Published in Proc Natl Acad Sci U S A on March 01, 1974
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Detection of carcinogens as mutagens: bacterial tester strains with R factor plasmids. Proc Natl Acad Sci U S A (1975) 5.51
Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals: discussion. Proc Natl Acad Sci U S A (1976) 3.46
Hair dyes are mutagenic: identification of a variety of mutagenic ingredients. Proc Natl Acad Sci U S A (1975) 2.55
Mutagenicity of chloroacetaldehyde, a possible metabolic product of 1,2-dichloroethane (ethylene dichloride), chloroethanol (ethylene chlorohydrin), vinyl chloride, and cyclophosphamide. Proc Natl Acad Sci U S A (1975) 1.81
Chemical induction of sperm abnormalities in mice. Proc Natl Acad Sci U S A (1975) 1.72
Concentration of mutagens from urine by absorption with the nonpolar resin XAD-2: cigarette smokers have mutagenic urine. Proc Natl Acad Sci U S A (1977) 1.58
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A combined bacterial and liver test system for detection and classification of carcinogens as mutagens. Genetics (1974) 0.79
Urine mutagenicity as an indicator of exposure to dietary mutagens formed during cooking of foods. Environ Health Perspect (1986) 0.79
Testing the environment for dispersed mutagens: use of plant bioconcentrators coupled with microbial mutagen assays. Environ Health Perspect (1978) 0.75
Activation of Polynuclear Aromatic Hydrocarbons to Mutagens by the Marine Ciliate Parauronema acutum. Appl Environ Microbiol (1981) 0.75
Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection. Proc Natl Acad Sci U S A (1973) 9.09
An improved bacterial test system for the detection and classification of mutagens and carcinogens. Proc Natl Acad Sci U S A (1973) 8.45
Carcinogens as frameshift mutagens: metabolites and derivatives of 2-acetylaminofluorene and other aromatic amine carcinogens. Proc Natl Acad Sci U S A (1972) 3.61
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The N- and ringhydroxylation of 2-acetylaminofluorene during carcinogenesis in the rat. Cancer Res (1960) 1.52
On the interaction of N-2-fluorenylhydroxylamine with nucleic acids in vitro. Biochem Biophys Res Commun (1965) 1.50
Mutagenicity of cycasin aglycone (methylazoxymethanol), a naturally occurring carcinogen. Science (1966) 1.31
N-hydroxy-2-fluorenylacetamide. Reaction of the carcinogen with guanosine, ribonucleic acid, deoxyribonucleic acid, and protein following enzymatic deacetylation or esterification. J Biol Chem (1969) 1.23
ENZYMATIC N-HYDROXYLATION OF THE CARCINOGEN 2-ACETYLAMINOFLUORENE AND THE METABOLISM OF N-HYDROXY-2-ACETYLAMINOFLUORENE-9-14C IN VITRO. J Biol Chem (1964) 1.12
ON THE STRUCTURE OF THE GLUCURONIDE OF N-HYDROXY-2-ACETYLAMINOFLUORENE. J Biol Chem (1965) 1.06
Microbial mutagenicity of streptozotocin in animal-mediated assays. Nature (1969) 1.04
Evidence for a glucuronic acid conjugate of N-hydroxy-4-aminobiphenyl in the urine of dogs given 4-aminobiphenyl. Cancer Res (1973) 1.01
Reactivity in vivo of the carcinogen N-hydroxy-2-acetylaminofluorene: increase by sulfate ion. Science (1970) 0.99
Reaction of the glucuronide of the carcinogen N-hydroxy-2-acetylaminofluorene with nucleic acids. Biochim Biophys Acta (1969) 0.89
Cyclophosphamide: pilot study of genetically active metabolites in the urine of a treated human patient. Induction of mitotic gene conversions in yeast. Mutat Res (1973) 0.88
A new method for testing genetically active metabolites. Urinary assay with cyclophosphamide (endoxan, cytoxan) and Saccharomyces cerevisiae. Mutat Res (1973) 0.88
The carcinogenic and mutagenic properties of N-hydroxy-aminonaphthalenes. Cancer Res (1968) 0.85
Differences in the metabolism of N-2-fluorenylacetamide in the guinea pig and the rat. Cancer Res (1958) 0.84
Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutat Res (1975) 17.12
Positive selection for loss of tetracycline resistance. J Bacteriol (1980) 15.79
Positive control of a regulon for defenses against oxidative stress and some heat-shock proteins in Salmonella typhimurium. Cell (1985) 12.51
Revised methods for the Salmonella mutagenicity test. Mutat Res (1983) 11.60
Bilirubin is an antioxidant of possible physiological importance. Science (1987) 11.26
The free radical theory of aging matures. Physiol Rev (1998) 9.83
Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. Science (1983) 9.38
Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection. Proc Natl Acad Sci U S A (1973) 9.09
Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals. Proc Natl Acad Sci U S A (1975) 8.66
An improved bacterial test system for the detection and classification of mutagens and carcinogens. Proc Natl Acad Sci U S A (1973) 8.45
Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis. Proc Natl Acad Sci U S A (1981) 8.45
Procedure for identifying nonsense mutations. J Bacteriol (1968) 8.16
Localized mutagenesis of any specific small region of the bacterial chromosome. Proc Natl Acad Sci U S A (1971) 7.98
A Series of Histidineless Mutants of Neurospora Crassa. Genetics (1952) 7.20
Classification of aminotransferase (C gene) mutants in the histidine operon. J Mol Biol (1966) 6.92
Oxidative damage and mitochondrial decay in aging. Proc Natl Acad Sci U S A (1994) 6.84
Complete analysis of cellular nucleotides by two-dimensional thin layer chromatography. J Biol Chem (1982) 6.69
Frameshift mutagenesis in Salmonella. Cold Spring Harb Symp Quant Biol (1966) 6.53
Compounds which serve as the sole source of carbon or nitrogen for Salmonella typhimurium LT-2. J Bacteriol (1969) 5.99
Iron uptake in Salmonella typhimurium: utilization of exogenous siderochromes as iron carriers. J Bacteriol (1972) 5.77
Transcriptional regulator of oxidative stress-inducible genes: direct activation by oxidation. Science (1990) 5.53
Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc Natl Acad Sci U S A (1988) 5.52
Detection of carcinogens as mutagens: bacterial tester strains with R factor plasmids. Proc Natl Acad Sci U S A (1975) 5.51
Hydrogen peroxide-inducible proteins in Salmonella typhimurium overlap with heat shock and other stress proteins. Proc Natl Acad Sci U S A (1986) 5.29
Transport of antibiotics and metabolite analogs by systems under cyclic AMP control: positive selection of Salmonella typhimurium cya and crp mutants. J Bacteriol (1978) 4.91
Oxygen radicals and human disease. Ann Intern Med (1987) 4.57
Iron transport in Salmonella typhimurium: mutants blocked in the biosynthesis of enterobactin. J Bacteriol (1970) 4.44
Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci U S A (1997) 4.38
Histidine regulatory mutants in Salmonella typhimurium II. Histidine regulatory mutants having altered histidyl-tRNA synthetase. J Mol Biol (1966) 4.15
Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine. Proc Natl Acad Sci U S A (1990) 4.06
Ascorbate is an outstanding antioxidant in human blood plasma. Proc Natl Acad Sci U S A (1989) 4.02
Oxidative decay of DNA. J Biol Chem (1997) 3.94
Histidine regulatory mutants in Salmonella typhimurium 3. A class of regulatory mutants deficient in tRNA for histidine. J Mol Biol (1966) 3.80
OxyR, a positive regulator of hydrogen peroxide-inducible genes in Escherichia coli and Salmonella typhimurium, is homologous to a family of bacterial regulatory proteins. Proc Natl Acad Sci U S A (1989) 3.77
An alkyl hydroperoxide reductase from Salmonella typhimurium involved in the defense of DNA against oxidative damage. Purification and properties. J Biol Chem (1989) 3.74
AppppA, heat-shock stress, and cell oxidation. Proc Natl Acad Sci U S A (1983) 3.68
Carcinogens as frameshift mutagens: metabolites and derivatives of 2-acetylaminofluorene and other aromatic amine carcinogens. Proc Natl Acad Sci U S A (1972) 3.61
Histidine regulation in Salmonella typhimurium. XI. The percentage of transfer RNA His charged in vivo and its relation to the repression of the histidine operon. J Mol Biol (1972) 3.60
[Mutant tRNA His ineffective in repression and lacking two pseudouridine modifications]. Nat New Biol (1972) 3.57
Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals: discussion. Proc Natl Acad Sci U S A (1976) 3.46
The leader mRNA of the histidine attenuator region resembles tRNAHis: possible general regulatory implications. Proc Natl Acad Sci U S A (1983) 3.43
Antioxidant defenses and lipid peroxidation in human blood plasma. Proc Natl Acad Sci U S A (1988) 3.42
Epoxides of carcinogenic polycyclic hydrocarbons are frameshift mutagens. Science (1972) 3.42
Adenosine 3':5'-cyclic monophosphate concentration in the bacterial host regulates the viral decision between lysogeny and lysis. Proc Natl Acad Sci U S A (1971) 3.39
Positive selection of mutants with deletions of the gal-chl region of the Salmonella chromosome as a screening procedure for mutagens that cause deletions. J Bacteriol (1975) 3.37
An alkyl hydroperoxide reductase induced by oxidative stress in Salmonella typhimurium and Escherichia coli: genetic characterization and cloning of ahp. J Bacteriol (1989) 3.37
Antioxidant activity of albumin-bound bilirubin. Proc Natl Acad Sci U S A (1987) 3.35
AppppA and related adenylylated nucleotides are synthesized as a consequence of oxidation stress. Cell (1984) 3.25
Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning? Free Radic Biol Med (2005) 3.13
Regulation of nonspecific acid phosphatase in Salmonella: phoN and phoP genes. J Bacteriol (1979) 3.09
Guanosine 5'-diphosphate 3'-diphosphate (ppGpp): positive effector for histidine operon transcription and general signal for amino-acid deficiency. Proc Natl Acad Sci U S A (1975) 3.05
Urinary 8-hydroxy-2'-deoxyguanosine as a biological marker of in vivo oxidative DNA damage. Proc Natl Acad Sci U S A (1989) 2.92
gamma-tocopherol, the major form of vitamin E in the US diet, deserves more attention. Am J Clin Nutr (2001) 2.91
Bacterial defenses against oxidative stress. Trends Genet (1990) 2.89
Oxidative DNA damage and senescence of human diploid fibroblast cells. Proc Natl Acad Sci U S A (1995) 2.89
Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein assay. Anal Biochem (1983) 2.85
Thymine glycol and thymidine glycol in human and rat urine: a possible assay for oxidative DNA damage. Proc Natl Acad Sci U S A (1984) 2.82
Regulation of two phosphatases and a cyclic phosphodiesterase of Salmonella typhimurium. J Bacteriol (1977) 2.68
A new Salmonella tester strain (TA102) with A X T base pairs at the site of mutation detects oxidative mutagens. Proc Natl Acad Sci U S A (1982) 2.67
Oxidative damage to DNA: relation to species metabolic rate and life span. Proc Natl Acad Sci U S A (1988) 2.62
Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells. Proc Natl Acad Sci U S A (1994) 2.55
Hair dyes are mutagenic: identification of a variety of mutagenic ingredients. Proc Natl Acad Sci U S A (1975) 2.55
Identification and molecular analysis of oxyR-regulated promoters important for the bacterial adaptation to oxidative stress. J Mol Biol (1989) 2.52
Spontaneous mutagenesis and oxidative damage to DNA in Salmonella typhimurium. Proc Natl Acad Sci U S A (1987) 2.51
Mode of action of the herbicide, 3-amino-1,2,4-triazole(amitrole): inhibition of an enzyme of histidine biosynthesis. Arch Biochem Biophys (1965) 2.46
Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication. Biochem J (1998) 2.41
Biosynthesis of pseudouridine in transfer ribonucleic acid. J Biol Chem (1974) 2.36
Effect of the alpha-hydrazino analogue of histidine on histidine transport and arginine biosynthesis. J Biol Chem (1966) 2.35
Pleiotropy of hisT mutants blocked in pseudouridine synthesis in tRNA: leucine and isoleucine-valine operons. Proc Natl Acad Sci U S A (1974) 2.31
Histidine regulatory mutants in Salmonella typhimurium. IV. A positive selection for polar histidine-requiring mutants from histidine operator constitutive mutants. J Mol Biol (1967) 2.30
Complete analysis of tRNA-modified nucleosides by high-performance liquid chromatography: the 29 modified nucleosides of Salmonella typhimurium and Escherichia coli tRNA. Anal Biochem (1983) 2.29
gamma-tocopherol and its major metabolite, in contrast to alpha-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells. Proc Natl Acad Sci U S A (2000) 2.29
Illicit transport: the oligopeptide permease. Proc Natl Acad Sci U S A (1973) 2.22
Identifying environmental chemicals causing mutations and cancer. Science (1979) 2.22
Ranking possible carcinogenic hazards. Science (1987) 2.06
Chronological supplement to the Carcinogenic Potency Database: standardized results of animal bioassays published through December 1982. Environ Health Perspect (1986) 2.06
Antioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brain. Proc Natl Acad Sci U S A (1988) 2.04
Histidine regulation in Salmonella typhimurium. IX. Histidine transfer ribonucleic acid of the regulatory mutants. J Biol Chem (1972) 2.04
Transfer RNA and the control of the histidine operon. Cold Spring Harb Symp Quant Biol (1966) 2.02
DNA oxidation matters: the HPLC-electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine. Proc Natl Acad Sci U S A (1998) 2.01
Endogenous oxidative damage of deoxycytidine in DNA. Proc Natl Acad Sci U S A (1992) 1.98
Alkyl hydroperoxide reductase from Salmonella typhimurium. Sequence and homology to thioredoxin reductase and other flavoprotein disulfide oxidoreductases. J Biol Chem (1990) 1.95
Gamma-tocopherol prevents airway eosinophilia and mucous cell hyperplasia in experimentally induced allergic rhinitis and asthma. Clin Exp Allergy (2007) 1.93
gamma-tocopherol traps mutagenic electrophiles such as NO(X) and complements alpha-tocopherol: physiological implications. Proc Natl Acad Sci U S A (1997) 1.91
A modified nucleotide in tRNA as a possible regulator of aerobiosis: synthesis of cis-2-methyl-thioribosylzeatin in the tRNA of Salmonella. Cell (1984) 1.90
Immobilization stress causes oxidative damage to lipid, protein, and DNA in the brain of rats. FASEB J (1996) 1.83
Hydroxymethyluracil DNA glycosylase in mammalian cells. Proc Natl Acad Sci U S A (1984) 1.83
Mitochondrial decay in hepatocytes from old rats: membrane potential declines, heterogeneity and oxidants increase. Proc Natl Acad Sci U S A (1997) 1.83
Resolution and purification of three periplasmic phosphatases of Salmonella typhimurium. J Bacteriol (1977) 1.83
Mutagenicity of chloroacetaldehyde, a possible metabolic product of 1,2-dichloroethane (ethylene dichloride), chloroethanol (ethylene chlorohydrin), vinyl chloride, and cyclophosphamide. Proc Natl Acad Sci U S A (1975) 1.81
Extensive oxidative DNA damage in hepatocytes of transgenic mice with chronic active hepatitis destined to develop hepatocellular carcinoma. Proc Natl Acad Sci U S A (1994) 1.79
Assay of excised oxidative DNA lesions: isolation of 8-oxoguanine and its nucleoside derivatives from biological fluids with a monoclonal antibody column. Proc Natl Acad Sci U S A (1992) 1.76
Detection of mutagenic activity in cigarette smoke condensates. Proc Natl Acad Sci U S A (1974) 1.74
Ascorbic acid protects against endogenous oxidative DNA damage in human sperm. Proc Natl Acad Sci U S A (1991) 1.74
Evaluation of an isoluminol chemiluminescence assay for the detection of hydroperoxides in human blood plasma. Anal Biochem (1988) 1.73
Gas phase oxidants of cigarette smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma. Protective effects of ascorbic acid. Biochem J (1991) 1.73
The Carcinogenic Potency Database: analyses of 4000 chronic animal cancer experiments published in the general literature and by the U.S. National Cancer Institute/National Toxicology Program. Environ Health Perspect (1991) 1.72
Pseudouridylation of tRNAs and its role in regulation in Salmonella typhimurium. J Biol Chem (1979) 1.72