U S A 1984 1.83
88 Mitochondrial decay in hepatocytes from old rats: membrane potential declines, heterogeneity and oxidants increase. Proc Natl Acad Sci U S A 1997 1.83
89 Resolution and purification of three periplasmic phosphatases of Salmonella typhimurium. J Bacteriol 1977 1.83
90 Mutagenicity of chloroacetaldehyde, a possible metabolic product of 1,2-dichloroethane (ethylene dichloride), chloroethanol (ethylene chlorohydrin), vinyl chloride, and cyclophosphamide. Proc Natl Acad Sci U S A 1975 1.81
91 Extensive oxidative DNA damage in hepatocytes of transgenic mice with chronic active hepatitis destined to develop hepatocellular carcinoma. Proc Natl Acad Sci U S A 1994 1.79
92 Assay of excised oxidative DNA lesions: isolation of 8-oxoguanine and its nucleoside derivatives from biological fluids with a monoclonal antibody column. Proc Natl Acad Sci U S A 1992 1.76
93 A simple method for the detection of mutagens in urine: studies with the carcinogen 2-acetylaminofluorene. Proc Natl Acad Sci U S A 1974 1.75
94 Detection of mutagenic activity in cigarette smoke condensates. Proc Natl Acad Sci U S A 1974 1.74
95 Ascorbic acid protects against endogenous oxidative DNA damage in human sperm. Proc Natl Acad Sci U S A 1991 1.74
96 Gas phase oxidants of cigarette smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma. Protective effects of ascorbic acid. Biochem J 1991 1.73
97 Evaluation of an isoluminol chemiluminescence assay for the detection of hydroperoxides in human blood plasma. Anal Biochem 1988 1.73
98 The Carcinogenic Potency Database: analyses of 4000 chronic animal cancer experiments published in the general literature and by the U.S. National Cancer Institute/National Toxicology Program. Environ Health Perspect 1991 1.72
99 Pseudouridylation of tRNAs and its role in regulation in Salmonella typhimurium. J Biol Chem 1979 1.72
100 Mutagenicity of quinones: pathways of metabolic activation and detoxification. Proc Natl Acad Sci U S A 1984 1.68
101 Detection and characterization of lipid hydroperoxides at picomole levels by high-performance liquid chromatography. Anal Biochem 1987 1.67
102 A method for detecting abasic sites in living cells: age-dependent changes in base excision repair. Proc Natl Acad Sci U S A 2000 1.67
103 Histidine regulation in Salmonella typhimurium. 8. Mutations of the hisT gene. J Bacteriol 1971 1.67
104 THE EFFECT OF POLYAMINES AND OF POLY U SIZE ON PHENYLALANINE INCORPORATION. Proc Natl Acad Sci U S A 1962 1.65
105 Histidine regulation in Salmonella typhimurium. XVI. A sensitive radiochemical assay for histidinol dehydrogenase. Anal Biochem 1975 1.64
106 Diadenosine 5',5"'-P1,P4-tetraphosphate and related adenylylated nucleotides in Salmonella typhimurium. J Biol Chem 1983 1.64
107 Second chronological supplement to the Carcinogenic Potency Database: standardized results of animal bioassays published through December 1984 and by the National Toxicology Program through May 1986. Environ Health Perspect 1987 1.64
108 Assays of oxidative DNA damage biomarkers 8-oxo-2'-deoxyguanosine and 8-oxoguanine in nuclear DNA and biological fluids by high-performance liquid chromatography with electrochemical detection. Methods Enzymol 1994 1.62
109 ZTP (5-amino 4-imidazole carboxamide riboside 5'-triphosphate): a proposed alarmone for 10-formyl-tetrahydrofolate deficiency. Cell 1982 1.61
110 Smoking and low antioxidant levels increase oxidative damage to sperm DNA. Mutat Res 1996 1.61
111 Concentration of mutagens from urine by absorption with the nonpolar resin XAD-2: cigarette smokers have mutagenic urine. Proc Natl Acad Sci U S A 1977 1.58
112 Cyclic 3', 5'-adenosine monophosphate phosphodiesterase mutants of Salmonella typhimurium. J Bacteriol 1975 1.58
113 Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations. Proc Natl Acad Sci U S A 1990 1.57
114 Naturally occurring carbonyl compounds are mutagens in Salmonella tester strain TA104. Mutat Res 1985 1.56
115 Classifying mutagens as to their specificity in causing the six possible transitions and transversions: a simple analysis using the Salmonella mutagenicity assay. Environ Mutagen 1986 1.53
116 Children absorb tris-BP flame retardant from sleepwear: urine contains the mutagenic metabolite, 2,3-dibromopropanol. Science 1978 1.53
117 Assays for 8-hydroxy-2'-deoxyguanosine: a biomarker of in vivo oxidative DNA damage. Free Radic Biol Med 1991 1.50
118 Another flame retardant, tris-(1,3-dichloro-2-propyl)-phosphate, and its expected metabolites are mutagens. Science 1978 1.46
119 Chronically and acutely exercised rats: biomarkers of oxidative stress and endogenous antioxidants. J Appl Physiol (1985) 2000 1.45
120 Potential role of conjugated bilirubin and copper in the metabolism of lipid peroxides in bile. Proc Natl Acad Sci U S A 1987 1.43
121 Biomarkers of oxidative stress study III. Effects of the nonsteroidal anti-inflammatory agents indomethacin and meclofenamic acid on measurements of oxidative products of lipids in CCl4 poisoning. Free Radic Biol Med 2005 1.42
122 Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity. Proc Natl Acad Sci U S A 1998 1.41
123 Some tautologous aspects of the comparison of carcinogenic potency in rats and mice. Fundam Appl Toxicol 1985 1.40
124 Sunlight ultraviolet and bacterial DNA base ratios. Science 1970 1.39
125 Isolation and characterization of a selenium metabolism mutant of Salmonella typhimurium. J Bacteriol 1988 1.38
126 Protein oxidation associated with aging is reduced by dietary restriction of protein or calories. Proc Natl Acad Sci U S A 1992 1.36
127 Near-UV stress in Salmonella typhimurium: 4-thiouridine in tRNA, ppGpp, and ApppGpp as components of an adaptive response. J Bacteriol 1988 1.35
128 A procedure for rapid extraction and high-pressure liquid chromatographic separation of the nucleotides and other small molecules from bacterial cells. Anal Biochem 1982 1.34
129 Properties of two phosphatases and a cyclic phosphodiesterase of Salmonella typhimurium. J Bacteriol 1977 1.32
130 Multidegenerate DNA recognition by the OxyR transcriptional regulator. J Biol Chem 1992 1.31
131 Heme deficiency selectively interrupts assembly of mitochondrial complex IV in human fibroblasts: revelance to aging. J Biol Chem 2001 1.30
132 Inflammation and NO(X)-induced nitration: assay for 3-nitrotyrosine by HPLC with electrochemical detection. Proc Natl Acad Sci U S A 1997 1.30
133 An apaH mutation causes AppppA to accumulate and affects motility and catabolite repression in Escherichia coli. Proc Natl Acad Sci U S A 1989 1.25
134 Third chronological supplement to the carcinogenic potency database: standardized results of animal bioassays published through December 1986 and by the National Toxicology Program through June 1987. Environ Health Perspect 1990 1.24
135 Flame-retardant additives as possible cancer hazards. Science 1977 1.24
136 Ascorbate is depleted by smoking and repleted by moderate supplementation: a study in male smokers and nonsmokers with matched dietary antioxidant intakes. Am J Clin Nutr 2000 1.22
137 Immunoaffinity isolation of urinary 8-hydroxy-2'-deoxyguanosine and 8-hydroxyguanine and quantitation of 8-hydroxy-2'-deoxyguanosine in DNA by polyclonal antibodies. Carcinogenesis 1991 1.22
138 8-Hydroxydeoxyguanosine and 8-hydroxyguanine as biomarkers of oxidative DNA damage. Methods Enzymol 1999 1.21
139 Histidine regulation in Salmonella typhimurium. VII. Purification and general properties of the histidyl transfer ribonucleic acid synthetase. J Biol Chem 1970 1.21
140 (R)-alpha-lipoic acid reverses the age-associated increase in susceptibility of hepatocytes to tert-butylhydroperoxide both in vitro and in vivo. Antioxid Redox Signal 2000 1.20
141 Induction of cytochrome P4501A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin or indolo(3,2-b)carbazole is associated with oxidative DNA damage. Proc Natl Acad Sci U S A 1996 1.17
142 Salmonella typhimurium mutants with alternate requirements for vitamin B 6 or isoleucine. J Bacteriol 1971 1.15
143 N-t-butyl hydroxylamine, a hydrolysis product of alpha-phenyl-N-t-butyl nitrone, is more potent in delaying senescence in human lung fibroblasts. J Biol Chem 2000 1.14
144 The OxyR regulon. Antonie Van Leeuwenhoek 1990 1.13
145 7-Methylguanine adducts in DNA are normally present at high levels and increase on aging: analysis by HPLC with electrochemical detection. Proc Natl Acad Sci U S A 1988 1.13
146 Oxidative stress and abnormal cholesterol metabolism in patients with adult respiratory distress syndrome. J Lab Clin Med 1990 1.12
147 Antioxidant activities of bile pigments: biliverdin and bilirubin. Methods Enzymol 1990 1.11
148 Histidine regulation in salmonella typhimurium. XIV. Interaction of the histidyl transfer ribonucleic acid synthetase with histidine transfer ribonucleic acid. J Biol Chem 1972 1.11
149 Assay of aldehydes from lipid peroxidation: gas chromatography-mass spectrometry compared to thiobarbituric acid. Anal Biochem 1997 1.08
150 Sequence specificity of tRNA-modifying enzymes. An analysis of 258 tRNA sequences. Biochim Biophys Acta 1983 1.08
151 The effect of folic acid deficiency and MTHFR C677T polymorphism on chromosome damage in human lymphocytes in vitro. Cancer Epidemiol Biomarkers Prev 2001 1.07
152 A new Salmonella tester strain, TA97, for the detection of frameshift mutagens. A run of cytosines as a mutational hot-spot. Mutat Res 1982 1.07
153 Spontaneous and mutagen-induced deletions: mechanistic studies in Salmonella tester strain TA102. Proc Natl Acad Sci U S A 1984 1.07
154 Oxidative damage increases with age in a canine model of human brain aging. J Neurochem 2002 1.07
155 Ascorbate: the most effective antioxidant in human blood plasma. Adv Exp Med Biol 1990 1.07
156 Endogenous oxidative damage of mtDNA. Mutat Res 1999 1.07
157 Oxidative mechanisms of toxicity of low-intensity near-UV light in Salmonella typhimurium. J Bacteriol 1987 1.07
158 Rodent carcinogens: setting priorities. Science 1992 1.06
159 Mitochondrial aging: open questions. Ann N Y Acad Sci 1998 1.06
160 In vivo oxidative DNA damage: measurement of 8-hydroxy-2'-deoxyguanosine in DNA and urine by high-performance liquid chromatography with electrochemical detection. Methods Enzymol 1990 1.06
161 Age-associated decline in ascorbic acid concentration, recycling, and biosynthesis in rat hepatocytes--reversal with (R)-alpha-lipoic acid supplementation. FASEB J 1998 1.06
162 Selective precipitation orthophosphate from mixtures containing labile phosphorylated metabolites. Anal Biochem 1982 1.05
163 Histidine regulation in Salmonella typhimurium. X. Kinetic studies of mutant histidyl transfer ribonucleic acid synthetases. J Biol Chem 1972 1.05
164 Analysis of uracil in DNA by gas chromatography-mass spectrometry. Anal Biochem 1994 1.05
165 Assay of malondialdehyde in biological fluids by gas chromatography-mass spectrometry. Anal Biochem 1994 1.05
166 Both iron deficiency and daily iron supplements increase lipid peroxidation in rats. J Nutr 2000 1.04
167 cis 2-Methylthio-ribosylzeatin (ms2io6A) is present in the transfer RNA of Salmonella typhimurium, but not Escherichia coli. Nucleic Acids Res 1982 1.04
168 The detection of environmental mutagens and potential carcinogens. Cancer 1984 1.00
169 Mechanisms of mutagenicity and toxicity of sodium selenite (Na2SeO3) in Salmonella typhimurium. Mutat Res 1988 1.00
170 The oxidation of blood plasma and low density lipoprotein components by chemically generated singlet oxygen. J Biol Chem 1993 1.00
171 Sixth plot of the carcinogenic potency database: results of animal bioassays published in the General Literature 1989 to 1990 and by the National Toxicology Program 1990 to 1993. Environ Health Perspect 1995 1.00
172 Low seminal plasma folate concentrations are associated with low sperm density and count in male smokers and nonsmokers. Fertil Steril 2001 0.99
173 Detection of picomole levels of lipid hydroperoxides using a dichlorofluorescein fluorescent assay. Methods Enzymol 1984 0.99
174 Histidyl-transfer ribonucleic acid synthetase mutants requiring a high internal pool of histidine for growth. J Bacteriol 1973 0.98
175 'Spontaneous' genetic damage in man: evaluation of interindividual variability, relationship among markers of damage, and influence of nutritional status. Mutat Res 1997 0.98
176 DNA damage in folate deficiency. Baillieres Clin Haematol 1995 0.98
177 Detection and quantification of oxidative adducts of mitochondrial DNA. Methods Enzymol 1996 0.98
178 Enriched selection of dominant mutations: histidine operator mutations. J Bacteriol 1971 0.97
179 Mitochondrial decay in aging. Reversal through supplementation of acetyl-L-carnitine and N-tert-butyl-alpha-phenyl-nitrone. Ann N Y Acad Sci 1998 0.97
180 The fifth plot of the Carcinogenic Potency Database: results of animal bioassays published in the general literature through 1988 and by the National Toxicology Program through 1989. Environ Health Perspect 1993 0.96
181 Fecalase: a model for activation of dietary glycosides to mutagens by intestinal flora. Proc Natl Acad Sci U S A 1980 0.96
182 Detection and classification of mutagens: a set of base-specific Salmonella tester strains. Proc Natl Acad Sci U S A 1994 0.96
183 The TD50: a proposed general convention for the numerical description of the carcinogenic potency of chemicals in chronic-exposure animal experiments. Environ Health Perspect 1984 0.96
184 Measurement of antioxidants in human blood plasma. Methods Enzymol 1994 0.96
185 An inexpensive Luer-fitting chromatographic column. Anal Biochem 1967 0.96
186 Mutagenicity of cancer chemotherapeutic agents in the Salmonella/microsome test. Cancer Res 1977 0.96
187 In reply: carcinogenic risk estimation. Science 1988 0.96
188 A simple method for detecting environmental carcinogens as mutagens. Ann N Y Acad Sci 1976 0.95
189 Supplementation of postmenopausal women with fish oil rich in eicosapentaenoic acid and docosahexaenoic acid is not associated with greater in vivo lipid peroxidation compared with oils rich in oleate and linoleate as assessed by plasma malondialdehyde and F(2)-isoprostanes. Am J Clin Nutr 2000 0.95
190 Methylenetetrahydrofolate reductase C677T polymorphism does not alter folic acid deficiency-induced uracil incorporation into primary human lymphocyte DNA in vitro. Carcinogenesis 2001 0.94
191 Antioxidant status and indexes of oxidative stress during consecutive days of exercise. J Appl Physiol (1985) 1993 0.92
192 Apoptosis of late-stage erythroblasts in megaloblastic anemia: association with DNA damage and macrocyte production. Blood 1997 0.92
193 Background levels of DNA damage in the population. Basic Life Sci 1986 0.92
194 Target sequences for mutagenesis in Salmonella histidine-requiring mutants. Environ Mutagen 1986 0.92
195 Oxidative damage to plasma constituents by ozone. FEBS Lett 1992 0.92
196 Pesticides, risk, and applesauce. Science 1989 0.91
197 Acetyl-L-carnitine and alpha-lipoic acid supplementation of aged beagle dogs improves learning in two landmark discrimination tests. FASEB J 2007 0.91
198 Fluorescence detection of 8-oxoguanine in nuclear and mitochondrial DNA of cultured cells using a recombinant Fab and confocal scanning laser microscopy. Free Radic Biol Med 2000 0.91
199 Response: paleolithic diet, evolution, and carcinogens. Science 1987 0.91
200 Extrapolation of carcinogenicity between species: qualitative and quantitative factors. Risk Anal 1992 0.91
201 Oxidative susceptibility of low density lipoprotein subfractions is related to their ubiquinol-10 and alpha-tocopherol content. Proc Natl Acad Sci U S A 1994 0.91
202 Assay of lipid hydroperoxides using high-performance liquid chromatography with isoluminal chemiluminescence detection. Methods Enzymol 1990 0.91
203 Immunocompetence and oxidant defense during ascorbate depletion of healthy men. Am J Clin Nutr 1991 0.90
204 Cytogenetic damage induced by folate deficiency in mice is enhanced by caffeine. Proc Natl Acad Sci U S A 1990 0.89
205 Cancer prevention and diet: help from single nucleotide polymorphisms. Proc Natl Acad Sci U S A 1999 0.89
206 An adduct between peroxynitrite and 2'-deoxyguanosine: 4,5-dihydro-5-hydroxy-4-(nitrosooxy)-2'-deoxyguanosine. Chem Res Toxicol 1996 0.88
207 Response. Science 1991 0.88
208 Validation of the Salmonella test: a reply to Rinkus and Legator. Cancer Res 1981 0.88
209 N-t-Butyl hydroxylamine is an antioxidant that reverses age-related changes in mitochondria in vivo and in vitro. FASEB J 2001 0.87
210 Energy charge and protein synthesis. Control of aminoacyl transfer ribonucleic acid synthetases. J Biol Chem 1970 0.87
211 Assay of malondialdehyde and other alkanals in biological fluids by gas chromatography-mass spectrometry. Methods Enzymol 1999 0.87
212 Detection of phosphate esters on chromatograms: an improved reagent. Anal Biochem 1981 0.87
213 Pre-treatment with R-lipoic acid alleviates the effects of GSH depletion in PC12 cells: implications for Parkinson's disease therapy. Neurotoxicology 2002 0.87
214 Quantitation of age-related mitochondrial DNA deletions in rat tissues shows that their pattern of accumulation differs from that of humans. Gene 1998 0.87
215 Detection of lipid hydroperoxides and hydrogen peroxide at picomole levels by an HPLC and isoluminol chemiluminescence assay. Free Radic Biol Med 1987 0.87
216 Carcinogens are mutagens: their detection and classification. Environ Health Perspect 1973 0.86
217 Discussion paper: the detection of mutagenic metabolites of carcinogens in urine with the Salmonella/microsome test. Ann N Y Acad Sci 1975 0.86
218 Antioxidant activity of diethyldithiocarbamate. Free Radic Res 1996 0.85
219 In reply: carcinogens and human health: part 1. Science 1990 0.85
220 Immunodetection of 3-nitrotyrosine in the liver of zymosan-treated rats with a new monoclonal antibody: comparison to analysis by HPLC. Free Radic Biol Med 2001 0.85
221 Compatibility of organic solvents with the Salmonella/microsome test. Mutat Res 1981 0.85
222 Oxidants and mitogenesis as causes of mutation and cancer: the influence of diet. Basic Life Sci 1993 0.85
223 What do animal cancer tests tell us about human cancer risk?: Overview of analyses of the carcinogenic potency database. Drug Metab Rev 1998 0.84
224 Response. Science 1991 0.84
225 The operon concept in bacteria and in higher organisms. Natl Cancer Inst Monogr 1967 0.84
226 Maternal dietary zinc influences DNA strand break and 8-hydroxy-2'-deoxyguanosine levels in infant rhesus monkey liver. Proc Soc Exp Biol Med 1993 0.84
227 Decreases in tissue levels of ubiquinol-9 and -10, ascorbate and alpha-tocopherol following spinal cord impact trauma in rats. Neurosci Lett 1990 0.83
228 A simpler, more robust method for the analysis of 8-oxoguanine in DNA. Free Radic Biol Med 2000 0.83
229 Re: E. Farber, Cell proliferation as a major risk factor for cancer: a concept of doubtful validity. Cancer Res., 55: 3759-3762, 1995. Cancer Res 1996 0.82
230 Detection of DNA adducts by high-performance liquid chromatography with electrochemical detection. Carcinogenesis 1989 0.82
231 International Commission for Protection Against Environmental Mutagens and Carcinogens. ICPEMC Publication No. 12. Inhibitors of mutagenesis and their relevance to carcinogenesis. Report by ICPEMC Expert Group on Antimutagens and Desmutagens. Mutat Res 1986 0.81
232 Carcinogenesis debate. Science 1990 0.81
233 Mutagenicity of nitric oxide in base pair-specific Salmonella tester strains: TA7000 series. Methods Enzymol 1996 0.81
234 Inhibition of simian virus 40 DNA replication in vitro by poly(ADP-ribosyl)ated diadenosine tetraphosphate. J Biol Chem 1987 0.80
235 Alterations in levels of 5'-adenyl dinucleotides following DNA damage in normal human fibroblasts and fibroblasts derived from patients with xeroderma pigmentosum. Mutat Res 1988 0.79
236 Ascorbic acid recycling in rat hepatocytes as measurement of antioxidant capacity: decline with age. Methods Enzymol 1999 0.79
237 Heterocyclic amines formed by cooking food: comparison of bioassay results with other chemicals in the Carcinogenic Potency Database. Cancer Lett 1994 0.79
238 N2-methyl-8-oxoguanine: a tRNA urinary metabolite--role of xanthine oxidase. Free Radic Biol Med 1996 0.79
239 Effect of ebselen on Ca2+ transport in mitochondria. Redox Rep 2000 0.79
240 A combined bacterial and liver test system for detection and classification of carcinogens as mutagens. Genetics 1974 0.79
241 Toxic hydroperoxides in intravenous lipid emulsions used in preterm infants. Pediatrics 1993 0.79
242 Sensitive fluorographic detection of 3H and 14C on chromatograms using methyl anthranilate as a scintillant. Anal Biochem 1983 0.78
243 Dietary carcinogens and anti-carcinogens. J Toxicol Clin Toxicol 1984 0.78
244 Cancer prevention, rodent high-dose cancer tests, and risk assessment. Risk Anal 1996 0.78
245 Food constituents as a source of mutagens, carcinogens, and anticarcinogens. Prog Clin Biol Res 1986 0.78
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